• Neural Foramina
    • Manas Sharma
    • Manas Sharma: Influence Statistics

      Manas Sharma

      Manas Sharma

      Department of Radiology, London Health Sciences Centre, London, Ontario, Canada | Department of Radiology, London Health Sciences Centre, London, Ontario, Canada . | ...

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      Manas Sharma:Expert Impact

      Concepts for whichManas Sharmahas direct influence:Neural foramina,Genomic deletions,Flexible nasopharyngoscopy,Angiographic source images,Acute stroke,Acute ischemic stroke,Unilateral cortical,White matter lesions.

      Manas Sharma:KOL impact

      Concepts related to the work of other authors for whichfor which Manas Sharma has influence:Multiple sclerosis,Central vein sign,Acute stroke,Autoimmune encephalitis,Angiography source images,Myelin oligodendrocyte,Iron rims.

      KOL Resume for Manas Sharma


      Department of Radiology, London Health Sciences Centre, London, Ontario, Canada


      London Health Sciences Centre, London, ON, Canada


      Consultant Neuroradiologists, University Hospital, London Health Sciences Centre, London, Ontario, Canada


      Department of Human Genetics (B.N., Q.S.P.), Graduate School of Public Health, University of Pittsburgh; Department of Medical Sciences (E.G., A.B.), University of Torino, Italy; Department of Radiology (R.R.), Uppsala University, Sweden; Department of Medical Genetics (A.L.), British Columbia Children's Hospital, Vancouver, Canada; Department of Genome Sciences (M. Spielmann), University of Washington, Seattle; Department of Pediatrics (M.K.K., R.A., M.K.), McGovern Medical School, University of Texas, Houston; Departments of Clinical Genomics and Neurology (R.G.), Mayo Clinic, Rochester, MN; Department of Pathology (M.A.), King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Imaging (M. Sharma), Western University, London, Canada; Departments of Pathology and Clinical Neurological Sciences (R.H.), Western University and London Health Sciences Centre, Canada; Office of the Clinical Director (W.A.G., C.T.), NHGRI; and NIH Undiagnosed Diseases Program (W.A.G., C.T.), Office of the Director, NIH, Bethesda, MD.


      Medical Imaging (B.Y.M.K., F.S., M.S.)

      Department of Clinical Neurological Sciences (M.S., M.K.), Western University and London Health Sciences Centre, London, Ontario, Canada


      3Medical Imaging, and.

      Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St N, N6A 5B7, London, Ontario, Canada


      Department of Medical Imaging, Western University, London, Ontario, Canada, .

      Digital Imaging Group (DIG), London, Ontario, Canada


      Department of Medical Biophysics, University of Western Ontario, London, Canada, ON


      From the Departments of Clinical Neurological Sciences (P.R., T.G.), Critical Care (F.M.), and Medical Imaging (M.S.), University of Western Ontario, London, Canada.

      Department of Medical Imaging, London Health Sciences Centre and Western University, London, Ontario, Canada


      Division of Neuroradiology, Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Ave, Room AG31D, Toronto, ON, Canada M4N 3M5.


      Department of Medical Imaging University of Toronto and Sunnybrook Health Sciences Centre Toronto, Ontario, Canada


      From the Department of Medical Imaging, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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      Sample of concepts for which Manas Sharma is among the top experts in the world.
      Concept World rank
      brainstem developmental #4
      flair antimog #4
      antimog flames #4
      cbv ctasi #5
      automatic vertebra recognition #7
      vertebra recognition #7
      cta cbv #7
      antimogassociated encephalitis seizures #7
      radiographic syndrome #8
      seizures flames #8
      modern multisection scanners #10
      lmnb1 upstream deletions #11
      deletions lmnb1 #11
      leukodystrophy lmnb1 #11
      increased lmnb1 expression #11
      lmnb1 duplications patients #11
      mri acgh #11
      progressive hypophonia #11
      deletions leukodystrophy #11
      antimogassociated encephalitis #12
      upstream lmnb1 #13
      lmnb1 upstream #13
      ctasi cbv #17
      patients genomic deletions #19
      lamin lead #20
      expression analysis patients #21
      cortical flair #22
      neural foraminal stenosis #23
      stenosis nfs #24
      acute stroke perfusion #25
      flexible nasopharyngoscopy #26
      vertebra locations #28
      3 independent families #29
      angiographic source images #29
      regression segmentation #29
      patients lmnb1 #30
      32 52 years #31
      glycoprotein seizures #36
      angiographic source #42
      neurologic mri #43
      atypical autosomal #47
      670 kb #51
      spine vertebra #51
      perfusion acute stroke #53
      upstream deletions #54
      mog encephalitis #57
      volume epidural #57
      duplications upstream #66
      disorders pseudotumor #69
      cortical symptoms #77
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      Prominent publications by Manas Sharma

      KOL-Index: 9769

      ObjectiveTo characterize the clinical symptoms and magnetic resonance imaging (MRI) findings of unilateral cortical FLAIR-hyperintense Lesions in Anti-MOG-associated Encephalitis with Seizures (FLAMES).MethodsThis is a case report and systematic review of the literature to identify cases of unilateral cortical FLAMES. Cases were reviewed to determine the frequency of clinical symptoms (seizures, headache, fever and cortical symptoms referable to FLAMES location), and to determine whether ...

      Known for Unilateral Cortical | Seizures Headache | Hyperintense Lesions | Meningeal Inflammation | Antimogassociated Encephalitis
      KOL-Index: 6425

      BACKGROUND AND PURPOSE: CTA-SI have been previously reported to correlate with CBV. We hypothesized that CTA-SI performed by modern multisection CT scanners are CBF-, not CBV-weighted.

      MATERIALS AND METHODS: Sixty-four consecutive patients with anterior circulation stroke symptoms were selected from a stroke data base between June 2007 and January 2009. Two independent blinded readers calculated defect volumes of CTA-SI and PCCT, CBF, and CBV images. Spearman correlation of lesion ...

      Known for Angiographic Source Images | Cta Cbv | Spearman Correlation | Lesion Volumes | Anterior Circulation
      KOL-Index: 6075

      BACKGROUND: A definitive diagnosis of multiple sclerosis (MS), as distinct from a clinically isolated syndrome, requires one of two conditions: a second clinical attack or particular magnetic resonance imaging (MRI) findings as defined by the McDonald criteria. MRI is also important after a diagnosis is made as a means of monitoring subclinical disease activity. While a standardized protocol for diagnostic and follow-up MRI has been developed by the Consortium of Multiple Sclerosis ...

      Known for Mri Diagnosis | Multiple Sclerosis | Resonance Imaging | Consensus Recommendations | Humans Magnetic
      KOL-Index: 4447

      BACKGROUND AND PURPOSE: Recently published North American Imaging in Multiple Sclerosis guidelines call for derivation of a specific radiologic definition of MS WM lesions and mimics. The purpose of this study was to use SWI and magnetization-prepared FLAIR images for sensitive differentiation of MS from benign WM lesions using the morphologic characteristics of WM lesions.

      MATERIALS AND METHODS: Seventeen patients with relapsing-remitting MS and 18 healthy control subjects were enrolled ...

      Known for White Matter | Central Vein | Wm Lesions | Field Mri | Multiple Sclerosis
      KOL-Index: 3979

      As a common disease in the elderly, neural foramina stenosis (NFS) brings a significantly negative impact on the quality of life due to its symptoms including pain, disability, fall risk and depression. Accurate boundary delineation is essential to the clinical diagnosis and treatment of NFS. However, existing clinical routine is extremely tedious and inefficient due to the requirement of physicians' intensively manual delineation. Automated delineation is highly needed but faces big ...

      Known for Neural Foramina | Boundary Delineation | Spinal Stenosis | Proposed Framework | Automated Accurate
      KOL-Index: 3722

      Computer-aided diagnosis of spine problems relies on the automatic identification of spine structures in images. The task of automatic vertebra recognition is to identify the global spine and local vertebra structural information such as spine shape, vertebra location and pose. Vertebra recognition is challenging due to the large appearance variations in different image modalities/views and the high geometric distortions in spine shape. Existing vertebra recognitions are usually ...

      Known for Vertebra Recognition | Spine Shape | Computeraided Diagnosis | Image Modalities | Ray Computed
      KOL-Index: 3354

      Accurate segmentation and area estimation of neural foramina from both CT and MR images are essential to clinical diagnosis of neural foramina stenosis. Existing clinical routine, relying on physician's purely manual segmentation, becomes very tedious, laborious, and inefficient. Automated segmentation is highly desirable but faces big challenges from diverse boundary, local weak/no boundary, and intra/inter-modality intensity inhomogeneity. In this paper, a novel boundary regression ...

      Known for Neural Foramina | Automated Segmentation | Proposed Framework | Regression Model | Support Vector
      KOL-Index: 3287

      Spontaneous intracranial hypotension (SIH) is a progressive clinical syndrome characterized by orthostatic headaches, nausea, emesis, and occasionally focal neurological deficits. Rarely, SIH is associated with neurocognitive changes. An epidural blood patch (EBP) is commonly used to treat SIH when conservative measures are inadequate, although some patients require multiple EBP procedures or do not respond at all. Recently, the use of a large-volume (LV) EBP has been described to treat ...

      Known for Epidural Blood | Intracranial Hypotension | Patch Ebp | Large Volume | Treat Sih
      KOL-Index: 3044

      BACKGROUND: Carotid stent fractures are rare, and multiple etiologies have been proposed to explain their occurrence. We describe a patient with an internal carotid artery (ICA) stent who developed in-stent restenosis. We performed balloon angioplasty to address in-stent restenosis, but he developed a carotid stent fracture after the procedure. To our knowledge, balloon angioplasty has not been reported to cause stent fractures.

      CASE DESCRIPTION: A 72-year-old man underwent stent ...

      Known for Stent Restenosis | Angioplasty Balloon | Vertebral Artery | Prosthesis Failure
      KOL-Index: 2427

      Adult-onset leukodystrophies are clinically and pathologically heterogeneous diseases, and the overlapping morphologic features among these disorders can lead to confusion in pathologic classification. We report 3 recent autopsy cases that illustrate the clinicopathologic distinction between the 3 entities. The first, autosomal dominant leukodystrophy, is characterized clinically by early autonomic dysfunction and genetically by LMNB1 (lamin B1 gene) duplication. Recently, another ...

      Known for Adult Onset | Axonal Spheroids | Pigmented Glia | Orthochromatic Leukodystrophy | Pathologic Features
      KOL-Index: 2196

      Patients with intractable temporal lobe epilepsy (TLE) undergo surgical resection of the anterior temporal lobe. Preoperative assessment of TLE patients involves a multidisciplinary assessment and may involve the use of invasive electroencephalogram (EEG) recording for lateralization of seizure focus in ambiguous cases. Understanding the white matter fibre tracts affected in TLE may assist in preoperative lateralization and planning. We studied pre- and postoperative white matter fibre ...

      Known for White Matter | Temporal Lobe | Corpus Callosum | Seizure Focus | Electroencephalogram Eeg
      KOL-Index: 2151

      Objective: Clinical, radiologic, and molecular analysis of patients with genomic deletions upstream of the LMNB1 gene.

      Methods: Detailed neurologic, MRI examinations, custom array comparative genomic hybridization (aCGH) analysis, and expression analysis were performed in patients at different clinical centers. All procedures were approved by institutional review boards of the respective institutions.

      Results: Five patients from 3 independent families presented at ages ranging from 32 to ...

      Known for Autosomal Dominant | Deletions Upstream | Lmnb1 Duplications | Structural Variants | Adult Onset
      KOL-Index: 1628

      PURPOSE: This study evaluates hippocampal pathology through usage of ultra-high field 9.4T ex-vivo imaging of resected surgical specimens in patients who have undergone temporal lobe epilepsy surgery.

      METHOD AND MATERIALS: This is a retrospective interpretation of prospectively acquired data. MRI scanning of resected surgical specimens from patients who have undergone temporal lobe epilepsy surgery was performed on a 9.4T small bore Varian MR magnet. Structural images employed a balanced ...

      Known for Temporal Lobe | Epilepsy Patients | Hippocampus Humans | Region Hippocampal | Ultra Field
      KOL-Index: 1289
      Known for Acute Stroke | Brain Ischemia | Ray Computed
      KOL-Index: 1242
      Known for Seizures Flames | Antimogassociated Encephalitis | Flair Antimog | Unilateral Cortical

      Key People For Neural Foramina

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      Department of Radiology, London Health Sciences Centre, London, Ontario, Canada | Department of Radiology, London Health Sciences Centre, London, Ontario, Canada . | Department of Medical Imaging Western University London Ontario Canada | Department

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