• Disease
  • Cell
  • Cell Adhesion
  • Melitta Schachner

    Prominent publications by Melitta Schachner

    KOL Index score: 23519

    The cellular and subcellular localization of the neural cell adhesion molecules L1, N-CAM, and myelin-associated glycoprotein (MAG), their shared carbohydrate epitope L2/HNK-1, and the myelin basic protein (MBP) were studied by pre- and post-embedding immunoelectron microscopic labeling procedures in developing mouse sciatic nerve. L1 and N-CAM showed a similar staining pattern. Both were localized on small, non-myelinated, fasciculating axons and axons ensheathed by non-myelinating ...

    Also Ranks for: Sciatic Nerve |  myelin basic protein |  l1 ncam |  adhesion molecules |  nodes ranvier
    KOL Index score: 23105

    The involvement of the adhesion molecules L1, N-CAM, and J1 in adhesion and neurite outgrowth in the peripheral nervous system was investigated. We prepared Schwann cells and fibroblasts (from sciatic nerves) and neurons (from dorsal root ganglia) from 1-d mice. These cells were allowed to interact with each other in a short-term adhesion assay. We also measured outgrowth of dorsal root ganglion neurons on Schwann cell and fibroblast monolayers. Schwann cells (which express L1, N-CAM, ...

    Also Ranks for: Schwann Cells |  adhesion molecules |  peripheral nervous |  l1 ncam |  neurite outgrowth
    KOL Index score: 21480

    Some neurons in the brain and spinal cord will regenerate axons into a living peripheral nerve graft inserted at the site of injury, others will not. We have examined the patterns of expression of four molecules thought to be involved in developmental and regenerative axonal growth, in the cerebellum and brainstem of adult rats, following the implantation into the cerebellum of peripheral nerve grafts. We also determined how the expression patterns observed correlate with the abilities ...

    Also Ranks for: Messenger Rnas |  axonal regeneration |  l1 chl1 |  purkinje cells |  cns neurons
    KOL Index score: 19406

    Schwann cells from early postnatal mouse sciatic nerve were obtained as a homogenous population and shown by indirect immunofluorescence to express the neural cell adhesion molecules L1, N-CAM and J1 and their common carbohydrate epitope L2/HNK-1. L1 and N-CAM are synthesized in molecular forms that are slightly different from those expressed by small cerebellar neurons or astrocytes. As in astrocytes, the J1 antigen is expressed by Schwann cells in multiple forms generally ranging from ...

    Also Ranks for: Schwann Cells |  cell adhesion |  l1 expression |  nerve growth factor |  monoclonal antigens
    KOL Index score: 19136

    The localization of the neural cell adhesion molecules L1, N-CAM, and the myelin-associated glycoprotein was studied by pre- and postembedding staining procedures at the light and electron microscopic levels in transected and crushed adult mouse sciatic nerve. During the first 2-6 d after transection, myelinated and nonmyelinated axons degenerated in the distal part of the proximal stump close to the transection site and over the entire length of the distal part of the transected nerve. ...

    Also Ranks for: L1 Ncam |  schwann cells |  adhesion molecules |  regrowing axons |  myelinassociated glycoprotein
    KOL Index score: 17893

    Because of the importance of neural recognition molecules expressed by glial cells to mediate interactions with neurons, growth factors and cytokines known to be functional during morphogenesis and in diseases of the nervous system were studied for their effects on recognition molecule expression by cultured immature and mature astrocytes from several brain regions. In cultures of immature astrocytes, transforming growth factors-beta 1 (TGF-beta 1) and -beta 2 (TGF-beta 2) and nerve ...

    Also Ranks for: Cultured Astrocytes |  beta 2 |  molecule expression |  growth factors |  northern blotting
    KOL Index score: 17836

    To gain insight into the possible molecular mechanisms underlying axonal regeneration of neurons of the adult central nervous system (CNS), we have investigated, by in situ hybridization and by immunocytochemistry, the localization and sites of synthesis of the neurite outgrowth-promoting cell surface molecules L1, N-CAM and its highly sialylated form, N-CAM-PSA, in and around peripheral nerve grafts implanted into the thalamus of adult rats. Normal unoperated adult rat thalamus contains ...

    Also Ranks for: Peripheral Nerve Grafts |  schwann cells |  molecular basis |  cell adhesion |  cns axons
    KOL Index score: 17173

    The occurrence of vimentin, a specific intermediate filament protein, has been studied by immunoflourescence microscopy in tissue of adult and embryonic brain as well as in cell cultures from nervous tissue. By double imminofluorescence labeling, the distribution of vimentin has been compared with that of subunit proteins of other types of intermediate filaments (glial fibrillary acidic [GFA] protein, neurofilament protein, prekeratin) and other cell-type specific markers (fibronectin, ...

    Also Ranks for: Ependymal Cells |  vimentin astrocytes |  mouse nervous |  immunocytochemical demonstration |  cell type
    KOL Index score: 17032

    Levels of the neural cell adhesion molecule N-CAM in muscle are regulated in parallel with the susceptibility of muscle to innervation: N-CAM is abundant on the surface of early embryonic myotubes, declines in level as development proceeds, reappears when adult muscles are denervated or paralyzed, and is lost after reinnervation (Covault, J., and J. R. Sanes, 1985, Proc. Natl. Acad. Sci. USA, 82:4544-4548). Here we used immunocytochemical methods to compare this pattern of expression ...

    Also Ranks for: Heparan Sulfate Proteoglycan |  ncam j1 |  adult skeletal muscle |  adhesion cell |  laminin fibronectin
    KOL Index score: 16986

    Parkinson's disease is the second most common neurodegenerative disease, after Alzheimer's disease, and the most common movement disorder. Drug treatment and deep brain stimulation can ameliorate symptoms, but the progressive degeneration of dopaminergic neurons in the substantia nigra eventually leads to severe motor dysfunction. The transplantation of stem cells has emerged as a promising approach to replace lost neurons in order to restore dopamine levels in the striatum and ...

    Also Ranks for: Stem Cell |  neural aggregates |  l1 overexpressing |  dopaminergic neurons |  functional recovery
    KOL Index score: 16257

    Peripheral nerves of P0-deficient mice display a severe dysmyelinating phenotype, confirming the view that P0 mediates myelin formation and compaction. In addition to the compromised myelin organization, an elevated expression of several cell recognition molecules was described in the axon-Schwann cell units of P0-deficient mice. The present study was performed to focus on the subcellular localization and functional roles of two of these up-regulated molecules, the neural cell adhesion ...

    Also Ranks for: Schwann Cell |  deficient mice |  myelin p0 |  knockout microscopy |  ncam mag
    KOL Index score: 16151

    The neural cell adhesion molecule NCAM and its associated polysialic acid (PSA) play important roles in synaptic plasticity in the CA1 and/or CA3 regions of the hippocampus in vitro. Here, we address the question of whether NCAM and PSA are involved in regulation of synaptic transmission and plasticity also in vivo at synapses formed by entorhinal cortex axons in the dentate gyrus of mice anaesthetized with urethane. We show that basal synaptic transmission, measured as the slope of ...

    Also Ranks for: Dentate Gyrus |  synaptic plasticity |  polysialic acid |  cell adhesion |  ncam mice
    KOL Index score: 15965

    Cell adhesion molecules (CAMs), particularly L1, are important for axonal growth on Schwann cells in vitro. We have used in situ hybridization to study the expression of mRNAs for L1 and its close homologue CHL1, by neurons regenerating their axons in vivo, and have compared CAM expression with that of GAP-43. Adult rat sciatic nerves were crushed (allowing functional regeneration), or cut and ligated to maintain axonal sprouting but prevent reconnection with targets. In other animals ...

    Also Ranks for: Sciatic Nerve |  motor neurons |  chl1 mrna |  dorsal root injury |  expression gap43
    KOL Index score: 15908

    Several glia-associated cell surface molecules have been implicated in myelin formation in the central (CNS) and peripheral nervous system (PNS). Recent studies in mice deficient for such molecules have been instrumental in understanding the role of these molecules during the formation of the spiraling loops around the axon, compaction of the spiraling loops, determination of the thickness of the myelin sheath, and myelin maintenance. In the PNS, the major peripheral myelin protein PO ...

    Also Ranks for: Myelin Formation |  cell surface |  mag maintenance |  mice molecules |  pmp22 mbp
    KOL Index score: 15770

    On neural cells, the cell adhesion molecule L1 is generally found coexpressed with N-CAM. The two molecules have been suggested, but not directly shown, to affect each other's function. To investigate the possible functional relationship between the two molecules, we have characterized the adhesive interactions between the purified molecules and between cultured cells expressing them. Latex beads were coated with purified L1 and found to aggregate slowly. N-CAM-coated beads did not ...

    Also Ranks for: L1 Ncam |  cell adhesion |  beads coated |  low ca2


    Melitta Schachner: Influence Statistics

    Sample of concepts for which Melitta Schachner is among the top experts in the world.
    Concept World rank
    m1 antigen astrocytes #1
    hippocampus ncam mice #1
    potentiation auditoryevoked potentials #1
    180 kd component #1
    antibody l1 #1
    gaba‐induced depolarization #1
    absence ncam #1
    spinal cord l1fc #1
    ranvier mag #1
    drd2 chl1 #1
    mvp locomotor recovery #1
    r184w #1
    juvenile chl1‐deficient mice #1
    tenascin‐c mutant mouse #1
    association l1 #1
    trka neurons axons #1
    tenascin immunoreactivity neostriatum #1
    homolog chl1 #1
    antibody hnk1 #1
    ncam total ncam #1
    astrocytes boundaries #1
    zebrafish development expression #1
    hnk1 l3 #1
    fniii domain immunoprecipitations #1
    histotypic pattern formation #1
    p59fyn activation #1
    messenger recovery function #1
    mag schwann cell #1
    n1 antigen cultures #1
    retinal neurite #1
    grey matter cells #1
    mag fyn mag #1
    neurite outgrowth nogoa #1
    antibodyinduced #1
    cell surfaces oligodendrocytes #1
    schwann cells molecules #1
    l1 140 #1
    chaseabc #1
    l1 pten #1
    binding hnk1 carbohydrate #1
    outgrowth l1 #1
    corticospinal axons axons #1
    footshock sensitization habituation #1
    l1 contact sites #1
    janusin cells #1
    neuron‐glia interactionsa #1
    adhesion molecule glia #1
    mice chl1 mice #1
    peripheral nerve p0 #1
    substantia nigra l1 #1

    Key People For Cell Adhesion

    Top KOLs in the world
    Richard O Hynes
    extracellular matrix cell adhesion alternative splicing
    Timothy A Springer
    monoclonal antigens cell adhesion lymphocyte function
    Erkki I Ruoslahti
    cell adhesion fibronectin receptor amniotic fluid
    Kenneth Manao Yamada
    cell adhesion branching morphogenesis fibronectin receptor
    Mark H Ginsberg
    integrin activation alpha iib cell migration
    Benjamin Geiger
    cell adhesion actin cytoskeleton focal contacts

    Melitta Schachner:Expert Impact

    Concepts for whichMelitta Schachnerhas direct influence:Cell adhesion,  Neurite outgrowth,  Adhesion molecule,  Spinal cord,  Schwann cells,  Adhesion molecules,  Neural cell,  Extracellular matrix.

    Melitta Schachner:KOL impact

    Concepts related to the work of other authors for whichfor which Melitta Schachner has influence:Spinal cord,  Cell adhesion,  Central nervous,  Neurite outgrowth,  Gene expression,  Growth factor,  Multiple sclerosis.



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    Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA. | Center for Neuroscience, Shantou University Medical College, 22 Xin Ling Road, Shantou, Guangdong 515041 China | Ke