• Disease
  • Spinal
  • Spinal Cord
  • Spinal Cord Injury
  • William H Donovan

    Prominent publications by William H Donovan

    KOL Index score: 11787

    OBJECTIVE: To determine differences between dalteparin and enoxaparin in patients with spinal cord injury.

    DESIGN: This prospective, randomized, open-label study was performed as a multiple hospital trial in a large urban setting. A total of 100 patients with acute (<3 mo) spinal cord injury were recruited. A total of 95 patients met all inclusion criteria. Fifty received enoxaparin, and 45 received dalteparin. Main outcome measures included deep venous thrombosis, bleeding, compliance, ...

    Also Ranks for: Deep Venous Thrombosis |  dalteparin enoxaparin |  spinal cord injury |  outcome venous |  patient compliance
    KOL Index score: 11669

    BACKGROUND: At the 2006 National Institute on Disability and Rehabilitation Research (NIDRR) sponsored pre-conference on spinal cord injury (SCI) outcomes, several gait and ambulation measures were evaluated for utility in clinical practice, validity, and reliability as research measurement tools. The Conference Subcommittee on Gait and Ambulation chose to review the Walking Index for Spinal Cord Injury II (WISCI II), 50-Foot Walk Test (50FTWT), 6-Minute Walk Test (6MWT), 10-Meter Walk ...

    Also Ranks for: Outcome Measure |  spinal cord injury |  wisci sci |  validity reliability |  improvement gait
    KOL Index score: 10666

    OBJECTIVE: To present data on neurologic recovery gathered by the Model Spinal Cord Injury (SCI) Systems over a 10-year period.

    DESIGN: Case series.

    SETTING: Twenty-one Model SCI Systems.

    PATIENTS: A total of 3,585 individuals with traumatic SCI admitted between January 1, 1988 and December 31, 1997.

    MAIN OUTCOME MEASURES: Neurologic impairment category; Frankel grade; American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade; motor score.

    RESULTS: SCI caused by violence is ...

    Also Ranks for: Neurologic Recovery |  cord injury |  traumatic spinal |  sacral sparing |  motor score
    KOL Index score: 10584

    PURPOSE: Escherichia coli 83972 was previously shown to establish bladder colonization in select patient groups. We evaluate the safety and feasibility of using bacterial interference with E. coli 83972 to prevent urinary tract infection in spinal cord injured patients.

    MATERIALS AND METHODS: A total of 21 men and women with neurogenic bladder secondary to spinal cord injury underwent intravesical inoculation with E. coli 83972. Frequency of symptomatic urinary tract infection before and ...

    Also Ranks for: Urinary Tract Infection |  coli 83972 |  neurogenic bladder |  spinal cord |  bacterial interference
    KOL Index score: 9278

    Chronic bacteriuria is a common occurrence among spinal-cord injury patients and others with neuropathic bladders. If bacteria are present in the urinary tract, the patient may develop symptoms of infection or remain asymptomatic. We have compared virulence properties of 28 Escherichia coli isolates from patients with symptomatic urinary tract infections (UTI) and 29 E. coli isolates from patients with asymptomatic bacteriuria (ABU). Bacteria from patients with symptomatic UTI were more ...

    Also Ranks for: Asymptomatic Bacteriuria |  coli isolates |  spinal cord |  virulence factors |  microbial escherichia
    KOL Index score: 9186

    The effects of intrathecal baclofen infusion were studied in 9 spinal cord injury patients whose spasticity had been refractory to oral medications. In a two stage, placebo controlled trial, baclofen was administered into the lumbar intrathecal space and subsequent clinical and neurophysiologic changes were assessed. In stage 1, 9 patients underwent a 5 day percutaneous infusion of baclofen and placebo via an external pump. Ashworth and reflex scores were assessed at time of enrollment, ...

    Also Ranks for: Intrathecal Baclofen |  spinal cord |  continuous infusion |  reflex score |  patients spasticity
    KOL Index score: 8784

    The results of omental transposition in chronic spinal cord injury have been reported in 160 patients operated upon in the United States, Great Britain, China, Japan, India and Mexico, with detailed outcomes reported in few studies. Recovery of function to a greater degree than expected by natural history has been reported. In this series, 15 patients with chronic traumatic spinal cord injury (>1.5 years from injury) underwent transposition of pedicled omentum to the area of spinal cord ...

    Also Ranks for: Spinal Cord |  omental transposition |  patients chronic |  1 year |  follow studies
    KOL Index score: 8648

    OBJECTIVES: To examine the safety and efficacy of bacterial interference in preventing symptomatic urinary tract infection (UTI).

    METHODS: A prospective, nonrandomized, pilot clinical trial was conducted in patients with spinal cord injury who had neurogenic bladder and had frequent episodes of symptomatic UTI. The bladder of patients was inoculated with a nonpathogenic prototype of Escherichia coli 83972. The rate of symptomatic UTI in successfully colonized patients while colonized ...

    Also Ranks for: Bacterial Interference |  symptomatic uti |  urinary tract infection |  pilot trial |  coli 83972
    KOL Index score: 8432

    OBJECTIVES: To compare the effectiveness of bacterial interference versus placebo in preventing urinary tract infection (UTI).

    METHODS: The main outcome measure was the numbers of episodes of UTI/patient-year. Randomization was computer generated, with allocation concealment by visibly indistinguishable products distributed from a core facility. The healthcare providers and those assessing the outcomes were unaware of the group allocation. Adult patients (n = 65) with neurogenic bladder ...

    Also Ranks for: Neurogenic Bladder |  bacterial interference |  urinary tract infection |  symptomatic uti |  spinal cord injury
    KOL Index score: 8424

    OBJECTIVE: To examine differences in perceived quality of life (QOL) at 1 year postinjury between people with tetraplegia who required mechanical ventilation assistance at discharge from rehabilitation and those who did not.

    DESIGN: Prospective cross-sectional examination of people with spinal cord injury (SCI) drawn from the SCI Model Systems National Database.

    SETTING: Community.

    PARTICIPANTS: People with tetraplegia (N=1635) who sustained traumatic SCI between January 1, 1994, and ...

    Also Ranks for: Mechanical Ventilation |  spinal cord |  life qol |  perceived quality |  1 year
    KOL Index score: 7945

    This is the first guideline describing the International Standards to document remaining Autonomic Function after Spinal Cord Injury (ISAFSCI). This guideline should be used as an adjunct to the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) including the ASIA Impairment Scale (AIS), which documents the neurological examination of individuals with SCI. The Autonomic Standards Assessment Form is recommended to be completed during the evaluation of ...

    Also Ranks for: International Standards |  autonomic function |  individuals sci |  neurological classification |  spinal cord injury
    KOL Index score: 7809

    The latest revision of the International Standards for the Neurological Classification of Spinal Cord Injury (ISNCSCI) was available in booklet format in June 2011, and is published in this issue of the Journal of Spinal Cord Medicine. The ISNCSCI were initially developed in 1982 to provide guidelines for the consistent classification of the neurological level and extent of the injury to achieve reliable data for clinical care and research studies. This revision was generated from the ...

    Also Ranks for: International Standards |  neurological classification |  spinal cord |  2011 revision |  reliable data
    KOL Index score: 7498

    Recent clinical studies suggest that the deliberate colonization of the human bladder with a prototypic asymptomatic bacteriuria-associated bacterium, Escherichia coli 83972, may reduce the frequency of urinary tract infection in individuals with spinal cord injuries. However, the mechanism by which E. coli 83972 colonizes the bladder is unknown. We examined the role in bladder colonization of the E. coli 83972 genes papG and fimH, which respectively encode P and type 1 receptor-specific ...

    Also Ranks for: Escherichia Coli |  bladder colonization |  urinary tract infection |  fimbriae bacterial |  fimbria specific
    KOL Index score: 7496

    Neuropathic pain develops in 40-70% of spinal cord injury (SCI) patients and markedly compromises quality of life. We examined plasma from SCI patients for autoantibodies to glial fibrillary acidic protein (GFAP) and collapsin response mediator protein-2 (CRMP2) and evaluated their relationship to the development of neuropathic pain. In study 1, plasma samples and clinical data from 80 chronic SCI patients (1-41 years post-SCI) were collected and screened for GFAP autoantibodies ...

    Also Ranks for: Neuropathic Pain |  spinal cord |  response mediator |  acidic protein |  glial fibrillary


    William H Donovan: Influence Statistics

    Sample of concepts for which William H Donovan is among the top experts in the world.
    Concept World rank
    antibiotics intervening organism #1
    previnaire #1
    computer measurements telemetry #1
    external immobilization devices #1
    intervening organism #1
    1231 ±953 minutes #1
    chronic sci subject #1
    1992 international #1
    minor scoring errors #1
    infusion pump reservoir #1
    aminopyridine cerebrospinal #1
    plasmid analysis bacteria #1
    participants senior author #1
    neurologic examination sensation #1
    isncsci details #1
    20th century animal #1
    recolonization identical #1
    optimistic overview #1
    4–5 vital signs #1
    sci senior author #1
    examination sensation #1
    symptomatic uti isolates #1
    single motor scale #1
    intervening organism relapse #1
    exam neurologic #1
    subject intrathecal catheter #1
    equipment payers #1
    intrathecal administration 4ap #1
    neurologic recovery previnaire #1
    shortening hospitalization tetraplegics #1
    4ap csf #1
    recolonizations strain #1
    intrathecal baclofen tolerance #1
    routine baclofen infusion #1
    plasmid analysis pa #1
    advancement individual #1
    examination physiology #1
    single asia #1
    hypothesis separate scales #1
    details exam #1
    sensory motor levels #1
    general george patton #1
    neurological issues #1
    needed role #1
    telemetry examination #1
    february facility #1
    study gu pathology #1
    baclofen dosage spasticity #1

    Key People For Spinal Cord Injury

    Top KOLs in the world
    Michael George Fehlings
    spinal cord degenerative cervical myelopathy surgical decompression
    Michael S Beattie
    spinal cord cell death data sharing
    Jacqueline C Bresnahan
    spinal cord cell death data commons
    D Michele Basso
    spinal cord locomotor recovery pet dogs
    BieringSørensen BIERING‐SØRENSEN
    spinal cord international standards basic data
    Charles H Tator
    spinal cord conservative management blood flow

    William H Donovan:Expert Impact

    Concepts for whichWilliam H Donovanhas direct influence:Spinal cord injury,  Spinal cord,  International standards,  Cord injury,  Bacterial interference,  Neurological classification,  Intrathecal baclofen,  Urinary tract infection.

    William H Donovan:KOL impact

    Concepts related to the work of other authors for whichfor which William H Donovan has influence:Spinal cord injury,  Cord injuries,  Neuropathic pain,  Intrathecal baclofen,  Sci patients,  Autonomic dysreflexia,  Urinary tract.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    The Institute for Rehabilitation and Research (TIRR), TIRR 1333 Moursund St., 77030, Houston, TX, USA | Department of Physical Medicine and Rehabilitation, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth),