Prominent publications by H Richard Tyler

KOL Index score: 3117

In a number of experimental situations exogenously administered gangliosides have been demonstrated to speed recovery from axonotmesis. First demonstrated for the pre-and postganglionic sympathetic fibers of the cat nictitating membrane,1 it has now been demonstrated also for the rat sciatic nerve2 and rat tail nerve.3 The mechanism of action seems to be stimulation of the sprouting process.3,4 Hence, gangliosides would be expected to be beneficial in conditions such as traumatic nerve ...

Also Ranks for: Ganglioside Therapy |  amyotrophic lateral sclerosis |  topic diabetes mellitus |  diabetic neuropathy |  1 diabetes
KOL Index score: 3087

A 58-year-old woman experienced incapacitating headache and occipital paresthesiae for 5 years after lumbar myelography. Conservative methods of treatment failed. Successive investigations for a suspected cerebrospinal fluid (CSF) leak were unrevealing. Leakage of CSF from the subarachnoid space into the epidural space in the lumbar region was finally confirmed when oil-soluble contrast material (Pantopaque), injected into the cervical subarachnoid space, was revealed by a specific ...

Also Ranks for: Lumbar Puncture |  dural defect |  cerebrospinal fluid |  leakage csf |  headache humans
KOL Index score: 2102

Although the sudden flap, or lapse of posture, known as "asterixis" has become familiar as a distinct entity, its classic descriptions have always encompassed more than one form of abnormality.In 1949 Adams and Foley1 described a "fixed tremor state" in certain patients with liver disease.Two years later the same authors referred to the phenomena as a "motor disturbance—so unique that it merits a more complete description" (Adams and Foley, 1951).2 They then suggested that two ...

Also Ranks for: Liver Disease |  movement disorders |  diagnosis differential |  dyskinesias electromyography |  adams foley
KOL Index score: 1435

A recent epidemic of botulism afforded us the opportunity of recording some physiological observations, made for the first time, on the effect of the toxin in man. Previous knowledge of the physiological action of the botulinus toxin was based primarily on laboratory experimentation in cold- and warm-blooded animals. The marked species differences in response to toxin suggested the importance of confirming these laboratory observations in man.In 1874 Pürkhauser1 first suggested that in ...

Also Ranks for: Human Botulism |  repetitive stimulation |  physiological action |  botulinus toxin
KOL Index score: 1197
Also Ranks for: Paraneoplastic Syndromes |  nervous diseases |  neurons muscular

Neurology of the Larynx

KOL Index score: 920
Also Ranks for: Myasthenia Gravis |  cord paralysis |  humans laryngeal |  nerve vocal


KOL Index score: 845

Botulism is an extremely rare, yet deadly, form of food poisoning. Because of the reputation of the botulinus toxin as the "most poisonous poison"1 known to man, it has long captivated the interest of laymen, scientists, and physicians.Although cases of "sausage poisoning" were described as early as 1735, the first significant outbreak occurred in 1793 in Würtemberg. The term botulism (from the latin word Botulus, which means sausage) was applied to this syndrome. By 1802 the condition ...


KOL Index score: 282
Also Ranks for: Neurologic Manifestations |  dyskinesias humans

Key People For Lumbar Puncture

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H Richard Tyler:Expert Impact

Concepts for whichH Richard Tylerhas direct influence:Lumbar puncture,  Paraneoplastic syndromes,  Neurological complications,  Ganglioside therapy,  Human botulism,  Amyotrophic lateral sclerosis,  Lateral sclerosis,  Amyotrophic lateral.

H Richard Tyler:KOL impact

Concepts related to the work of other authors for whichfor which H Richard Tyler has influence:Measles virus,  Unilateral asterixis,  Botulinum toxin,  Hepatic encephalopathy,  Paraneoplastic syndromes,  Infant botulism,  Amyotrophic lateral sclerosis.



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Professor of Neurology, Harvard Medical School. Director, Neurological Services, Brigham and Women’s Hospital, Boston, Massachusetts | Section of Neurology, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA | Peter Bent Brigham Ho