H Richard Tyler

In a number of experimental situations exogenously administered gangliosides have been demonstrated to speed recovery from axonotmesis. First demonstrated for the pre-and postganglionic sympathetic fibers of the cat nictitating membrane,1 it has now been demonstrated also for the rat sciatic nerve2 and rat tail nerve.3 The mechanism of action seems to be stimulation of the sprouting process.3,4 Hence, gangliosides would be expected to be beneficial in conditions such as traumatic nerve ...

A 58-year-old woman experienced incapacitating headache and occipital paresthesiae for 5 years after lumbar myelography. Conservative methods of treatment failed. Successive investigations for a suspected cerebrospinal fluid (CSF) leak were unrevealing. Leakage of CSF from the subarachnoid space into the epidural space in the lumbar region was finally confirmed when oil-soluble contrast material (Pantopaque), injected into the cervical subarachnoid space, was revealed by a specific ...

Although the sudden flap, or lapse of posture, known as "asterixis" has become familiar as a distinct entity, its classic descriptions have always encompassed more than one form of abnormality.In 1949 Adams and Foley1 described a "fixed tremor state" in certain patients with liver disease.Two years later the same authors referred to the phenomena as a "motor disturbance—so unique that it merits a more complete description" (Adams and Foley, 1951).2 They then suggested that two ...

A recent epidemic of botulism afforded us the opportunity of recording some physiological observations, made for the first time, on the effect of the toxin in man. Previous knowledge of the physiological action of the botulinus toxin was based primarily on laboratory experimentation in cold- and warm-blooded animals. The marked species differences in response to toxin suggested the importance of confirming these laboratory observations in man.In 1874 Pürkhauser1 first suggested that in ...

Botulism is an extremely rare, yet deadly, form of food poisoning. Because of the reputation of the botulinus toxin as the "most poisonous poison"1 known to man, it has long captivated the interest of laymen, scientists, and physicians.Although cases of "sausage poisoning" were described as early as 1735, the first significant outbreak occurred in 1793 in Würtemberg. The term botulism (from the latin word Botulus, which means sausage) was applied to this syndrome. By 1802 the condition ...