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    • Barry L Smith
    • Barry L Smith: Influence Statistics

      Barry L Smith

      Barry L Smith

      AgResearch, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton, New Zealand | AgResearch, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton 2001, ...

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      Barry L Smith:Expert Impact

      Concepts for whichBarry L Smithhas direct influence:New zealand,Facial eczema,Bracken fern,Ryegrass staggers,Body temperature,Butylated hydroxyanisole,Electromyographic activity.

      Barry L Smith:KOL impact

      Concepts related to the work of other authors for whichfor which Barry L Smith has influence:New zealand,Facial eczema,Pteridium aquilinum,Bracken fern,Ergot alkaloids,Urinary bladder,Perennial ryegrass.

      KOL Resume for Barry L Smith

      Year
      2007

      AgResearch, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton, New Zealand

      2005

      AgResearch, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton 2001, New Zealand

      2003

      Food Science Group, AgResearch, Ruakura Research Centre, PB 3123, Hamilton, New Zealand

      2002

      Toxinology and Food Safety Research Group, AgResearch, Ruakura Research Centre, Hamilton, New Zealand.

      2001

      Toxinology and Food Safety Research Group, New Zealand Pastoral Agricultural Research Institute, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton, New Zealand

      1999

      Toxinology and Food Safety Research Group, New Zealand Pastoral Agriculture Research Institute (Ltd), Hamilton, PB 3123, New Zealand

      1998

      AgResearch, Ruakura Agricultural Research Centre, East Street, Private Bag 3123, Hamilton, New Zealand

      1997

      New Zealand Pastoral Agricultural Research Institute Ltd, Ruakura Research Centre, Hamilton, New Zealand

      1996

      New Zealand Pastoral Agriculture Research Institute, Ruakara Agricultural Research Centre, Hamilton New Zealand

      1995

      Senior Scientist, AgResearch, New Zealand Pastoral Agriculture Research Institute Ltd., Ruakura Agricultural Centre, East Street, Private Bag 3123, Hamilton, New Zealand

      1994

      New Zealand Pastoral Agriculture Research Institute, Hamilton, New Zealand

      1993

      New Zealand Pastoral Agriculture Research Institute (Ltd), Ruakura Agricultural Centre, Private Bag, Hamilton, New Zealand

      1992

      MAF Technology, Ruakura Agricultural Centre, Private Bag, Hamilton, New Zealand

      1991

      Ruakura Agricultural Centre, Private Bag, Hamilton, New Zealand.

      1989

      Ruakura Agricultural Centre, Ministry of Agriculture and Fisheries Private Bag, Hamilton New Zealand

      1987

      Ruakura Agricultural Research Centre, Ministry of Agriculture and Fisheries, Private Bag, Hamilton, New Zealand

      1986

      Ruakura Agricultural Research Centre, Private Bag, Hamilton, New Zealand.

      Sample of concepts for which Barry L Smith is among the top experts in the world.
      Concept World rank
      liver injury sporidesmin #1
      zinc pancreopathy #1
      developed liver lesions #1
      dosed nonsporidesmin #1
      508 450 units #1
      dosing loge #1
      prior sporidesmin intoxication #1
      lowest ranked bulls #1
      liver injury scores #1
      sporidesmin producing #1
      original field test #1
      sporidesmin minor #1
      extracts nonsporidesmin #1
      pancreopathy minor #1
      zincinduced pancreatic injury #1
      “low” bulls #1
      sporidesmin toxicity groups #1
      nonsporidesminproducing strain #1
      nonsporidesmin producing #1
      sporidesmin induced injury #1
      2yearold daughters #1
      isolate charturum #1
      pithomyces charturum #1
      spores sporidesmin #1
      sporidesmin dosing #1
      zinc sporidesmin challenge #1
      65 jersey bulls #1
      nonsporidesmin #1
      bulls susceptibility #1
      loge ggt values #1
      zinc liver injury #1
      prior sporidesmin #1
      charturum #1
      zinc sporidesmin #1
      seventyfour experimental calves #1
      sporidesminproducing isolate #1
      200 zn bodyweight #1
      sporidesmin cell culture #1
      pancreopathy zinc #1
      examination pancreopathy #1
      churtarum #1
      minor pancreatic injury #1
      charturum sporidesmin #1
      receiving sporidesmin #1
      toxicity nonsporidesmin #1
      injury pancreopathy #1
      caused sporidesmin #1
      bodyweight spread #1
      disruption digestion #2
      ergotamines kinetics #2

      Prominent publications by Barry L Smith

      KOL-Index: 9886

      AIMS: To study the increase in phylloerythrin concentration in plasma and the disposition of phylloerythrin in skin and other tissues of sheep in which the hepatogenous photosensitisation,facial eczema, had been experimentally induced by dosing with the mycotoxin, sporidesmin. Spectroscopic differences between plasma and skin measurements of animals kept inside and outside after dosing were also studied in order to establish whether phylloerythrin undergoes photodegradation when exposed ...

      Known for Facial Eczema | Phylloerythrin Plasma | Healthy Sheep | Emission Spectra | Exposed Sunlight
      KOL-Index: 8581

      Ryegrass staggers is a seasonal mycotoxicosis of grazing livestock characterised by tremors, in coordination and a staggering gait almost unaccompanied by physical lesions. Deaths occur only as a consequence of accident or starvation. Outbreaks, in summer and autumn, occur only on pasture in which endophyte (Neotyphodium lolii)-infected perennial ryegrass (Lolium perenne) predominates and usually on which animals are grazed intensively. Animals recover when moved to a different type of ...

      Known for Ryegrass Staggers | Lolium Perenne | Neotyphodium Lolii | Secondary Metabolites | Endophyte Infection
      KOL-Index: 8565

      The mycotoxic tremorgens penitrem, paxilline and lolitrem B had profound effects on electromyographic (EMG) activity of smooth muscle of the reticulorumen in conscious sheep, with a similar time course of action to their respective characteristic effects on the induction (1 to 2, 15 to 20 and 20 to 30 minutes) and the duration (1 to 2, 1 to 2 and 8 to 12 hours) of tremoring. Responses to penitrem revealed a greater sensitivity of smooth muscle than skeletal muscle. Effects included an ...

      Known for Electromyographic Activity | Tremorgenic Mycotoxins | Smooth Muscle | Penitrem Lolitrem | Conscious Sheep
      KOL-Index: 7849

      It has previously been shown that rats pre-treated with butylated hydroxyanisole (BHA), a well-known inducer of the enzyme DT-diaphorase, are protected against the toxic effects of 2-methyl-1,4-naphthoquinone but are made more susceptible to the harmful action of 2-hydroxy-1,4-naphthoquinone. In the present experiments, the effects of BHA have been compared with those of other inducers of DT-diaphorase. Rats were dosed with BHA, butylated hydroxytoluene (BHT), ethoxyquin (EQ), dimethyl ...

      Known for Inducers Dtdiaphorase | Naphthoquinone Rats | Enzyme Diaphorase | 2 Hydroxy14 | Butylated Hydroxyanisole
      KOL-Index: 7727

      The electromyographic (EMG) activity of skeletal muscle was investigated as a method of recording the tremorgenic activity of the mycotoxins penitrem, paxilline and lolitrem B in sheep. EMG recordings were made concurrently from the abomasal antrum and duodenum to study the effects of these tremorgens on smooth muscle of the gut. Penitrem (2.2 to 7.5 micrograms kg-1) induced mild to moderate tremors within 15 to 20 minutes of injection which lasted for two to four hours. Paxilline (0.66 ...

      Known for Smooth Muscle | Electromyographic Activity | Paxilline Lolitrem | Inhibitory Effects | Indole Alkaloids
      KOL-Index: 7563

      The enzyme DT-diaphorase catalyses the 2-electron reduction of quinones. This reaction may facilitate the detoxification of such compounds, since the hydroquinone so formed can be converted into non-toxic conjugates. There is evidence for the involvement of DT-diaphorase in the detoxification of menadione (2-methyl-1,4-naphthoquinone) in a wide range of cells and tissues in vitro, but no information is available on the possible influence of this enzyme on the harmful effects of menadione ...

      Known for Butylated Hydroxyanisole | Haemolytic Anaemia | Enzyme Diaphorase | Harmful Effects | Dehydrogenase Quinone
      KOL-Index: 6735

      OBJECTIVE: To compare the effects of the ergot alkaloid ergovaline with effects of ergotamine on blood pressure, heart rate, respiratory rate, and body temperature in conscious sheep.

      ANIMALS: 3 sheep with indwelling arterial catheters.

      PROCEDURE: Ergotamine and ergovaline were injected IV (20 nmol/kg), and their effects on arterial blood pressure, heart rate, respiratory rate and pattern, body temperature, and skeletal muscle electromyographic activity were compared with control values ...

      Known for Effects Ergotamine | Heart Rate | Sheep Ergovaline | Blood Pressure | Body Temperature
      KOL-Index: 6568

      It has previously been shown that rats pre-treated with butylated hydroxyanisole (BHA), a well-known inducer of the enzyme DT-diaphorase, are protected against the harmful effects of 2-methyl-1,4-naphthoquinone. This is consistent with a role for diaphorase in the detoxification of this quinone, but it is not known if increased tissue levels of this enzyme give protection against other naphthoquinone derivatives. In the present study, rats were dosed with BHA and then challenged with a ...

      Known for Butylated Hydroxyanisole | Rats Bha | Enzyme Diaphorase | Quinone Naphthoquinones | 2 Hydroxy14
      KOL-Index: 6404

      OBJECTIVE: To investigate the effects of IV administration of ergotamine and ergovaline and intraruminal administration of ergotamine on electromyographic (EMG) activity of reticuloruminal smooth muscle in conscious sheep.

      ANIMALS: 3 sheep with indwelling electrodes in the musculature of the reticulum and rumen.

      PROCEDURE: In a crossover design study, reticuloruminal motility before and after IV administration of ergotamine (5, 10, 20, and 40 nmol/kg) or ergovaline (2.5, 5, and 10 ...

      Known for Smooth Muscle | Rumen Sheep | Effects Ergotamine | Vasoconstrictor Agents | Administration 40
      KOL-Index: 5766

      Facial eczema (pithomycotoxicosis), a photosensitisation of ruminants grazing pasture, has been known in New Zealand for over 100 years, but its cause, a toxin produced by a largely saprophytic fungus, Pithomyces chartarum, growing on litter at the base of pasture and sporing profusely under warm moist conditions in late summer and autumn, was found only 50 years ago. As the fungus spores it produces the toxin sporidesmin which, when eaten by sheep, cattle, goats or deer, causes liver ...

      Known for Facial Eczema | New Zealand | Toxin Sporidesmin | Pithomyces Chartarum | Bile Ducts
      KOL-Index: 5698

      Bracken fern (Pteridium esculentum) was harvested from two sites LB and TB one of which (TB) was on a central North Island New Zealand farm where bovine enzootic haematuria (BEH) was known to occur. The fern was dried, ground and incorporated (25% w/w) into a pelleted diet and fed to female rats for a total of 162 days. Fifteen weeks later when the rats were autopsied it was found that numerous tumours, mainly of the ileum and urinary bladder were present in the animals fed the bracken ...

      Known for New Zealand | Pteridium Esculentum | Bracken Fern | Bovine Enzootic Haematuria | Urinary Bladder
      KOL-Index: 5545

      Mycotoxicoses are some of the most important diseases of animals grazing pastures in New Zealand, especially in northern areas where the disease, facial eczema, occurs. New Zealand scientists have led the world in research on facial eczema and endophyte-related diseases associated with tremoring. Facial eczema (pithomycotoxicosis) was one of the first mycotoxicoses to be studied systematically and successful methods for its control now exist. Toxicity is caused by the concentration of ...

      Known for New Zealand | Grazing Animals | Facial Eczema | Fusarium Spp | Sheep Cattle
      KOL-Index: 5330

      Bracken fern (Pteridium spp.) causes cancer of the oesophagus and the urinary bladder in cattle and sheep. Ptaquiloside (PT) is believed to be the carcinogenic principle which alkylates DNA when activated to its unstable dienone form (APT) under alkaline conditions. In this report we present evidence for the presence of PT-DNA adducts in the ileum of bracken fem-fed calves using the 32P-postlabelling assay. H-ras mutations were also observed in the ileum using single strand conformation ...

      Known for Bracken Fern Carcinogenesis | Urinary Bladder | Dna Alkylation | Alkaline Conditions | Plants Toxic

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      AgResearch, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton, New Zealand | AgResearch, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton 2001, New Zealand | Toxicology, AgResearch, Ruakura Research Centre, Hamilton, Ne

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