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    • Tseggai Gherezghiher
    • Tseggai Gherezghiher

      Tseggai Gherezghiher

      Departments of Pharmacology and Ophthalmology, University of Oklahoma College of Medicine, P.O. Box 26901, Oklahoma City, OK 73190, U.S.A. | Dean A. McGee Eye Institute, ...



      KOL Resume for Tseggai Gherezghiher


      Departments of Pharmacology and Ophthalmology, University of Oklahoma College of Medicine, P.O. Box 26901, Oklahoma City, OK 73190, U.S.A.


      Dean A. McGee Eye Institute, University of Oklahoma, Health Sciences Center, 608 Stanton L. Young Boulevard, Oklahoma City, OK 73104, U.S.A.


      Dean A. McGee Eye Institute, University of Oklahoma, Oklahoma City.


      Department of Ophthalmology, Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City.


      Dean A. McGee Eye Institute and Department of Ophthalmology University of Oklahoma, 608 Stanton L. Young Blvd, City, OK 73104, U.S.A.


      Dean A. McGee Eye Institute, 608 Stanton L. Young Blvd, Oklahoma City, OK 73104, U.S.A.


      Dean A. McGee Institute, Oklahoma City.


      Departments of Pharmacology and of Ophthalmology, University of Oklahoma Health Sciences Center and Dean McGee Eye Institute, Oklahoma City, OK 73190 U.S.A.

      Department of Pharmacology, Texas College of Osteopathic Medicine, Fort Worth


      Dean McGree Eye Institute, 608 Stanton L. Young Boulevard, 73104, Oklahoma City, Oklahoma, USA


      Department of Pharmacology Texas College of Osteopathic Medicine Fort Worth, Texas 76107, USA


      Departments of Pharmacology and of Ophthalmology and McGee Eye Institute, University of Okhalahoma Health Sciences Center, P.O. Box 26901, Oklahoma City, Okla. 73190, U.S.A.



      Tseggai Gherezghiher: Influence Statistics

      Sample of concepts for which Tseggai Gherezghiher is among the top experts in the world.
      Concept World rank
      yag sclerostomy #3


      Prominent publications by Tseggai Gherezghiher

      KOL-Index: 8444

      Electrical stimulation of the preganglionic cervical sympathetic nerve produced frequency-related contraction of the nictitating membrane (NM) and dilation of the pupil in anesthetized cats. Observations of the effects of alpha-adrenoceptor blockade on these effectors were made simultaneously from the same preparations. All of the alpha1 -adrenoceptor antagonists tested produced a doserelated blockade of the NM with the relative potencies being prazosin > WB-4101 > phentolamine > ...

      Known for Nictitating Membrane | Pupillary Responses | Nerve Stimulation | Anesthetized Cats | Relative Potencies
      KOL-Index: 7529

      Inhibition of parasympathetic neural tone to the iris was produced by electrical stimulation of the afferent sciatic nerve, medullary reticular formation, and posterior hypothalamus in anesthetized cats in which only the parasympathetic nerves to the eye were intact. Stimulation of all 3 sites of activation produced a graded pupillary dilation and reduction of tonic nerve activity in the short ciliary nerves. Intravenous administration of the alpha-2-adrenoceptor antagonist, yohimbine ...

      Known for Oculomotor Tone | Pupillary Dilation | Posterior Hypothalamus | Sciatic Nerve | Electrical Stimulation
      KOL-Index: 5650

      The specificity of ethyl 8-fluro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo (1,5-a) (1,4) benzodiazepine-3-carboxylate (RO 15-1788) in reversing the effectiveness of diazepam and des-methylclobazam, but not of pentobarbital, in antagonizing discriminative stimuli produced by pentylenetetrazol is described. Male hooded rats were trained to discriminate pentylenetetrazol-induced interoceptive discriminative-stimuli (IDS) in a two-lever choice paradigm on an FR10 schedule of food reinforcement. ...

      Known for Discriminative Stimuli | Anxiolytic Action | 15 1788 | Diazepam 10 | Food Reinforcement
      KOL-Index: 5477

      The relationship between intraocular pressure (IOP) and arterial blood pressure (BP) was analyzed in response to two pressor agents (norepinephrine and angiotensin II) and two depressor agents (methacholine and isoproterenol) in pentobarbital anesthetized cats. Both IOP and BP were measured manometrically in the same animals. Intravenous norepinephrine and angiotensin II produced dose-dependent increases, whereas intravenous methacholine and isoproterenol produced dose-dependent ...

      Known for Intraocular Pressure | Systemic Blood | Produced Dose | Pentobarbital Anesthetized Cats | Angiotensin Animals
      KOL-Index: 5083

      Pupillary dilation and nictitating membrane (NM) contraction were elicited by pharmacological activation of alpha-adrenoceptors in vivo in anesthetized cats. A constant intravenous infusion of the alpha 1-adrenoceptor selective agonist phenylephrine (150 micrograms/min) was administered to produce a near maximal activation of both organs. Steady-state responses were attained about 15 minutes after starting the phenylephrine infusion. Administration of the alpha 1-adrenoceptor selective ...

      Known for Anesthetized Cats | Pupil Receptors Adrenergic | Alpha Adrenoceptor | Nictitating Membrane | Phenylephrine Prazosin
      KOL-Index: 4948

      Summaryalpha-methyl-Dopa (10–100 mg/kg, i.v.) produced a dose-dependent mydriasis in cats anaesthetized with pentobarbital (30 mg/kg, i.p.). The onset was gradual, reaching a maximum plateau in 2–2.5 h. Intracerebroventricular administration of 1 or 3 mg of alpha-methyl Dopa (MD) also produced pupillary dilation with a similar time course. These dosages were without effect when given intravenously. Pretreatment with the alpha2-adrenoceptor antagonist, yohimbine (0.5 mg/kg, i.v.), blocked ...

      Known for Pupillary Dilation | Induced Mydriasis | Methyl Dopa | Maximum Plateau | Yohimbine Animals
      KOL-Index: 4588

      Pupillary responses to clonidine (3--100 micrograms/kg, i.v.) and epinephrine (1--30 micrograms/kg, i.v.) were observed in anesthetized rats. Clonidine caused a dose-dependent mydriasis which was effectively antagonized by pretreatment with yohimbine (1.5 mg/kg, i.v.). Pretreatment with phentolamine (5 mg/kg, i.v.) was less effective in antagonizing this clonidine-induced mydriasis. Phenoxybenzamine (2 mg/kg, i.v.) was almost without effect. In contrast, both phentolamine and ...

      Known for Clonidine Mydriasis | Pupillary Dilation | Anesthetized Rats | Yohimbine 15 | Adrenergic Alpha
      KOL-Index: 4210

      Graded pupillary dilations and nictitating membrane (NM) contractions were elicited in anesthetized cats by electrical stimulation of the preganglionic sympathetic nerve or by i.a. administration of norepinephrine (NE) or phenylephrine into the carotid artery. Pupil and NM responses were measured simultaneously from the same side. Alpha-adrenoceptor antagonists were administered intravenously. All of the alpha 1-adrenoceptor blockers tested produced a dose-related reduction of NM ...

      Known for Nictitating Membrane | Adrenergic Sympathetic Nervous | Pupillary Dilations | Electrical Stimulation | Anesthetized Cats
      KOL-Index: 4100

      Intra-arterial administration of (+)- and (−)isomers of adrenaline and noradrenaline produced doserelated contraction of the nictitating membrane (NM) and dilation of the pupil in anesthetized cats. The relative potencies were (−)-adrenaline > (+)-adrenaline = (−)-noradrenaline > (+)-noradrenaline. Observations of the effects of α-adrenoceptor antagonists on (−)-noradrenaline activation of these two effectors were made simultaneously. All of the α1-adrenoceptor antagonists tested ...

      Known for Nictitating Membrane | Adrenoceptor Activation | Anesthetized Cats | Adrenergic Alpha | Iris Dilator
      KOL-Index: 3945

      Electrical or chemical activation of the oculomotor nucleus (ONC) was performed in pentobarbital anesthetized cats to determine the role of parasympathetic nervous input to the eye in modulating intraocular pressure (IOP). In all animals, the vagosympathetic nerve trunks were sectioned bilaterally at the mid-cervical level. Intracranial stimulation of the ONC produced miosis and a bilateral sustained rise in IOP with little or no cardiovascular response. During stimulation, IOP increased ...

      Known for Intraocular Pressure | Parasympathetic Nervous | Nerve Fibers | Animals Atropine | Electric Stimulation
      KOL-Index: 3667

      Argon laser energy was applied to the trabecular meshwork of pigmented rabbits in an attempt to develop an animal model of 'glaucoma'. Laser energy was varied to determine the optimal level needed to produce sustained ocular hypertension. An initial response of ocular hypertension followed by hypotension was observed in all of the animals tested. Approximately half of the laser-treated rabbits developed a secondary buphthalmus and sustained ocular hypertension. In these animals outflow ...

      Known for Ocular Hypertension | Trabecular Meshwork | Animal Model | Pigmented Rabbits | Outflow Facility
      KOL-Index: 3663

      The short-term effect of argon laser trabeculoplasty (ALT) was studied in a nonhuman primate model. The ALT treatment produced a consistent intraocular pressure elevation in the treated eye for eight hours. A statistically significant indomethacin-resistant increase in aqueous humor protein concentration was also observed. Morphologic observations using light microscopy and scanning and transmission electron microscopy revealed evidence of a fibrinous material covering the trabecular ...

      Known for Argon Laser Trabeculoplasty | Intraocular Pressure | Tissue Debris | Light Microscopy | Treated Eye
      KOL-Index: 3620

      Because of the need to develop ocular hypotensive agents with low incidence of side effects, the dextrorotatory enantiomers of adrenergic agents have prompted some attention. In the present study, the relative potency and efficacy of various adrenergic stereoisomers with respect to their ocular hypotensive and mydriatic effects have been determined after topical administration to conscious rabbits. The relative order of potency was found to be, iris: 1-epinephrine much greater than ...

      Known for Ocular Effects | Conscious Rabbits | 1 Epinephrine | Pressure Iop | Stereoisomerism Animals
      KOL-Index: 3555

      In pentobarbital anaesthetized cats, intravenous administration of 30 mg/kg, alpha-methyl-DOPA produced mydriasis that reached a maximum plateau in 2–2.5 h. The oculomotor nucleus was perfused with saline using a pushpull cannula system chronically implanted over the nucleus. Perfusate samples were collected and subsequently analyzed by liquid chromatography with electrochemical detection (LC-EC). Alpha-methyl-DOPA administration resulted in a gradual build up of ...

      Known for Pupil Size | Mydriatic Response | Intravenous Administration | Alpha Methyl | Induced Mydriasis

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      Tseggai Gherezghiher:Expert Impact

      Concepts for whichTseggai Gherezghiherhas direct influence:Nictitating membrane,  Yag sclerostomy,  Intraocular pressure,  Anesthetized cats,  Intraocular pressure iop,  Ocular hypertension,  Yag laser,  Ocular effects.

      Tseggai Gherezghiher:KOL impact

      Concepts related to the work of other authors for whichfor which Tseggai Gherezghiher has influence:Intraocular pressure,  Laser sclerostomy,  Choroidal blood flow,  Trabecular meshwork,  Pupillary dilation,  Nictitating membrane,  Aqueous humor.



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      Departments of Pharmacology and Ophthalmology, University of Oklahoma College of Medicine, P.O. Box 26901, Oklahoma City, OK 73190, U.S.A. | Dean A. McGee Eye Institute, University of Oklahoma, Health Sciences Center, 608 Stanton L. Young Boulevard,

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