• Disease
  • Heart
  • Heart Failure
  • Mark A Creager

    Prominent publications by Mark A Creager

    KOL Index score: 22426

    CONTEXT: Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis that is common and is associated with an increased risk of death and ischemic events, yet may be underdiagnosed in primary care practice.

    OBJECTIVE: To assess the feasibility of detecting PAD in primary care clinics, patient and physician awareness of PAD, and intensity of risk factor treatment and use of antiplatelet therapies in primary care clinics.

    DESIGN AND SETTING: The PAD Awareness, Risk, ...

    Also Ranks for: Pad Cvd |  primary practice |  disease detection |  risk treatment |  patients prior
    KOL Index score: 15962

    BACKGROUND: Vorapaxar is a novel antagonist of protease-activated receptor-1, the primary receptor for thrombin on human platelets that is also present on vascular endothelium and smooth muscle. Patients with peripheral artery disease are at risk of systemic atherothrombotic events, as well as acute and chronic limb ischemia and the need for peripheral revascularization.

    METHODS AND RESULTS: The Trial to Assess the Effects of SCH 530348 in Preventing Heart Attack and Stroke in Patients ...

    Also Ranks for: Peripheral Artery Disease |  vorapaxar patients |  hazard ratio |  myocardial infarction |  limb ischemia
    KOL Index score: 15117

    BACKGROUND: The endothelium synthesizes and releases a relaxing factor with the physiochemical properties of nitric oxide (NO). However, the role of endothelium-derived NO in the basal regulation of systemic and pulmonary vascular resistance in humans is not known. Our primary objectives were to determine the effects of inhibiting NO synthesis on blood pressure and systemic vascular resistance and to establish the role of endothelium-derived NO in the regulation of normoxic pulmonary ...

    Also Ranks for: Pulmonary Vascular |  healthy humans |  nitric oxide |  blood pressure |  cardiac output
    KOL Index score: 14554

    OBJECTIVES: The aim of this study was to assess the efficacy of flosequinan in chronic heart failure.

    BACKGROUND: Flosequinan is a new vasodilator drug that acts by interfering with the inositol-triphosphate/protein kinase C pathway, an important mechanism of vasoconstriction. The drug dilates both peripheral arteries and veins, is orally active and has a long duration of action that permits once-daily dosing. Previous studies have shown that flosequinan produces sustained hemodynamic ...

    Also Ranks for: Chronic Heart Failure |  flosequinan patients |  placebo treatment |  exercise tolerance |  ventricular ejection fraction
    KOL Index score: 14459

    In addition to inhibiting cholesterol biosynthesis, statins also inhibit the formation of isoprenoid intermediates, which are required for the activation of the Rho/Rho kinase (ROCK) pathway. Increased ROCK activity has been implicated in causing endothelial dysfunction and atherosclerosis. However, it is not known whether statins, at doses used to lower cholesterol levels, inhibit ROCK activity in humans with atherosclerosis. Furthermore, it is not known whether lipophilic and ...

    Also Ranks for: Rock Activity |  versus atorvastatin |  atherosclerosis statins |  rosuvastatin fmd |  rho kinase
    KOL Index score: 14303

    Enalapril is a recently developed angiotensin-converting enzyme inhibitor that improves cardiac function at rest in patients with congestive heart failure. This study investigated the acute effects of enalapril on the cardiovascular response to exercise, and then evaluated the long-term effects of enalapril on exercise capacity and functional status during a 12 week placebo-controlled trial in patients with heart failure. Ten patients underwent hemodynamic monitoring while at rest and ...

    Also Ranks for: Enalapril Patients |  heart failure |  rest exercise |  cardiac function |  systemic vascular resistance
    KOL Index score: 13940

    BACKGROUND: The endogenous nucleoside adenosine plays an important role in the regulation of vascular tone, especially during ischemia. Experimental data derived from animal models suggest that nitric oxide (NO) contributes to the vasodilator effect of adenosine. The primary purpose of this investigation was to determine whether the endothelial release of NO contributes to adenosine-induced vasodilation in humans.

    METHODS AND RESULTS: Venous occlusion plethysmography was used to assess ...

    Also Ranks for: Nitric Oxide |  adenosine humans |  drug endothelium |  nmma infusion |  vascular tone
    KOL Index score: 13830

    BACKGROUND: Patients with peripheral artery disease (PAD) are at heightened risk of acute limb ischemia (ALI), a morbid event that may result in limb loss. We investigated the causes, sequelae, and predictors of ALI in a contemporary population with symptomatic PAD and whether protease-activated receptor 1 antagonism with vorapaxar reduced ALI overall and by type.

    METHODS AND RESULTS: The Trial to Assess the Effects of Vorapaxar in Preventing Heart Attack and Stroke in Patients With ...

    Also Ranks for: Acute Limb Ischemia |  ali patients |  symptomatic pad |  artery disease |  limb loss
    KOL Index score: 13776

    OBJECTIVES: The relation between endothelium-dependent vasodilator function in the brachial and coronary arteries was determined in the same subjects.

    BACKGROUND: Coronary artery endothelial dysfunction precedes the development of overt atherosclerosis and is important in its pathogenesis. A noninvasive assessment of endothelial function in a peripheral conduit vessel, the brachial artery, was recently described, but the relation between brachial artery function and coronary artery ...

    Also Ranks for: Endothelial Function |  brachial artery patients |  coronary artery |  response acetylcholine |  vasodilation vasodilator
    KOL Index score: 13772

    Endothelium-dependent vasodilation is impaired in humans with diabetes mellitus. Inactivation of endothelium-derived nitric oxide by oxygen-derived free radicals contributes to abnormal vascular reactivity in experimental models of diabetes. To determine whether this observation is relevant to humans, we tested the hypothesis that the antioxidant, vitamin C, could improve endothelium-dependent vasodilation in forearm resistance vessels of patients with non-insulin-dependent diabetes ...

    Also Ranks for: Dependent Vasodilation |  diabetes mellitus |  vitamin patients |  intraarterial infusion |  type 2 endothelium
    KOL Index score: 13670

    Intensive antithrombotic therapy reduces major adverse cardiovascular events (MACE) and major adverse limb events (MALE) in patients with peripheral artery disease (PAD). Recent studies have suggested heterogeneity in risk and benefit in those with and without concomitant coronary artery disease (CAD) and peripheral revascularization. We evaluated the risk of MACE and MALE in patients with PAD stratified by history of concomitant CAD and prior peripheral revascularization and whether the ...

    Also Ranks for: Patients Pad |  peripheral artery disease |  mace male |  coronary artery |  timi 50
    KOL Index score: 13624

    Importance: Clinical practice guidelines support home-based exercise for patients with peripheral artery disease (PAD), but no randomized trials have tested whether an exercise intervention without periodic medical center visits improves walking performance.

    Objective: To determine whether a home-based exercise intervention consisting of a wearable activity monitor and telephone coaching improves walking ability over 9 months in patients with PAD.

    Design, Setting, and Participants: ...

    Also Ranks for: Walking Performance |  peripheral artery disease |  based exercise |  clinical trial |  patients pad
    KOL Index score: 13319

    BACKGROUND: Nitric oxide (NO) attenuates the contractile response to beta-adrenergic stimulation in cultured cardiac myocytes in vitro and in myocardium in vivo. We tested the hypothesis that NO synthesized in the heart inhibits the positive inotropic response to beta-adrenergic stimulation in humans with left ventricular (LV) dysfunction.

    METHODS AND RESULTS: Patients with various degrees of LV dysfunction and free from epicardial coronary artery disease were instrumented with an ...

    Also Ranks for: Nitric Oxide |  ventricular dysfunction |  positive inotropic response |  intracoronary infusion |  betaadrenergic stimulation
    KOL Index score: 13300

    CONTEXT: Complications of atherosclerosis cause most morbidity and mortality in patients with diabetes mellitus. Despite the frequency and severity of disease, proven medical therapy remains incompletely understood and underused.

    OBJECTIVE: To review the epidemiology, pathophysiology, and medical and invasive treatment of atherosclerosis in patients with diabetes mellitus.

    DATA SOURCES: Using the index terms diabetes mellitus, myocardial infarction, peripheral vascular diseases, ...

    Also Ranks for: Atherosclerosis Diabetes |  epidemiology pathophysiology |  data extraction |  risk myocardial infarction |  cerebrovascular accident
    KOL Index score: 13148

    The objective of this study was to determine whether abnormal flow-induced endothelium-dependent vasodilation in the brachial artery identifies young patients with coronary artery disease (CAD). High-resolution ultrasonography was used to measure vascular reactivity in a peripheral conduit vessel, the brachial artery, in 14 young men with CAD and in 11 age-matched, healthy, male volunteers. Endothelium-dependent vasodilation was determined by measuring the change in brachial artery ...

    Also Ranks for: Brachial Artery |  flow vasodilation |  40 years |  patients cad |  reactive hyperemia


    Mark A Creager: Influence Statistics

    Sample of concepts for which Mark A Creager is among the top experts in the world.
    Concept World rank
    smokers control subjects #1
    ethanol induced vasodilation #1
    background endothelium #1
    calf thigh muscle #1
    knockout mice hli #1
    lipodystrophic diabetes pcos #1
    estradiol therapy progesterone #1
    vascular tone subjects #1
    peripheral atherosclerosis patients #1
    hyperhomocysteinemic humans #1
    lname pva #1
    vasodilation measured #1
    combination endothelium cad #1
    bq123 p0001 #1
    regional circulatory response #1
    brachial diameters #1
    placebo atorvastatin 80mg #1
    caprie trial #1
    role vascular dysfunction #1
    patients intraoperative ischemia #1
    decades global incidence #1
    paclitaxel coalition #1
    foundation mission #1
    pns incremental infusion #1
    hypoxia systemic vasodilation #1
    pwt plc #1
    ly333531 inhibition #1
    methacholine 4 #1
    creation messages #1
    update alternative #1
    hscrp statin #1
    ankle brachial crp #1
    subjects endothelium #1
    arginine dobutamine #1
    training vascular medicine #1
    atorvastatin vascular ultrasonography #1
    distinct signal characteristics #1
    sustained oral therapy #1
    concomitant infusion vitamin #1
    22 degrees room #1
    differences t2weighted measurements #1
    raynauds patients prazosin #1
    100 mcg nitroprusside #1
    progesterone vasodilation #1
    t2weighted measurements #1
    slight calf venodilatation #1
    specific phospholipase adpla #1
    reducing nontraumatic #1
    fibrinogen 600 #1
    elasticity normal subjects #1

    Key People For Heart Failure

    Top KOLs in the world
    John J J V McMurray
    heart failure myocardial infarction atrial fibrillation
    John George Franklin Cleland
    heart failure patients hf atrial fibrillation
    Stephan D Anker
    heart failure iron deficiency cardiac cachexia
    Greegg C Fonarow
    heart failure atrial fibrillation united states
    Karl B Swedberg
    heart failure reduced ejection fraction myocardial infarction
    Piotr P Ponikowski
    heart failure iron deficiency reduced ejection fraction

    Mark A Creager:Expert Impact

    Concepts for whichMark A Creagerhas direct influence:Heart failure,  Peripheral artery disease,  Peripheral arterial disease,  Nitric oxide,  Endothelial function,  Heart association,  Intermittent claudication,  Congestive heart failure.

    Mark A Creager:KOL impact

    Concepts related to the work of other authors for whichfor which Mark A Creager has influence:Endothelial function,  Nitric oxide,  Heart failure,  Cardiovascular disease,  Diabetes mellitus,  Oxidative stress,  Blood pressure.



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    Section of Cardiovascular Medicine, Heart and Vascular Center Dartmouth-Hitchcock Medical Center Lebanon NH. | Section of Cardiovascular Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA | Dartmouth‐Hitchcock M