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    • Maurine R Hobbs
    • Maurine R Hobbs

      Maurine R Hobbs

      Centralized Zebrafish Animal Resource, University of Utah, Salt Lake City, Utah. | CZAR Zebrafish Core Facility, University of Utah, Salt Lake City, Utah. | Core Research ...



      KOL Resume for Maurine R Hobbs


      Centralized Zebrafish Animal Resource, University of Utah, Salt Lake City, Utah.


      CZAR Zebrafish Core Facility, University of Utah, Salt Lake City, Utah.


      Core Research Facilities, University of Utah, Salt Lake City (M.R.H.)


      Department of Internal Medicine, Division of Infectious Diseases, University of Utah, Salt Lake City, Utah, United States of America


      Division of Infectious Diseases, Department of Internal Medicine


      Divisions of Infectious Diseases and Endocrinology, University of Utah and VA Medical Centers, Utah, USA


      Salt Lake VA Medical Center, Salt Lake City, UT, USA


      Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.


      Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA


      Division of Infectious Diseases, VA and University of Utah School of Medicine, Salt Lake City, Utah


      Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA


      Division of Infectious Diseases, VA and University of Utah Medical Centers, Salt Lake City, UT, USA


      Division of Infectious Diseases, University of Utah, Salt Lake City, UT, USA


      Department of Internal Medicine, University of Utah Medical Center, Salt Lake City, UT


      Department of Medicine, University of Utah Medical Center, Salt Lake City, Utah


      Human Genetics, University of Utah Medical School, Salt Lake City, Utah 84108, USA


      Myriad Genetics, Inc., 421 Wakara Way, Salt Lake City, Utah 84108; Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709; Department of Surgery, Duke University Medical Center, Duke University, Durham, North Carolina 27710; and Department of Genetic Epidemiology, University of Utah, Salt Lake City, Utah 84108


      Department of Immunology, Genentech, Inc., South San Francisco, California 94080.


      Department of Immunobiology, Genentech, Inc., South San Francisco, California 94080.


      Department of Microbiology and Immunology, Stanford University, Stanford, CA, U.S.A.



      Maurine R Hobbs: Influence Statistics

      Sample of concepts for which Maurine R Hobbs is among the top experts in the world.
      Concept World rank
      3 hptjt patients #2
      mechanism hrpt2 #2
      hrpt2 gene expression #2
      samples parathyroid tumors #2
      parathyroid carcinoma hptjt #2
      11 parathyroid carcinomas #2
      methylation hrpt2 #2
      3 patients hptjt #2
      hptjt 2 tumors #2
      c21orf91 snp #3
      herpes cold sore #3
      cold sore frequency #3
      association c21orf91 #3
      parentdt #3
      c21orf91 region #3
      susceptibility hsl #3
      hrpt2 publication chromosomes #3
      identified c21orf91 #3
      c21orf91 genotypes correlate #3
      147cm locus hrpt2 #3
      frequent hsl #3
      hsl frequency #3
      annual hsl frequency #3
      parentdt analysis #3
      sore frequency #3
      repeat nos2 #3
      147cm locus #3
      c21orf #3
      c21orf91 genotypes #3
      3megabase region #3
      hyperparathyroidism jaw hrpt2 #4
      linkage cold #4
      hiv1mn cd4 #6
      positions 423 #6
      region d17s78 #6
      hiv1 strains studies #6
      d17s1184 brca1 #6
      cd4blocking monoclonal #6
      d17s78 d17s1183 #6
      mixture 7 yacs #6
      strain specificity antibodies #6
      epb3 d17s183 #6
      6 parathyroid adenomas #6
      1 strain hiv1mn #6
      d17s78 gp2b #6
      substrain iiib #6
      stscontent mapping artificial #6
      physical map gp2b #6
      c4 domain gp120 #6
      encompassing gp2b #6


      Prominent publications by Maurine R Hobbs

      KOL-Index: 14869

      BACKGROUND: Familial hypocalciuric hypercalcemia is a genetically heterogeneous disorder with three variants: types 1, 2, and 3. Type 1 is due to loss-of-function mutations of the calcium-sensing receptor, a guanine nucleotide-binding protein (G-protein)-coupled receptor that signals through the G-protein subunit α11 (Gα11). Type 3 is associated with adaptor-related protein complex 2, sigma 1 subunit (AP2S1) mutations, which result in altered calcium-sensing receptor endocytosis. We ...

      Known for Function Mutations | Protein Subunit | Type 2 | Unrelated Patients | Hypercalcemia Hypocalcemia
      KOL-Index: 14602

      BACKGROUND: Nitric oxide (NO) is a mediator of immunity to malaria, and genetic polymorphisms in the promoter of the inducible NO synthase gene (NOS2) could modulate production of NO. We postulated that NOS2 promoter polymorphisms would affect resistance to severe malaria.

      METHODS: We assessed genomic DNA from healthy children and from those diagnosed with malaria from Tanzania (n=47 and n=138, respectively) and Kenya (n=1106) for polymorphisms by single-stranded conformational ...

      Known for Severe Malaria | Nos2 Promoter | Nitric Oxide | Genetic Polymorphism | Tanzanian Children
      KOL-Index: 13280

      The binding properties of seven CD4-blocking monoclonal antibodies raised against recombinant gp120 of human immunodeficiency virus type 1 strain MN (HIV-1MN) and two CD4-blocking monoclonal antibodies to recombinant envelope glycoproteins gp120 and gp160 of substrain IIIB of HIVLAI were analyzed. With a panel of recombinant gp120s from seven diverse HIV-1 isolates, eight of the nine antibodies were found to be strain specific and one was broadly cross-reactive. Epitope mapping revealed ...

      Known for C4 Domain | Monoclonal Antibodies | Human Immunodeficiency | Binding Gp120 | Type 1
      KOL-Index: 12342

      Interleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of IL-12 and susceptibility to Type 1 diabetes. We therefore investigated whether IL12B polymorphisms may affect the outcome of severe malaria. Homozygosity for a polymorphism in the IL12B promoter was associated with increased mortality ...

      Known for Cerebral Malaria | Nitric Oxide | Promoter Polymorphism | Il12b Gene | Interleukin12 Il12
      KOL-Index: 11728

      Nitric oxide (NO) plays an important role in host resistance to infection with a variety of organisms. Two recent reports from Gabon and Gambia identified associations of malaria disease severity with the inducible NO synthase (NOS2) promoter G-954C and short allele (<11 repeats) pentanucleotide microsatellite polymorphisms, respectively. It was postulated that there would be a correlation of these polymorphisms with malaria disease severity and with measures of NO production in our ...

      Known for Nitric Oxide | Tanzanian Children | Cerebral Malaria | Promoter Polymorphisms | Synthase Type
      KOL-Index: 10511

      Vaccines prepared from the envelope glycoprotein, gp120, of the common laboratory isolate of human immunodeficiency virus type 1 (HIV-1) (IIIB/LAV-1) elicit antibodies that neutralize the homologous virus but show little if any cross-neutralizing activity. This may be because the principal neutralizing determinant (PND) of gp120 is highly unusual in the IIIB/LAV-1 strain and is not representative of those found in the majority of field isolates. We have now examined the immunogenicity of ...

      Known for Virus Type | Antibodies Hiv | Recombinant Gp120 | Envelope Glycoprotein | Crossneutralizing Activity
      KOL-Index: 9869

      We report here the identification of a gene associated with the hyperparathyroidism–jaw tumor (HPT–JT) syndrome. A single locus associated with HPT–JT (HRPT2) was previously mapped to chromosomal region 1q25–q32. We refined this region to a critical interval of 12 cM by genotyping in 26 affected kindreds. Using a positional candidate approach, we identified thirteen different heterozygous, germline, inactivating mutations in a single gene in fourteen families with HPT–JT. The proposed ...

      Known for Jaw Tumor | Encoding Parafibromin | Suppressor Proteins | Gene Hyperparathyroidism | Mutation Screening
      KOL-Index: 9654

      Ten monoclonal antibodies prepared against a soluble, recombinant form of gp160, derived from the IIIB isolate of HIV-1, were characterized. Four of the antibodies neutralized HIV-1IIIB infectivity in vitro, three blocked the binding of recombinant gp120 to CD4, three were reactive with gp41, and one preferentially reacted with an epitope on gp120 within the gp160 precursor. All three CD4 blocking antibodies bound to distinct epitopes, with one mapping to the C1 domain, one mapping to ...

      Known for Monoclonal Antibodies | Recombinant Gp120 | Block Binding | Protein Gp160 | C4 Domain
      KOL-Index: 8217

      Multiple sclerosis (MS) is a demyelinating disease of unknown origin that affects the central nervous system of an estimated 400,000 Americans. GBV-C or hepatitis G is a flavivirus that is found in the serum of 1-2% of blood donors. It was originally associated with hepatitis, but is now believed to be a relatively non-pathogenic lymphotropic virus. Fifty frozen specimens from the brains of deceased persons affected by MS were obtained along with 15 normal control brain specimens. RNA ...

      Known for Deep Sequencing | Multiple Sclerosis | Gb Virus Gbvc | Viral Hepatitis | Central Nervous
      KOL-Index: 7946

      Cerebral malaria is associated with decreased production of nitric oxide and decreased levels of its precursor, l-arginine. Abnormal amino acid metabolism may thus be an important factor in malaria pathogenesis. We sought to determine if other amino acid abnormalities are associated with disease severity in falciparum malaria. Subjects were enrolled in Dar es Salaam, Tanzania (children) (n = 126), and Papua, Indonesia (adults) (n = 156), in two separate studies. Plasma samples were ...

      Known for Severe Malaria | Plasma Phenylalanine | Fluorescence Detection | Nitric Oxide | Children Cerebral
      KOL-Index: 7816

      BACKGROUND: Most of the United States population is infected with either herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2, or both. Reactivations of HSV-1 infection cause herpes simplex labialis (HSL; cold sores or fever blisters), which is the most common recurring viral infection in humans.

      METHODS: To investigate the possibility of a human genetic component conferring resistance or susceptibility to cold sores (i.e., a HSL susceptibility gene), we conducted a genetic ...

      Known for Herpes Simplex | Human Chromosome | Cold Sores | Susceptibility Region | Hsv1 Infection
      KOL-Index: 7605

      Utilizing first-strand cDNA from different stages, a gene family was identified that is expressed in bloodstream form trypanosomes but not in cultured procyclic forms. This family of 50-100 genes, termed bloodstream-specific 1 (BS1), shares a chromosomal distribution pattern similar to the variant surface glycoprotein (VSG) genes and the expression-site-associated genes (ESAGs). The BS1 genes are expressed in several variants of Trypanosoma brucei brucei and in Trypanosoma brucei ...

      Known for Variant Surface | Glycoprotein Gene | Brucei Trypanosoma | Antigenic Variation | Sequence Analysis

      Key People For Nitric Oxide

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      Maurine R Hobbs:Expert Impact

      Concepts for whichMaurine R Hobbshas direct influence:Nitric oxide,  Severe malaria,  Cerebral malaria,  Malaria severity,  Oxide synthase,  Tanzanian children,  Brca1 region,  Nos2 promoter.

      Maurine R Hobbs:KOL impact

      Concepts related to the work of other authors for whichfor which Maurine R Hobbs has influence:Parathyroid carcinoma,  Nitric oxide,  Cerebral malaria,  Parafibromin expression,  Trypanosoma brucei,  Plasmodium falciparum,  Hrpt2 gene.



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      Centralized Zebrafish Animal Resource, University of Utah, Salt Lake City, Utah. | CZAR Zebrafish Core Facility, University of Utah, Salt Lake City, Utah. | Core Research Facilities, University of Utah, Salt Lake City (M.R.H.) | Department of Interna

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