KOL | Steven B AbramsonDiv. of Rheumatology, Dept. of Med., NYU Grossman Sch. of Med., New York, NY | Department of Medicine, NYU Grossman School of Medicine, New York, NY. | Division of ... |
KOL Resume for Steven B Abramson
| Year | |
|---|---|
| 2022 | Div. of Rheumatology, Dept. of Med., NYU Grossman Sch. of Med., New York, NY |
| 2021 | Division of Rheumatology, NYU School of Medicine and NYU Langone Orthopaedic Hospital, New York, USA New York University Langone Health, New York, NY |
| 2020 | Department of Medicine, Division of Rheumatology, NYU School of Medicine, 301 East 17th Street, Suite 1612A, NY 10003, USA |
| 2019 | Division of Rheumatology, Department of Medicine, NYU School of Medicine, New York, NY, 10003, USA |
| 2018 | Division of Rheumatology, Department of Medicine, New York University Langone Health, New York, NY, USA |
| 2017 | NYU Langone Medical Center, New York, NY, USA Professor and Dean, Rutgers Robert Wood Johnson Medical School New York University Langone Medical Center, New York, New York Chief of Rheumatology, Department of Medicine, Omaha Veterans Affairs, Omaha, Nebraska |
| 2016 | Department of Medicine, New York University School of Medicine and Hospital for Joint Diseases, New York, NY, USA New York University Medical Center, New York, New York. |
| 2015 | New York University School of Medicine and Hospital for Joint Diseases, NYU Langone Medical Center, New York, NY, USA |
| 2014 | Department of Rheumatology, New York University Hospital for Joint Diseases, 301 East 17th Street, suite 1410, 10003, New York, NY, USA New York University and New York University Hospital for Joint Diseases New York New York |
| 2013 | Department of Medicine, New York University School of Medicine and Hospital for Joint Diseases, 301 E17th Street, New York, NY 10003, USA Muirhead Professor of Medicine, Director, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom Professor of Medicine, Director, Vermont Center for Immunology and Infectious Diseases, The University of Vermont College of Medicine, Burlington, Vermont From NYU Langone Medical Center, New York. |
| 2012 | Division of Rheumatology, Department of Medicine and Pathology, New York University Hospital for Joint Diseases, 301 East 17th Street, Room 1410, New York, NY 10003 New York University and New York University Hospital for Joint Diseases, New York, New York |
| 2011 | Chief, Division of Rheumatology, Professor of Medicine, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA Division of Rheumatology, Department of Medicine, NYU School of Medicine, NYU Hospital for Joint Diseases, New York, NY 10003, United States Professor, Rheumatic Diseases Epidemiology, University of Manchester, Manchester, UK Chairman, Second Department of Medicine, Center for Rheumatic Diseases, Hietzing Hospital, Vienna, Austria John R. and Eileen K. Riedman Professor of Medicine, Harvard Medical School; |
| 2010 | Division of Rheumatology, New York University School of Medicine and New York University Hospital for Joint Diseases, New York, NY 10003, USA. Affiliations for Committee members' can be found in the following section: Members of the OARSI Treatment Guidelines Committee |
| 2009 | Professor Emeritus, Department of Internal Medicine, Division of Rheumatology, Allergy, and Immunology, Virginia Commonwealth University School of Medicine at the Medical College of Virginia, Richmond, Virginia New York University Hospital for Joint Diseases, New York, USA |
Steven B Abramson: Influence Statistics
| Concept | World rank |
|---|---|
| pge2mediated processes | #1 |
| cox2 cartilage damage | #1 |
| cartilage ep4 receptor | #1 |
| area curve cartilage | #1 |
| implications mirna biology | #1 |
| inflammatory plasma lipids | #1 |
| meniscal tears kl | #1 |
| postn ddr1 | #1 |
| prednisone placebo therapy | #1 |
| improvement 96 weeks | #1 |
| nsaids gtp | #1 |
| progression skoa | #1 |
| plasma membranes acetaminophen | #1 |
| elevated level c4d | #1 |
| greiss | #1 |
| hydrocortisone pge2 production | #1 |
| comp fragments serum | #1 |
| oaaffected cartilage cartilage | #1 |
| additional catabolic mediators | #1 |
| membrane viscosity nsaids | #1 |
| locally synovial fluid | #1 |
| vasp acetylcholine | #1 |
| 347 189 | #1 |
| degradation snitrosothiols | #1 |
| cmts cox2 | #1 |
| periostin interaction | #1 |
| nsaids neutrophil functions | #1 |
| inflammation synovitisdriven osteoarthritis | #1 |
| coxibs nonsteroidal arthritis | #1 |
| quantitative sv | #1 |
| conclusionsin vivo dti | #1 |
| grade dcjsw | #1 |
| c4d pregnant patients | #1 |
| skoa | #1 |
| averaged md | #1 |
| psoriatic arthritis scfas | #1 |
| osteoarthritis potential targets | #1 |
| upregulation surface cr3 | #1 |
| membrane translocation p21rac2 | #1 |
| thiazines rheumatoid | #1 |
| postn deficiency postn | #1 |
| bioactive intermediary | #1 |
| evidence redox derivatives | #1 |
| biomarkers osteoarthritis patients | #1 |
| sle measurements | #1 |
| nuclear accumulation lamin | #1 |
| jsn cindunistat | #1 |
| human interleukin17 | #1 |
| receptor familyrelated genes | #1 |
| rheumatoid cells models | #1 |
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Prominent publications by Steven B Abramson
PURPOSE: As a prelude to developing updated, evidence-based, international consensus recommendations for the management of hip and knee osteoarthritis (OA), the Osteoarthritis Research Society International (OARSI) Treatment Guidelines Committee undertook a critical appraisal of published guidelines and a systematic review (SR) of more recent evidence for relevant therapies.
METHODS: Sixteen experts from four medical disciplines (primary care two, rheumatology 11, orthopaedics one and ...
| Known for Critical Appraisal | Knee Osteoarthritis | Treatment Guidelines | Oarsi Recommendations | Management Hip |
OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines
[ PUBLICATION ]
PURPOSE: To develop concise, patient-focussed, up to date, evidence-based, expert consensus recommendations for the management of hip and knee osteoarthritis (OA), which are adaptable and designed to assist physicians and allied health care professionals in general and specialist practise throughout the world.
METHODS: Sixteen experts from four medical disciplines (primary care, rheumatology, orthopaedics and evidence-based medicine), two continents and six countries (USA, UK, France, ...
| Known for Consensus Guidelines | Knee Osteoarthritis | Management Hip | Based Evidence | Chondroitin Sulphate |
Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin
[ PUBLICATION ]
OBJECTIVE: As we previously reported, ADAMTS-7 and ADAMTS-12, two members of ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) family, degrade cartilage oligomeric matrix protein (COMP) in vitro and are significantly induced in the cartilage and synovium of arthritic patients [Liu CJ, Kong W, Ilalov K, Yu S, Xu K, Prazak L, et al. ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. FASEB J 2006;20(7):988-90; Liu CJ, ...
| Known for Adamts7 Adamts12 | Matrix Protein | Cartilage Oligomeric | Comp Degradation | Human Chondrocytes |
Nitric oxide provokes vasodilation and inhibits platelet aggregation. We examined the effect of nitric oxide on superoxide anion production by three sources: activated intact neutrophils, xanthine oxidase/hypoxanthine, and the NADPH oxidase. Nitric oxide significantly inhibited the generation of superoxide anion by neutrophils exposed to either FMLP (10(-7)M) or PMA (150 ng/ml) (IC50 = 30 microM). To determine whether the effect of nitric oxide on the respiratory burst was due to simple ...
| Known for Nitric Oxide | Nadph Oxidase | Direct Action | Anion Production | O2 Generation |
OBJECTIVE: To perform a randomized, double-blind, crossover clinical trial of diclofenac + misoprostol versus acetaminophen in ambulatory patients with osteoarthritis of the hip or knee.
METHODS: Patients in 12 ambulatory care settings were eligible if they were age >40 years and if they had Kellgren/Lawrence radiographic grade 2-4 osteoarthritis of the knee or hip and a score of > or =30 mm on a 100-mm visual analog pain scale. Patients were randomized to one of two groups, 75 mg ...
| Known for Patients Osteoarthritis | Hip Knee | 6 Weeks | Clinical Trial | Diclofenac Acetaminophen |
Transcriptional Repression of Matrix Metalloproteinase Gene Expression by the Orphan Nuclear Receptor NURR1 in Cartilage*
[ PUBLICATION ]
The NR4A orphan receptors (Nur77, NURR1, and NOR-1) are emerging as key regulators of cytokine and growth factor action in chronic inflammatory diseases. In this study, we address the role of these receptors in cartilage homeostasis during inflammatory joint disease. We document for the first time expression of the NR4A receptors in osteoarthritic cartilage. Relative to Nur77 and NOR-1, NURR1 is expressed at the highest level and correlates with cyclooxygenase-2 levels in cartilage. ...
| Known for Gene Expression | Transcriptional Repression | Receptor Nurr1 | Matrix Metalloproteinase | Orphan Nuclear |
Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription
[ PUBLICATION ]
OBJECTIVE: To address the role of the nuclear receptor 4A (NR4A) family of orphan nuclear receptors in synoviocyte transformation, hyperplasia, and regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in models of inflammatory arthritis.
METHODS: NR4A messenger RNA levels in synovial tissue and primary synoviocytes were measured by quantitative reverse transcription-polymerase chain reaction (RT-PCR). NR4A2 was stably overexpressed in normal ...
| Known for Nuclear Receptor | Expression Nr4a2 | Matrix Metalloproteinase | Migration Invasion | Synovial Tissue |
The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
[ PUBLICATION ]
The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We report that PGRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFα-TNFR interaction. PGRN-deficient mice were susceptible to collagen-induced arthritis, and administration of PGRN reversed inflammatory arthritis. Atsttrin, an engineered protein composed of three PGRN fragments, exhibited ...
| Known for Inflammatory Arthritis | Growth Factor | Tnf Receptors | Knockout Mice | Progranulin Binds |
Matrix Metalloproteinase Secretion by Gastric Epithelial Cells Is Regulated by E Prostaglandins and MAPKs*
[ PUBLICATION ]
Because matrix metalloproteinases (MMPs) play roles in inflammatory tissue injury, we asked whether MMP secretion by gastric epithelial cells may contribute to gastric injury in response to signals involved in Helicobacter pylori-induced inflammation and/or cyclooxygenase inhibition. Tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and epidermal growth factor (EGF) stimulated gastric cell MMP-1 secretion, indicating that MMP-1 secretion occurs in inflammatory as well as ...
| Known for Matrix Metalloproteinase | Epithelial Cell | Mmp1 Secretion | Erk Activation | Protein Kinases |
Abstract.Objective and Design: Cyclosporin, FK-506 and rapamycin have similar but distinct modes of interaction with cyclophilins, calcineurins and transcription factors. These immunosuppressive drugs have also been shown to inhibit cytotoxic and inflammatory responses in macrophage. Therefore, we evaluated the mechanism of action of these drugs on iNOS and COX-2 expression by macrophages, the products of which (NO and PGE2) have cytotoxic and pro-inflammatory activities.¶Materials and ...
| Known for Nitric Oxide | Immunosuppressive Drugs | Fk506 Rapamycin | Pge2 Production | Inflammatory Effects |
Up‐Regulation of Endothelial Cell Adhesion Molecules Characterizes Disease Activity in Systemic Lupus Erythematosus
[ PUBLICATION ]
OBJECTIVE: To test the hypothesis that during exacerbations of systemic lupus erythematosus (SLE), endothelial cells are activated to increase their expression of adhesion molecules.
METHODS: Endothelial cell expression of E-selectin, vascular cell adhesion molecule 1 (VCAM-1), and intercellular adhesion molecule 1 (ICAM-1) was quantitated immunohistochemically in 20 biopsy specimens from nonlesional, non-sun-exposed skin from 16 SLE patients. Disease activity was evaluated with the SLE ...
| Known for Adhesion Molecules | Endothelial Cell | Systemic Lupus | Patients Sle | Vcam1 Icam1 |
Elevated levels of fibronectin (Fn) in articular cartilage have been linked to the progression of both rheumatoid and osteoarthritis. In this study, we examined intracellular events which follow ligation of Fn to its receptor, the integrin alpha5beta1. In addition, we examined the regulatory influence of nitric oxide on these events, since this free radical has been implicated in cartilage degradation. Exposure of chondrocytes to Fn-coated beads resulted in the circumferential clustering ...
| Known for Nitric Oxide | Focal Adhesion | Alpha5beta1 Integrin | Protein Tyrosine | Signaling Complex |
Cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib
[ PUBLICATION ]
BACKGROUND: Evidence suggests that both selective cyclooxygenase (COX)-2 inhibitors and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of cardiovascular events. However, evidence from prospective studies of currently available COX-2 inhibitors and non-selective NSAIDs is lacking in patients at high cardiovascular risk who are taking aspirin.
OBJECTIVE: To determine the cardiovascular outcomes in high risk patients with osteoarthritis treated with ...
| Known for Cardiovascular Outcomes | Ibuprofen Naproxen | Cox2 Inhibitors | Selective Cyclooxygenase | Patients Osteoarthritis |
Key People For Nitric Oxide
Steven B Abramson:Expert Impact
Concepts for whichSteven B Abramsonhas direct influence:Nitric oxide, Rheumatoid arthritis, Systemic lupus erythematosus, Knee osteoarthritis, Articular cartilage, Lupus erythematosus, Symptomatic knee, Inflammatory mediators.
Steven B Abramson:KOL impact
Concepts related to the work of other authors for whichfor which Steven B Abramson has influence:Nitric oxide, Rheumatoid arthritis, Gut microbiota, Articular cartilage, Systemic lupus erythematosus, Gene expression, Synovial fluid.
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