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    • Johan Van De Walle
    • Johan Van de Walle

      Johan Van de Walle

      Department of Pediatric Nephrology, University Hospital Ghent, Ghent, Belgium | Utoped, ERKnet, Ghent University Hospital, Ghent, Belgium | Paediatric Nephrology and ...



      KOL Resume for Johan Van de Walle


      Department of Pediatric Nephrology, University Hospital Ghent, Ghent, Belgium


      Department of Pediatric Nephrology, Utoped, Universitair Ziekenhuis Gent


      Ghent University Hospital, 9000 Ghent, Belgium;, (E.H.);, (W.V.B.);, (A.R.);, (G.G.);, (J.V.W.);, (R.V.);, (S.E.)

      Departments of, Pediatrics, Pediatric Nephrology


      Department of Pediatrics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium


      Pediatrics, Department of Child Nephrology, Ghent University Hospital, Ghent, Belgium


      Paediatric Nephrology, Ghent University Hospital, Ghent, Belgium


      University Hospital of Gent Department of Pediatric Nephrology Gent Belgium


      Pediatric Urology and Nephrology, Gent University Hospital, Ghent, Belgium


      UZ Gent, Gent, Belgium

      4Ghent University Hospital


      Pediatric Urologic Nephrologic Center, Ghent University Hospital, Ghent, Belgium


      Pediatric Uronephrological Center, University Hospital Ghent, Ghent, Belgium


      Ghent University Hospital, Paediatrics, Gent, BELGIUM


      Departments of Paediatric Urology and Nephrology (AR, JVW), Ghent University Hospital, Gent, Belgium


      Pediatric Uro/Nephrological Center, Ghent University Hospital, Ghent, Belgium

      Consenso de la SINUG y del Grupo Español de Urodinámica. Traducción inicial de. aspectos urológicos. aspectos de terminología. anorrectal/gastrointestinal. Consensuado en el Congreso XX aniversario de la SINUG en Barcelona. The Standardization of Terminology of Lower Urinary Tract Function in Children and Adolescents: Report from the Standardisation Committee of the International Children’s Continence Society


      Divisions of Pediatric Nephrology, University Hospital, Gent, Belgium


      Department of Urology, Harvard Medical School, Hunnewell 3, 300 Longwood Avenue, Boston, MA 02115, USA

      Paediatric Uro-Nephrological Centre, University Hospital Gent, Gent, Belgium


      Paediatric UrolNephrological Centre, Ghent University Hospital, Ghent, Belgium


      Department of Paediatrics, Paediatric Uro-Nephrological Centre (PUNC), Ghent University Hospital, De Pintelaan185, B-9000 Ghent, Belgium


      Paediatric Uro/Nephrologic Centre, Ghent University Hospital Paediatric Uro/Nephrologic Centre, Ghent University Hospital, and Department of Clinical Psychology, Research Group Developmental Disorders, Ghent University Paediatric Uro/Nephrologic Centre, Ghent University Hospital, Belgium Department of Clinical Psychology, Research Group Developmental Disorders, Ghent University, Belgium


      Departments of Paediatric Nephrology,

      Department of Paediatrics, Paediatric Uro-Nephrologic Centre, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium


      University Hospital, Ghent, Belgium;


      *Departments of Paediatric Urology and †Paediatric Nephrology, Ghant University Hospital, Belgium


      Departments of Urology, Paediatrics and Nursing, Paediatric Uro-Nephrologic Centre, University Hospital Gent, Gent, Belgium


      Department of Pediatric Nephrology, University of Ghent, Belgium




      Johan Van de Walle: Influence Statistics

      Sample of concepts for which Johan Van de Walle is among the top experts in the world.
      Concept World rank
      melt improves #1
      sleep debilitating condition #1
      nonmonosymptomatic enuresis #1
      deceased‐ #1
      desmopressin melt #1
      desmopressin melt patients #1
      renal circadian rhythms #1
      μg urinary osmolality #1
      formulation increased compliance #1
      uroflow emg measurement #1
      response rate desmopressin #1
      highdose tablets #1
      subgroup nephrotic children #1
      improvement voids #1
      belgian tertiary center #1
      enuresis attention #1
      8 sampling periods #1
      known• disturbance #1
      sodium ratio #1
      mirabegron pediatric #1
      apparent systemic vasculopathy #1
      rhythms enuresis #1
      enuresis psychological #1
      clearance fwc #1
      tablet odds #1
      predictive wet nights #1
      weight child volume #1
      nocturnal enuresis treatment #1
      polyuria based #1
      sum potassium #1
      reasons living donation #1
      provisional study #1
      tablet compliance #1
      consistent therapeutic effects #1
      enuresis treatment #1
      glomerular filtration hypovolemia #1
      groups statistical findings #1
      enuresis 4 #1
      daytime sodium #1
      weightbased dosing algorithm #1
      oral lyophilisate children #1
      kidney nocturnal #1
      hus efficacy #1
      refractory nocturnal enuresis #1
      enuresis medication #1
      enuresis desmopressin #1
      enuresis presence #1
      polyuria subgroup #1
      debilitating condition quality #1


      Prominent publications by Johan Van de Walle

      KOL-Index: 14215

      Vitamin D deficiency is widely prevalent and often severe in children and adults with chronic kidney disease (CKD). Although native vitamin D {25-hydroxyvitamin D [25(OH)D]} is thought to have pleiotropic effects on many organ systems, its skeletal effects have been most widely studied. The 25(OH)D deficiency is causally linked with rickets and fractures in healthy children and those with CKD, contributing to the CKD-mineral and bone disorder (MBD) complex. There are few studies to ...

      Known for Children Ckd | Chronic Kidney Disease | Native Vitamin | Practice Recommendations | Stages 2–5
      KOL-Index: 14055

      In patients with chronic kidney disease (CKD), renal synthesis of active vitamin D [1,25-dihydroxyvitamin D (1,25(OH)2D)] declines and is associated with hypocalcaemia, secondary hyperparathyroidism and the spectrum of CKD-mineral and bone disorder (MBD). In advanced CKD, active vitamin D analogues, including alfacalcidol, calcitriol and paricalcitol, are routinely administered. There are few studies on the use of vitamin D analogues in children with CKD and on dialysis. It is difficult ...

      Known for Active Vitamin | Chronic Kidney Disease | Children Ckd | Practice Recommendations | Stages 2–5
      KOL-Index: 12635

      In children with chronic kidney disease (CKD), optimal control of bone and mineral homeostasis is essential, not only for the prevention of debilitating skeletal complications and achieving adequate growth but also for preventing vascular calcification and cardiovascular disease. Complications of mineral bone disease (MBD) are common and contribute to the high morbidity and mortality seen in children with CKD. Although several studies describe the prevalence of abnormal calcium, ...

      Known for Dietary Management | Ckd Stages | Pediatric Renal | Nutrition Taskforce | Cprs Prnt
      KOL-Index: 11768

      OBJECTIVE: To analyse the treatment of girls with recurrent urinary tract infections (UTIs, at least two periods confirmed) and urodynamically confirmed dysfunctional voiding with pelvic-floor therapy.

      PATIENTS AND METHODS: Forty-two girls with recurrent UTIs were treated prospectively during a study period of 18 months. Training consisted of an individually adapted voiding and drinking schedule, pelvic-floor relaxation biofeedback, instructions on toilet behaviour and biofeedback ...

      Known for Dysfunctional Voiding | Urinary Tract | Reflux Girls | Pelvic‐floor Therapy | Psychology Child
      KOL-Index: 11618

      PURPOSE: Monosymptomatic nocturnal enuresis is frequently associated with nocturnal polyuria and low urinary osmolality during the night. Initial studies found decreased vasopressin levels associated with low urinary osmolality overnight. Together with the documented desmopressin response, this was suggestive of a primary role for vasopressin in the pathogenesis of enuresis in the absence of bladder dysfunction. Recent studies no longer confirm this primary role of vasopressin. Other ...

      Known for Nocturnal Polyuria | Circadian Rhythm | Filtration Rate | Sodium Excretion | Low Urinary Osmolality
      KOL-Index: 11217

      Leber Congenital Amaurosis (LCA), the most severe inherited retinal dystrophy, is genetically heterogeneous, with 14 genes accounting for 70% of patients. Here, 91 LCA probands underwent LCA chip analysis and subsequent sequencing of 6 genes (CEP290, CRB1, RPE65, GUCY2D, AIPL1and CRX), revealing mutations in 69% of the cohort, with major involvement of CEP290 (30%). In addition, 11 patients with early-onset retinal dystrophy (EORD) and 13 patients with Senior-Loken syndrome (SLS), ...

      Known for Modifier Alleles | Lca Cep290 | Proteins Retinal | 11 Patients | Genetic Screening
      KOL-Index: 11183

      PURPOSE: Although the relationship between enuresis and psychopathology has been studied intensively, little is known about the prevalence of specific psychiatric disorders. We investigate the prevalence of attention deficit/hyperactivity disorder (ADHD) in children with nocturnal enuresis and correlate these data with clinical subtypes of enuresis/incontinence.

      MATERIALS AND METHODS: A total of 120 children with nocturnal enuresis 6 to 12 years old participated in a prevalence study. A ...

      Known for Nocturnal Enuresis | Attention Deficit | Adhd Children | Hyperactivity Disorder | Diagnostic Interview
      KOL-Index: 11076

      PURPOSE: The current study focuses on the construction and validation of the Short Screening Instrument for Psychological Problems in Enuresis, for emotional problems and symptoms of attention deficit hyperactivity disorder, in a population of children with enuresis.

      MATERIALS AND METHODS: In phase I factor analyses were performed on 31 items of the Internalizing scale of the Child Behavior Checklist and on 18 items of the Attention Deficit Disorder scale of the Disruptive Behavior ...

      Known for Psychological Problems | Short Screening Instrument | Children Enuresis | Child Behavior Checklist | Behavior Disorders
      KOL-Index: 10706

      INTRODUCTION: Mirabegron, a selective β3-adrenoreceptor agonist, is a well-established alternative to antimuscarinics in adults with overactive bladder (OAB) symptoms and is under development for use in pediatric patients. Understanding drug pharmacokinetics (PK) in pediatric patients is needed to determine appropriate dosing. Conducting these studies is ethically complex, particularly as regulatory guidance requires that PK is assessed in pediatric patients with a therapeutic need for ...

      Known for Pediatric Patients | Mirabegron Children | Neurogenic Detrusor Overactivity | Oral Suspension | Overactive Bladder
      KOL-Index: 10479

      PURPOSE: In a specialized university setting the prevalence of attention deficit hyperactivity disorder in general and particularly the inattentive subtype attention deficit hyperactivity disorder of the predominantly inattentive subtype is highly increased. We replicated previous research findings that enuresis is associated with a brainstem deficit and investigated the impact of attention deficit hyperactivity disorder on this brainstem deficit in enuresis.


      Known for Attention Deficit | Hyperactivity Disorder | Children Enuresis | Sensory Gating | Brainstem Inhibition
      KOL-Index: 10291

      Objectives: The objective of this study was to characterize cefazolin serum pharmacokinetics in children before, during and after cardiopulmonary bypass (CPB), in order to derive an evidence-based dosing regimen.

      Patients and methods: This study included children who received cefazolin before surgical incision, before cessation of CPB and after surgery. Blood samples of total and unbound cefazolin concentrations were collected before, during and after CPB. The cefazolin ...

      Known for Cardiopulmonary Bypass | Cardiac Surgery | Population Pharmacokinetics | Cpb Cefazolin | Dosing Regimens
      KOL-Index: 10255

      PURPOSE: The prevalence of attention deficit-hyperactivity disorder was increased in a predominantly nonmonosymptomatic nocturnal enuresis population reported on previously. At 2 years after onset of treatment for enuresis attention deficit-hyperactivity disorder seemed to be a risk factor for continuing enuresis. In the current 4-year followup study we sought to determine whether the original attention deficit-hyperactivity disorder diagnosis could be reconfirmed, thereby reflecting the ...

      Known for Attention Deficit | Hyperactivity Disorder | Nocturnal Enuresis | Prevalence Children | Comorbidity Female
      KOL-Index: 9804

      Atypical hemolytic uremic syndrome (aHUS) is caused by alternative complement pathway dysregulation, leading to systemic thrombotic microangiopathy (TMA) and severe end-organ damage. Based on 2 prospective studies in mostly adults and retrospective data in children, eculizumab, a terminal complement inhibitor, is approved for aHUS treatment. Here we prospectively evaluated efficacy and safety of weight-based dosing of eculizumab in eligible pediatric patients with aHUS in an open-label ...

      Known for Pediatric Patients | Atypical Hemolytic | Uremic Syndrome | Efficacy Safety | Complete Tma Response
      KOL-Index: 9257

      PURPOSE: The impact of the original International Children's Continence Society terminology document on lower urinary tract function resulted in the global establishment of uniformity and clarity in the characterization of lower urinary tract function and dysfunction in children across multiple health care disciplines. The present document serves as a stand-alone terminology update reflecting refinement and current advancement of knowledge on pediatric lower urinary tract ...

      Known for Lower Urinary | Tract Function | Continence Society | International Children | Medical Terminology
      KOL-Index: 9246

      OBJECTIVE: To study the self-image of children between 8 and 12 years with nocturnal enuresis, and to correlate the findings with age, sex, clinical symptoms, primary versus secondary enuresis and treatment failures.

      METHODS: The study-group embraced 50 university hospital, and therefore selected therapy-resistant nocturnal enuresis-children, 27 boys and 23 girls. The mean age was 9.8, which means children aged between 8 and 12 years. Children were classified into two age groups: I=8-9 ...

      Known for Nocturnal Enuresis | Age Children | Successful Treatment | 12 Years | Sex Factors

      Key People For Nocturnal Enuresis

      Top KOLs in the world
      Soeren Rittig
      nocturnal enuresis nephrotic syndrome diabetes insipidus
      Jens Christian Djurhuus
      nocturnal enuresis pelvic pressure ureteral obstruction
      Kelm Hjälmås
      nocturnal enuresis bladder dysfunction vitamin b12
      Johan Van de Walle
      nocturnal enuresis circadian rhythm urinary incontinence
      Chung Kwong Yeung
      nocturnal enuresis bladder dysfunction hong kong
      Alexander von Gontard
      nocturnal enuresis urinary incontinence daytime wetting

      Johan Van de Walle:Expert Impact

      Concepts for whichJohan Van de Wallehas direct influence:Nocturnal enuresis,  Nocturnal polyuria,  Circadian rhythm,  Problem behavior,  Wet nights,  Psychological problems,  Glomerular filtration,  Urinary incontinence.

      Johan Van de Walle:KOL impact

      Concepts related to the work of other authors for whichfor which Johan Van de Walle has influence:Nocturnal enuresis,  Overactive bladder,  Urinary incontinence,  Dysfunctional voiding,  Chronic kidney disease,  Vesicoureteral reflux,  Pediatric patients.



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      Department of Pediatric Nephrology, University Hospital Ghent, Ghent, Belgium | Utoped, ERKnet, Ghent University Hospital, Ghent, Belgium | Paediatric Nephrology and Rheumatology Section, Department of Paediatrics, Ghent University Hospital, Corneel

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