Johan Van de Walle

Johan Van de Walle

From The Paediatric Uro Nephrologic Centre, Department Of Rehabilitation Sciences And Physical Therapy, Gent University Hospital, Gent, Belgium

Direct Impact

Concepts for which Johan Van de Walle has direct influence:

nocturnal enuresis
circadian rhythm
urinary incontinence
chronic kidney
atypical hemolytic uremic syndrome
wet nights
problem behavior

External impact

Concepts related to the work of other authors for which Johan Van de Walle has influence:

nocturnal enuresis
muc1 mutation
chronic kidney
rare musculoskeletal
hyp mice
sodium clearance
pediatric renal nutrition taskforce

Prominent publications by Johan Van de Walle

KOL-Index: 152 X-linked hypophosphatemia (XLH) is the most common genetic form of hypophosphatemic rickets and osteomalacia. In this disease, mutations in the PHEX gene lead to elevated levels of the hormone fibroblast growth factor 23 (FGF23), resulting in renal phosphate wasting and impaired skeletal and dental mineralization. Recently, international guidelines for the diagnosis and treatment of this ...
Known for
Recommendations Xlh
KOL-Index: 83 Desmopressin is a synthetic analogue of the natural antidiuretic hormone arginine vasopressin. Over the years, it has been clinically used to manage nocturnal polyuria in children with enuresis. Various pharmaceutical formulations of desmopressin have been commercialized for this indication—nasal spray, nasal drops, oral tablet and oral lyophilizate. Despite the fact that desmopressin is a ...
Known for
Lyophilizate Desmopressin
KOL-Index: 62 Urea is the most abundant and the largest contributing factor for urine osmolality. Urinary urea excretion is highly interrelated with dietary protein intake. Accordingly, an increase of urinary urea excretion due to high protein diet may lead to urea-induced osmotic diuresis. This study aims to explore the association between nocturnal polyuria (NP) and urea. This is a post hoc analysis of ...
Known for
Clearance Creatinine | Higher Nighttime | Osmolality Urinary | Polyuria Urea
KOL-Index: 61 Obesity and metabolic syndrome (O&MS) due to the worldwide obesity epidemic affects children at all stages of chronic kidney disease (CKD) including dialysis and after kidney transplantation. The presence of O&MS in the pediatric CKD population may augment the already increased cardiovascular risk and contribute to the loss of kidney function. The Pediatric Renal Nutrition Taskforce (PRNT) ...
Known for
Nutritional Management | Oms Pediatric | Children Kidney | Stages 2–5
KOL-Index: 53 Pediatric drug development, especially in disease areas that only affect children, can be stimulated by using juvenile animal models not only for general safety studies, but also to gain knowledge on the pharmacokinetic and pharmacodynamic properties of the drug. Recently, the conventional growing piglet has been suggested as juvenile animal model. However, more studies with different ...
KOL-Index: 47 Autosomal-dominant tubulo-interstitial kidney disease (ADTKD) encompasses a group of disorders characterized by renal tubular and interstitial abnormalities, leading to slow progressive loss of kidney function requiring dialysis and kidney transplantation. Mutations in UMOD, MUC1, and REN are responsible for many, but not all, cases of ADTKD. We report on two families with ADTKD and ...
KOL-Index: 44 OBJECTIVE: To capture the early effects of the coronavirus disease 2019 (COVID-19) pandemic on pediatric clinical research. STUDY DESIGN: Pediatric clinical research networks from 20 countries and 50 of their affiliated research sites completed two surveys over one month from early May to early June 2020. Networks liaised with their affiliated sites and contributed to the interpretation of ...
Known for
Early Detecting | Capacities | Pan-European Canadian Snapshot | Dates
KOL-Index: 39 A large number of falls in hospitals occur on the way to the toilet. Accordingly, a literature search was conducted in Web of Science, PubMed, Embase, and the Cochrane Library to identify fall risk screening and assessment metrics published between 1980 and 2019 and to study the inclusion of lower urinary tract symptoms (LUTS) and their related parameters in these screening tools. In ...
Known for
23 Fall Scales | Luts Luts-Related Parameter | 12 Tools | Community-Dwelling Older People
KOL-Index: 39 Enuresis, particularly in children during sleep, can be a debilitating condition, affecting the quality of life of the child and his or her family. The pathophysiology of nocturnal enuresis, though not clear, revolves around the inter-related mechanisms of overactive bladder, excessive nocturnal urine production, and sleep fragmentation. The first mechanism is more related to isolated ...
Known for
Tools Options | Understanding Pathophysiology | Enuresis Diagnostic
KOL-Index: 36 Objectives: The objective of this study was to characterize cefazolin serum pharmacokinetics in children before, during and after cardiopulmonary bypass (CPB), in order to derive an evidence-based dosing regimen. Patients and methods: This study included children who received cefazolin before surgical incision, before cessation of CPB and after surgery. Blood samples of total and unbound ...
Known for
Unbound Cefazolin Concentrations | Maximum Protein Binding Capacity | Cefazolin Concentration-Time Profiles | Two-Compartment Model

From the Paediatric Uro Nephrologic Centre, Department of Rehabilitation Sciences and Physical Therapy, Gent University Hospital, Gent, Belgium

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