• Disease
  • Coppadis
  • Coppadis Cohort
  • Diego Santos‐garcía

    Prominent publications by Diego Santos‐García

    KOL Index score: 12072

    BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder causing motor and non-motor symptoms that can affect independence, social adjustment and the quality of life (QoL) of both patients and caregivers. Studies designed to find diagnostic and/or progression biomarkers of PD are needed. We describe here the study protocol of COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015), an integral PD project based on four aspects/concepts: 1) PD as ...

    Also Ranks for: Serum Biomarkers |  parkinson disease |  genetic studies |  patients caregivers |  global –clinical evaluations
    KOL Index score: 9548

    OBJECTIVE: To investigate the impact of non-motor symptoms on health-related and perceived quality of life in Parkinson's disease (PD).

    METHODS: One hundred and fifty PD patients (57.3% males; 70.9±8.6years old) were included in this cross-sectional, monocenter, evaluation study. Multiple linear regression methods were used to evaluate the direct impact of non-motor symptoms (as assessed by the Non-Motor Symptoms Scale [NMSS]) on 1) the 39-item PD Quality of Life Questionnaire Summary ...

    Also Ranks for: Motor Symptoms |  quality life |  illness surveys |  parkinsons disease |  direct impact
    KOL Index score: 8943

    BACKGROUND: Gait impairment in Parkinson's disease (PD) patients is characterized by the inability to generate appropriate stride length. Treadmill training has been proposed as a therapeutic tool for PD patients. However, it remains unknown whether treadmill training effects are different from overground walking training. Thus, our goal was to explore the effects of two training programs, walking on a treadmill and walking overground, in PD patients.

    METHODS: 22 PD patients were ...

    Also Ranks for: Walking Training |  stride length |  gait parameters |  balance patients |  parkinsons disease
    KOL Index score: 8179

    BACKGROUND AND OBJECTIVE: To analyze the main determinants of burden and stress in caregivers of Spanish Parkinson's disease (PD) patients.

    METHODS: One-hundred and twenty-one non-demented patients with PD (57.9% males; 70.9 ± 8.2 years old) were included in this cross-sectional, monocenter, evaluation study. Caregivers (n = 121; 71.9% females; 60.2 ± 15 years old) were assessed using the Zarit Caregiver Burden Inventory (ZCBI) and Caregiver Strain Index (CSI). Multiple linear regression ...

    Also Ranks for: Zcbi Csi |  illness cross |  factors caregivers |  parkinson disease |  caregiver strain
    KOL Index score: 8127

    BACKGROUND: Continuous duodenal levodopa infusion (DLI) is an effective therapy that improves quality of life (QoL) in advanced Parkinson's disease (PD). However, in which aspects improve the patients their QoL has been poorly documented.

    METHODS: We evaluated 39-item Parkinson's disease Quality of Life Questionnaire Summary Index score (PDQ-39SI) changes analyzing its different domains in nine patients with advanced PD treated with DLI.

    RESULTS: All the patients (64.7 ± 11.1 years, ...

    Also Ranks for: Quality Life |  patients qol |  carbidopa infusion |  duodenal levodopa |  6 months
    KOL Index score: 7718

    Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson's disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January ...

    Also Ranks for: Coppadis Cohort |  v0 v2 |  symptoms burden |  year follow |  nmss total score
    KOL Index score: 7688

    BACKGROUND AND PURPOSE: Brachial arterial flow-mediated dilation (FMD) reflects endothelium-dependent vasodilation function. FMD is diminished in patients with endothelial dysfunction (ED). Our aim was to investigate the relationship between FMD and outcome for patients with acute ischemic stroke.

    METHODS: We measured FMD in 120 consecutive patients (58.3% male, median age 73 years) with acute ischemic stroke within the first 48 h of onset of the stroke, using high-resolution ...

    Also Ranks for: Acute Ischemic Stroke |  fmd patients |  poor outcome |  mediated dilation |  brachial artery
    KOL Index score: 7003

    BACKGROUND: Continuous duodenal levodopa infusion (DLI) is an effective therapy that improves quality of life (QoL) in advanced Parkinson's disease (PD). However, the impact of DLI on caregivers' stress and burden has not been reported.

    METHODS: We evaluated prospectively open-label seven advanced PD patients (65.7 ± 9.6 years, 71.4% men) treated with DLI. Schwab & England Activities of Daily Living Scale (ADLS), 39-item Parkinson's disease QoL Questionnaire Summary Index score ...

    Also Ranks for: Duodenal Levodopa |  carbidopa infusion |  parkinson disease |  advanced patients |  caregiver burden
    KOL Index score: 6757

    BACKGROUND AND PURPOSE: In Parkinson's disease (PD), the course of the disorder is highly variable between patients. Well-designed, prospective studies for identifying PD progression biomarkers are necessary. Our aim was to show the results of baseline evaluations of an ongoing global PD project, COPPADIS-2015 (Cohort of Patients with PArkinson's DIsease in Spain, 2015).

    METHODS: This was an observational, descriptive, nationwide study (Spain). The recruitment period ended in October ...

    Also Ranks for: Impulse Control |  parkinsons disease |  baseline evaluation |  cohort patients |  626 ±
    KOL Index score: 6596

    OBJECTIVE: We investigated the role of the frontostriatal system in contextual processing, by examining neural correlates of local contextual processing in Parkinson's disease (PD). Local context was defined as the occurrence of a short predictive series of visual stimuli occurring before delivery of a target event.

    METHODS: EEG was recorded in eight PD patients and eight controls. Recording blocks consisted of targets preceded by randomized sequences of standards and by sequences ...

    Also Ranks for: Contextual Processing |  parkinson disease |  random targets |  local context |  target event
    KOL Index score: 6128

    Functional connectivity was evaluated in patients with schizophrenia (SC) and in patients with Parkinson's disease (PD) during the performance of a local contextual processing paradigm, to investigate the proposition that functional disconnection is involved with contextual processing deficits in these populations. To this end, we utilized event-related EEG signals, synchronization likelihood and graph theoretical analysis. Local context was defined as the occurrence of a predictive ...

    Also Ranks for: Contextual Processing |  functional connectivity |  predictive sequence |  schizophrenia patients |  predicted targets
    KOL Index score: 5997

    Objective: 5- (5 times oral levodopa tablet taken/day) 2- (2 hours of OFF time/day) 1- (1 hour/day of troublesome dyskinesia) criteria have been proposed by a Delphi expert consensus panel for diagnosing advanced Parkinson's disease (PD). The aim of the present study is to compare quality of life (QoL) in PD patients with "5-2-1 positive criteria" vs QoL in PD patients without "5-2-1 positive criteria" (defined as meeting ≥1 of the criteria).

    Methods: This is a cross-sectional, ...

    Also Ranks for: 1 Criteria |  qol patients |  5 2 |  screening tool |  troublesome dyskinesia
    KOL Index score: 5945

    INTRODUCTION: The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients.

    METHODS: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed by the Spanish version of the Parkinson's disease Sleep Scale version 1 (PDSS-1). An overall score below 82 or a score below 5 on at least 1 item was ...

    Also Ranks for: Sleep Problems |  symptoms burden |  coppadis cohort |  35 centers |  parkinsons disease
    KOL Index score: 5594

    BACKGROUND AND PURPOSE: The objective of this study was to analyze the relationship between motor complications and non-motor symptom (NMS) burden in a population of patients with Parkinson's disease (PD) and also in a subgroup of patients with early PD.

    METHODS: Patients with PD from the COPPADIS cohort were included in this cross-sectional study. NMS burden was defined according to the Non-Motor Symptoms Scale (NMSS) total score. Unified Parkinson's Disease Rating Scale (UPDRS) part IV ...

    Also Ranks for: Motor Complications |  patients parkinson disease |  nms burden |  total score |  coppadis cohort


    Diego Santos‐García: Influence Statistics

    Sample of concepts for which Diego Santos‐García is among the top experts in the world.
    Concept World rank
    bdi iii #1
    csi bdi #1
    mortality nondemented patients #1
    updrs mood #1
    updrsiv nms #1
    methods adls #1
    updrsiv nmss #1
    adls zcbi #1
    nmss mortality #1
    variables zarit #1
    factors caregivers stress #1
    nmss csi #1
    bdi zcbi #1
    contributing caregivers #1
    updrsiv 95 #1
    versus nonmotor symptoms #1
    nmss adls #1
    2010 marcide #2
    advanced treatment spain #2
    3–34 years #2
    dli mobility #2
    gastrostomy september #2
    spain duodopa #2
    duodopa clinical characteristics #2
    627±106 4474 years #2
    improved pdq39si #2
    duodopa spain #2
    pdq39si 6 #2
    dli activities #2
    dyskinesia 666 #2
    tests daw #2
    males 709 #2
    factors daw #2
    withdrawal daw #2
    levodopa intraduodenal #2
    pdq39 schwabengland #2
    24±125 #2
    pq10 61 #2
    dli daily living #2
    schwabengland capacity #2
    advanced pdmethodswe #2
    duodopa 627±106 #2
    duodopain patients #2
    staging 37±05 #2
    marcide hospital #2
    daw patients #2
    score pdq39si #2
    pq10 eurohis #2
    male duodopa #2
    39item parkinsons disease #2

    Key People For Coppadis Cohort

    Top KOLs in the world
    Paolo Barone
    parkinson disease impulse control essential tremor
    Pablo Martinez‐Martin
    parkinson disease motor symptoms quality life
    Jaime J Kulisevsky
    parkinson disease cognitive impairment minor hallucinations
    Maria José Martı́
    parkinson disease cervical dystonia cortical thinning
    Jon Infante
    spinocerebellar ataxia type parkinson disease g2019s mutation
    Pablo Mir
    parkinson disease tourette syndrome coppadis cohort

    Diego Santos‐García:Expert Impact

    Concepts for whichDiego Santos‐Garcíahas direct influence:Coppadis cohort,  Sleep problems,  Parkinson disease,  Parkinsons disease,  Functional dependency,  Quality life,  Walking economy,  Motor complications.

    Diego Santos‐García:KOL impact

    Concepts related to the work of other authors for whichfor which Diego Santos‐García has influence:Parkinson disease,  Caregiver burden,  Motor symptoms,  Treadmill training,  Endothelial function,  Quality life,  Chronic pain.



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    Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain | CHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain | Department of Neurology, Hospital Universitario de A Coruña (HUAC), Complejo Hospitalario Universitar