Prominent publications by Ajit Sood

KOL Index score: 16098

The advent of biological therapy has revolutionized inflammatory bowel disease (IBD) care. Nonetheless, not all patients require biological therapy. Selection of patients depends on clinical characteristics, previous response to other medical therapy, and comorbid conditions. Availability, reimbursement guidelines, and patient preferences guide the choice of first-line biological therapy for luminal Crohn's disease (CD). Infliximab (IFX) has the most extensive clinical trial data, but ...

Also Ranks for: Biological Therapy |  london position statement |  monoclonal antibodies |  ifx patients |  loss response
KOL Index score: 13550

BACKGROUND: Celiac disease, as of today, is said to exist in almost all parts of the world, although it is rare among people of purely African-Caribbean, Japanese and Chinese background. The disease has also been considered uncommon in India until recently. Hospital records have revealed an increasing trend of the disease in predominantly wheat-eating areas of North India. The aim of the present study was to determine the prevalence of celiac disease among school children in Punjab, ...

Also Ranks for: Celiac Disease |  north india |  school children |  anti ttg |  study prevalence
KOL Index score: 13123

Hepatitis C virus (HCV) genotypes help to tailor the treatment response, but their influence on the disease severity and association with hepatic steatosis is not well understood. The prevalence of HCV genotypes and their correlation with the histopathological severity of liver disease and steatosis in Indian patients were studied. HCV-RNA and genotyping was carried out in 398 patients with chronic hepatitis C. Liver biopsy was available in 292 (73.4%) patients. The severity of liver ...

Also Ranks for: Liver Disease |  genotype 3 |  patients chronic hepatitis |  hepatic steatosis |  histological activity
KOL Index score: 12892

OBJECTIVES: Cirrhotics with minimal hepatic encephalopathy (MHE) have a poor health-related quality of life (HRQOL). Treatment of MHE is still evolving. The aim of this double-blind randomized pilot study was to assess the efficacy of rifaximin in improving neuropsychometric (NP) test performance and HRQOL in patients with MHE.

METHODS: MHE was diagnosed if any two NP tests (number and figure connection tests, picture completion, digit symbol, and block design tests) were deranged beyond ...

Also Ranks for: Patients Mhe |  life hrqol |  minimal hepatic encephalopathy |  8 weeks |  rime trial
KOL Index score: 12200

OBJECTIVES: To study the role of faecal microbiota transplantation [FMT] in maintenance of remission in ulcerative colitis [UC].

METHODS: In this pilot study, patients with UC in clinical remission achieved after multi-session FMT were randomly allocated to either maintenance FMT or placebo colonoscopic infusion every 8 weeks, for 48 weeks. The standard of care [SOC] therapy was continued in all patients. The primary endpoint was maintenance of steroid-free clinical remission [Mayo score ...

Also Ranks for: Patients Fmt |  ulcerative colitis |  microbiota transplantation |  clinical remission |  mayo score
KOL Index score: 11706

INTRODUCTION: Ulcerative colitis occurs worldwide. It is considered common in most of Europe and North America and uncommon in most of the developing Asian countries. The incidence/prevalence of ulcerative colitis varies not only according to geographical region but also with race and ethnicity. There are no reported data from India on the incidence of the disease and its prevalence.

MATERIAL AND METHODS: A house to house survey was conducted by questionnaire, formulated to enquire about ...

Also Ranks for: Ulcerative Colitis |  north india |  incidence prevalence |  suspected cases |  100 000 inhabitants
KOL Index score: 11499

BACKGROUND AND AIMS: In chronic hepatitis C virus (HCV) infection with genotype 3, therapy with pegylated interferon (peg-IFN) alfa-2b in a dose of 1.5 mug/kg/week and ribavirin (800-1000 mg/day) is recommended for 24 weeks. Reduced doses of peg-IFN may increase compliance and decrease cost and adverse events. This study aimed to assess the safety and efficacy of two different regimens of peg-IFN alfa-2b, in combination with ribavirin, in genotype 3 patients.

METHODS: A total of 103 ...

Also Ranks for: Pegylated Interferon |  genotype 3 |  patients groups |  24 weeks |  peg ifn
KOL Index score: 10843

BACKGROUND AND AIM: There is limited data on predictors of acute kidney injury in acute on chronic liver failure. We developed a PIRO model (Predisposition, Injury, Response, Organ failure) for predicting acute kidney injury in a multicentric cohort of acute on chronic liver failure patients.

PATIENTS AND METHODS: Data of 2360 patients from APASL-ACLF Research Consortium (AARC) was analysed. Multivariate logistic regression model (PIRO score) was developed from a derivation cohort ...

Also Ranks for: Acute Kidney Injury |  liver failure |  multivariate analysis |  validation cohort |  tests prognosis
KOL Index score: 10616

BACKGROUND: Lower hepatitis B virus DNA (HBV DNA) levels are associated with better responses in chronic hepatitis B (CHB). It is unclear whether an initial phase of antiviral treatment to lower HBV DNA levels before adding immunomodulator therapy is more effective than the strategy of using immunomodulators from the beginning.

AIM: The aim of the study was to compare the efficacy of lamivudine followed by pegylated-interferon (peg-IFN) therapy with placebo followed by peg-IFN therapy in ...

Also Ranks for: Hbv Dna |  chronic hepatitis |  antiviral therapy |  hbeag loss |  peg ifn
KOL Index score: 10513

BACKGROUND: Three common disease susceptibility variants in the NOD2 gene are associated with inflammatory bowel disease in Caucasians, but not in Asians. Aim To screen for NOD2 variants and examine susceptibility for inflammatory bowel disease in North Indians.

METHODS: A case-control study was carried out in Punjab, India. Confirmed cases of ulcerative colitis and Crohn's disease and healthy controls matched for age (+/-10 years) and ethnicity were studied. Besides genotyping the three ...

Also Ranks for: Ulcerative Colitis |  north indians |  nod2 variants |  inflammatory bowel disease |  allelic heterogeneity
KOL Index score: 10257

The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. With international groups volunteering to join, the "APASL ACLF Research Consortium (AARC)" was formed in 2012, which continued to collect prospective ACLF patient data. Based on the prospective data analysis of nearly 1400 patients, the AARC consensus was published in 2014. In the past nearly ...

Also Ranks for: Liver Failure |  autoimmune hepatitis |  asian pacific association |  acute chronic |  apasl aclf
KOL Index score: 10077

BACKGROUND & AIMS: Lactulose and rifaximin have already been shown to improve both cognitive functions and health related quality of life (HRQOL) in MHE patients. We aimed to compare the efficacy of rifaximin with lactulose in reversal of MHE and improvement in HRQOL in cirrhotic patients with MHE.

METHOD: This prospective, randomized, open label, non-inferiority trial, was conducted at the Gastroenterology department of a tertiary care institute in Northern India. MHE was diagnosed if ...

Also Ranks for: Rifaximin Lactulose |  patients mhe |  hepatic encephalopathy |  liver cirrhosis |  neuropsychological tests
KOL Index score: 9978

Background and aimsAcute-on-chronic liver failure (ACLF) is a progressive disease associated with rapid clinical worsening and high mortality. Early prediction of mortality and intervention can improve patient outcomes. We aimed to develop a dynamic prognostic model and compare it with the existing models.MethodsA total of 1402 ACLF patients, enrolled in the APASL-ACLF Research Consortium (AARC) with 90-day follow-up, were analyzed. An ACLF score was developed in a derivation cohort ...

Also Ranks for: Liver Failure |  apasl aclf |  sofa models |  hepatic encephalopathy |  total bilirubin
KOL Index score: 9930

Overall prevalence of HCV infection in India has been estimated to be approximately 1.3% in the general population. Recent introduction of sofosbuvir in India at a relatively affordable price has led to great optimism about prospects of cure for these patients. This drug is likely to form the backbone of current and future treatment regimes for HCV infection, displacing pegylated interferon. Availability of directly acting antiviral drugs (DAAs) has necessitated revision of INASL ...

Also Ranks for: Hcv Infection |  antiviral therapy |  indian national association |  pegylated interferon |  inasl guidelines treatment
KOL Index score: 9603

AIM: To evaluate the role of azathioprine (AZA) in Indian patients with ulcerative colitis over longer duration of time.

METHODS: One hundred fifty six patients with ulcerative colitis who were treated with AZA from January 1995 to December 2003 were reviewed. The indications for its use were as follows: (1) steroid dependent and steroid refractory disease; (2) Azathioprine monotherapy for naive patients with severe disease; and (3) combination therapy (AZA + sulfasalazine or ...

Also Ranks for: Ulcerative Colitis |  azathioprine aza |  drug therapy |  gastrointestinal agents |  humans immunosuppressive

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Ajit Sood:Expert Impact

Concepts for whichAjit Soodhas direct influence:Ulcerative colitis,  Celiac disease,  Chronic hepatitis,  North india,  North indians,  Inflammatory bowel disease,  Pegylated interferon,  Northern india.

Ajit Sood:KOL impact

Concepts related to the work of other authors for whichfor which Ajit Sood has influence:Inflammatory bowel disease,  Ulcerative colitis,  Gut microbiota,  Hepatic encephalopathy,  Liver failure,  Chronic hepatitis,  Pancreatic cancer.



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Department of Gastroenterology, Dayanand Medical College and Hospital, 141 001, Ludhiana, India | Dayanand Medical College, Civil Lines, Tagore Nagar, Ludhiana, Punjab, India 141001 | Department of Gastroenterology, Dayanand Medical College and Hospi