• Disease
  • Sleep
  • Sleep Apnea
  • Nanfang Li

    Prominent publications by Nanfang Li

    KOL Index score: 13601

    BACKGROUND: Chinese Uygur, Kazakh, Mongolian and Han populations represent >90% of the total population of Xinjiang Uygur Autonomous Region, and their genetic backgrounds, customs, culture, and food consumption are different. The effect of ethnic differences on cardiovascular disease risk factors (CRFs; hypertension, obesity, diabetes, dyslipidemia, smoking) can be striking but is rarely studied. We report here the findings of the relationship among these ethnic groups and their CRFs ...

    Also Ranks for: Ethnic Disparities |  mongolian populations |  cardiovascular disease |  xinjiang uygur |  factors crfs
    KOL Index score: 12206

    BACKGROUND: Hypertension affects > 18.8% of adults in China. Indeed, hypertension is the most prevalent risk factor for cardiovascular morbidity and mortality worldwide. Genetic variation is thought to contribute to the etiology of hypertension. NEDD4L is a candidate gene for hypertension, both functionally and genetically. The purpose of the current study was to investigate the relationship between the variation in NEDD4L and essential hypertension in Kazakh, which is a relatively ...

    Also Ranks for: Essential Hypertension |  genetic variation |  interaction nedd4l genotype |  dominant model |  casecontrol study
    KOL Index score: 10455

    Hypertension is a common global health problem including China. This study aimed to assess the prevalence and awareness of hypertension, and evaluate risk factors associated with hypertension among multi-ethnic population in northwest China using a random sampling cross-sectional data.A cross-sectional survey was conducted between 2014 and 2015 as part of a nationwide survey using stratified four-stage random sampling in Xinjiang. Hypertension was defined as mean systolic blood pressure ...

    Also Ranks for: Northwest China |  risk factors hypertension |  prevalence awareness |  antihypertensive medication |  crosssectional analysis
    KOL Index score: 8219

    BACKGROUND: Even through narrowing of the upper-airway plays an important role in the generation of obstructive sleep apnea (OSA), the peripheral airways is implicated in pre-obese and obese OSA patients, as a result of decreased lung volume and increased lung elastic recoil pressure, which, in turn, may aggravate upper-airway collapsibility.

    METHODS: A total of 263 male (n = 193) and female (n = 70) subjects who were obese to various degrees without a history of lung diseases and an ...

    Also Ranks for: Sleep Apnea |  lung volume |  respiratory resistance |  osa airway |  obese patients
    KOL Index score: 8195

    Background: Hypertension is the leading cause of cardiovascular disease. Distribution of hypertension and related factors among multiethnic population in Northwest China remains scarce. The aim was to determine prevalence, awareness, treatment, control, and risk factors associated with hypertension among multiethnic population in Northwest China.

    Methods: We conducted a blood pressure (BP) screening project covering a third of adults in Emin Xinjiang, Northwest China, during 2014-2016. ...

    Also Ranks for: Northwest China |  control hypertension |  prevalence awareness |  cardiovascular disease |  defined systolic
    KOL Index score: 7530

    BACKGROUND: Since the control rate of blood pressure is lower in mainland China, the aim of this study is to investigate the proportion of secondary causes and coexisting diseases of hypertension in hypertensive patients.

    METHODS: Data on consecutive patients with hypertension who visited the Hypertension Center. Diseases were detected using an established strict screening protocol.

    RESULTS: Detection rate of secondary causes and coexisting diseases of hypertension was 39.5% among 3003 ...

    Also Ranks for: Hypertension Osa |  hypertensive patients |  primary aldosteronism |  obstructive sleep apnea |  pa common
    KOL Index score: 6881

    Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a complex chronic inflammatory respiratory disease with multiple pathogenic factors and high morbidity and mortality. Serum levels of nuclear factor-κB (NF-κB), hypoxia-inducible factor-1 alpha (HIF-1α), and surfactant protein D (SPD) were investigated in OSAHS patients, to determine their clinical significance and correlation with the pathogenesis. Patients were classified into a mild and moderate OSAHS group (n = 25) and severe OSAHS ...

    Also Ranks for: Obstructive Sleep |  severe osahs |  hypopnea syndrome |  serum levels |  inflammatory markers
    KOL Index score: 6878

    PurposePrevious studies have shown that surfactant proteins are affected by oxygen concentration and mechanic stretches, although the alteration of serum surfactant proteins in individuals with obstructive sleep apnea (OSA) is still unclear. Therefore, the aim of this study is to examine whether serum concentrations of surfactant proteins A and D are altered and related to hypopnea index (HI) in OSA.MethodsThis is a cross-sectional study. Consecutive 140 males, suspicious of OSA, were ...

    Also Ranks for: Surfactant Proteins |  spd osa |  obstructive statistics |  protein pulmonary |  sleep apnea
    KOL Index score: 6562

    BACKGROUND: To examine trends in serum lipids in population in Northwestern Xinjiang between 1998 and 2015 and to provide clues for future prevention.

    METHODS: We enrolled 5,142 adults aged ≥30 years from seven independent cross-sectional studies conducted in 1998-2000, 2007-2008, and 2015. Blood lipid profiles, such as total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were measured.

    RESULTS: The mean ...

    Also Ranks for: Prevalence Dyslipidemia |  total cholesterol |  adults aged |  1998 2015 |  serum lipids
    KOL Index score: 5686

    Uncertainty remains about the association of hypertension with mild cognitive impairment (MCI) in less-developed areas.This is a cross-sectional survey conducted in Xinjiang, a less-developed region in China between April and October 2019. We used multi-stage stratified sampling method to obtain study population aged ≥45 years, and we analyzed complete data for 3282 subjects. The Mini-Mental State Examination (MMSE) was used to assess cognitive function. MCI is defined as an MMSE ...

    Also Ranks for: Mild Cognitive Impairment |  prevalence mci |  mmse score |  cognitive function |  hypertensive subjects
    KOL Index score: 5255

    BACKGROUND: High mobility group box 1 (HMGB1) is a kind of proinflammatory mediator to stimulate the innate and adaptive immune system and participates in a number of acute and chronic inflammatory processes after sterile injury or microbial invasion. HMGB1 has been suggested to be involved in the pathogenesis of many autoimmune diseases. However, the results are contradictory or inconclusive among these findings. The aim of this study was to investigate whether serum/plasma HMGB1 levels ...

    Also Ranks for: Autoimmune Diseases |  hmgb1 levels |  box 1 |  protein humans |  biomarkers female
    KOL Index score: 4952

    OBJECTIVE: Excessive daytime sleepiness (EDS) is a prevalent phenomenon in adults, and although cohort studies have reported an association between EDS and adverse health outcomes, the results are inconclusive. This meta-analysis summarizes the evidence from longitudinal cohort studies on the relationship between EDS and the risk of cardiovascular disease (CVD) or all-cause mortality.

    DESIGN: A meta-analysis of prospective cohort studies was conducted.


    Also Ranks for: Excessive Daytime Sleepiness |  cardiovascular disease |  association eds |  allcause mortality |  prospective cohort
    KOL Index score: 4913

    BackgroundSurfactant proteins B and C are mainly synthesized, secreted by alveolar type II cells, and affected by hypoxia and mechanical stretches. We hypothesized that their serum levels might be altered by intermittent hypoxia and swing of intrathoracic pressure of obstructive sleep apnea (OSA).MethodsConsecutive 140 middle-aged males, suspicious of OSA determined by polysomnography, were studied. Surfactant proteins B and C were determined by ELISA.ResultsSurfactant protein B ...

    Also Ranks for: Surfactant Protein |  sleep apnea |  severe osa |  intermittent hypoxia
    KOL Index score: 4801

    Few attention has been directed to the potential effects of intermittent hypoxia experienced in obstructive sleep apnea on the integrity and permeability of intestinal barrier, particularly in adults. Therefore, we evaluated alteration in serum d-lactate concentration in middle-aged males with obstructive sleep apnea to value permeability of intestinal barrier. In this current cross-sectional study, consecutive 159 males were studied. Obstructive sleep apnea was determined by ...

    Also Ranks for: Intestinal Barrier |  obstructive sleep apnea |  intermittent hypoxia |  aged polysomnography |  humans inflammation
    KOL Index score: 4751

    Background: Hypertension is a global problem, for which high-altitude residents exhibit higher burden. Hypertension in Tajik nomads from Pamirs with an average altitude above 4000 m remains less studied. We aimed to determine the prevalence, awareness, treatment, control, and risk factors associated with hypertension among Tajik population in Pamirs.

    Methods: A cross-sectional survey was conducted between August and September 2015 using stratified three-stage random sampling in Taxkorgan ...

    Also Ranks for: Prevalence Hypertension |  antihypertensive medication |  hypertensive patients


    Nanfang Li: Influence Statistics

    Sample of concepts for which Nanfang Li is among the top experts in the world.
    Concept World rank
    mmse hypertensive subjects #1
    osa 1939 #1
    emin china #1
    raising urban #1
    hhcy stock #1
    885 45·9 #1
    totally 1147 subjects #1
    24h mmse score #1
    raising regions #1
    stockraising regions #1
    deficiency lifestyles #1
    lactate subclinical #1
    2000 479 #1
    consecutive 159 males #1
    pa nomogram model #1
    trend 479 #1
    95 0·319 #1
    mci lessdeveloped region #1
    mmol 2007 #1
    raising populations #1
    μg obese nonosa #1
    mci hypertensive population #1
    totally 1926 subjects #1
    urban region covariates #1
    potassium ratio 24h #1
    serum calciumphosphorus product #1
    xinjiang ldl #1
    nonobese middleaged males #1
    24una β 0·184 #1
    1939 ± 467 #1
    adults northwestern xinjiang #1
    validation primary aldosteronism #1
    3·38 95 1·77 #1
    obese nonosa #1
    dcaresultsfemale gender #1
    complete urine sample #1
    raising agriculture #1
    nonobese 1939 #1
    stockraising region #1
    northwestern xinjiang ldlc #1
    health behaviour questionnaires #1
    obese nonosa μg #1
    subclinical hyperpermeability #1
    mci hypertensive subjects #1
    137435 8161735 μg #1
    816 1735 #1
    xinjiang 1998 #1
    nonobese osa males #1
    osa 137435 #1
    5142 adults #1

    Key People For Sleep Apnea

    Top KOLs in the world
    Terry B Young
    sleep apnea disordered breathing blood pressure
    Susan S Redline
    sleep apnea african americans cardiovascular disease
    Mari Palta
    type 1 diabetes sleep apnea united states
    Guilleminault Guilleminault
    sleep apnea disordered breathing blood pressure
    James B Skatrud
    nrem sleep mechanical ventilation periodic breathing
    Paul E Peppard
    sleep apnea disordered breathing health wisconsin

    Nanfang Li:Expert Impact

    Concepts for whichNanfang Lihas direct influence:Sleep apnea,  Obstructive sleep apnea,  Primary aldosteronism,  Northwest china,  Hypertensive patients,  Patients hypertension,  Obstructive sleep,  Renal involvement.

    Nanfang Li:KOL impact

    Concepts related to the work of other authors for whichfor which Nanfang Li has influence:Obstructive sleep apnea,  Primary aldosteronism,  Essential hypertension,  Excessive daytime sleepiness,  Intermittent hypoxia,  Hypertensive patients,  Mild cognitive impairment.



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    National Health Committee Key Laboratory of Hypertension Clinical Research, Ürümqi, China | Key Laboratory of Xinjiang Uygur Autonomous Region, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China | Xinj