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    • Nucleus Accumbens
    • George F Koob
    • George F Koob: Influence Statistics

      George F Koob

      George F Koob

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      National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md. | Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, ...

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      George F Koob:Expert Impact

      Concepts for whichGeorge F Koobhas direct influence:Nucleus accumbens,Animal models,Drug addiction,Alcohol dependence,Wistar receptors,Alcohol drinking,Opiate withdrawal,Extended access.

      George F Koob:KOL impact

      Concepts related to the work of other authors for whichfor which George F Koob has influence:Nucleus accumbens,Alcohol dependence,Prefrontal cortex,Animal models,Drug addiction,Locomotor activity,Ventral tegmental area.

      KOL Resume for George F Koob

      Year
      2022

      National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md.

      Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, United States

      2021

      National Institute on Alcohol and Alcoholism, National Institutes of Health, Bethesda, MD, USA

      2020

      Neurobiology of Addiction Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA

      National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland

      2019

      National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA

      NIH/NIAAA, Bethesda, Maryland

      Integrative Neuroscience Research Branch and.

      2018

      National Institutes of Health, Bethesda, Maryland 20892.

      Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 92037, La Jolla, CA, USA

      2017

      Neurobiology of Addiction Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Baltimore, Maryland, USA

      The Scripps Research Institute, La Jolla, CA, United States

      2016

      National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA.

      Office of the Director, Bethesda, Maryland

      Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037,

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      Sample of concepts for which George F Koob is among the top experts in the world.
      Concept World rank
      addiction key role #1
      memory actions avp #1
      responsethis work #1
      depression serotonin norepinephrine #1
      cortistatin activity #1
      responsesuppressing effects #1
      reinforcement negative #1
      negative motivational state #1
      withdrawal measures #1
      meleu37crf #1
      operant heroin #1
      operant conditions sex #1
      lga drn #1
      crf physical stress #1
      heroin icss #1
      plasma acth amph #1
      nk1r sha #1
      500ng dose npy #1
      “euphoria #1
      rats ethanol administration #1
      nicotine intake rats #1
      schedule antagonism #1
      drives negative #1
      hedonic allostasis #1
      extrahypothalamic stress #1
      protracted abstinence females #1
      withincircuit #1
      angiotensinogen crf #1
      condition tailpinch #1
      anxiogenic behavioral effects #1
      n8 ucn #1
      crf ethanol selfadministration #1
      carrier 15 minutes #1
      systems corticotropin #1
      cocaine lga #1
      σreceptors #1
      ethanol administration rats #1
      mpzp #1
      lga mpzp #1
      10 free feeding #1
      npy tail pinch #1
      chronic relapsing disorder #1
      participants abt436 #1
      heroin process #1
      knockout periodicity receptors #1
      pvn ucn ucn #1
      indirect sympathomimetics #1
      crf produced #1
      doses neurotensin #1
      time‐dependent expression #1
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      Prominent publications by George F Koob

      KOL-Index: 19153

      The purpose of this study was to test the hypothesis that activation of the dynorphin/kappa (κ)-opioid system has a role in the increased consumption of ethanol in dependent animals. The effects of three opioid receptor antagonists with different effects on opioid receptors, naltrexone, nalmefene, and nor-binaltorphimine (nor-BNI), were compared in their ability to decrease ethanol self-administration in nondependent and ethanol-dependent male Wistar rats. Nalmefene and naltrexone are ...

      Known for Ethanol Dependence | Naltrexone Nalmefene | Opioid Systems | Wistar Receptors | Dependent Animals
      KOL-Index: 16167

      BACKGROUND: Gamma-aminobutyric acid-B (GABA(B)) receptor agonists have been shown to suppress operant self-administration of ethanol in nondependent rats. However, little work has focused on the effects of GABA(B) receptor agonists on self-administration of ethanol in dependent animals.

      METHODS: In the present experiment, the GABA(B) receptor agonist baclofen was tested for the ability to modulate both fixed- (FR) and progressive-ratio (PR) responding for ethanol in rats while ...

      Known for Dependent Rats | Schedule Reinforcement | Animals Ethanol Vapor | Baclofen Ethanol | Operant Administration
      KOL-Index: 16024

      Corticotropin-releasing factor (CRF) and its family of peptides are critical coordinators of homeostasis whose actions are mediated through their receptors, CRF receptor 1 (CRFR1) and CRFR2, found throughout the CNS and periphery. The phenotypes of mice deficient in either CRFR1 or CRFR2 demonstrate the critical role these receptors play. CRFR1-mutant mice have an impaired stress response and display decreased anxiety-like behavior, whereas CRFR2-mutant mice are hypersensitive to stress ...

      Known for Crfr1 Crfr2 | Stress Response | Messenger Receptors | Mice Deficient | Anxiety Behavior
      KOL-Index: 15740

      BACKGROUND: Ethanol self-administering rats exhibit enhanced responding during withdrawal from continuous exposure to ethanol vapor. This study compared self-administration of ethanol during withdrawal from continuous versus intermittent ethanol vapor.

      METHODS: Experiment 1 examined self-administration of ethanol in rats trained to self-administer ethanol after continuous, intermittent (14 hr on and 10 hr off), or no (i.e., controls) ethanol vapor exposure. Exposure time was equalized ...

      Known for Vapor Exposure | 2 Weeks | Ethanol Withdrawal | Continuous Intermittent | Enhanced Alcohol
      KOL-Index: 15371

      Abstinence from alcohol is associated with the recruitment of neurons in the central nucleus of the amygdala (CeA) in nondependent rats that binge drink alcohol and in alcohol-dependent rats. However, whether the recruitment of this neuronal ensemble in the CeA is causally related to excessive alcohol drinking or if it represents a consequence of excessive drinking remains unknown. We tested the hypothesis that the recruitment of a neuronal ensemble in the CeA during abstinence is ...

      Known for Alcohol Dependence | Neuronal Ensemble | Central Nucleus | Nondependent Rats | Oncogene Proteins
      KOL-Index: 15355

      The role of opioids, dopamine and serotonin in ethanol (EtOH) reward and preference was investigated in non-deprived, Alcohol-Preferring (P), and genetically heterogenous Wistar rats. Operant responding for ethanol was initiated using sweet-solution substitution procedures. The rats were then trained in 30-min daily sessiosn to respond for ethanol (10% v/v) versus water under a two-lever, free-choice contingency. All testing was conducted in the absence of water and food deprivation or ...

      Known for Wistar Rats | Alcohol Preferring | Ethanol Water | Operant Responding | Dose Dependent
      KOL-Index: 14821

      The GABAergic system in the central amygdala (CeA) plays a major role in ethanol dependence and the anxiogenic-like response to ethanol withdrawal. Alcohol dependence is associated with increased corticotropin releasing factor (CRF) influence on CeA GABA release and CRF type 1 receptor (CRF(1)) antagonists prevent the excessive alcohol consumption associated with dependence. Genetically selected Marchigian Sardinian (msP) rats have an overactive extrahypothalamic CRF(1) system, are ...

      Known for Gabaergic Transmission | Marchigian Sardinian | Msp Rats | Central Nucleus | Sprague Dawley
      KOL-Index: 14500

      Spontaneous locomotor activity and the locomotor response to amphetamine and apomorphine were studied in rats subjected to either radiofrequency (RF), 6-hydroxydopamine (6-OHDA) or both RF and 6-OHDA lesions of the mesolimbic dopamine (DA) system. Large 6-OHDA lesions of the ventral tegmental area (VTA) or of the nucleus accumbens (N.Acc.) produced hypo-activity in the open field, a complete blockade of the locomotor stimulating effects of D-amphetamine and a profound supersensitive ...

      Known for Mesolimbic Dopamine | Amphetamine Apomorphine | Lesions Vta | Nucleus Accumbens Nacc | 6 Ohda
      KOL-Index: 14148

      Alcoholism can be defined by a compulsion to seek and take drug, loss of control in limiting intake, and the emergence of a negative emotional state when access to the drug is prevented. Alcoholism impacts multiple motivational mechanisms and can be conceptualized as a disorder that includes a progression from impulsivity (positive reinforcement) to compulsivity (negative reinforcement). The compulsive drug seeking associated with alcoholism can be derived from multiple neuroadaptations, ...

      Known for Alcohol Addiction | Negative Reinforcement | Extended Amygdala | Brain Stress Systems | Ventral Striatum
      KOL-Index: 14081

      BACKGROUND: Corticotropin-releasing factor (CRF) and gamma-aminobutyric acid (GABA)ergic systems in the central amygdala (CeA) are implicated in the high-anxiety, high-drinking profile associated with ethanol dependence. Ethanol augments CeA GABA release in ethanol-naive rats and mice.

      METHODS: Using naive and ethanol-dependent rats, we compared electrophysiologic effects and interactions of CRF and ethanol on CeA GABAergic transmission, and we measured GABA dialyzate in CeA after ...

      Known for Corticotropin Releasing Factor | Alcohol Dependence | Aminobutyric Acid | Dependent Rats | Crf Ethanol

      Key People For Nucleus Accumbens

      Top KOLs in the world
      #1
      Peter William Kalivas
      nucleus accumbens ventral pallidum behavioral sensitization
      #2
      George F Koob
      nucleus accumbens animal models drug addiction
      #3
      Gaetano Di Chiara
      nucleus accumbens prefrontal cortex dopamine transmission
      #4
      Piers Christopher Emson
      rat brain nitric oxide situ hybridization
      #5
      Roy A Wise
      nucleus accumbens ventral tegmental area brain stimulation
      #6
      Eric J Nestler
      nucleus accumbens chronic morphine gene expression

      National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md. | Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, United States | National Institute on Alcohol Abuse and Alcoholism, Bethesda

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