 | Gary N FoulksDepartment of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA | Department of Ophthalmology, University of ... |
KOL Resume for Gary N Foulks (ichthyosis, congenital ichthyosis, congenital, birth, defect)
| Year | |
|---|---|
| 2020 | Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA |
| 2019 | Department of Ophthalmology, University of Louisville, Louisville, Kentucky, USA. |
| 2017 | Emeritus Professor of Ophthalmology, University of Louisville School of Medicine, Louisville, KY, USA |
| 2016 | Department of Ophthalmology and Vision Science, School of Medicine, University of Louisville, Louisville, KY |
| 2015 | University of Louisville Department of Ophthalmology and Vision Science, Louisville, KY |
| 2014 | Department of Ophthalmology and Vision Science, University of Louisville, Louisville, Kentucky Emeritus Professor of Ophthalmology, University of Louisville; Editor-in-Chief, The Ocular Surface, USA |
| 2013 | Director of Cornea, Cincinnati Eye Institute, Professor of Ophthalmology, University of Cincinnati, Cincinnati, Ohio, USA University of Louisville, Department of Ophthalmology & Visual Science, Kentucky Lions Eye Center, Louisville, Kentucky |
| 2012 | Department of Ophthalmology & Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, Kentucky |
| 2011 | Department of Ophthalmology and Visual Science, The Kentucky Lions Eye Center, University of Louisville, Louisville, Kentucky Professor of Ophthalmology, University of Cincinnati, Director, Cornea Services, Cincinnati Eye Institute, Cincinnati OH, USA |
| 2010 | Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY, USA Kentucky Lions Eye Center, University of Louisville, Louisville, Kentucky; |
| 2009 | Department of Ophthalmology, University of Louisville, Louisville, KY, USA. Arthur and Virginia Keeney Professor of Ophthalmology, University of Louisville, School of Medicine, Louisville, Ky. |
| 2008 | From the Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, School of Medicine, University of Louisville, Louisville, Kentucky Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, 301 East Muhammad Ali Boulevard, Louisville, KY 40202, USA |
| 2007 | Department of Ophthalmology and Vision Science, University of Louisville, Louisville, KY, USA University of Louisville School of Medicine, Louisville, Kentucky |
| 2006 | University of Louisville, School of Medicine, Louisville, Kentucky Department of Ophthalmology and Visual Science |
| 2005 | Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky |
| 2003 | Ear and Eye Institute, 203 Lothrop Street, Pittsburgh, PA 15213, USA |
| 2002 | Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA |
| 2000 | Department of Ophthalmology, University of Pittsburgh Medical Center, Eye and Ear Institute, Room 642, 203 Lothrop St., 15213, Pittsburgh, PA |
| 1999 | Jaeb Center for Health Research, Tampa, Florida (R.W.B., R.L.G.); the University of California, Davis, Sacramento, California (M.J.M.); the University of Minnesota, Minneapolis, Minnesota (E.J.H.); the University of Texas Southwestern Medical Center, Dallas, Texas (H.D.C., E.L.H.); the Eye and Ear Institute, University of Pittsburgh, Pittsburgh, Pennsylvania (G.N.F.); the Virginia Mason Medical Center, Seattle, Washington (T.L.); the West Virginia University Health Sciences Center, Morgantown, West Virginia (M.S.M.); the Doheny Eye Institute, Los Angeles, California (R.E.S.); the Johns Hopkins Hospital, Baltimore, Maryland (W.J.S.); the Emory University School of Medicine, Atlanta, Georgia (R.D.S.); and the University of Illinois, Chicago, Illinois, U.S.A. (J.S.). |
| 1995 | From the Department of Ophthalmology, Duke University Medical Center, Durham Duke University Eye Center |
| 1994 | Duke University Eye Center, Durham, North Carolina |
| 1993 | From the Duke University Eye Center, Durham, North Carolina |
| 1992 | Duke Eye Center, Durham |
| 1991 | Department of Ophthalmology, Duke University Medical Center, Durham. Durham, North Carolina |
| 1990 | Duke Eye Center, Duke University, Durham |
| 1987 | Duke University Medical Center, Durham |
| 1986 | The Corneal Service of Duke Eye Center, Durham, North Carolina From the Departments of Ophthalmology, Duke University Medical Center |
| 1985 | From the Department of Ophthalmology, Duke University Medical Center, North Carolina. |
| 1984 | Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina |
| 1983 | From the Duke University Medical Center, Durham VA Medical Center, Durham, North Carolina. |
| 1982 | Department of Ophthalmology, Duke University Medical Center, and the Durham Veterans Administration Medical Center, Durham, North Carolina |
| 1981 | Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina |
Prominent publications by Gary N Foulks
PURPOSE: Meibomian gland dysfunction (MGD) is a common clinical problem that is often associated with evaporative dry eye disease. Alterations of the lipids of the meibomian glands have been identified in several studies of MGD. This prospective, observational, open-label clinical trial documents the improvement in both clinical signs and symptoms of disease as well as spectroscopic characteristics of the meibomian gland lipids after therapy with topical azithromycin ophthalmic solution ...
| Known for Topical Azithromycin | Oral Doxycycline | Symptoms Mgd | Meibomian Gland | Lipid Metabolism |
Tofacitinib (CP-690,550), a Janus Kinase Inhibitor for Dry Eye Disease Results from a Phase 1/2 Trial
[ PUBLICATION ]
OBJECTIVE: To evaluate safety and efficacy of topical ophthalmic tofacitinib (CP-690,550), a novel Janus kinase inhibitor, in treating dry eye disease (DED).
DESIGN: A phase 1/2 prospective, randomized, double-masked, multicenter, vehicle- and comparator-controlled trial (NCT00784719).
PARTICIPANTS: Patients (n = 327) 18 years of age and older with a DED diagnosis for 6 months or more.
METHODS: Tofacitinib (0.0003% twice daily, n = 46; 0.001% in both eyes twice daily, n = 47; 0.003% ...
| Known for Dry Eye Disease | Janus Kinase | Tofacitinib Vehicle | Patients Ded | 8 Week |
PURPOSE: To evaluate the use of tear osmolarity in the diagnosis of dry eye disease.
DESIGN: A prospective, observational case series to determine the clinical usefulness of tear osmolarity and commonly used objective tests to diagnose dry eye disease.
METHODS: A multicenter, 10-site study consisting of 314 consecutive subjects between 18 and 82 years of age. Bilateral tear osmolarity, tear film break-up time (TBUT), corneal staining, conjunctival staining, Schirmer test, and meibomian ...
| Known for Tear Osmolarity | Dry Eye Disease | Diagnostic Techniques | Sensitivity Specificity | Objective Tests |
Topical Azithromycin Therapy for Meibomian Gland Dysfunction: Clinical Response and Lipid Alterations
[ PUBLICATION ]
PURPOSE: Meibomian gland dysfunction (MGD) is a common clinical problem that is often associated with evaporative dry eye disease. Alterations of the lipids of the meibomian glands have been identified in several studies of MGD. This prospective, observational, open-label clinical trial documents the improvement in both clinical signs and symptoms of disease and spectroscopic behavior of the meibomian gland lipids after therapy with topical azithromycin ophthalmic solution.
METHODS: ...
| Known for Meibomian Gland | Topical Azithromycin | Symptoms Mgd | Clinical Signs | Meibum Lipid |
PURPOSE: Raman spectroscopy could potentially be used as a diagnostic tool for the detection of meibomian gland dysfunction by measuring the composition, conformation, and amount of meibum lipid on the lid margin. Toward this goal and to test our studies of meibum lipid using infrared spectroscopy, we measured the Raman spectra of samples from human donors with and without meibomian gland dysfunction.
MATERIALS AND METHODS: Human meibum was expressed from the eyelids and collected on a ...
| Known for Human Meibum | Raman Spectroscopy | Meibomian Gland Dysfunction | Lid Margin | Lipid Saturation |
Human Meibum Lipid Conformation and Thermodynamic Changes with Meibomian-Gland Dysfunction
[ PUBLICATION ]
PURPOSE: Instability of the tear film with rapid tear break-up time is a common feature of aqueous-deficient and evaporative dry eye diseases, suggesting that there may be a shared structural abnormality of the tear film that is responsible for the instability. It may be that a change in the normal meibum lipid composition and conformation causes this abnormality. Principle component analyses of infrared spectra of human meibum indicate that human meibum collected from normal donors (Mn) ...
| Known for Human Meibum | Lipid Conformation | Phase Transition | Tear Film | Cholesterol Esters |
MUC1 splice variants in human ocular surface tissues: Possible differences between dry eye patients and normal controls
[ PUBLICATION ]
Mucins are highly glycosylated proteins that are vital to the maintenance of healthy epithelial surfaces including the ocular surface. Mucins act as lubricants, protectants, and mediators of signal transduction. The majority of the O-glycosylation sites on the transmembrane mucin MUC1 are found in a highly polymorphic core region containing a variable number of tandem repeats (VNTR). MUC1 alleles can be divided into size classes that contain small (30-45) or large (60-90) numbers of ...
| Known for Ocular Surface | Dry Eye | Splice Variants | Conjunctiva Muc1 | Tandem Repeats |
Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: clinical implications
[ PUBLICATION ]
PURPOSE: To evaluate the relationship between signs and symptoms of dry eye disease (DED) in a clinic-based population.
METHODS: In a retrospective analysis, clinical signs and symptoms were evaluated for 344 subjects (n = 82, normal; n = 263, dry eye), across 11 sites from the EU and United States. Pearson correlations between signs and symptoms (r(2) ) and an independent components analysis (ICA) mixing matrix were derived from the data set. Similar analysis was performed on an ...
| Known for Symptoms Ded | Dry Eye | Clinical Implications | Schirmer Test | Objective Signs |
Dry eye syndrome is a collection of common disorders of multifactorial etiology. Although the epidemiology of dry eye has been well studied, reports of genetic patterns that might influence susceptibility to dry eye are few. We reported that the frequency of non-Sjögren's aqueous-deficient dry eye patients expressing only the MUC1/A splice variant of the mucin MUC1 may be lower than that of a normal control group [Imbert, Y., Darling, D.S., Jumblatt, M.M., Foulks, G.N., Couzin, E.G., ...
| Known for Dry Eye | Estrogen Receptor | Ocular Surface | Gene Polymorphism | Muc1 Genotype |
Removal of INTACS for myopia1 1The INTACS inserts U. S. Phase II and III trials were supported by KeraVision, Inc.
[ PUBLICATION ]
OBJECTIVE: To evaluate the safety and efficacy of the removal of INTACS.
DESIGN: Subgroup analysis from a nonrandomized comparative interventional trial.
PARTICIPANTS: Four hundred fifty-two patients with best spectacle-corrected visual acuity of 20/20 or better and myopia (1.0-3.5 diopters [D]) were enrolled in the U.S. Food and Drug Administration clinical trials of INTACS. Forty-six eyes among a total of 684 underwent INTACS removal.
INTERVENTION: INTACS removal.
METHODS: Safety and ...
| Known for Manifest Refraction | Visual Acuity | Intacs Eyes | 2 Lines | Spectacle Corrected |
Although antigens of the human major histocompatibility complex, HLA, appear to be involved in the rejection of corneal allografts, the expression of these antigens by cells of the human cornea remains controversial. Using sensitive immunoperoxidase techniques, we readily demonstrated class I HLA antigens on corneal epithelial, stromal, and endothelial cells, regardless of donor age. Moreover, the expression of class I antigens by epithelium increased markedly from the central to the ...
| Known for Hla Antigens | Human Cornea | Expression Class | Donor Age | Central Peripheral |
Patient Tolerance and Ocular Surface Staining Characteristics of Lissamine Green versus Rose Bengal
[ PUBLICATION ]
PURPOSE: To determine patient tolerance and ocular surface staining characteristics of 1% lissamine green versus 1% rose bengal solutions in patients with dry eye and in those with normal ocular surfaces by comparison of subjective sensation and objective staining scores.
METHODS: Twelve patients with keratoconjunctivitis sicca and eight subjects with no ocular surface disease recorded their symptoms on a graded scale (0-5) and the duration of symptoms after instillation of one drop of ...
| Known for Rose Bengal | Ocular Surface | Lissamine Green | Keratoconjunctivitis Sicca | Staining Characteristics |
Distribution of Aqueous-Deficient and Evaporative Dry Eye in a Clinic-Based Patient Cohort
[ PUBLICATION ]
PURPOSE: To evaluate in a general clinic-based cohort of patients with dry eye disease (DED) the distribution of patients with aqueous-deficient or evaporative subtype of DED.
METHODS: Schirmer tests and meibomian gland dysfunction (MGD) (Foulks-Bron scoring) were evaluated in both eyes of 299 normal subjects and DED patients (218 women and 81 men) across 10 sites in the European Union and the United States. Using the more severe measurement of the 2 eyes, subjects were considered to ...
| Known for Dry Eye | Mgd Subjects | Patients Ded | Aqueous Deficient | Schirmer Tests |
Both lipids and mucins contribute to the stability of the tear film and lipids may inhibit tears from evaporating. Younger people have lower lipid viscosity, higher lipid volume, and a lower rate of tear evaporation. Since age-related changes in human meibum composition and conformation have never been investigated, as a basis for the study of lipid-associated changes with meibomian gland dysfunction, we used the power of infrared spectroscopy to characterize hydrocarbon chain ...
| Known for Infrared Spectroscopy | Human Meibum | Aging Child Child | Tear Film | Meibomian Gland Dysfunction |
Gary N Foulks: Influence Statistics
| Concept | World rank |
|---|---|
| therapies aqueous production | #1 |
| vehicle drops | #1 |
| lenses therapeutic | #1 |
| meibum cholesteryl | #1 |
| infrared spectra meibum | #1 |
| chemical analysis purpose | #1 |
| fully 63 | #1 |
| tfl layer composition | #1 |
| environment meibum | #1 |
| eigenvectors age | #1 |
| meibum spectra | #1 |
| 18 91 cases | #1 |
| ded received | #1 |
| ded kpi121 | #1 |
| tfl layer | #1 |
| susceptibility muc1 | #1 |
| loteprednol etabonate subjects | #1 |
| peripheral capsular support | #1 |
| wider selection lenses | #1 |
| keratoplasty changing | #1 |
| wax ester variability | #1 |
| 10 meibomian | #1 |
| md meibum | #1 |
| dry eye pathophysiology | #1 |
| conformational hydrocarbon chains | #1 |
| pathophysiology evolution | #1 |
| corneal graft technique | #1 |
| received kpi121 | #1 |
| tears infants | #1 |
| dysfunction principal | #1 |
| meibum md | #1 |
| green rose | #1 |
| crossmatch study | #1 |
| 334°c md | #1 |
| solutions squalene | #1 |
| syndromes fatty acids | #1 |
| suspension loteprednol | #1 |
| tears lipidlipid interactions | #1 |
| terpenoids meibum | #1 |
| lens fluorescein | #1 |
| lid margin meibum | #1 |
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Key People For Dry Eye
Gary N Foulks:Expert Impact
Concepts for whichGary N Foulkshas direct influence:Dry eye, Dry eye disease, Meibomian gland dysfunction, Contact lenses, Human meibum, Ocular surface, Meibum lipid, Acanthamoeba keratitis.
Gary N Foulks:KOL impact
Concepts related to the work of other authors for whichfor which Gary N Foulks has influence:Dry eye, Ocular surface, Tear film, Meibomian gland, Contact lens, Silicone oil, Cataract surgery.
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