• Disease
  • Hip
  • Hip Fracture
  • Jane A Cauley

    Prominent publications by Jane A Cauley

    KOL Index score: 26789

    IMPORTANCE: Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention.

    OBJECTIVE: To report a comprehensive, integrated overview of findings from the 2 Women's Health Initiative (WHI) hormone therapy trials with extended postintervention follow-up.

    DESIGN, SETTING, AND PARTICIPANTS: A total of 27,347 postmenopausal women aged 50 to 79 years were enrolled at 40 US centers.

    INTERVENTIONS: Women with an intact ...

    Also Ranks for: Health Outcomes |  women cee |  menopausal hormone therapy |  risks benefits |  mpa placebo
    KOL Index score: 20641

    The association between type 2 diabetes, BMD, and bone volume was examined to determine the effect of lean and fat mass and fasting insulin in the Health, Aging, and Body Composition Study, which included white and black well-functioning men and women 70-79 years of age (N = 2979). Diabetes predicted higher hip, whole body, and volumetric spine BMD, and lower spine bone volume, independent of body composition and fasting insulin.

    INTRODUCTION: The purpose of this study was to determine ...

    Also Ranks for: Body Composition |  older white |  lean mass |  higher bmd |  bone volume
    KOL Index score: 20515

    PURPOSE: To determine the relationship between measures of body size and the risk of hip fracture in elderly women.

    PARTICIPANTS AND METHODS: The association between measures of body size and hip fracture risk was assessed in 8,011 ambulatory, nonblack women 65 years of age or older enrolled in the Study of Osteoporotic Fractures with measurements of total body weight, percent weight change since age 25, hip girth, lean mass, fat mass, percent body fat, body mass index, modified body ...

    Also Ranks for: Hip Fracture |  body size |  older women |  bmd examination |  lean mass
    KOL Index score: 20000

    Two factors generally reported to influence bone density are body composition and muscle strength. However, it is unclear if these relationships are consistent across race and sex, especially in older persons. If differences do exist by race and/or sex, then strategies to maintain bone mass or minimize bone loss in older adults may need to be modified accordingly. Therefore, we examined the independent effects of bone mineral-free lean mass (LM), fat mass (FM), and muscle strength on ...

    Also Ranks for: Muscle Strength |  mineral density |  soft tissue |  lm fm |  race sex
    KOL Index score: 19924

    CONTEXT: Type 2 diabetes mellitus (DM) is associated with higher bone mineral density (BMD) and paradoxically with increased fracture risk. It is not known if low BMD, central to fracture prediction in older adults, identifies fracture risk in patients with DM.

    OBJECTIVE: To determine if femoral neck BMD T score and the World Health Organization Fracture Risk Algorithm (FRAX) score are associated with hip and nonspine fracture risk in older adults with type 2 DM.


    Also Ranks for: Frax Score |  dm hip fracture |  type 2 |  neck bmd |  risk older
    KOL Index score: 19677

    OBJECTIVES: To test the hypothesis that unintentional weight loss increases the rate of bone loss and risk of hip fracture more than intentional weight loss.

    DESIGN: Prospective cohort study.

    SETTING: Four communities within the United States.

    PARTICIPANTS: Six thousand seven hundred eighty-five elderly white women with measurement of weight change and assessment of intention to lose weight.

    MEASUREMENTS: Weight change between baseline and fourth examinations (average 5.7 years between ...

    Also Ranks for: Weight Loss |  hip fracture |  older women |  body mass bmi |  increase bone
    KOL Index score: 19221

    CONTEXT: Black women have a lower rate of fracture than white women, but whether bone mineral density (BMD) predicts fracture risk as well in black women as it does in white women is not established.

    OBJECTIVE: To examine the association between BMD and incident nonspinal fractures in older black and white women.

    DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study of baseline data collected from 1986 through 1990 (7334 white women aged 67-99 years) and from 1996 through 1998 (636 ...

    Also Ranks for: White Women |  bone mineral density |  bmd risk |  femoral neck |  fracture black
    KOL Index score: 18753

    CONTEXT: Mammography is recommended and is cost-effective for women aged 50 to 69 years, but the value of continuing screening mammography after age 69 years is not known. In particular, older women with low bone mineral density (BMD) have a lower risk of breast cancer and may benefit less from continued screening.

    OBJECTIVE: To compare life expectancy and cost-effectiveness of screening mammography in elderly women based on 3 screening strategies.

    DESIGN: Decision analysis and ...

    Also Ranks for: Screening Mammography |  life expectancy |  women aged |  situ carcinoma |  incremental cost
    KOL Index score: 18427

    CONTEXT: The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain.

    OBJECTIVE: To compare the effects of discontinuing alendronate treatment after 5 years vs continuing for 10 years.

    DESIGN AND SETTING: Randomized, double-blind trial conducted at 10 US clinical centers that participated in the Fracture Intervention Trial (FIT).

    PARTICIPANTS: One thousand ninety-nine postmenopausal women who had been randomized to alendronate in FIT, with a mean of 5 years ...

    Also Ranks for: 5 Years |  fracture intervention trial |  risk women |  continuing alendronate |  biochemical markers
    KOL Index score: 18394

    CONTEXT: In the Women's Health Initiative trial of estrogen-plus-progestin therapy, women assigned to active treatment had fewer fractures.

    OBJECTIVE: To test the hypothesis that the relative risk reduction of estrogen plus progestin on fractures differs according to risk factors for fractures.

    DESIGN, SETTING, AND PARTICIPANTS: Randomized controlled trial (September 1993-July 2002) in which 16 608 postmenopausal women aged 50 to 79 years with an intact uterus at baseline were recruited ...

    Also Ranks for: Estrogen Progestin |  risk fracture |  bone humans |  medroxyprogesterone acetate |  health initiative
    KOL Index score: 18101

    BACKGROUND: The randomized, double-blind Multiple Outcomes of Raloxifene Evaluation (MORE) trial found that 4 years of raloxifene therapy decreased the incidence of invasive breast cancer among postmenopausal women with osteoporosis by 72% compared with placebo. We conducted the Continuing Outcomes Relevant to Evista (CORE) trial to examine the effect of 4 additional years of raloxifene therapy on the incidence of invasive breast cancer in women in MORE who agreed to continue in ...

    Also Ranks for: Cancer Incidence |  continuing outcomes relevant |  raloxifene placebo |  core trial |  4 years
    KOL Index score: 17556

    BACKGROUND: Previous studies have shown that alendronate can increase bone mineral density (BMD) and prevent radiographically defined (morphometric) vertebral fractures. The Fracture Intervention Trial aimed to investigate the effect of alendronate on the risk of morphometric as well as clinically evident fractures in postmenopausal women with low bone mass.

    METHODS: Women aged 55-81 with low femoral-neck BMD were enrolled in two study groups based on presence or absence of an existing ...

    Also Ranks for: Vertebral Fractures |  women alendronate |  randomised trial |  risk clinical fracture |  low bone mass
    KOL Index score: 17502

    In a large cohort of U.S. women aged 65 and older, we report the relationships of BMD measured at several sites, and subsequent fracture risk at multiple sites over > 8 years of follow-up. Although we found almost all fracture types to be related to low BMD, the overall proportion of fractures attributable to low BMD is modest.

    INTRODUCTION: Although several studies have reported the relationship between bone mineral density (BMD) and subsequent fracture risk, most have been limited by ...

    Also Ranks for: Multiple Sites |  risk fracture |  low bmd |  women aged |  large cohort
    KOL Index score: 17500

    CONTEXT: Raloxifene hydrochloride is a selective estrogen receptor modulator that has antiestrogenic effects on breast and endometrial tissue and estrogenic effects on bone, lipid metabolism, and blood clotting.

    OBJECTIVE: To determine whether women taking raloxifene have a lower risk of invasive breast cancer.

    DESIGN AND SETTING: The Multiple Outcomes of Raloxifene Evaluation (MORE), a multicenter, randomized, double-blind trial, in which women taking raloxifene or placebo were followed ...

    Also Ranks for: Breast Cancer |  postmenopausal women |  raloxifene risk |  3 years |  multiple outcomes
    KOL Index score: 17478

    BACKGROUND: Previous studies have suggested that depression is associated with falls and with low bone density, but it is not known whether depression leads to an increased risk of fracture.

    SUBJECTS AND METHODS: We conducted a prospective cohort study in elderly white women who were recruited from population-based listings in the United States. At a second visit (1988-1990), 7414 participants completed the 15-item Geriatric Depression Scale and were considered depressed if they reported ...

    Also Ranks for: Older Women |  depression falls |  female fractures |  risk fracture |  bone density


    Jane A Cauley: Influence Statistics

    Sample of concepts for which Jane A Cauley is among the top experts in the world.
    Concept World rank
    factors bone mass #1
    older sleep duration #1
    repeat bone #1
    society scientific statement #1
    sof study #1
    aac fracture risk #1
    d3 muscle mass #1
    fractures prospective #1
    aggregate measure #1
    quartile 4 95 #1
    sof women #1
    risk multiple types #1
    hip nonspine fracture #1
    albuminuria lower bmd #1
    bmd hip #1
    menopause‐related bone loss #1
    visit04 #1
    bone loss hip #1
    chairstand time #1
    lifestyle predicts #1
    association dish #1
    weight loss risk #1
    stage crp #1
    anterolisthesis retrolisthesis #1
    annualized percentage rate #1
    testosterone concentrations risk #1
    menopausal bone #1
    frax mof mht #1
    visit12 #1
    loss risk #1
    mets15 #1
    n5497 #1
    z3p3 #1
    osteoporotic fractures #1
    dm menopause #1
    65 69 #1
    bmd frax bmd #1
    genotype women #1
    ntx early postmenopause #1
    bmd lower #1
    endogenous pregnenolone #1
    fracture black women #1
    women lower #1
    bmi direct assay #1
    women reduced egfr #1
    ht vitamin intake #1
    vfx hospitalization #1
    states absorptiometry #1
    mof hip irrs #1

    Key People For Hip Fracture

    Top KOLs in the world
    Cyrus C Cooper
    hip fracture grip strength hertfordshire cohort study
    Steven Ron Cummings
    hip fracture breast cancer older women
    Lee Joseph Melton,
    olmsted county fracture risk irritable bowel syndrome
    John A Kanis
    hip fracture postmenopausal women intervention thresholds
    Jay S Magaziner
    hip fracture nursing homes zoledronic acid
    Olof Johnell
    hip fracture bone mineral density internal fixation

    Jane A Cauley:Expert Impact

    Concepts for whichJane A Cauleyhas direct influence:Hip fracture,  Older women,  Breast cancer,  Postmenopausal women,  Osteoporotic fractures,  Bone mineral density,  Physical activity,  Fracture risk.

    Jane A Cauley:KOL impact

    Concepts related to the work of other authors for whichfor which Jane A Cauley has influence:Breast cancer,  Postmenopausal women,  Hip fracture,  Physical activity,  Bone mineral density,  Body composition,  Gait speed.



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    Department of Epidemiology Graduate School of Public Health University of Pittsburgh, Pittsburgh, PA, USA | Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Penn. | Department of Epidemiology, Gradua