• Disease
  • Olfactory
  • Olfactory Dysfunction
  • Richard L Doty

    Prominent publications by Richard L Doty

    KOL Index score: 13175

    BACKGROUND: Although adverse neuropsychological and neurological health effects are well known among workers with high manganese (Mn) exposures in mining, ore-processing and ferroalloy production, the risks among welders with lower exposures are less well understood.

    METHODS: Confined space welding in construction of a new span of the San Francisco-Oakland Bay Bridge without adequate protection was studied using a multidisciplinary method to identify the dose-effect relationship between ...

    Also Ranks for: Manganese Exposure |  pulmonary function |  bridge welders |  welding fume |  confined space
    KOL Index score: 11267

    OBJECTIVE: To determine the predictive utility of baseline odor identification deficits for future cognitive decline and the diagnosis of Alzheimer disease (AD) dementia.

    METHODS: In a multiethnic community cohort in North Manhattan, NY, 1,037 participants without dementia were evaluated with the 40-item University of Pennsylvania Smell Identification Test (UPSIT). In 757 participants, follow-up occurred at 2 years and 4 years.

    RESULTS: In logistic regression analyses, lower baseline ...

    Also Ranks for: Cognitive Decline |  olfactory deficits |  alzheimer dementia |  urban community |  identification test
    KOL Index score: 10665

    OBJECTIVES: To estimate the prevalence of, and explore potential risk factors for, taste and smell dysfunction in the general population of the USA.

    DESIGN: A cross-sectional study.

    SETTING: A cross-sectional analysis of data collected in the National Health and Nutrition Examination Survey (NHANES 2013-2014).

    PARTICIPANTS: A total of 3519 men and women aged 40 years and older who participated in NHANES 2013-2014.

    MAIN OUTCOME MEASURES: Using the NHANES Pocket Smell Test, smell ...

    Also Ranks for: Smell Impairment |  higher prevalence |  crosssectional study |  taste dysfunction |  representative sample
    KOL Index score: 10417

    NaCl detection thresholds were determined for 12.5- and 50-mm(2) lingual areas at four anterior tongue locations in eight subjects using a device that allowed for accurate temporal and spatial presentation of tastants to small regions of the anterior tongue. The locations, all on the right side of the tongue, were the tongue tip, an area 1.7 cm posterior to the tongue tip, and regions 1.7 and 3.4 cm posterior to the tip along the tongue's lateral margin. Stimulus duration was 0.75 s. ...

    Also Ranks for: Fungiform Papillae |  anterior tongue |  stimulus duration |  stimulated regions |  125 mm2
    KOL Index score: 10328

    Smell and taste disorders are common in the general population, yet little is known about their nature or cause. This article describes a study of 750 patients with complaints of abnormal smell or taste perception from the University of Pennsylvania Smell and Taste Center, Philadelphia. Major findings suggest that: chemosensory dysfunction influences quality of life; complaints of taste loss usually reflect loss of smell function; upper respiratory infection, head trauma, and chronic ...

    Also Ranks for: Pennsylvania Smell |  taste disorders |  head trauma |  sex factors |  patients chemosensory dysfunction
    KOL Index score: 10052

    OBJECTIVE: There is a substantial genetic contribution to schizophrenia but no way to readily identify individuals at risk. Biological abnormalities reflecting greater genetic vulnerability may be discovered by examining healthy family members of patients with schizophrenia. There is evidence that olfactory impairments are common in patients. The authors previously reported that patients have abnormal olfactory bulbs, assessed by magnetic resonance imaging (MRI). This study examined ...

    Also Ranks for: Olfactory Bulb |  patients schizophrenia |  genetic vulnerability |  degree relatives |  endophenotypic marker
    KOL Index score: 9925

    OBJECTIVE: The authors' goal was to compare the size and linear density of Purkinje cells in the cerebellar vermis of subjects with and without schizophrenia.

    METHOD: Blocks of alcohol-fixed cerebellar vermis were dissected at autopsy from the brains of 14 elderly patients with schizophrenia and 13 elderly subjects with no history of neuropsychiatric illness. The blocks of vermis were sectioned and stained with 1% cresyl violet. The linear density and cross-sectional area of Purkinje ...

    Also Ranks for: Cerebellar Vermis |  purkinje cell |  patients schizophrenia |  linear density |  brain regions
    KOL Index score: 9745

    BACKGROUND: The utility of combining early markers to predict conversion from mild cognitive impairment (MCI) to Alzheimer's Disease (AD) remains uncertain.

    METHODS: Included in the study were 148 outpatients with MCI, broadly defined, followed at 6-month intervals. Hypothesized baseline predictors for follow-up conversion to AD (entire sample: 39/148 converters) were cognitive test performance, informant report of functional impairment, apolipoprotein E genotype, olfactory ...

    Also Ranks for: Age Mmse |  early markers |  mild cognitive |  mci curve sensitivity |  informant report
    KOL Index score: 9136

    Mexico City (MC) residents are exposed to severe air pollution and exhibit olfactory bulb inflammation. We compared the olfactory function of individuals living under conditions of extreme air pollution to that of controls from a relatively clean environment and explore associations between olfaction scores, apolipoprotein E (APOE) status, and pollution exposure. The olfactory bulbs (OBs) of 35 MC and 9 controls 20.8+/-8.5 years were assessed by light and electron microscopy. The ...

    Also Ranks for: Olfactory Function |  air pollution |  ultrafine particles |  mc residents |  exposed children
    KOL Index score: 9031

    BACKGROUND: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), is responsible for the largest pandemic since the 1918 influenza A virus subtype H1N1 influenza outbreak. The symptoms presently recognized by the World Health Organization are cough, fever, tiredness, and difficulty breathing. Patient-reported smell and taste loss has been associated with COVID-19 infection, yet no empirical olfactory testing on a cohort ...

    Also Ranks for: Smell Dysfunction |  test scores |  60 patients |  covid19 infection |  taste loss
    KOL Index score: 9019

    The development of the first standardized "scratch 'n sniff" olfactory test is described. Over 1600 subjects participated in five experiments. In Experiment 1, 50 microencapsulated odorants were rated as to their intensity, pleasantness, irritation, coolness, and familiarity, and two procedures for releasing them were compared. In Experiment 2, the results of the first experiment and other data were used in the development of the test, which was administered to a large number of ...

    Also Ranks for: Olfactory Function |  experiment test |  pennsylvania smell |  odor detection |  normal controls
    KOL Index score: 8776

    The subjective recording in diary cards of symptoms of itch, sneeze, nose running, and blockage, with the use of a rating scale to indicate the level of severity, is usual for clinical trials in allergic rhinitis. The primary outcome measure is usually a composite score that enables a single total symptoms score endpoint. It is appreciated, however, that rhinitis has a greater effect on the individual than is reflected purely by the recording of anterior nasal symptoms. Nasal obstruction ...

    Also Ranks for: Allergic Rhinitis |  intranasal steroids |  quality life |  nasal obstruction |  daytime sleepiness
    KOL Index score: 8625

    Acoustic rhinometry is a recently developed method for the objective assessment of nasal patency. In this study, acoustic rhinometry was used to measure changes in nasal cavity dimensions in the immediate response to nasal allergen challenge in eight pollen-sensitive subjects. Acoustic rhinometric changes were compared with subjective symptoms, as well as histamine in nasal secretions, cytology of nasal mucosal scrapings, and changes in olfactory function. A significantly greater ...

    Also Ranks for: Acoustic Rhinometry |  olfactory function |  allergen challenge |  nasal patency |  objective assessment


    Richard L Doty: Influence Statistics

    Sample of concepts for which Richard L Doty is among the top experts in the world.
    Concept World rank
    new cultural adaptation #1
    studies smoking effects #1
    profound olfactory dysfunction #1
    range perithreshold concentrations #1
    40item upsit #1
    olfactory test measures #1
    leaking natural #1
    total anosmia hypogeusia #1
    women taste tests #1
    allergic seasonal smell #1
    threshold r056 #1
    smell temporal lobe #1
    richard doty #1
    reversibility cohort studies #1
    alcohol smell #1
    swm threshold #1
    odorguided behaviors paper #1
    chemosensory malingerers #1
    conflicting odorous sensations #1
    pvods #1
    antibiotics smell dysfunction #1
    10week test period #1
    nonmalingerers malingerers #1
    stominger #1
    olfactory auras epilepsy #1
    study acoustic rhinometry #1
    microsmics #1
    tongue regions #1
    esz saliva #1
    measured brain structures #1
    anosmia severe microsmia #1
    olfactory capacities aging #1
    partial anosmia #1
    superior nasal septum #1
    ssts stt #1
    taste smell disorders #1
    clinical olfactory tests #1
    01 propylthiouracil ptu #1
    physical concentration functions #1
    post3mi test day #1
    brain structures resection #1
    ensuring fiveyear period #1
    80 years dysfunction #1
    47 nasallyinhaled chemicals #1
    semantic rehearsal #1
    procedure intertrial intervals #1
    patients severe microsmia #1
    odorguided behaviors #1
    nonmalingerers age #1
    disorders olfactory bulb #1

    Key People For Olfactory Dysfunction

    Top KOLs in the world
    Thomas C Hummel
    olfactory function odor identification taste disorders
    Richard L Doty
    olfactory dysfunction pennsylvania smell odor identification
    Steven Nordin
    normative data olfactory dysfunction odor identification
    Paul Shaman
    neuritic outgrowth pennsylvania smell taste disorders
    Gerd Kobal
    nasal mucosa evoked potentials odor identification
    Antje Haehner
    olfactory function smell loss parkinson disease

    Richard L Doty:Expert Impact

    Concepts for whichRichard L Dotyhas direct influence:Olfactory dysfunction,  Olfactory function,  Odor detection performance,  Odor identification,  Pennsylvania smell,  Myasthenia gravis,  Neurodegenerative diseases,  Smell function.

    Richard L Doty:KOL impact

    Concepts related to the work of other authors for whichfor which Richard L Doty has influence:Olfactory dysfunction,  Parkinson disease,  Odor identification,  Air pollution,  Allergic rhinitis,  Chronic rhinosinusitis,  Taste disorders.



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    Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA | Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Hospita