Richard L DotyShow email address
Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA | Smell and Taste Center, Department of Otorhinolaryngology: Head and ...
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Richard L Doty:Expert Impact
Concepts for whichRichard L Dotyhas direct influence:Olfactory dysfunction,Olfactory function,Odor detection performance,Odor identification,Pennsylvania smell,Myasthenia gravis,Neurodegenerative diseases,Smell function.
Richard L Doty:KOL impact
Concepts related to the work of other authors for whichfor which Richard L Doty has influence:Olfactory dysfunction,Parkinson disease,Odor identification,Air pollution,Allergic rhinitis,Chronic rhinosinusitis,Taste disorders.
KOL Resume for Richard L Doty
Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:
Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
University of Pennsylvania, Philadelphia, Pennsylvania, USA
Smell & Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA
Smell and Taste Center, Department of Otorhinolaryngology—Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Smell and Taste Center, Department of Otorhinolaryngology - Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Perelman School of Medicine, University of Pennsylvania, 5 Ravdin Pavilion, PA 19104, Philadelphia, USA
Department of Otorhinolarynology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania, 5 Ravdin Building, 3400 Spruce Street, 19104-4823, Philadelphia, PA, USA
Smell & Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
From the Division of Geriatric Psychiatry, Department of Psychiatry (D.P.D.), Department of Neurology and the Gertrude H. Sergievsky Center and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.M., H.A., N.S., Y.S., L.B.Z., E.D.L., R.M.), College of Physicians and Surgeons, Columbia University, New York; Division of Biostatistics (S.L.), New York State Psychiatric Institute and Columbia University, New York; and University of Pennsylvania (R.L.D.), Philadelphia.
Smell and Test Center, Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, 5 Ravdin 3400 Spruce Street, Philadelphia, PA 19104, USA.
Department of Otorhinolaryngology: Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
From the Monell Chemical Senses Center (P.D., C.M.), Philadelphia; Smell and Taste Center and Department of Otorhinolaryngology: Head and Neck Surgery (R.L.D.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; San Diego State University (C.M.), San Diego, CA; Ohio University (R.F.), Athens, OH; Epidemiology and Statistics Program (H.J.H.), National Institute on Deafness and Other, Communication Disorders, National Institutes of Health, Bethesda, MD; and Department of Medical Social Sciences (M.A.K., J.S.), Northwestern University, Chicago, IL.
Smell and Taste Center, Department of Otorhinolaryngology: Head & Neck Surgery; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Otolaryngology, São Paulo/SP, Brazil.
Smell & Taste Center, Department of Otorhinolaryngology, Perelman School of Medicine, University of Pennsylvania, USA
Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania School of Medicine
Smell & Taste Center, University of Pennsylvania School of Medicine, USA
Smell and Taste Center, University of Pennsylvania
Smell & Taste Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104-4283, USA.
Department of Otorhinolaryngology: Head and Neck Surgery, School of Medicine, University of Pennsylvania Medical Center, 5 Silverstein Building, 3400 Spruce St, Philadelphia, PA 19104, USA
From the Department of Otolaryngology, Head and Neck Surgery (n.m., s.k.a.), University of Pennsylvania and the Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, U.S.A.; the Department of Radiation Oncology (m.m.), Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.; the Department of Radiation Oncology (p.a.d.), Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, U.S.A.; the Department of Biostatistics and Epidemiology (a.t.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A.; and the Smell and Taste Center (r.l.d.), University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.
Smell and Taste Center, University of Pennsylvania School of Medicine, 5 Ravdin Pavilion, 3400 Spruce Street, Philadelphia, PA 19104
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|epilepsy olfactory domains||#1|
|categorical ambulatory ability||#1|
|studies smoking effects||#1|
|odor detection hypothyroidism||#1|
|clinical disorders olfaction||#1|
|disordered smell function||#1|
|highprecision olfactometry sensitivity||#1|
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Prominent publications by Richard L Doty
Dose–effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders
[ PUBLICATION ]
BACKGROUND: Although adverse neuropsychological and neurological health effects are well known among workers with high manganese (Mn) exposures in mining, ore-processing and ferroalloy production, the risks among welders with lower exposures are less well understood.
METHODS: Confined space welding in construction of a new span of the San Francisco-Oakland Bay Bridge without adequate protection was studied using a multidisciplinary method to identify the dose-effect relationship between ...
|Known for Manganese Exposure | Pulmonary Function | Bridge Welders | Welding Fume | Confined Space|
[ PUBLICATION ]
METHODS: In a multiethnic community cohort in North Manhattan, NY, 1,037 participants without dementia were evaluated with the 40-item University of Pennsylvania Smell Identification Test (UPSIT). In 757 participants, follow-up occurred at 2 years and 4 years.
RESULTS: In logistic regression analyses, lower baseline ...
|Known for Cognitive Decline | Olfactory Deficits | Alzheimer Dementia | Urban Community | Identification Test|
Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study
[ PUBLICATION ]
OBJECTIVES: To estimate the prevalence of, and explore potential risk factors for, taste and smell dysfunction in the general population of the USA.
DESIGN: A cross-sectional study.
SETTING: A cross-sectional analysis of data collected in the National Health and Nutrition Examination Survey (NHANES 2013-2014).
PARTICIPANTS: A total of 3519 men and women aged 40 years and older who participated in NHANES 2013-2014.
MAIN OUTCOME MEASURES: Using the NHANES Pocket Smell Test, smell ...
|Known for Smell Impairment | Higher Prevalence | Crosssectional Study | Taste Dysfunction | Representative Sample|
NaCl thresholds: relationship to anterior tongue locus, area of stimulation, and number of fungiform papillae
[ PUBLICATION ]
NaCl detection thresholds were determined for 12.5- and 50-mm(2) lingual areas at four anterior tongue locations in eight subjects using a device that allowed for accurate temporal and spatial presentation of tastants to small regions of the anterior tongue. The locations, all on the right side of the tongue, were the tongue tip, an area 1.7 cm posterior to the tongue tip, and regions 1.7 and 3.4 cm posterior to the tip along the tongue's lateral margin. Stimulus duration was 0.75 s. ...
|Known for Fungiform Papillae | Anterior Tongue | Stimulus Duration | Stimulated Regions | 125 Mm2|
Smell and Taste Disorders, A Study of 750 Patients From the University of Pennsylvania Smell and Taste Center
[ PUBLICATION ]
Smell and taste disorders are common in the general population, yet little is known about their nature or cause. This article describes a study of 750 patients with complaints of abnormal smell or taste perception from the University of Pennsylvania Smell and Taste Center, Philadelphia. Major findings suggest that: chemosensory dysfunction influences quality of life; complaints of taste loss usually reflect loss of smell function; upper respiratory infection, head trauma, and chronic ...
|Known for Pennsylvania Smell | Taste Disorders | Head Trauma | Sex Factors | Patients Chemosensory Dysfunction|
OBJECTIVE: There is a substantial genetic contribution to schizophrenia but no way to readily identify individuals at risk. Biological abnormalities reflecting greater genetic vulnerability may be discovered by examining healthy family members of patients with schizophrenia. There is evidence that olfactory impairments are common in patients. The authors previously reported that patients have abnormal olfactory bulbs, assessed by magnetic resonance imaging (MRI). This study examined ...
|Known for Olfactory Bulb | Patients Schizophrenia | Genetic Vulnerability | Degree Relatives | Endophenotypic Marker|
[ PUBLICATION ]
OBJECTIVE: The authors' goal was to compare the size and linear density of Purkinje cells in the cerebellar vermis of subjects with and without schizophrenia.
METHOD: Blocks of alcohol-fixed cerebellar vermis were dissected at autopsy from the brains of 14 elderly patients with schizophrenia and 13 elderly subjects with no history of neuropsychiatric illness. The blocks of vermis were sectioned and stained with 1% cresyl violet. The linear density and cross-sectional area of Purkinje ...
|Known for Cerebellar Vermis | Purkinje Cell | Patients Schizophrenia | Linear Density | Brain Regions|
Combining Early Markers Strongly Predicts Conversion from Mild Cognitive Impairment to Alzheimer's Disease
[ PUBLICATION ]
BACKGROUND: The utility of combining early markers to predict conversion from mild cognitive impairment (MCI) to Alzheimer's Disease (AD) remains uncertain.
METHODS: Included in the study were 148 outpatients with MCI, broadly defined, followed at 6-month intervals. Hypothesized baseline predictors for follow-up conversion to AD (entire sample: 39/148 converters) were cognitive test performance, informant report of functional impairment, apolipoprotein E genotype, olfactory ...
|Known for Age Mmse | Early Markers | Mild Cognitive | Mci Curve Sensitivity | Informant Report|
Urban air pollution: Influences on olfactory function and pathology in exposed children and young adults
[ PUBLICATION ]
Mexico City (MC) residents are exposed to severe air pollution and exhibit olfactory bulb inflammation. We compared the olfactory function of individuals living under conditions of extreme air pollution to that of controls from a relatively clean environment and explore associations between olfaction scores, apolipoprotein E (APOE) status, and pollution exposure. The olfactory bulbs (OBs) of 35 MC and 9 controls 20.8+/-8.5 years were assessed by light and electron microscopy. The ...
|Known for Olfactory Function | Air Pollution | Ultrafine Particles | Mc Residents | Exposed Children|
[ PUBLICATION ]
BACKGROUND: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), is responsible for the largest pandemic since the 1918 influenza A virus subtype H1N1 influenza outbreak. The symptoms presently recognized by the World Health Organization are cough, fever, tiredness, and difficulty breathing. Patient-reported smell and taste loss has been associated with COVID-19 infection, yet no empirical olfactory testing on a cohort ...
|Known for Smell Dysfunction | Test Scores | 60 Patients | Covid19 Infection | Taste Loss|
Development of the university of pennsylvania smell identification test: A standardized microencapsulated test of olfactory function
[ PUBLICATION ]
The development of the first standardized "scratch 'n sniff" olfactory test is described. Over 1600 subjects participated in five experiments. In Experiment 1, 50 microencapsulated odorants were rated as to their intensity, pleasantness, irritation, coolness, and familiarity, and two procedures for releasing them were compared. In Experiment 2, the results of the first experiment and other data were used in the development of the test, which was administered to a large number of ...
|Known for Olfactory Function | Experiment Test | Pennsylvania Smell | Odor Detection | Normal Controls|
The subjective recording in diary cards of symptoms of itch, sneeze, nose running, and blockage, with the use of a rating scale to indicate the level of severity, is usual for clinical trials in allergic rhinitis. The primary outcome measure is usually a composite score that enables a single total symptoms score endpoint. It is appreciated, however, that rhinitis has a greater effect on the individual than is reflected purely by the recording of anterior nasal symptoms. Nasal obstruction ...
|Known for Allergic Rhinitis | Intranasal Steroids | Quality Life | Nasal Obstruction | Daytime Sleepiness|
Acoustic rhinometry is a recently developed method for the objective assessment of nasal patency. In this study, acoustic rhinometry was used to measure changes in nasal cavity dimensions in the immediate response to nasal allergen challenge in eight pollen-sensitive subjects. Acoustic rhinometric changes were compared with subjective symptoms, as well as histamine in nasal secretions, cytology of nasal mucosal scrapings, and changes in olfactory function. A significantly greater ...
|Known for Acoustic Rhinometry | Olfactory Function | Allergen Challenge | Nasal Patency | Objective Assessment|