Hideaki Yokoo

Hideaki Yokoo

International Agency For Research On Cancer (Iarc), 150 Cours Albert-Thomas, Cedex 08f-69372, Lyon, France

Direct Impact

Concepts for which Hideaki Yokoo has direct influence:

oligodendroglial tumors
central nervous
cerebral malaria
epithelioid glioblastoma
malignant transformation
perivascular cells
choroid plexus

External impact

Concepts related to the work of other authors for which Hideaki Yokoo has influence:

central nervous
cortical superficial siderosis
esophageal carcinosarcoma
rhabdoid tumor
atypical teratoid
gabaergic neurons
neuromyelitis optica

Prominent publications by Hideaki Yokoo

KOL-Index: 106 Atypical teratoid/rhabdoid tumors (AT/RTs) are highly malignant tumors of the central nervous system that predominantly occur in infants, and are characterized by the presence of rhabdoid cells and inactivation of INI1 or (rarely) BRG1. Most AT/RT are identified as primary tumors; however, rare AT/RT or INI1-deficient RTs arising from other primary tumors have been reported. Here, we report ...
Known for
Designation | Proliferative Activity | Infiltrative | 1 Cns Lgdit-Ini1
KOL-Index: 76 Recurrent fusion genes involving C11orf95, C11orf95-RELA, have been identified only in supratentorial ependymomas among primary CNS tumors. Here, we report hitherto histopathologically unclassifiable high-grade tumors, under the tentative label of "ependymoma-like tumors with mesenchymal differentiation (ELTMDs)," harboring C11orf95-NCOA1/2 or -RELA fusion. We examined the ...
Known for
Mesenchymal Components | Proliferative Activity | Ependymoma-Like Tumors | T-Distributed Stochastic Neighbor
KOL-Index: 60 Primary central nervous system lymphomas (PCNSLs) rarely exhibit intratumoral hemorrhage. The differential diagnosis of hemorrhagic neoplasms of the central nervous system (CNS) currently includes metastatic carcinomas, melanomas, choriocarcinomas, oligodendrogliomas, and glioblastomas. Here we present the clinical, radiological, pathological, and molecular genetic features of six cases of ...
Known for
Therapeutic Modalities | Conventional Hemorrhagic Neoplasms | Perfusion Magnetic Resonance Imaging | Myd88
KOL-Index: 60 In Alzheimer's disease, the apolipoprotein E gene (APOE) ε2 allele is a protective genetic factor, whereas the APOE ε4 allele is a genetic risk factor. However, both the APOE ε2 and the APOE ε4 alleles are genetic risk factors for lobar intracerebral hemorrhage. The reasons for the high prevalence of lobar intracerebral hemorrhage and the low prevalence of Alzheimer's disease with the APOE ...
Known for
18f-Thk5351 | Mao-B | Alzheimer Homozygous | Allele Recurrent
KOL-Index: 58 Cerebellar liponeurocytoma (cLNC), categorized as a World Health Organization grade II tumor, is a rare neoplasm characterized by advanced neuronal/neurocytic differentiation and focal lipid accumulation in neuroepithelial tumor cells. However, the expression and genetic profiling of cLNC have been poorly studied. A 44-year-old woman with a three-year history of cerebellar ataxia and ...
Known for
Liponeurocytoma | Expression Genetic | Accumulation Lipid | Lower Vermis
KOL-Index: 56 Here, we review the recent literature on molecular discoveries in ependymomas and pediatric diffuse gliomas. Ependymomas can now be categorized into three location-related subgroups according to their biological profile: posterior fossa ependymomas, group A (PFA) and B (PFB), and supratentorial ependymomas. Although no recurrently mutated genes were found throughout these groups of ...
Known for
Tyrosine Kinase Domain | Location-Related Subgroups | Non-Brainstem High-Grade Tumors | Recurrently Mutated Genes
KOL-Index: 54 Desmoplastic myxoid tumor (DMT), SMARCB1-mutant is a recently proposed brain tumor that occurs in the pineal region of adults. This tumor is characterized by desmoplastic stroma and various degrees of myxoid matrix. Tumor cells with low-grade morphology show polyphenotypic immunoreactivity, and rhabdoid cells are rare. We herein present a case with some uncommon features such as no myxoid ...
Known for
Rhabdoid Cells | Myxoid Matrix | Preferentially Arising | Uncommon Features
KOL-Index: 51 The pathogenesis of sarcomatous component in spindle cell carcinoma (SpCC) of the esophagus is unclear. To investigate the involvement of epithelial-mesenchymal transition (EMT) in sarcomatous differentiation, we performed immunohistochemistry for Slug, Twist, ZEB1, and ZEB2, transcription factors associated with EMT and E-cadherin, in 14 cases of SpCC of the esophagus. In order to verify ...
Known for
P53 Expression Pattern | Conventional Esophageal Squamous Carcinoma | Membranous E-Cadherin Expression | Emt Sarcomatous
KOL-Index: 45 EGFR amplification is a frequent genetic alteration in primary (de novo) glioblastomas, and is often associated with structural alterations. Most common is variant III (EGFRvIII), which results from a non-random 801 bp in-frame deletion of exons 2 to 7 of the EGFR gene. We assessed amplification and overexpression of EGFRvIII and wild-type EGFR in 30 glioblastoma biopsies. ...
Known for
Copy Numbers | Structural Alterations | 20 67 | Serial Sections
KOL-Index: 44 Atypical teratoid/rhabdoid tumors (AT/RTs) are rare aggressive tumors of the central nervous system that predominantly affect infants. Although adult AT/RT are rare, accumulated cases have revealed adult-specific AT/RT in the sellar region. Twelve previously reported cases of sellar AT/RT exclusively occurred in adult females, suggesting biological differences from conventional infant AT/RT. ...
Known for
Alterations Ini1 | Teratoid Rhabdoid | Splice Site | Histology Sellar

International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Cedex 08F-69372, Lyon, France

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