Prominent publications by Thewarach Laha

KOL Index score: 11852

BACKGROUND: The liver fluke Opisthorchis viverrini infects several million people in Southeast Asia. Adult flukes live in the bile ducts of humans, where they cause hepatobiliary pathology, including cholangiocarcinoma. Here, we investigated the potential of extracellular vesicles (EVs) secreted by the fluke and defined recombinant proteins derived from EVs to generate protective immunity in a hamster vaccination-challenge model.


Known for Challenge Infection |  Extracellular Vesicles |  Opisthorchis Viverrini |  Adult Flukes |  Worms Hamsters
KOL Index score: 11594

BACKGROUND: The liver fluke Opisthorchis viverrini is classified as a class I carcinogen due to the association between cholangiocarcinoma and chronic O. viverrini infection. During its feeding activity within the bile duct, the parasite secretes several cathepsin F cysteine proteases that may induce or contribute to the pathologies associated with hepatobiliary abnormalities.

METHODOLOGY/PRINCIPAL FINDINGS: Here, we describe the cDNA, gene organization, phylogenetic relationships, ...

Known for Liver Fluke |  Opisthorchis Viverrini |  Cysteine Protease |  Ov Cf1 |  Cathepsin Gene
KOL Index score: 11296

More than 750 million people are at risk of infection with foodborne liver flukes. Opisthorchis viverrini is considered among the most important of these parasites, due to its strong association with cholangiocarcinoma (CCA). O. viverrini infection results in a chronic inflammatory challenge to the host, which can lead to advanced, pathogen-specific disease sequelae including obstructive jaundice, hepatomegaly, cholecystitis, as well as CCA. However, before disease sequelae are apparent, ...

Known for Advanced Periductal Fibrosis |  Opisthorchis Viverrini |  Elevated Levels |  Risk Infection |  Human Liver
KOL Index score: 11188

BACKGROUND: It is becoming apparent that perhaps as much as half of the genome of the human blood fluke Schistosoma mansoni is constituted of mobile genetic element-related sequences. Non-long terminal repeat (LTR) retrotransposons, related to the LINE elements of mammals, comprise much of this repetitive component of the schistosome genome. Of more than 12 recognized clades of non-LTR retrotransposons, only members of the CR1, RTE, and R2 clades have been reported from the schistosome ...

Known for Schistosoma Mansoni |  Rte Clade |  Human Blood Fluke |  Ltr Retrotransposons |  Sequence Analysis
KOL Index score: 10782

Opisthorchis viverrini and other foodborne trematode infections are major health problem in Thailand, the Lao People's Democratic Republic, Vietnam and Cambodia. Differential diagnosis of O. viverrini based on the microscopic observation of parasite eggs is difficult in areas where Clonorchis sinensis and minute intestinal flukes coexist. We therefore established a rapid, sensitive and specific method for detecting O. viverrini infection from the stool samples using the loop-mediated ...

Known for Opisthorchis Viverrini |  Rapid Detection |  Isothermal Amplification |  Differential Diagnosis |  Helminth Dna
KOL Index score: 10639

The human liver fluke, Opisthorchis viverrini, induces inflammation of the hepatobiliary system. Despite being constantly exposed to inimical oxygen radicals released from inflammatory cells, the parasite survives for many years. The mechanisms by which it avoids oxidative damage are unknown. In this study, thioredoxin peroxidase (TPx), a member of the peroxiredoxin superfamily, was cloned from an O. viverrini cDNA library. O. viverrini TPx cDNA encoded a polypeptide of 212 amino acid ...

Known for Thioredoxin Peroxidase |  Opisthorchis Viverrini |  Liver Fluke |  Antioxidant Enzyme |  Carcinogenic Human
KOL Index score: 10556

The present study compared the genetic variation among 14 different geographical isolates of Opisthorchis viverrini sensu lato from Thailand and Lao PDR using sequence data for 2 mitochondrial DNA genes, the subunit 1 of NADH dehydrogenase gene (nad1) and cytochrome c oxidase gene (cox1). Four different nad1 haplotypes were detected among isolates, all of which were identical at the amino acid sequence level. Nucleotide sequence variation among 14 isolates ranged from 0 to 0.3% for nad1. ...

Known for Lao Pdr |  Opisthorchis Viverrini |  Sequence Variation |  Mitochondrial Dna |  Phylogenetic Relationships
KOL Index score: 10547

The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically relevant species of the trematode family Opisthorchiidae, and the causative agent of opisthorchiasis felinea over an extensive range that spans regions of Eurasia. The International Agency for Research on Cancer classifies the infection with the liver flukes Opisthorchis viverrini and Clonorchis sinensis as group 1 agents and a major risk factor for cholangiocarcinoma. However, the carcinogenic potential ...

Known for Opisthorchis Felineus |  Biliary Tract |  Liver Fluke |  Intraepithelial Neoplasia |  Clonorchis Sinensis
KOL Index score: 10484

We characterized the consensus sequence and structure of a long terminal repeat (LTR) retrotransposon from the genome of the human blood fluke, Schistosoma japonicum, and have named this element, Gulliver. The full length, consensus Gulliver LTR retrotransposon was 4788 bp, and it was flanked at its 5'- and 3'-ends by LTRs of 259 bp. Each LTR included RNA polymerase II promoter sequences, a CAAT signal and a TATA box. Gulliver exhibited features characteristic of a functional LTR ...

Known for Schistosoma Japonicum |  Ltr Retrotransposon |  Sequence Analysis |  Terminal Repeat |  Blood Fluke
KOL Index score: 10423

The human liver fluke, Opisthorchis viverrini, infects millions of people throughout south-east Asia and is a major cause of cholangiocarcinoma, or cancer of the bile ducts. The mechanisms by which chronic infection with O. viverrini results in cholangiocarcinogenesis are multi-factorial, but one such mechanism is the secretion of parasite proteins with mitogenic properties into the bile ducts, driving cell proliferation and creating a tumorigenic environment. Using a proteomic approach, ...

Known for Host Cells |  Growth Factor |  Ov Grn1 |  Carcinogenic Liver Fluke |  Opisthorchis Viverrini
KOL Index score: 10401

A new RTE-like, non-long terminal repeat retrotransposon, termed SjR2, from the human blood fluke, Schistosoma japonicum, is described. SjR2 is approximately 3.9 kb in length and is constituted of a single open reading frame encoding a polyprotein with apurinic/apyrimidinic endonuclease and reverse transcriptase domains. The open reading frame is bounded by 5'- and 3'-terminal untranslated regions and, at its 3'-terminus, SjR2 bears a short (TGAC)(3) repeat. Phylogenetic analyses based ...

Known for Schistosoma Japonicum |  Human Blood Fluke |  Terminal Repeat |  Reverse Transcriptase |  Sequence Homology
KOL Index score: 9956

A newly described non-long terminal repeat (non-LTR) retrotransposon element was isolated from the genome of the Oriental schistosome, Schistosoma japonicum. At least 1000 partial copies of the element, which was named pido, were dispersed throughout the genome of S. japonicum. As is usual with non-LTR retrotransposons, it is expected that many pido elements will be 5'-truncated. A consensus sequence of 3564 bp of the truncated pido element was assembled from several genomic fragments ...

Known for Schistosoma Japonicum |  Repeat Retrotransposon |  Amino Acid Transcription |  Blood Fluke |  Long Terminal
KOL Index score: 9857

Surface and secreted proteins of schistosomes orchestrate the basic physiologic requirements of a parasitic existence. These proteins are often exposed to host tissues during penetration, migration, feeding, and immune evasion, and they are obvious targets for control strategies. Signal sequence trap (SST) represents a novel approach that selects for cDNAs encoding secreted and surface proteins with N-terminal signal peptides, so we constructed a randomly primed adult Schistosoma mansoni ...

Known for Cdnas Encoding |  Schistosoma Mansoni |  Signal Sequence |  Membrane Proteins |  Immune Evasion
KOL Index score: 9743

Determining of the success of a parasite's infectiveness in its snail host clearly depends on environmental conditions. Temperature, one of the most influential factors impinging on metabolism of cold-blooded animals, is believed to be an important factor in parasitic infection in snails. In order to elucidate the influence of temperature, sex and size of snails on infectivity of Opisthorchis viverrini to its first intermediate host, Bithynia siamensis goniomphalos, 960 snails were ...

Known for Opisthorchis Viverrini |  Intermediate Host |  Bithynia Siamensis |  Infection Snails |  Temperature Animals
KOL Index score: 9664

The snail Bithynia siamensis goniomphalos acts as the first intermediate host for the human liver fluke Opisthorchis viverrini, the major cause of cholangiocarcinoma (CCA) in Northeast Thailand. The undisputed link between CCA and O. viverrini infection has precipitated efforts to understand the molecular basis of host-parasite interactions with a view to ultimately developing new control strategies to combat this carcinogenic infection. To date most effort has focused on the ...

Known for Opisthorchis Viverrini |  Siamensis Goniomphalos |  Liver Fluke |  Intermediate Host |  Northeast Thailand


Thewarach Laha: Influence Statistics

Sample of concepts for which Thewarach Laha is among the top experts in the world.
Concept World rank
techniques opisthorchiasis #1
viverrini irrigation #1
anti fluke #1
3°c intervals #1
human liver fluke #1
detection viverrini dna #1
viverrini trematodes #1
acts intermediate #1
egg metacercaria #1
opisthorchis sequence #1
data opisthorchis #1
stages viverrini #1
area aestivation #1
snails study period #1
major cholangiocarcinoma #1
embryonated uterineeggs #1
parasites infectiveness #1
carcinogenic liver fluke #1
viverrini public #1
roles ov #1
viverrini microsatellite #1
aestivation mortality rate #1
goniomphalos acts #1
size small medium #1
carcinogenic liver #1
protein ov #1
foodborne trematode #1
cricetinae cyprinidae #1
month aestivation #1
aestivation mortality #1
viverrini dna #1
ban phai #1
infection opisthorchis viverrini #1
opisthorchis phylogeny #1
viverrini intermediate host #1
aestivation snail #1
960 snails #1
viverrini food #1
4monthdried period #1
female male opisthorchiasis #1
viverrini major #1
sequence ovfbpa1 #2
lawa lake thailand #2
epical surface #2
abnormalities hba #2
ovfabp #2
ban phai chonnabot #2

Key People For Opisthorchis Viverrini

Top KOLs in the world
Paiboon Sithithaworn
opisthorchis viverrini lao pdr northeast thailand
Banchob Sripa
opisthorchis viverrini liver fluke helicobacter pylori
Sasithorn Kaewkes
opisthorchis viverrini liver fluke northeast thailand
Paul James Brindley
schistosoma mansoni opisthorchis viverrini liver fluke
Thewarach Laha
opisthorchis viverrini liver fluke lao pdr
Smarn Tesana
opisthorchis viverrini lao pdr northeast thailand

Thewarach Laha:Expert Impact

Concepts for whichThewarach Lahahas direct influence:Opisthorchis viverrini,  Liver fluke,  Carcinogenic liver fluke,  Lao pdr,  Advanced periductal fibrosis,  Fluke opisthorchis,  Human liver fluke,  Southeast asia.

Thewarach Laha:KOL impact

Concepts related to the work of other authors for whichfor which Thewarach Laha has influence:Opisthorchis viverrini,  Clonorchis sinensis,  Liver fluke,  Schistosoma mansoni,  Extracellular vesicles,  Lao pdr,  Fasciola hepatica.



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Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand | Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. Electronic address: | Department of Parasitol

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