• Disease
  • Oral
  • Oral Cavity
  • Sadru P Kabani

    Prominent publications by Sadru P Kabani

    KOL Index score: 7910

    This study was designed to investigate the site of lateral pterygoid muscle insertion into the temporomandibular joint (TMJ) disk, and the relationship between that attachment and the disk displacement. One hundred and ten TM joints from 78 cadavers were collected and sectioned in the sagittal plane. Sixty-two unilateral specimens were available and 16 additional specimens were selected randomly from the remaining cadavers in which both condyles were available. Thus statistical ...

    Also Ranks for: Disk Displacement |  temporomandibular joint |  muscle attachment |  superior head |  aged pterygoid
    KOL Index score: 7396

    BACKGROUND: Understanding the development and progression of head and neck squamous cell carcinoma is key in the quest for the early diagnosis and prevention of this type of malignancy. The current study correlated early biochemical and histologic changes in oral tissue with spectral features in fluorescence, reflectance, and light scattering spectra acquired in vivo to diagnose early stages of oral malignancies.

    METHODS: A total of 91 tissue sites from 15 patients with varying degrees ...

    Also Ranks for: Oral Carcinoma |  spectroscopic detection |  sensitivity specificity |  radiation spectrometry |  trimodal spectroscopy
    KOL Index score: 7187

    Imatinib mesylate (STI-571, Gleevec®), a tyrosine kinase inhibitor, is a first-line medication for treating chronic myeloid leukemia (CML). Clinical studies revealed very good hematological responses without significant side effects. However, imatinib may lead to mucosal pigmentation. Three patients, two males aged 64 and 53 and one female aged 29 presented with a painless, diffuse, grey-blue pigmentation of the mucosa of the hard palate. Both male patients had a history of CML and had ...

    Also Ranks for: Mucosal Pigmentation |  imatinib mesylate |  hard palate |  chronic myeloid leukemia |  tyrosine kinase inhibitor
    KOL Index score: 7053

    We recently demonstrated that eosinophils infiltrate prominently into cutaneous wounds in the Syrian hamster and represent a source of transforming growth factor-alpha and transforming growth factor-beta. In this study, we assessed the role of the eosinophil and eosinophil-derived transforming growth factors in human oral ulcers that exhibit delayed healing, descriptively termed traumatic ulcerative granuloma with stromal eosinophilia. Our aim was to determine whether eosinophils, which ...

    Also Ranks for: Stromal Eosinophilia |  transforming growth |  traumatic ulcerative granuloma |  human eosinophils |  oral ulcer
    KOL Index score: 6821

    OBJECTIVE: To explore the potential of autofluorescence spectroscopy as a tool for early detection of upper aerodigestive tract cancer.

    DESIGN: Autofluorescence spectral characteristics of 19 untreated oral and oropharyngeal lesions in 13 patients were studied with excitation wavelengths of 370 and 410 nm generated by a nitrogen pumped dye laser. Ten healthy volunteers were recruited to characterize the fluorescence spectra of normal mucosa at different oral sites and to study individual ...

    Also Ranks for: Early Diagnosis |  aerodigestive tract |  excitation wavelengths |  autofluorescence spectroscopy |  fluorescence spectra
    KOL Index score: 6743

    Sclerosing polycystic adenosis (SPCA) of the salivary gland is a rarely encountered lesion of uncertain pathogenesis that shares histologic features with sclerosing adenosis and fibrocystic disease of the mammary gland. To date, fewer than 40 cases of SPCA have been reported in the literature; all but one have arisen in the major salivary glands. We report 3 cases of SPCA involving minor salivary glands and discuss the characteristic histopathologic features of SPCA , which include a ...

    Also Ranks for: Salivary Gland |  polycystic adenosis |  cysts diagnosis |  differential female |  features sclerosing
    KOL Index score: 5374

    BACKGROUND: The authors evaluated the effectiveness of the oral brush biopsy technique as a diagnostic tool in detecting dysplastic oral lesions.

    METHODS: In this cross-sectional study, pathologic reports (n = 152) from the scalpel biopsies (tissue samples) in patients who previously tested either "positive" (n = 3) or "atypical" (n = 149) for dysplasia by brush biopsy (OralCDx) were evaluated. Information on the age and sex of the patient, the site of the lesion, the brush biopsy ...

    Also Ranks for: Brush Biopsy |  oral lesions |  positive predictive |  scalpel biopsies |  tissue samples
    KOL Index score: 5246

    Forty cases of oral cavity non-Hodgkin's lymphoma (NHL) were evaluated for sex, age, location, clinical presentation, and World Health Organization (WHO) histological subtype. Fifty-three percent were female and the mean age was 71. The upper jaw (maxilla or palatal bone), mandible, palatal soft tissue, and vestibule and gingivae (maxillary or mandibular soft tissue involvement only) were, respectively, the most common locations. Swelling, ulceration, and radiographic destruction of bone ...

    Also Ranks for: Health Organization |  majority cases |  cell lymphoma |  oral cavity |  clinical presentation
    KOL Index score: 5101

    In order to evaluate the impact of anatomy on the spectral properties of oral tissue, we used reflectance and fluorescence spectroscopy to characterize nine different anatomic sites. All spectra were collected in vivo from healthy oral mucosa. We analyzed 710 spectra collected from the oral cavity of 79 healthy volunteers. From the spectra, we extracted spectral parameters related to the morphological and biochemical properties of the tissue. The parameter distributions for the nine ...

    Also Ranks for: Oral Cavity |  spectral properties |  anatomic sites |  spectrometry fluorescence |  humans models
    KOL Index score: 4844

    BACKGROUND: The fluorescence characteristics of tissues depend upon their biochemical composition and histomorphological architecture, both of which undergo a change during malignant transformation. These changes are detectable as an alteration in the fluorescence spectral profile of the tissues.

    METHODS: Biopsy specimens from clinically suspicious lesions and normal-appearing oral mucosa were obtained from patients. Fluorescence spectroscopic measurements were obtained to study the ...

    Also Ranks for: Oral Mucosa |  autofluorescence characteristics |  specificity spectrometry |  differences fluorescence |  abnormal tissues
    KOL Index score: 4709

    OBJECTIVE: Lichen planus pemphigoides (LPP), which is a rare autoimmune blistering mucocutaneous disease of the pemphigoid family of diseases, is characterized by the development of vesiculobullous lesions on or adjacent to the areas of lichen planus (LP). LPP primarily affects the skin, and oral involvement alone is rare. The objective of this case series was to report four new cases of oral LPP.

    STUDY DESIGN: We present four cases with clinical, histologic, and direct ...

    Also Ranks for: Lichen Planus |  mucous membrane pemphigoid |  dif studies |  diagnosis biopsy |  oral male
    KOL Index score: 4681

    Oral hairy leukoplakia (HL) is a lesion that occurs predominantly on the tongue in HIV-infected persons. Evidence strongly indicates that HL is related to the presence of Epstein-Barr virus in the epithelial cells. The lesion appears on the lateral border of the tongue as a painless, white plaque varying in size from a few millimeters to extensive lingual involvement. Histopathologically, the characteristic findings are hyperparakeratosis, hyperplasia, and ballooning of prickle cells ...

    Also Ranks for: Oral Hairy Leukoplakia |  hl lesion |  hiv infection |  epithelial cells |  lateral border
    KOL Index score: 4433

    An experimental radiopaque resin root canal sealer was tested for tissue biocompatibility in rat connective tissue. The controls were four widely used sealers: Sealapex, Kerr's sealer, AH-26, and Roth's sealer. Polyethylene tubes were filled with the sealers and allowed to set for 24 hours in 100% humidity. Each sealer was implanted in the connective tissue of Sprague-Dawley rats and removed after 3, 10, 20, 30, and 60 days, fixed, and histologically prepared for light microscope ...

    Also Ranks for: Connective Tissue |  polyethylene tubes |  practically difference |  root canal |  filling materials
    KOL Index score: 4257

    Laser-induced fluorescence (LIF) of tissues depends on their biochemical and histomorphologic characteristics. LIF spectroscopic properties of 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced precancerous and early cancerous lesions in a hamster buccal pouch mucosa model were studied. Fluorescence spectra from neoplastic lesions showed a characteristic fluorescence peak in the red region of the visible spectrum centered between 630 and 640 nm when excited with 410-nm light. Using this as ...

    Also Ranks for: Precancerous Lesions |  fluorescence spectroscopy |  animal model |  situ carcinoma |  early diagnosis
    KOL Index score: 3934

    OBJECTIVE: We report intraoral granulomatous foreign body reactions in patients treated with calcium hydroxylapatite (CHA) or poly-l-lactic acid (PLA).

    STUDY DESIGN: Clinical and histopathologic data were obtained from 25 patients who developed orofacial nodules or swelling after dermal filler injections.

    RESULTS: All 25 patients were women aged 35 to 78 years (median, 55 years). All had a history of injection of CHA (n = 13) or PLA (n = 12) to the lips, nasolabial area, or mental area. ...

    Also Ranks for: Foreign Body |  filler migration |  biocompatible materials pla |  calcium hydroxylapatite |  granulomatous reactions


    Sadru P Kabani: Influence Statistics

    Sample of concepts for which Sadru P Kabani is among the top experts in the world.
    Concept World rank
    juxtacortical radiography #3
    atypical brush biopsy #4
    mouthrinses effects #4
    060 combination #5
    reflectance fluorescence spectroscopy #5
    imatinib mucosal pigmentation #6
    distinct parameter distributions #6
    45 49 lesions #6
    sites spectral properties #6
    fluorescence stomatitis #6
    spectral parameters sites #6
    mucosal pigmentation imatinib #6
    atypical brush #6
    anatomy spectral properties #6
    dysplastic lesions increase #6
    lif tissues #6
    710 spectra #6
    nonkeratinized sites #6
    injection lips #6
    stomatitis 910 #6
    anatomic sites spectra #6
    followup suspected lesions #6
    otolaryngology center #6
    anatomybased algorithms #6
    differences 19 lesions #6
    diagnostic algorithms combinations #6
    lif spectroscopic properties #6
    notably hard palate #6
    tongue accurate #6
    biological mouth reproducibility #6
    sites spectral parameters #6
    parameter distributions sites #6
    oral nonhodgkin lymphoma #6
    sites anatomy #6
    fluorescence anatomic sites #6
    fluorescence stomatitis lif #6
    histomorphological architecture #7
    differences excitation wavelength #7
    lateral surface tongue #7
    normal mucosa individual #7
    tongue yielded #7
    technique abnormal tissues #7
    fluorescence biopsy diagnosis #7
    tongue rocauc #8
    anatomy spectral #8
    fluorescence spectroscopy reflectance #8
    410 nm differences #8
    rocauc lateral surface #8
    dermal cosmetic #9
    extraneural sclerosing #9

    Key People For Oral Cavity

    Top KOLs in the world
    Jatin P Shah
    neck dissection squamous cell thyroid cancer
    Crispian M Scully
    oral cancer lichen planus recurrent aphthous stomatitis
    Maura L Gillison
    human papillomavirus united states squamous cell
    Isaa¨c van der Waal
    oral leukoplakia squamous cell carcinoma lichen planus
    Luiz Paulo Kowalski
    squamous cell oral cancer neck dissection
    Silvia F Franceschi
    breast cancer human papillomavirus northern italy

    Sadru P Kabani:Expert Impact

    Concepts for whichSadru P Kabanihas direct influence:Oral cavity,  Lichen planus,  Fluorescence spectroscopy,  Brush biopsy,  Disk displacement,  Buccal mucosa,  Salivary gland,  Polycystic adenosis.

    Sadru P Kabani:KOL impact

    Concepts related to the work of other authors for whichfor which Sadru P Kabani has influence:Oral cancer,  Diffuse reflectance,  Early detection,  Polycystic adenosis,  Fluorescence spectroscopy,  Sensitivity specificity,  Lateral pterygoid muscle.



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    Center for Oral Pathology, StrataDx, Lexington, MA, USA | Co-Director and Associate Pathologist, Center for Oral Pathology, StrataDx, Lexington, MA, USA | Strata Pathology Services, Lexington, MA, USA | From the G. R. Harrison Spectroscopy Laboratory