KOL | Masashi SuzukiFaculty of Medicine, Department of Otorhinolaryngology, Head and Neck Surgery, Oita University, Oita, Japan | Department of Otolaryngology Head and Neck Surgery, Faculty of ... |
KOL Resume for Masashi Suzuki
| Year | |
|---|---|
| 2022 | Faculty of Medicine, Department of Otorhinolaryngology, Head and Neck Surgery, Oita University, Oita, Japan |
| 2021 | Department of Otolaryngology & Head and Neck Surgery, Faculty of Medicine, Oita University, Oita, Japan |
| 2019 | 1 Department of Otolaryngology, Faculty of Medicine, Oita University, Oita, Japan. |
| 2018 | Oita University, Faculty of Medicine, Department of Otolaryngology, Japan. Electronic address: |
| 2017 | Department of Otolaryngology, Head and Neck Surgery, Oita University Faculty of Medicine, Oita, Japan |
| 2016 | Department of Otolaryngology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hazama-machi, Yufu, Oita 879-5593, Japan |
| 2015 | Department of Otolaryngology, Faculty of Medicine, Oita University, Oita, Japan |
| 2013 | Department of Otolaryngology, Faculty of Medicine, Oita University, Oita 879-5593, Japan |
| 2012 | Department of Otolaryngology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hazama-Machi, Yufu, Oita 879-5593, Japan |
| 2011 | Department of Otolaryngology, Oita University Faculty of Medicine, Yufu, Oita, Japan |
| 2010 | Department of Otolaryngology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hazama-machi, Yufu, Oita 879-5593, Japan |
| 2009 | Department of Otolaryngology, Faculty of Medicine, Oita University, Oita, Oita University Faculty of Medicine |
| 2008 | Otolaryngology, Faculty of Medicine, Oita University, Oita, Japan |
| 2007 | Department of Otolaryngology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hazama-machi, 879-5593, Oita, Yufu, Japan |
| 2006 | Otolaryngology, Faculty of Medicine, Oita University, Yufu and From the Department of Otolaryngology (n.a., s.k., t.h., m.e., m.s.), Oita University Faculty of Medicine, 1-1 Idaigaoka, Hazama-machi, Yufu, Oita, Japan. |
| 2005 | Department of Otolaryngology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan |
| 2004 | From the Departments of Otolaryngology, Faculty of Medicine, Oita University (k.m., t.h., i.i., m.s., g.m.), Oita, and Kagoshima University (y.k.), Kagoshima, Japan. Department of Otolaryngology, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan |
| 2003 | Department of Immunology and Allergy, Otorhinolaryngology, Oita Medical University, Oita, JAPAN |
| 2002 | Department of Otolaryngology, Oita Medical University Hospital, Oita Medical University, Japan |
| 2001 | Department of Otolaryngology, Oita Medical University, Hasama-machi, Oita 879-5593, Japan |
| 2000 | Department of Otolaryngology, Oita Medical University, 1-1 Idaigaoka, Hasama-cho, Oita 879-5593, Japan |
| 1999 | Department of Otolaryngology, Oita Medical University, 1-1, Idaigaoka, Hasama-machi, Oita 879-5593, Japan |
| 1998 | Department of Otolaryngology, Oita Medical University, Japan. |
| 1997 | Department of Otolaryngology Oita Medical University 1‐1 Idaigaoka, Hazama‐machi Oita‐gun, Oita‐ken 856‐55, Japan |
| 1995 | From the Division of Otolaryngology—Head and Neck Surgery, University of California, San Diego, and The Research Service, Veterans Administration, San Diego, California. Dr Suzuki is currently at the Department of Otolaryngology, Oita Medical University, Oita, Japan. |
| 1992 | Department of Otolaryngology, Medical College of Oita, Oita, Japan |
| 1989 | From the Department of Otolaryngology, Medical College of Oita, Oita, Japan. |
| 1988 | Department of Otolaryngology, Medical College of Oita, Japan. |
Masashi Suzuki: Influence Statistics
| Concept | World rank |
|---|---|
| neutralization p6 | #2 |
| otolaryngologists iga humans | #2 |
| abscesssite | #2 |
| esthesioneuroblastoma arising | #2 |
| maxillectomy solitary | #2 |
| survivin cancer tissues | #2 |
| nthi p6 protein | #2 |
| lifu groups | #2 |
| nasopharynx nasal vaccination | #2 |
| washes 6 | #2 |
| addition p6 | #2 |
| ear immunoexpression | #2 |
| sft lacrimal sac | #2 |
| nthi flt3l | #2 |
| combined approach emmm | #2 |
| neck area sfts | #2 |
| 4 tlr4mutant mice | #2 |
| sft middle | #2 |
| influenzae interleukin1beta | #2 |
| dni cases | #2 |
| tonsillectomy cooperative | #2 |
| mucosal immunoglobulin interleukin6 | #2 |
| possesses immunological | #2 |
| dni pta | #2 |
| sfts nasal | #2 |
| tlr4 nasopharyngeal | #2 |
| flt3l application | #2 |
| mem 2 months | #2 |
| diabetes mellitus dni | #2 |
| haemophilus influenzae‐specific | #2 |
| matrixm vaccines haemophilus | #2 |
| catarrhalis enhance | #2 |
| fibrocytes regulation | #2 |
| galactosylceramides haemophilus | #2 |
| mucosa tregs | #2 |
| p6specific antibody responses | #2 |
| p6 flt3l | #2 |
| flt3l effective regimen | #2 |
| mees reduced | #2 |
| p6 galcer | #2 |
| ccl20 nasal vaccination | #2 |
| fibrinogen lifu | #2 |
| reduced mees | #2 |
| ccl20 mucosal | #2 |
| nosii messenger | #2 |
| odn p6 | #2 |
| nasal ccl20 | #2 |
| tregs omp | #2 |
| treg mees | #2 |
| nasopharynx 6 12 | #2 |
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Prominent publications by Masashi Suzuki
Nontypeable Haemophilus influenzae (NTHI) is a major pathogen of otitis media. One of the outer membrane proteins of NTHI, P6, is an antigen common to all strains and is considered as a candidate for mucosal vaccine. To elucidate the possibility of developing a nasal vaccine against nontypeable Haemophilus influenzae (NTHI) and to investigate mucosal immune responses in the middle ear, mice were immunized intranasally with the P6 outer membrane protein of NTHI, and P6-specific immune ...
| Known for Intranasal Immunization | Middle Ear | Immune Responses | Nontypeable Haemophilus | P6 Outer |
OBJECTIVES: Nasal vaccination is an effective therapeutic regimen for preventing otitis media. Since cholera toxin (CT) is toxic, an alternative adjuvant is required for the development of a nasal vaccine. The efficacy of CpG oligodeoxynucleotide (ODN) as a mucosal adjuvant was examined.
METHODS: Mice were immunized intranasally with P6 protein of non-typeable Haemophilus influenzae (NTHi) and adjuvant, CT, or CpG ODN, and P6-specific antibody responses were examined. The expression of ...
| Known for Nasal Vaccination | Cpg Oligodeoxynucleotide | Haemophilus Influenzae | Protective Immunity | Immunologic Administration |
Nontypeable Haemophilus influenzae (NTHi) is a major pathogen causing otitis media (OM). One of the outer membrane proteins of NTHi, P6, is a common antigen to all strains and is considered a candidate for mucosal vaccine. We have previously reported that intranasal immunization with P6 and cholera toxin (CT) could induce P6-specific immunoglobulin A (IgA) antibodies in the middle ear. In the present study, we assessed the effect of intranasal immunization for the protection against ...
| Known for Intranasal Immunization | Otitis Media | Immunized Mice | Nontypeable Haemophilus | Middle Ear |
Nasal vaccination is an effective therapeutic regimen for preventing otitis media. In the development of nasal vaccine, an appropriate adjuvant is required. In the present study, we examined the efficacy of fms-like tyrosine kinase receptor-3 ligand (Flt3L) as a mucosal adjuvant. Flt3L was administered intranasally or peritoneally to mice, which were then immunized intranasally with P6 protein of nontypeable Haemophilus influenzae (NTHi), and P6-specific immune responses were examined. ...
| Known for Haemophilus Influenzae | Nasal Vaccination | Immune Responses | Immunologic Administration | Tyrosine Kinase |
The Wnt signaling pathway is essential for normal development and organogenesis. However, inappropriate activation of Wnt signaling, which results in the nuclear translocation of β-catenin, is associated with the development of various types of neoplasm. In this study, we investigated possible mutations in the genes for components of this pathway, namely, CTNNB1 (the gene for β-catenin), AXIN1, and APC, in adenoid cystic carcinoma, by PCR, analysis of single-strand conformational ...
| Known for Adenoid Cystic | Wnt Signaling | Components Pathway | Protein Carcinoma | Salivary Gland |
Acute otitis media (AOM) is one of the most common infectious diseases in children. Nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, Gram-negative bacteria, are considered major pathogens of AOM and respiratory tract infections. In this study, we used monophosphoryl lipid A (MPL) as a Toll-like receptor (TLR4) agonist to induce innate immune responses before challenge with NTHi and M. catarrhalis to enhance bacterial clearance from the nasopharynx. Mice were ...
| Known for Moraxella Catarrhalis | Monophosphoryl Lipid | Mpl Nthi | Nasopharynx Mice | Haemophilus Influenzae |
Nontypeable Haemophilus influenzae (NTHi) is associated with chronic otitis media (COM). In this study, we generated a murine model of COM by using eustachian tube (ET) obstruction and NTHi (10(7) CFU) inoculation into the tympanic bulla, and we investigated the relationship between regulatory T cells (Treg) and chronic inflammation in the middle ear. Middle ear effusions (MEEs) and middle ear mucosae (MEM) were collected at days 3 and 14 and at 1 and 2 months after inoculation. ...
| Known for Middle Ear | Nontypeable Haemophilus | Chronic Otitis Media | Mouse Model | Eustachian Tube |
Aberrant methylation in promoter regions of cyclin‐dependent kinase inhibitor genes in adenoid cystic carcinoma of the salivary gland
[ PUBLICATION ]
Adenoid cystic carcinoma (ACC) is a common malignant neoplasm of the salivary gland. The mechanism underlying ACC carcinogenesis is not fully elucidated, although data on associated genetic alterations are accumulating. Cyclin-dependent kinase inhibitors (CKIs) act as tumor suppressors in various cancers, and aberrant methylation in the CKI gene promoter region has been linked to gene silencing and downregulation of expression. The present study investigated methylation of CKI genes, ...
| Known for Salivary Gland | Kinase Inhibitor | Adenoid Cystic Carcinoma | Promoter Regions | Cyclin Dependent |
To determine the efficacy of a mucosal vaccine against nontypeable Haemophilus influenzae (NTHi), mice were immunized nasally, orally, intratracheally, or intraperitoneally with NTHi antigen together with cholera toxin. Antigen-specific IgA antibody titers in nasal washes and the numbers of antigen-specific IgA-producing cells in nasal passages showed the greatest increases in mice immunized nasally. Cytokine analysis showed that interferon-gamma, interleukin (IL)-2, IL-5, IL-6, and ...
| Known for Nasal Immunization | Haemophilus Influenzae | Mucosal Iga | Protective Immunity | Mice Nthi |
Dexamethasone inhibits tumor necrosis factor-α-induced cytokine secretion from spiral ligament fibrocytes
[ PUBLICATION ]
To investigate the effect of proinflammatory cytokines on spiral ligament (SL) fibrocytes and regulation of cytokines by dexamethasone (Dex), in vitro studies were performed in murine secondary cell cultures. Cultured SL fibrocytes were stimulated with tumor necrosis factor-alpha (TNF-alpha), and the secretion of various mediators was measured by enzyme-linked immunosorbent assay (ELISA) and reverse transcribed-polymerase chain reaction (RT-PCR). After stimulation with TNF-alpha, levels ...
| Known for Spiral Ligament | Necrosis Factor | Dexamethasone Dex | Cultured Fibrocytes | Proinflammatory Cytokines |
The efficacy of alpha-galactosylceramide (alpha-GalCer) as a mucosal adjuvant was examined. Mice were immunized intranasally with nontypeable Haemophilus influenzae (NTHi) P6 protein and alpha-GalCer. P6-specific antibody responses in the form of P6-specific IgA in nasal washes and serum IgG titers were significantly elevated. Splenic CD4(+) T cells expressed P6-specific Th1 and Th2 cytokine mRNA. In addition, NTHi was quantified in nasal washes following NTHi challenges, and the ...
| Known for Nasal Vaccination | Haemophilus Influenzae | Outer Membrane | Immunologic Administration | Nkt Cell Activation |
This study was designed to investigate the expression of intercellular adhesion molecule-1 (ICAM-1) on the spiral modiolar vein (SMV) with its collecting venules (CVs) and the venules of the endolymphatic sac during inner ear inflammation. These data will further elucidate the role of adhesion molecules in extravasation of inflammatory cells from blood vessels during an inner ear immune response. Labyrinthitis was induced in rats by inoculation of keyhole limpet hemocyanin into the scala ...
| Known for Ear Inflammation | Intercellular Adhesion | Icam1 Expression | Endolymphatic Sac | Immune Cells |
Role of Toll‐like receptor 4 in innate immune responses in a mouse model of acute otitis media
[ PUBLICATION ]
Nontypeable Haemophilus influenzae (NTHi) is considered a major pathogen underlying middle ear infection. This study characterized the role of Toll-like receptor 4 in the innate immune responses to acute otitis media induced by NTHi in mice. We used C3H/HeJ mice, which have nonfunctional Toll-like receptor 4, and normal wild-type C3H/HeN mice. NTHi were injected into the tympanic bulla, and middle ear effusions and tissues were collected. In C3H/HeN mice, the severity of acute otitis ...
| Known for Otitis Media | Innate Immune Responses | Middle Ear | Mouse Model | Receptor 4 |
Antibody responses to survivin and their clinical significance in patients with head and neck cancer
[ PUBLICATION ]
BACKGROUND: Survivin is highly expressed in cancer cells but shows little or no expression in normal tissues. Little is known about antibody responses to survivin in patients with head and neck cancer.
METHODS: Anti-survivin antibody responses in patients with head and neck cancer were investigated by enzyme-linked immunosorbent assay. Anti-p53 antibody and squamous cell carcinoma antigen were also examined.
RESULTS: Sera from 69 of 97 patients (71.1%) were positive for anti-survivin, ...
| Known for Neck Cancer | Antibody Responses | Survivin Patients | Clinical Significance | Apoptosis Proteins |
Key People For Otitis Media
Masashi Suzuki:Expert Impact
Concepts for whichMasashi Suzukihas direct influence:Otitis media, Middle ear, Nasal vaccination, Intranasal immunization, Allergic rhinitis, Nontypeable haemophilus, Solitary fibrous tumor, Haemophilus influenzae.
Masashi Suzuki:KOL impact
Concepts related to the work of other authors for whichfor which Masashi Suzuki has influence:Otitis media, Middle ear, Intranasal immunization, Spiral ligament, Haemophilus influenzae, Immune responses, Peritonsillar abscess.
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