Direct Impact

Concepts for which Samuel Chi‐ho Mok has direct influence:

ovarian cancer
gestational trophoblastic
papillary serous carcinoma
molecular subtypes
allelic loss
normal placenta
pax2 expression

External impact

Concepts related to the work of other authors for which Samuel Chi‐ho Mok has influence:

ovarian cancer
uterine papillary serous carcinoma
cyclin d1
dopamine receptor
milky spots
mrna expression
hydatidiform mole

Prominent publications by Samuel Chi‐ho Mok

KOL-Index: 78 Uterine serous carcinoma (USC) is an aggressive variant of endometrial cancer that has not been well characterized. It accounts for less than 10% of all endometrial cancers and 80% of endometrial cancer-related deaths. Currently, staging surgery together with chemotherapy or radiotherapy, especially vaginal cuff brachytherapy, is the main treatment strategy for USC. Whole-exome sequencing ...
Known for
Endometrial Cancer-Related Deaths | Molecular Pathogenesis | Frequently Altered Genes | Vaginal Cuff Brachytherapy
KOL-Index: 67 PURPOSE: To evaluate the prognostic value of fibroblast growth factor receptor 4 (FGFR4) protein expression in patients with advanced-stage, high-grade serous ovarian cancer, delineate the functional role of FGFR4 in ovarian cancer progression, and evaluate the feasibility of targeting FGFR4 in serous ovarian cancer treatment. EXPERIMENTAL DESIGN: Immunolocalization of FGFR4 was conducted on ...
Known for
Fibroblast Growth Factor Receptor | Immunolocalization | Silencing Fgfr4 | Decreased Survival
KOL-Index: 56 Ovarian cancer is a leading cause of gynecologic cancer death among women. Tumors diagnosed early (in stage I) have a cure rate approaching 90%. However, because specific symptoms and screening tools are lacking, most ovarian cancers are very advanced when finally diagnosed. CA125 expression and pelvic ultrasonography are of limited efficacy in screening, and the search for new, ...
Known for
Biomarker Ovarian
KOL-Index: 50 Increasing evidence indicates that the tumor microenvironment has critical roles in all aspects of cancer biology, including growth, angiogenesis, metastasis and progression. Although chemokines and their receptors were originally identified as mediators of inflammatory diseases, it is being increasingly recognized that they serve as critical communication bridges between tumor cells and ...
Known for
| Cancer Biology | Stromal-Derived Factor | Critical Communication Bridges
KOL-Index: 45 Uterine serous cancer (USC) is an aggressive subtype of endometrial cancer, with poor survival and high recurrence rates. The development of novel and effective therapies specific to USC would aid in its management. However, few studies have focused solely on this rare subtype. The current study demonstrated that the orally bioavailable, investigational new drug and novel imipridone ONC206 ...
Known for
Oxidative Phosphorylation | Effective Therapies | Survival Onc206 | Recurrence Rates
KOL-Index: 40 Ovarian cancer is a histologically, clinically, and molecularly diverse disease with a five-year survival rate of less than 30%. It has been estimated that approximately 21,980 new cases of epithelial ovarian cancer will be diagnosed and 14,270 deaths will occur in the United States in 2015, making it the most lethal gynecologic malignancy. Ovarian tumor tissue is composed of cancer cells ...
Known for
Potential Ovarian Cancer | Stroma-Derived | Ovarian Tumor Tissue | Stroma-Specific Signaling Pathways
KOL-Index: 38 BACKGROUND: Recent efforts to improve outcomes for high-grade serous ovarian cancer, a leading cause of cancer death in women, have focused on identifying molecular subtypes and prognostic gene signatures, but existing subtypes have poor cross-study robustness. We tested the contribution of cell admixture in published ovarian cancer molecular subtypes and prognostic gene signatures. METHODS: ...
Known for
Subtypes Admixture | Stroma Ovarian | Bulk Tumors | Molecular Subtype
KOL-Index: 37 Ovarian cancer is the fifth leading cause of cancer deaths among North American women. Regrettably, there is currently no reliable circulating biomarker that can detect ovarian cancer in its early stages. The CA125 biomarker is very useful for treatment response monitoring, but its sensitivity is very low for early detection. Thus, there is an urgent need for the identification of new ...
Known for
Strategies Biomarkers | North American Women | Reliable Circulating Biomarker | Cancer Diagnostic
KOL-Index: 36 Gynecologic diseases in general are diseases that involved the female reproductive track. These diseases include benign and malignant tumors, pregnancy-related diseases, infection, and endocrine diseases. Among them, malignant tumors are the most common cause of death. In recent years, the causes of some of these diseases have been elucidated. For example, human papillomavirus infection has ...
Known for
Tumors Female | Pregnancy Infection | Chapter Molecular
KOL-Index: 34 Chromatin accessibility data can elucidate the developmental origin of cancer cells and reveal the enhancer landscape of key oncogenic transcriptional regulators. We develop a computational strategy called PSIONIC (patient-specific inference of networks informed by chromatin) to combine chromatin accessibility data with large tumor expression data and model the effect of enhancers on ...
Known for
45 Basal Breast Tumors | Cancers Chromatin | Computational Framework | Psionic-Predicted Activity

M. D. Anderson Cancer Center, Houston, TX, USA

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