• Disease
  • Ischemic
  • Ischemic Stroke
  • Aneesh Bhim Singhal

    Prominent publications by Aneesh Bhim Singhal

    KOL Index score: 16953

    OBJECTIVE: Although several recent studies have suggested that the incidence of vasospasm after aneurysmal subarachnoid hemorrhage is lower in patients undergoing aneurysmal coiling as compared with clipping, other studies have had conflicting results. We reviewed our experience over 8 years and assessed whether clipping, craniotomy, or coiling affects patient outcomes or the risk for vasospasm.

    METHODS: We included 515 patients with aneurysmal subarachnoid hemorrhage, identified ...

    Also Ranks for: Subarachnoid Hemorrhage |  symptomatic vasospasm |  patients coiling |  poor outcome |  hess grade
    KOL Index score: 15745

    OBJECT: The aim of this study was to assess the diagnostic yield of imaging tests performed in patients in whom the cause of subarachnoid hemorrhage (SAH) had not been demonstrated on initial angiography.

    METHODS: By reviewing medical records of 806 patients with SAH who had been admitted during a 6.5-year period, the authors identified 86 in whom initial transfemoral catheter angiography failed to reveal the cause of SAH. Clinical and radiological data were analyzed to determine the ...

    Also Ranks for: Diagnostic Yield |  initial angiography |  patients sah |  subarachnoid hemorrhage |  imaging tests
    KOL Index score: 13119

    BACKGROUND: In animal models of acute ischaemic stroke, blocking of the leukocyte-endothelium adhesion by antagonism of α4 integrin reduces infarct volumes and improves outcomes. We assessed the effect of one dose of natalizumab, an antibody against the leukocyte adhesion molecule α4 integrin, in patients with acute ischaemic stroke.

    METHODS: In this double-blind, phase 2 study, patients with acute ischaemic stroke (aged 18-85 years) from 30 US and European clinical sites were randomly ...

    Also Ranks for: Acute Ischaemic Stroke |  patients natalizumab |  infarct volume |  day 90 |  animal models
    KOL Index score: 13080

    BACKGROUND AND PURPOSE: The role of noninvasive methods in the evaluation of collateral circulation has yet to be defined. We hypothesized that a favorable pattern of leptomeningeal collaterals, as identified by CT angiography, correlates with improved outcomes.

    METHODS: Data from a prospective cohort study at 2 university-based hospitals where CT angiography was systematically performed in the acute phase of ischemic stroke were analyzed. Patients with complete occlusion of the ...

    Also Ranks for: Leptomeningeal Collaterals |  stroke patients |  independent predictors |  intracranial occlusion |  function severity
    KOL Index score: 12670

    The pattern and role of brain plasticity in stroke recovery has been incompletely characterized. Both ipsilesional and contralesional changes have been described, but it remains unclear how these relate to functional recovery. Our goal was to correlate brain activation patterns with tissue damage, hemodynamics, and neurologic status after temporary stroke, using functional magnetic resonance imaging (fMRI). Transverse relaxation time (T2)-weighted, diffusion-weighted, and perfusion MRI ...

    Also Ranks for: Functional Magnetic |  resonance imaging |  brain reorganization |  ischemic damage |  stroke recovery
    KOL Index score: 12605

    BACKGROUND AND PURPOSE: Multimodal imaging is gaining an important role in acute stroke. The benefit of obtaining additional clinically relevant information must be weighed against the detriment of increased cost, delaying time to treatment, and adverse events such as contrast-induced nephropathy. Use of National Institutes of Health Stroke Scale (NIHSS) score to predict a proximal arterial occlusion (PO) is suggested by several case series as a viable method of selecting cases ...

    Also Ranks for: National Institutes |  proximal occlusion |  nihss score |  patients acute stroke |  acute cerebral ischemia
    KOL Index score: 12388

    BACKGROUND: Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19.

    METHODS: In an open-label, adaptive, multiplatform, randomized clinical trial, critically ill patients with severe Covid-19 were randomly assigned to a pragmatically defined regimen of either therapeutic-dose anticoagulation with ...

    Also Ranks for: Therapeutic Anticoagulation |  critically patients |  hospital discharge |  organ supportfree |  95 credible interval
    KOL Index score: 12371

    BACKGROUND: The widespread use of tissue plasminogen activator (tPA), the only FDA-approved acute stroke treatment, remains limited by its narrow therapeutic time window and related risks of brain hemorrhage. Normobaric oxygen therapy (NBO) may be a useful physiological strategy that slows down the process of cerebral infarction, thus potentially allowing for delayed or more effective thrombolysis. In this study we investigated the effects of NBO started simultaneously with intravenous ...

    Also Ranks for: Normobaric Oxygen |  combination therapy |  nbo tpa |  ischemic stroke |  1 hour
    KOL Index score: 12371

    BACKGROUND AND PURPOSE: Patients with large vessel occlusion strokes (LVOS) may be better served by direct transfer to endovascular capable centers avoiding hazardous delays between primary and comprehensive stroke centers. However, accurate stroke field triage remains challenging. We aimed to develop a simple field scale to identify LVOS.

    METHODS: The Field Assessment Stroke Triage for Emergency Destination (FAST-ED) scale was based on items of the National Institutes of Health Stroke ...

    Also Ranks for: Stroke Triage |  emergency destination |  sensitivity specificity |  field assessment |  positive predictive
    KOL Index score: 11162

    IMPORTANCE: Limited data exist regarding the natural history of proximal intracranial arterial occlusions. OBJECTIVE To investigate the outcomes of patients who had an acute ischemic stroke attributed to an anterior circulation proximal intracranial arterial occlusion.

    DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study at 2 university-based hospitals from 2003 to 2005 in which nonenhanced computed tomography scans and computed tomography angiograms were obtained at admission ...

    Also Ranks for: Computed Tomography |  arterial occlusion |  anterior circulation |  studies stroke |  nihss score
    KOL Index score: 10987

    BACKGROUND: Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.

    METHODS: In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with Covid-19 and who were not critically ill (which was defined as an ...

    Also Ranks for: Therapeutic Anticoagulation |  hospital discharge |  noncritically patients |  organ support |  95 credible interval
    KOL Index score: 10937

    PURPOSE: To retrospectively compare sensitivity and specificity of admission nonenhanced computed tomographic (CT) scans with those of CT angiographic source images in detection of early ischemic changes in middle cerebral artery (MCA) stroke and to retrospectively compare admission nonenhanced CT scans with CT angiographic source images in delineation of final infarct extent, with follow-up images as reference.

    MATERIALS AND METHODS: Informed consent and institutional review board ...

    Also Ranks for: Angiographic Source Images |  sensitivity specificity |  detection early ischemic |  infarct extent |  aspects follow
    KOL Index score: 10801

    BACKGROUND AND PURPOSE: Patients with atrial fibrillation and previous ischemic stroke (IS)/transient ischemic attack (TIA) are at high risk of recurrent cerebrovascular events despite anticoagulation. In this prespecified subgroup analysis, we compared warfarin with edoxaban in patients with versus without previous IS/TIA.

    METHODS: ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) was a ...

    Also Ranks for: Versus Warfarin |  patients atrial fibrillation |  intracranial hemorrhage |  tia risk |  ischemic stroke
    KOL Index score: 10613

    The authors provide the first in vitro and in vivo evidence that perturbations in mitogen-activated protein kinase (MAPK) signal-transduction pathways are involved in the pathophysiology of traumatic brain injury. In primary rat cortical cultures, mechanical trauma induced a rapid and selective phosphorylation of the extracellular signal-regulated kinase (ERK) and p38 kinase, whereas there was no detectable change in the c-jun N-terminal kinase (JNK) pathway. Treatment with PD98059, ...

    Also Ranks for: Traumatic Brain Injury |  protein kinase |  jnk pathway |  male mice mice |  survival cells
    KOL Index score: 10576

    BACKGROUND AND PURPOSE: Therapies that transiently prevent ischemic neuronal death can potentially extend therapeutic time windows for stroke thrombolysis. We conducted a pilot study to investigate the effects of high-flow oxygen in acute ischemic stroke.

    METHODS: We randomized patients with acute stroke (<12 hours) and perfusion-diffusion "mismatch" on magnetic resonance imaging (MRI) to high-flow oxygen therapy via facemask for 8 hours (n=9) or room air (controls, n=7). Stroke scale ...

    Also Ranks for: Oxygen Therapy |  acute ischemic stroke |  24 hours |  1 week |  3 months


    Aneesh Bhim Singhal: Influence Statistics

    Sample of concepts for which Aneesh Bhim Singhal is among the top experts in the world.
    Concept World rank
    sah rcvssah #1
    stroke pulseless disease #1
    acute cst injury #1
    hemorrhagic female hemorrhagic #1
    rcvs migraine #1
    sah rcvs #1
    stroke oxygen therapy #1
    psr episode frequency #1
    clinical radiological syndrome #1
    recurrent thunderclap headaches #1
    benign prognosis rcvs #1
    proximal vasoconstriction #1
    conditions obstetric stroke #1
    syndromes rcvs #1
    infarcts vasogenic edema #1
    benzodiazepine triggered #1
    callfleming syndrome #1
    motor strip infarct #1
    rcvs worse outcome #1
    stroke psr episode #1
    diagnosing rcvs #1
    cerebral vasoconstriction #1
    recrudescence psr #1
    rcvs sah #1
    csah infarction #1
    controls coexisting #1
    rcvs triggers #1
    transient male return #1
    stroke trimester #1
    skeletal plaque #1
    patients vasoconstrictioninduced stroke #1
    obstetric stroke #1
    oxygen therapy stroke #1
    vasoconstrictive medications patients #1
    rcvs score #1
    cerebral microembolism doppler #1
    persistent clinical worsening #1
    ppa cerebral #1
    csah occurred #1
    vasoconstrictioninduced stroke article #1
    rcvs brain imaging #1
    interrelationships mechanisms #1
    concentration spasmogenic factors #1
    psr triggered #1
    csah proximal vasoconstriction #1
    intracranial guillain‐barré syndrome #1
    insomnia stress benzodiazepine #1
    escalating vasoactive drugs #1
    historical aspects imaging #1
    pathologic diagnosis intracranial #1

    Key People For Ischemic Stroke

    Top KOLs in the world
    Ralph L Sacco
    ischemic stroke northern manhattan study carotid plaque
    Harold P Jr Adams
    ischemic stroke cerebral infarction subarachnoid hemorrhage
    José Biller
    ischemic stroke cerebral infarction neurologic complications
    Laurens Jaap Kappelle
    ischemic stroke type 2 diabetes cognitive impairment
    Geoffrey Alan Donnan
    ischemic stroke atrial fibrillation intracerebral haemorrhage
    Jeffrey L Saver
    acute ischemic stroke endovascular thrombectomy united states

    Aneesh Bhim Singhal:Expert Impact

    Concepts for whichAneesh Bhim Singhalhas direct influence:Ischemic stroke,  Cerebral vasoconstriction,  Oxygen therapy,  Acute ischemic stroke,  Poor outcome,  Focal cerebral ischemia,  Subarachnoid hemorrhage,  Stroke patients.

    Aneesh Bhim Singhal:KOL impact

    Concepts related to the work of other authors for whichfor which Aneesh Bhim Singhal has influence:Ischemic stroke,  Central nervous,  Subarachnoid hemorrhage,  Atrial fibrillation,  Cardiac arrest,  Magnetic resonance,  Mechanical thrombectomy.



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    Massachusetts General Hosp | From the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kans