• Disease
  • Antiidiotypic
  • Antiidiotypic Antibodies
  • Jan C Schmolling

    Prominent publications by Jan C Schmolling

    KOL Index score: 12079

    We have generated an immunoglobulin G1 (IgG1) murine monoclonal anti-idiotype antibody (Ab2) designated ACA125, which mimics a specific epitope on the tumor-associated antigen CA125. This antigen is expressed by most of malignant ovarian tumors. Patients with CA125-positive tumors are immunologically tolerant to CA125. We used ACA125 as a surrogate for the tumor-associated antigen CA125 for vaccine therapy of 16 patients with advanced epithelial ovarian cancer or recurrences. Each of the ...

    Also Ranks for: Ovarian Cancer |  immunological responses |  ca125 antigen |  anti idiotype |  murine monoclonal
    KOL Index score: 7450

    Abstract This study documents values of biochemical markers of bone remodeling in 106 patients with breast cancer. Based on scintigraphic and radiological findings, patients were divided into 3 groups: 19 patients with bone metastases, 65 patients without bone metastases and normal bone scintigrams, and 22 patients with pathological, non-malignant findings on scintigraphy without proof of bone metastases. Urinary cross-linked type I collagen N-telopeptides (NTx) and serum cross-linked ...

    Also Ranks for: Breast Cancer |  bone metastases |  collagen type |  biochemical markers |  3 groups
    KOL Index score: 6778

    Immunotherapy with monoclonal antibodies has become a hopeful approach to the adjuvant therapy of cancer patients. Recently, formation of antiidiotypic antibodies (Ab2) has been demonstrated in ovarian cancer patients after immunization with F(ab')2 fragments of the monoclonal antibody OC 125 (MAb OC 125). Preliminary results suggested that patients with high Ab2 serum concentrations had better survival rates compared to those where low or no Ab2 serum levels were detected. Beginning in ...

    Also Ranks for: Antiidiotypic Antibodies |  monoclonal antibody |  ovarian cancer |  mab b723 |  ab2 serum concentrations
    KOL Index score: 6456

    Clinical observations suggest that flecainide might pass the placenta more easily than digoxin, and that its transfer is less disturbed in case of hydrops fetalis than that of digoxin. The purpose of the study was to compare the materno-fetal transplacental transfer of digoxin, flecainide, and amiodarone, another antiarrhythmic agent used in the treatment of fetal tachyarrhythmia, and to assess the effect of an elevated umbilical venous pressure (UVP) on the transfer rate. Isolated ...

    Also Ranks for: Transplacental Transfer |  placenta pregnancy |  tachycardia supraventricular |  fetal diseases |  anti arrhythmia
    KOL Index score: 5989

    IntroductionIn the pregnant uterus oxytocin and the oxytocin receptor play a major part for uterine contractility and the induction of labor. Clinical evidence implicates that with regard to contractility associated disorders like for example dysmenorrhea also in the nonpregnant and very early pregnant myometrium oxytocin and the oxytocin receptor seem to be more important than believed at the moment. However, little is known about the mutual dependence of the oxytocin receptor, oxytocin ...

    Also Ranks for: Oxytocin Receptor |  nonpregnant uterus |  uterine contractility |  extracorporeally perfused |  vitro techniques
    KOL Index score: 5687

    ObjectiveAtosiban has been shown to be an effective tocolytic agent with a low rate of side effects during 24 to 33 weeks of gestation. Atosiban acts through selective, competitive inhibition of both oxytocin and vasopressin, so that there are reasons to assume that a tocolytic effect can also be achieved earlier in the pregnancy.Study designIn this prospective, randomized pilot study, 20 women in the 18th through 24th week of gestation who presented at our hospital with preterm labor ...

    Also Ranks for: Obstetric Labor |  gestation atosiban |  oxytocin tocolytic |  pregnancy outcome |  vasotocin adult
    KOL Index score: 4847

    BackgroundThe aim of the prospective study was to compare standard parameters as Doppler ultrasound and 24-h blood pressure measurement with possible maternal serological markers regarding their prognostic value in predicting hypertensive diseases in pregnancy.MaterialsTwenty-four-hour blood pressure measurement was performed before and after 32+0 gestational week in 57 pregnant women with either chronic hypertension (n=13), preeclampsia (n=21), pregnancy-induced hypertension (PIH; n=12) ...

    Also Ranks for: Adhesion Molecules |  blood pressure |  hypertension pregnancy |  women preeclampsia |  vascular cell
    KOL Index score: 4581

    Oxytocin (OT) and the oxytocin receptor (OTR) seem to be less important for uterine contractility-associated disorders of the non-pregnant uterus compared to the pregnant uterus. In the present study, we investigated the mutual dependence of OTR, OT and 17beta-estradiol (E(2)) with regard to the localization of OTR in the non-pregnant uterus. Utilizing our established model for extracorporeal perfusion of the human uterus, we perfused 15 human uteri for 27 h under physiological ...

    Also Ranks for: Oxytocin Receptor |  human myometrium |  otr expression |  nonpregnant uterus |  extracorporeally perfused
    KOL Index score: 4408

    Recorded concentrations of the tumour-associated glycoprotein 72 (TAG-72) in ovarian cancer patients after repeated infusion of the antibody B72.3 were found to be falsely elevated when measured with an homologous immunometric assay involving the anti-TAG-72 antibody B72.3 (Test 1), or with an heterologous assay involving CC49 capture and B72.3 detector antibodies (Test 2). Test 1 yielded falsely elevated values up to 10(4) kU/l. Test 2 gave slightly false positive elevations up to 10(2) ...

    Also Ranks for: Idiotypic Antibodies |  human anti |  glycoprotein 72 |  ovarian cancer patients
    KOL Index score: 3443

    The aim of this study was to evaluate the influence of different maternal and fetal albumin concentrations on the transplacental transfer and the placental tissue accumulation of digoxin. Digoxin passage across the isolated lobules of 15 human placentae was calculated from repeated fetal and maternal perfusate samples, and placental tissue digoxin concentrations were measured at the end of the experiments. Metildigoxin (Lanitop) was added to the maternal medium at a concentration of 5.70 ...

    Also Ranks for: Albumin Concentrations |  fetal maternal |  placenta pregnancy |  anti arrhythmia |  humans vitro
    KOL Index score: 3199

    Experimental perfusion of various organs has primarily been used in transplantation medicine to study the physiology, pathophysiology and metabolism of tissues and cells. The purpose of this study was to establish an experimental model for the extracorporeal perfusion of the human uterus with recirculation of a modified, oxygenated Krebs-Henselait solution, in comparison with a non-recirculating perfusion system. With consent of the patients we obtained 25 uteri after standard ...

    Also Ranks for: Experimental Model |  extracorporeal perfusion |  human uterus |  lactate dehydrogenase |  vitro techniques
    KOL Index score: 2994

    An immunoradiometric assay is described for the determination of human anti-idiotypic anti-B72.3 IgG. The latter is formed in ovarian cancer patients after treatment with the murine monoclonal antibody B72.3, which is directed against the tumour-associated glycoprotein 72 (TAG-72). A gel coupled with Fc-specific anti-human IgG antibodies is used as a solid phase for the extraction of serum IgG. The anti-B72.3 IgG is then specifically detected by incubation with radiolabelled B72.3 ...

    Also Ranks for: Antibodies Anti |  cross reactions |  ovarian neoplasms |  glycoproteins humans
    KOL Index score: 2861

    Neonaticide is a serious allegation that needs a complete chain of criminal investigations. In this context, a nuchal cord is considered to be responsible for an infant’s death, but there is a clear lack of evidence. The purpose of our study is to reveal if a nuchal cord can be responsible for stillbirth, poor perinatal outcome, or neonatal death in the forensic aspect. We conducted a prospective study in collaboration with the Augustinian Sisters’ Hospital in Cologne, Germany in the ...

    Also Ranks for: Nuchal Cord |  newborn intensive units |  apgar score |  adverse perinatal |  1 5
    KOL Index score: 2576

    Based on the network theory, anti-tumor antibodies (Ab1) can trigger the immune system of the host into a response against tumor cells. Through an immunological cascade, anti-idiotypic antibodies bearing the internal image of epitopes of the nominal antigen (Ab2 beta) are produced that themselves can induce cellular and humoral cytotoxic effects against the antigen-expressing tumor cell. Formation of such antibodies has been shown to be associated with prolonged survival of melanoma, ...

    Also Ranks for: Ovarian Carcinoma |  antibodies anti |  tumor cells |  induce humoral


    Jan C Schmolling: Influence Statistics

    Sample of concepts for which Jan C Schmolling is among the top experts in the world.
    Concept World rank
    amiodarone transfer #3

    Key People For Antiidiotypic Antibodies

    Top KOLs in the world
    N K Jerne
    antibody formation biological standards agglutinating activity
    univalent fragments rabbit antibody light chains
    Heinz V Kohler
    immune response antiidiotypic antibodies monoclonal anti
    Constantin A Bona
    influenza virus monoclonal antibodies inbred balb mice
    William W Busse
    severe asthma allergic rhinitis lung function
    Pierre‐André Cazenave
    cerebral malaria inbred balb mice monoclonal antibodies

    Jan C Schmolling:Expert Impact

    Concepts for whichJan C Schmollinghas direct influence:Antiidiotypic antibodies,  Oxytocin receptor,  Maternal serum,  Ovarian carcinoma,  Extracorporeal perfusion,  Ovarian cancer,  Human uterus,  Ovarian cancer patients.

    Jan C Schmolling:KOL impact

    Concepts related to the work of other authors for whichfor which Jan C Schmolling has influence:Ovarian cancer,  Preterm labor,  Bone metastases,  Maternal serum,  Oxytocin receptor,  Uterine peristalsis,  Embryo transfer.



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    Krankenhaus der Augustinerinnen, Gynecology and Maternity Clinic, Jakobstraße 27-31, 50678 Cologne, Germany. | Krankenhaus der Augustinerinnen, Gynecology and maternity clinic, Jakobstraße 27- 31, 50678, Cologne, Germany | Krankenhaus der Augustineri