On the Role of P2X7 Receptors in Dopamine Nerve Cell Degeneration in a Rat Model of Parkinson’s Disease: Studies With the P2X7 Receptor Antagonist a-438079

Authors: Kjell G KjellLuigi Francesco AGNATIJan KehrDaniel J MarcellinoTakashi YoshitakeAlicia RiveraJosé Ángel AguirreShimako YoshitakeBeth HagmanDiana Suárez‐BoomgaardMaría Dolores SánchezReina
Year: 2010
Times cited: 65

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On the role of P2X7 receptors in dopamine nerve cell degeneration in a rat model of Parkinson’s disease: studies with the P2X7 receptor antagonist A-438079


The role of the ATP-gated receptor, P2X7, has been evaluated in the unilateral 6-OHDA rat model of Parkinson’s disease using the P2X7 competitive antagonist A-438079. Nigral P2X7 immunoreactivity was mainly located in microglia but also in astroglia. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. However, this was not associated with a reduction of DA cell loss. Blockade of P2X7 receptors may represent a novel protective strategy for striatal DA terminals in Parkinson’s disease and warrants further future investigation.

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