David Peter Kelsell: Influence Statistics

David Peter Kelsell

David Peter Kelsell

Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT UK | Cell Biology and Cutaneous Research, Blizard ...


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David Peter Kelsell: Expert Impact

Concepts for which David Peter Kelsell has direct influence: Palmoplantar keratoderma , Harlequin ichthyosis , Skin disease , Connexin mutations , Oesophageal cancer , Human pair .

David Peter Kelsell: KOL impact

Concepts related to the work of other authors for which for which David Peter Kelsell has influence: Breast cancer , Genetic testing , Brca1 brca2 , Gap junctions , Hearing loss , Cell carcinoma , Hereditary leiomyomatosis .

KOL Resume for David Peter Kelsell

Year
2021

Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT UK

2020

Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Barts and The London School of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK

Blizard Institute, Queen Mary University of London, London, United Kingdom

2019

Centre for Cell Biology and Cutaneous Research, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, E1 2AT, London, UK

Blizard Institute, Queen Mary University of London, London, U.K.

2018

Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, E1 2AT, London, UK

2017

Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, Whitechapel, E1 2AD London, United Kingdom

Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, 3800, VIC, Australia

London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London, UK

2016

Cell Biology and Cutaneous Research, Blizard Institute, QMUL, London, United Kingdom

Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

2015

Centre for Cell Biology and Cutaneous Research, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4AT UK

2014

Department of Centre for Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

2013

Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London E1 2AT, UK

2012

Centre for Cutaneous Research, The Blizard Institute, Barts The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

Blizard Institute of Cell and Molecular Science, Barts and The London, London, United Kingdom

2011

Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, University of London, London E1 2AT, UK

From the Blizard Institute, Barts and the London School of Medicine and Dentistry (D.C.B., P.B., R.M.C., M.A.B., D.A.H., M.T., A.W., E.A.O., J.E.M., T.V., T.T.M., D.P.K.), and the Cardiology Research Department, Barts and the London National Health Service Trust, St. Bartholomew's Hospital (D.J.A.), Queen Mary University of London

2010

Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, University of London, London, UK

2009

Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London, Queen Mary University of London, 4 Newark Street, Whitechapel, London E1 4AT, UK

2008

Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, University of London, Whitechapel, London E1 4AT, UK

2007

Centre for Cutaneous Research, Institute of Cell and Molecular Science, Queen Mary, University of London, Whitechapel, London, UK

2006

Centre for Cutaneous Research, Institute for Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, 2 Newark Street, Whitechapel, London E1 2AT, United Kingdom; and

2005

Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, 4 Newark Street, London E1 2AT, UK

2004

Light Microscopy, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, London WC2A 3PX, U.K

Centre for Cutaneous Research, St Bartholomew's and the Royal London School of Medicine and Dentistry, University of London, London, UK;

GlaxoSmithKline, UK

2003

Centre for Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, 2 Newark Street, Whitechapel E1 2AT, UK

2002

Centre for Cutaneous Research, Barts and The London, Queen Mary's School of Medicine and Dentistry, 2 Newark Street, Whitechapel, London E1 2AT, UK

2001

Centre for Cutaneous Research, St. Bartholomews’ and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London

2000

ICRF Skin Tumour Laboratory, Centre for Cutaneous Research, St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK

Centre for Cutaneous Research, St Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London

Prominent publications by David Peter Kelsell

KOL-Index: 16372 . Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. Individual variation in the toxicity and therapeutic efficacy of these drugs is associated with a common genetic polymorphism that controls levels of TPMT activity and immunoreactive protein in human tissues. Because of the clinical significance of the "pharmacogenetic" regulation of this enzyme, it would ...
Known for Human Gene | Tpmt Activity | Thiopurine Methyltransferase | Blood Samples
KOL-Index: 14287 . BRCA1 is a tumour suppressor gene located on chromosome band 17q21. It is estimated that mutations in the BRCA1 gene account for approximately 45% of the breast cancer families and almost all of the breast/ovarian cancer families. We have used single strand conformation polymorphism analysis, direct sequencing, allele specific oligonucleotide hybridisation, and reverse transcription ...
Known for Brca1 Gene | Alternative Splicing | Cancer Families | Breast Ovarian
KOL-Index: 13983 . Germline mutations in the breast cancer-associated genes BRCA1 and BRCA2 confer a lifetime risk of malignancy. Distinctive morphological features have been attributed to these familial tumours; however, in sporadic breast cancer, the inter-relationship between loss of heterozygosity (LOH) of these loci and tumour morphology remains to be fully elucidated. We studied a series of 120 ...
Known for Loh Brca1 | Sporadic Breast Cancer | Loss Heterozygosity | Situ Carcinoma
KOL-Index: 13030 . BACKGROUND & AIMS: Esophageal squamous cell carcinoma (ESCC) is the predominant form of esophageal cancer in Japan. Smoking and drinking alcohol are environmental risk factors for ESCC, whereas single nucleotide polymorphisms in ADH1B and ALDH2, which increase harmful intermediates produced by drinking alcohol, are genetic risk factors. We conducted a large-scale genomic analysis of ESCCs ...
Known for Esophageal Squamous | Tumor Carcinoma | Genomic Landscape | Escc Japan
KOL-Index: 11474 . Basal cell carcinoma is the most common human cancer with increasing incidence reported worldwide. Despite the aberrant signaling role of the Hedgehog pathway, little is known about the genetic mechanisms underlying basal cell carcinomas. Towards a better understanding of global genetic events, we have employed the Affymetrix Mapping 10K single nucleotide polymorphism (SNP) microarray ...
Known for Basal Cell | Uniparental Disomy | Single Nucleotide | Heterozygosity Loh
KOL-Index: 11074 . The p16(INK4a) and p14(ARF) tumor suppressor genes (TSGs) are encoded within the CDKN2A locus on chromosome 9p21 and function as cell cycle regulatory proteins in the p53 and RB pathways. Inactivation of these genes by genetic and epigenetic changes has been described in some human cancers, but their importance in cutaneous squamous cell carcinoma (SCC) has not been established. Our ...
Known for Squamous Cell | Tumor Suppressor | Promoter Methylation | P16ink4a P14arf
KOL-Index: 10896 . The growth and metastasis of many cancers is due in part to loss of cell–cell adhesion. E-cadherin, plakoglobin and β-catenin are important in cell adhesion. Our aim was to examine the presence of these molecules in Paget's disease of the vulva and Paget's disease of the breast, and to correlate any differences in their expression with the presence of invasive disease or an underlying ...
Known for Pagets Disease | Vulva Breast | Paget Cells | Carcinoma Situ
KOL-Index: 10825 . BACKGROUND: Keratitis-ichthyosis-deafness (KID) syndrome is a rare congenital disorder characterized by the association of skin lesions, hearing loss and vascularizing keratitis. KID syndrome is caused by autosomal dominant mutations in the connexin 26 gene (GJB2). OBJECTIVES: To establish whether there is a correlation between genotype and phenotype in KID syndrome. METHODS: Clinical ...
Known for Deafness Syndrome | Connexin 26 | Germinal Mosaicism | Molecular Analysis
KOL-Index: 10788 . Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is known about their etiology and pathogenesis1,2,3. We previously mapped a gene that predisposes to multiple fibroids, cutaneous leiomyomata and renal cell carcinoma to chromosome 1q42.3–q43 (refs 4–6). Here we show, through a combination of mapping critical recombinants, identifying individuals with ...
Known for Uterine Fibroids | Papillary Carcinoma | Fh Predispose | Renal Cell
KOL-Index: 10365 . The protease ADAM17 (a disintegrin and metalloproteinase 17) catalyzes the shedding of various transmembrane proteins from the surface of cells, including tumor necrosis factor (TNF) and its receptors. Liberation of TNF receptors (TNFRs) from cell surfaces can dampen the cellular response to TNF, a cytokine that is critical in the innate immune response and promotes programmed cell death ...
Known for Cytoplasmic Domain | Irhom1 Irhom2 | Tumor Necrosis Factor | Tnf Receptors
KOL-Index: 10218 . Tylosis esophageal cancer (TOC) is an autosomal-dominant syndrome characterized by palmoplantar keratoderma, oral precursor lesions, and a high lifetime risk of esophageal cancer. We have previously localized the TOC locus to a small genomic interval within chromosomal region 17q25. Using a targeted capture array and next-generation sequencing, we have now identified missense mutations ...
Known for Esophageal Cancer | Rhbdf2 Mutations | Human Pair | Palmoplantar Keratoderma
KOL-Index: 10217 . Several BRCA1 mutations have now been found to occur in geographically diverse breast and ovarian cancer families. To investigate mutation origin and mutation-specific phenotypes due to BRCA1, we constructed a haplotype of nine polymorphic markers within or immediately flanking the BRCA1 locus in a set of 61 breast/ovarian cancer families selected for having one of six recurrent BRCA1 ...
Known for Brca1 Mutations | International Study | Mutation Ovarian | Breast Neoplasms
KOL-Index: 10169 . Desmosomes are anchoring junctions that exist in cells that endure physical stress such as cardiac myocytes. The importance of desmosomes in maintaining the homeostasis of the myocardium is underscored by frequent mutations of desmosome components found in human patients and animal models. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a phenotype caused by mutations in ...
Known for Sudden Death | Intercalated Discs | Ventricular Cardiomyopathy | P53 Iaspp

Key People For Palmoplantar Keratoderma

Top KOLs in the world
#1
Irene M Leigh
palmoplantar keratoderma type vii collagen keratin expression
#2
David Peter Kelsell
palmoplantar keratoderma harlequin ichthyosis skin disease
#3
Howard P STEVENS
palmoplantar keratoderma esophageal cancer skin disease
#4
Hans Christian Hennies
palmoplantar keratoderma human pair cohen syndrome
#5
Colin S Munro
palmoplantar keratoderma pachyonychia congenita darier disease
#6
W H Irwin McLean
atopic dermatitis pachyonychia congenita peanut allergy

Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT UK | Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary U