• Disease
  • Pancreatic
  • Pancreatic Cancer
  • Vay Liang W W Go

    Prominent publications by Vay Liang W W Go

    KOL Index score: 15865

    To evaluate the cyclic patterns of interdigestive pancreatic and biliary flows into the duodenum and to correlate these and the plasma levels of pancreatic polypeptide and motilin with duodenal interdigestive motor activity, five dogs were surgically prepared with three indwelling duodenal catheters. Through the first catheter, located just distal to the pylorus, a nonabsorbable marker was perfused at 3 ml/min. The second catheter, opposite the main pancreatic duct orifice, was ...

    Also Ranks for: Pancreatic Polypeptide |  motor activity |  bile acids |  plasma levels |  motilin dogs
    KOL Index score: 13735

    Epithelial neutrophil-activating peptide-78 (CXCL5), a member of the CXC chemokine family, has been shown to be involved in angiogenesis, tumor growth, and metastasis. The objective of this study was to determine the relationship between CXCL5 expression and tumor progression in human pancreatic cancer and to elucidate the mechanism underlying CXCL5-mediated tumor angiogenesis and cancer growth. We report herein that CXCL5 is overexpressed in human pancreatic cancer compared with paired ...

    Also Ranks for: Pancreatic Cancer |  poor survival |  overexpression cxcl5 |  tumor growth |  cakt rna
    KOL Index score: 13697

    Investigators have shown that green tea and its main catechin epigallocatechin-3 gallate (EGCG) may decrease the risk of cancer. Our previous study showed that green tea extract (GTE) as well as its individual catechin components inhibited MDA-MB231 breast cancer cell and human umbilical vein endothelial cell (HUVEC) proliferation. Further, GTE suppressed breast cancer xenograft size and decreased the tumor vessel density in vivo. In the current study, we investigated the effect of GTE ...

    Also Ranks for: Endothelial Growth |  cancer cells |  green tea |  human breast |  conditioned media
    KOL Index score: 13408

    To investigate the reported association between idiopathic chronic constipation and morphologic abnormalities of enteric nerves, we measured the concentrations of six neuropeptides, vasoactive intestinal peptide, peptide histidine-methionine, substance P, methionine5-enkephalin, neuropeptide Y, and the bombesinlike intestinal peptides, in descending colon from 4 patients with idiopathic chronic constipation. Decreased concentrations of vasoactive intestinal peptide (707 +/- 112 ng/g wet ...

    Also Ranks for: Idiopathic Chronic Constipation |  vasoactive intestinal peptide |  colon patients |  nerve fibers |  smooth muscle
    KOL Index score: 12806

    1. The present experiments examine the physiology and pharmacology of the release of substance P-like immunoreactivity (SP-l.i.), from the spinal cord in the halothane-anaesthetized, artificially ventilated cat. 2. Resting release of SP-l.i. was 36 +/- 4 fmol/30 min (mean +/- S.E.; n = 106). Bilateral stimulation of the sciatic nerves at intensities which evoked activity in fibres conducting at A beta conduction velocities (greater than 40 m/s), resulted in no change in blood pressure, ...

    Also Ranks for: Spinal Cord |  release spli |  nerve stimulation |  blood pressure |  10 microm
    KOL Index score: 12505

    Intrathecal injections of capsaicin (CAP) and 4 other homovanillic acid (HMV) derivatives related to the structure of CAP were carried out. Capsaicin, 1-nonenoylvanillylamide (NVA), HMV-dodecylamide (DCA) (but not HMV-cyclohexylamide (CHA) or HMV-hexadecylamide (HDC] reduced the spinal content of substance P (SP), as measured by radioimmunoassay (RIA), and increased the tail-flick latency. Similar injection of kainic acid and piperine reduced levels of SP but failed to affect the ...

    Also Ranks for: Spinal Substance |  intrathecal capsaicin |  primary afferents |  vasoactive intestinal |  acid injections
    KOL Index score: 12263

    By radioimmunoassay vasoactive intestinal peptide (VIP) and cholecystokinin (CCK) are found in the cat lumbar spinal ganglion and spinal cord with levels in dorsal greater than ventral horn. Unilateral rhizotomy, but not cervical hemisection produced a significant but incomplete depletion of CCK and VIP immunoreactivity in dorsal, but not ventral horn. Intrathecal capsaicin (0.5 mg) had no effect on the levels of spinal VIP or CCK. Intrathecal colchicine (0.5 mg)produced a significant ...

    Also Ranks for: Spinal Cord |  cck vip |  intestinal peptide |  ventral horn |  intrathecal capsaicin
    KOL Index score: 12060

    Spontaneous contractions, inhibitory responses produced by electrical field stimulation, and some electrophysiologic properties of circular smooth muscle from normal sigmoid colon and from sigmoid colon of ulcerative colitis patients were compared in vitro using simultaneous recordings of mechanical and intracellular electrical activity. In normal colonic circular muscle obtained from 21 patients, the frequency of spontaneous summation contractions ranged from 3 to 7 per 4 min, whereas ...

    Also Ranks for: Ulcerative Colitis |  spontaneous contractions |  sigmoid colon |  circular muscle |  electrical field stimulation
    KOL Index score: 11723

    BACKGROUND: Green and black tea polyphenols have been extensively studied as cancer chemopreventive agents. Many in vitro experiments have supported their strong antioxidant activity. Additional in vivo studies are needed to examine the pharmacokinetic relation of absorption and antioxidant activity of tea polyphenols administered in the form of green or black tea or tea extract supplements.

    OBJECTIVE: The purpose of this study was to compare the pharmacokinetic disposition of tea ...

    Also Ranks for: Green Tea |  antioxidant activity |  catechin cross |  vivo studies |  dietary supplements
    KOL Index score: 11386

    Interactions between bile acids (taurocholate, TC; taurochenodeoxycholate, TCDC; or taurodeoxycholate, TDC) and digestive products (essential amino acids, EAA or monoolein, MO) in the lumen of the proximal small bowel, affecting pancreatic enzyme secretion and gallbladder contraction, were studied in 77 healthy volunteers by a perfusion method. Perfusion of EAA or MO caused significant increases in pancreatic enzyme output together with gallbladder contraction; MO was more potent and ...

    Also Ranks for: Bile Acid |  gallbladder contraction |  pancreatic enzyme secretion |  cck pz |  stimulatory action
    KOL Index score: 11163

    ABSTRACTS: Because duodenal motor activity differs between preterm and term infants during fasting, this study evaluated the responses of motor activity and peptide release in response to feeding. In the first study, fasting concentrations of gastrin, gastric inhibitory peptide, neurotensin, and peptide YY (PYY) were determined in 53 preterm and 20 term infants. Plasma concentrations of gastrin and neurotensin were significantly lower in preterm infants than in healthy adults reported ...

    Also Ranks for: Motor Activity |  term infants |  response feeding |  newborn infant |  gestational age
    KOL Index score: 11146

    The aim of this study was to assess if infusion of oleic acid into the ileal pouch would slow gastric emptying and small-bowel transit, delay defecation, and increase plasma levels of enteroglucagon, neurotensin, or peptide YY in patients with colectomy and ileal pouch-anal anastomosis. Eight subjects with chronic ulcerative colitis who had undergone the operation were studied on 2 consecutive days. On 1 day, saline (154 mM NaCl) was infused into the ileal pouch, and on the other day ...

    Also Ranks for: Ileal Pouch |  oleic acid |  gastrointestinal transit |  anal anastomosis |  gastric emptying
    KOL Index score: 11067

    AIM: To determine the effect of ellagic acid on apoptosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid.

    METHODS: The effect of ellagic acid on apoptosis was assessed by measuring phosphatidylserine externalization, caspase activity, mitochondrial membrane potential and DNA fragmentation; and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized ...

    Also Ranks for: Ellagic Acid |  pancreatic cancer cells |  apoptosis proliferation |  nuclear factor |  nf kappa
    KOL Index score: 10950

    Increased intake of phytoestrogens may be associated with a lower risk of cancer in the breast and several other sites, although there is controversy surrounding this activity. One of the mechanisms proposed to explain the activity of phytoestrogens is their ability to bind and activate human estrogen receptor alpha (ERalpha) and human estrogen receptor beta (ERbeta). Nine phytoestrogens were tested for their ability to transactivate ERalpha or ERbeta at a range of doses. Mammary ...

    Also Ranks for: Estrogen Receptor |  eralpha erbeta |  cancer cells |  transfected breast |  lower risk


    Vay Liang W W Go: Influence Statistics

    Sample of concepts for which Vay Liang W W Go is among the top experts in the world.
    Concept World rank
    peptide immunoreactivities fibers #1
    tissue mucosal antrectomy #1
    groups bioavailability #1
    species islet cells #1
    peptide yy concentrations #1
    mucosal antrectomy #1
    hpp level #1
    prednisolone groups #1
    gemcitabine quercetin #1
    neuropeptide aganglionic colon #1
    yy canine #1
    gk rats zc #1
    animals βglucuronidase #1
    concentrations peptide yy #1
    observations substance #1
    motor activity motilin #1
    duodenal allograft #1
    cancer metabolism balance #1
    metabolomics ribose diet #1
    intravenous cckpz #1
    hypercalcemia pancreatic gallbladder #1
    pig pancreas islets #1
    ileal brake gastric #1
    colonic neuropeptides #1
    migrating complexes #1
    npy tk #1
    npy rat pancreas #1
    cholecystokinin estrous cycle #1
    ductal openings presence #1
    method gastric secretions #1
    observed phenotype study #1
    secretion intraluminal #1
    radioimmunoassay antisera #1
    insuloacinar #1
    neurotensin enteroglucagon levels #1
    cholecystectomy bile secretion #1
    insulin rx77368 #1
    gastric emptying osmolality #1
    apcmin mouse effects #1
    pancreatic duct dogs #1
    fat malabsorption improvement #1
    hpp grades #1
    rice dietary #1
    meal secretions #1
    cck hypothalamus #1
    perfusion essential #1
    iii lad #1
    nka united states #1
    peripheral atropine #1

    Key People For Pancreatic Cancer

    Top KOLs in the world
    Ralpha H Hruban†
    pancreatic cancer gene expression tumor carcinoma
    Ahmedin M Jemal
    united states breast cancer addis ababa
    Rebecca L Siegel
    united states colorectal cancer incidence rates
    Anirban Maitra
    pancreatic cancer precursor lesions early detection
    Markus Wolfgang Büchler†
    pancreatic cancer chronic pancreatitis liver transplantation
    Helmut M Friess†
    pancreatic cancer chronic pancreatitis growth factor

    Vay Liang W W Go:Expert Impact

    Concepts for whichVay Liang W W Gohas direct influence:Pancreatic cancer,  Early detection,  Cerebral cortex,  Peptide yy,  Green tea,  Spinal cord,  Pancreatic insufficiency,  United states.

    Vay Liang W W Go:KOL impact

    Concepts related to the work of other authors for whichfor which Vay Liang W W Go has influence:Pancreatic cancer,  Chronic pancreatitis,  Insulin resistance,  Green tea,  Gastric emptying,  Carney complex,  Metabolic syndrome.



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    The UCLA Agi Hirshberg Center for Pancreatic Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA | UCLA Center for Excellence in Pancreatic Diseases, University of California, Los Angeles, Los Angeles, CA | UCLA Center for Excellence i