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    • Volker Arolt
    • Volker Arolt

      Volker Arolt

      Department of Psychiatry, University of Münster, Münster, Germany | Institute for Translational Psychiatry, University of Münster, Münster, Germany. | Department of ...



      KOL Resume for Volker Arolt


      Department of Psychiatry, University of Münster, Münster, Germany


      Department of Mental Health, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany


      Otto Creutzfeldt Center for Cognitive and Behavioural Neuroscience, University of Münster, Munich, Germany

      Department of Psychiatry, University of Münster, Münster, DE


      Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude A 9, 48149, Münster, Deutschland

      From the Department of Psychiatry, University of Münster, Germany (Repple, Zaremba, Meinert, Grotegerd, Redlich, Förster, Dohm, Opel, Hahn, Enneking, Leehr, Böhnlein, Dzvonyar, Sindermann, Winter, Goltermann, Arolt, Dannlowski); and the Institute of Clinical Radiology, Medical Faculty, University of Münster, and University Hospital Münster, Germany (Kugel, Bauer, Heindel).

      Department of Psychiatry, University of Münster, Münster, Nordrhein-Westfalen, DE Germany


      Department of Psychiatry, University Hospital Münster, Münster, Germany


      Department of Psychiatry and Psychotherapy, Wilhelm University, Muenster, Germany

      Cluster of Excellence EXC 1003, Cells in Motion, Universität Münster, Münster, Deutschland

      Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Münster.


      Department of Psychiatry, University of Muenster, Muenster, Germany.

      Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Geb. A9, 48149, Münster, Deutschland

      Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Germany

      Discipline of Psychiatry, School of Medicine University of Adelaide Adelaide SA Australia


      Department of Psychiatry, University Hospital Münster, Münster, Germany.

      Institut für Klinische Psychologie und Psychotherapie, Technische Universität Dresden, Dresden, Deutschland;, Institut für Klinische Psychologie und Psychotherapie, Universität Köln, Köln, Deutschland;, Christoph-Dornier Stiftung für Klinische Psychologie an der Universität Bremen, Bremen, Deutschland;, Institut für klinische Psychologie und Psychotherapie, Universität Hamburg, Hamburg, Deutschland;, Institut für Psychologie/Psychotherapie, Ernst-Moritz-Arndt Universität Greifswald, Greifswald, Deutschland;, Klinik für Psychiatrie und Psychotherapie, Charité - Universitätsmedizin Berlin, Berlin, Deutschland;, Institut für Psychologie, Humboldt Universität Berlin, Berlin, Deutschland;, Universitätsklinik für Psychiatrie und Psychotherapie, Marburg, Deutschland;, Lehrstuhl Klinische Psychologie und Biologische Psychologie und Psychotherapie, Fakultät für Sozialwissenschaften, Universität Mannheim, Mannheim, Deutschland;, Klinik für Psychiatrie, Psychosomatik und Psychotherapie, Universität Würzburg, Würzburg, Deutschland;, Klinik für Psychiatrie, Universität Münster, Münster, Deutschland


      UHLMANN, UNSER, AROLT, and LENCER: University Hospital Muenster, Muenster, Germany; KAEHLER: University Hospital Muenster and University of Groningen, Groningen, Netherlands; HARRIS: Jesse Brown VA Medical Center, Chicago, IL

      Department of Psychiatry University of Muenster Muenster Germany


      University of Münster – Department of Psychiatry

      Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Münster, Münster, Deutschland



      Volker Arolt: Influence Statistics

      Sample of concepts for which Volker Arolt is among the top experts in the world.
      Concept World rank
      covert faces disgust #1
      encoding angry faces #1
      anxiety sensitivity nogop3 #1
      study circulating cells #1
      singleton families #1
      lte genetic receptors #1
      vulnerability markers mdd #1
      ctq life events #1
      erp computerassisted statistics #1
      s100b psychiatric disorders #1
      torontoalexithymiascales #1
      fkbp5 depressive symptoms #1
      iat brain response #1
      gmv amygdala gmv #1
      putative trait marker #1
      mononuclear suicide tlymphocytes #1
      muenster cohort #1
      alexithymia construct alexithymia #1
      precuneus associations #1
      western blotting s100b #1
      discontinuity hypothesis repressors #1
      csf antinmdareceptor encephalitis #1
      affective priming controls #1
      emotionrelated disorders #1
      placebo early processing #1
      anova higher activity #1
      improvements visual memory #1
      transgenic mice field #1
      food‐related stimuli #1
      questionnaires vocabulary anhedonia #1
      emotional learning women #1
      familial schizophrenia families #1
      singleton etd #1
      psychiatrie genetische forschung #1
      biological sex classification #1
      hc 03 #1
      higher prevalence etd #1
      s100b levels baseline #1
      rs3762555 #1
      cytokine hpa #1
      neuroplastic properties #1
      ccl22 receptor ccr4 #1
      inflammatory phenotypes depression #1
      angry faces repressors #1
      serotonin major emotions #1
      genetics mdd #1
      inflammation clusters downregulation #1
      automatic processing verbal #1
      automatic stages processing #1


      Prominent publications by Volker Arolt

      KOL-Index: 14266

      IMPORTANCE: Electroconvulsive therapy (ECT) is one of the most effective treatments for severe depression. However, biomarkers that accurately predict a response to ECT remain unidentified.

      OBJECTIVE: To investigate whether certain factors identified by structural magnetic resonance imaging (MRI) techniques are able to predict ECT response.

      DESIGN, SETTING, AND PARTICIPANTS: In this nonrandomized prospective study, gray matter structure was assessed twice at approximately 6 weeks apart ...

      Known for Electroconvulsive Therapy | Individual Response | Magnetic Resonance | Ect Sample | Cinguli Humans
      KOL-Index: 13332

      OBJECTIVE: Although exposure-based cognitive-behavioral therapy (CBT) is an effective treatment option for panic disorder with agoraphobia, the neural substrates of treatment response remain unknown. Evidence suggests that panic disorder with agoraphobia is characterized by dysfunctional safety signal processing. Using fear conditioning as a neurofunctional probe, the authors investigated neural baseline characteristics and neuroplastic changes after CBT that were associated with ...

      Known for Panic Disorder | Neural Substrates | Behavioral Therapy | Agoraphobia Cbt | Fear Conditioning
      KOL-Index: 12937

      The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed ...

      Known for Cortical Abnormalities | Adolescents Mdd | Major Depressive | 20 Cohorts | Neuroimaging Studies
      KOL-Index: 12823

      Recently, several genome-wide association studies (GWAS) on bipolar disorder (BPD) suggested novel risk genes. However, only few of them were followed up and further, the specificity of these genes is even more elusive. To address these issues, we genotyped SNPs in ANK3, CACNA1C, CMTM8, DGKH, EGFR, and NPAS3, which were significantly associated with BPD in previous GWAS, in a sample of 380 BPD patients. Replicated SNPs were then followed up in patients suffering from unipolar depression ...

      Known for Bipolar Disorder | Risk Genes | Adult Adhd | Unipolar Depression | Bpd Dgkh
      KOL-Index: 12720

      OBJECTIVE: Cognitive-behavioral therapy (CBT) is a first-line treatment for panic disorder with agoraphobia (PD/AG). Nevertheless, an understanding of its mechanisms and particularly the role of therapist-guided exposure is lacking. This study was aimed to evaluate whether therapist-guided exposure in situ is associated with more pervasive and long-lasting effects than therapist-prescribed exposure in situ.

      METHOD: A multicenter randomized controlled trial, in which 369 PD/AG patients ...

      Known for Panic Disorder | Controlled Trial | Guided Exposure | Agoraphobic Avoidance | Psychological Treatment
      KOL-Index: 12389

      Recent observations indicate that sex and level of steroid hormones may influence cortical networks associated with specific cognitive functions, in particular visuo-spatial abilities. The present study probed the influence of sex, menstrual cycle, and sex steroid hormones on 3D mental rotation and brain function using 3-T fMRI. Twelve healthy women and 12 men were investigated. Menstrual cycle and hormone levels were assessed. The early follicular and midluteal phase of the menstrual ...

      Known for Menstrual Cycle | Steroid Hormones | Mental Rotation | Functional Anatomy | Testosterone Levels
      KOL-Index: 11918

      BACKGROUND: Major depressive disorder (MDD) is a disabling mood disorder, and despite a known heritable component, a large meta-analysis of genome-wide association studies revealed no replicable genetic risk variants. Given prior evidence of heterogeneity by age at onset in MDD, we tested whether genome-wide significant risk variants for MDD could be identified in cases subdivided by age at onset.

      METHODS: Discovery case-control genome-wide association studies were performed where cases ...

      Known for Onset Mdd | Depressive Disorder | Major Depression | Genetic Studies | Genome Wide
      KOL-Index: 11843

      BACKGROUND: Childhood maltreatment represents a strong risk factor for the development of depression and posttraumatic stress disorder (PTSD) in later life. In the present study, we investigated the neurobiological underpinnings of this association. Since both depression and PTSD have been associated with increased amygdala responsiveness to negative stimuli as well as reduced hippocampal gray matter volume, we speculated that childhood maltreatment results in similar functional and ...

      Known for Magnetic Resonance | Childhood Maltreatment | Amygdala Responsiveness | Ctq Scores | Development Depression
      KOL-Index: 11760

      IMPORTANCE: The structural abnormalities in the brain that accurately differentiate unipolar depression (UD) and bipolar depression (BD) remain unidentified.

      OBJECTIVES: First, to investigate and compare morphometric changes in UD and BD, and to replicate the findings at 2 independent neuroimaging sites; second, to differentiate UD and BD using multivariate pattern classification techniques.

      DESIGN, SETTING, AND PARTICIPANTS: In a 2-center cross-sectional study, structural gray matter ...

      Known for Bipolar Depression | Pattern Classification | Based Morphometry | Independent Sample | Structural Abnormalities
      KOL-Index: 11721

      BACKGROUND: Panic disorder with agoraphobia is characterized by panic attacks and anxiety in situations where escape might be difficult. However, neuroimaging studies specifically focusing on agoraphobia are rare. Here we used functional magnetic resonance imaging (fMRI) with disorder-specific stimuli to investigate the neural substrates of agoraphobia.

      METHOD: We compared the neural activations of 72 patients suffering from panic disorder with agoraphobia with 72 matched healthy control ...

      Known for Panic Disorder | Neural Correlates | Agoraphobia Specific | Ventral Striatum | Resonance Imaging
      KOL-Index: 11684

      BACKGROUND: In recent years, schizophrenia has increasingly been recognized as a neurocognitive disorder, which has led to a growing literature on cognitive rehabilitation, and suggested several potential enhancements to cognitive function. For instance, it has been shown that executive functioning deficits as measured by the Wisconsin Card Sorting Test (WCST) can be modified in a subgroup of schizophrenic patients. The neurobiological basis of cognitive remediation has not been ...

      Known for Learning Potential | Anterior Cingulate Cortex | Schizophrenic Patients | Resonance Spectroscopy | Naa Dlpfc
      KOL-Index: 11632

      BACKGROUND: Cognitive theories of depression predict mood-congruent negative biases already at automatic stages of processing, although several behavioral studies seem to contradict this notion. That is, depression should potentiate emotional reactivity to negative emotional cues, whereas it should reduce reactivity in response to positive emotional stimuli. Assessing neurobiological substrates of automatic emotion processing might be a more sensitive challenge for automatic negative ...

      Known for Amygdala Responses | Major Depression | Masked Facial | Emotional Stimuli | Depressed Patients
      KOL-Index: 11611

      BACKGROUND: Cardiovascular diseases (CVD) and affective disorders are both very prevalent in the general population. However, it is unclear on a population level if the prevalence of different subtypes of affective disorders like unipolar major depression or dysthymia is different in individuals with specific CVDs.

      METHODS: In 4,181 participants of the general population, lifetime prevalences for affective disorders were assessed through the Composite International Diagnostic Interview ...

      Known for Bipolar Disorder | Cardiovascular Diseases | Major Depression | Adult Population | Coronary Heart Disease
      KOL-Index: 11560

      BACKGROUND: Fear conditioning involves the amygdala as the main neural structure for learning fear responses whereas fear extinction mainly activates the inhibitory prefrontal cortex (PFC). In this study we investigated whether individual differences in trait anxiety affect amygdala and dorsal anterior cingulate cortex (dACC) activation during fear conditioning and extinction.

      METHOD: Thirty-two healthy subjects were investigated by functional magnetic resonance imaging (fMRI) at 3 T ...

      Known for Fear Extinction | Trait Anxiety | Mapping Conditioning | Amygdala Activation | Individual Differences
      KOL-Index: 11353

      Importance: More than half of all patients with major depressive disorder (MDD) experience a relapse within 2 years after recovery. It is unclear how relapse affects brain morphologic features during the course of MDD.

      Objective: To use structural magnetic resonance imaging to identify morphologic brain changes associated with relapse in MDD.

      Design, Setting, and Participants: In this longitudinal case-control study, patients with acute MDD at baseline and healthy controls were recruited ...

      Known for Relapse Patients | Depressive Disorder | Cortical Thickness | Orbitofrontal Cortex | Mdd Female Follow

      Key People For Panic Disorder

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      Volker Arolt:Expert Impact

      Concepts for whichVolker Arolthas direct influence:Panic disorder,  Major depression,  Major depressive disorder,  Depressive disorder,  Childhood maltreatment,  Depressive symptoms,  Anxiety disorders,  Schizophrenic patients.

      Volker Arolt:KOL impact

      Concepts related to the work of other authors for whichfor which Volker Arolt has influence:Bipolar disorder,  Major depression,  Depressive symptoms,  Magnetic resonance,  Childhood trauma,  Mental health,  Prefrontal cortex.



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      Department of Psychiatry, University of Münster, Münster, Germany | Institute for Translational Psychiatry, University of Münster, Münster, Germany. | Department of Psychiatry, University of Münster, Münster, Germany. Electronic address: Arolt@uni-mu

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