Volker Arolt

Volker Arolt

Mood And Anxiety Disorders Research Unit, Department Of Psychiatry And Psychotherapy, Albert-Schweitzer-Campus 1, University Of Muenster, Muenster, Germany

Direct Impact

Concepts for which Volker Arolt has direct influence:

panic disorder
major depression
depressive symptoms
childhood maltreatment
antidepressant response
personality traits
electroconvulsive therapy

External impact

Concepts related to the work of other authors for which Volker Arolt has influence:

panic disorder
depressive symptoms
major depression
monoamine oxidase
polygenic scores
trauma exposure
anxiety sensitivity

Prominent publications by Volker Arolt

KOL-Index: 146 OBJECTIVE: Cognitive-behavioral therapy (CBT) has been hypothesized to act by reducing the pathologically enhanced semantic, anxiety-related associations of patients with panic disorder. This study investigated the effects of CBT on the behavioral and neural correlates of the panic-related semantic network in patients with panic disorder. METHODS: An automatic semantic priming paradigm ...
KOL-Index: 114 Selective serotonin reuptake inhibitors (SSRIs) are first-line antidepressants for the treatment of major depressive disorder (MDD). However, treatment response during an initial therapeutic trial is often poor and is difficult to predict. Heterogeneity of response to SSRIs in depressed patients is partly driven by co-occurring somatic disorders such as coronary artery disease (CAD) and ...
Known for
Binary Logistic Regression | Pgss Cad | Cross Trait | Co-Occurring Somatic Disorders
KOL-Index: 86 Major depressive disorder and the anxiety disorders are highly prevalent, disabling and moderately heritable. Depression and anxiety are also highly comorbid and have a strong genetic correlation (rg ≈ 1). Cognitive behavioural therapy is a leading evidence-based treatment but has variable outcomes. Currently, there are no strong predictors of outcome. Therapygenetics research aims to ...
Known for
Complex Traits | Largest Therapygenetics | Genetic Associations | Genome-Wide Meta-Analysis
KOL-Index: 79 As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In this context, polygenic risk scores (PRSs) quantifying the additive effects of multiple common genetic variants hold the potential to predict complex ...
Known for
Diagnostic Prognostic Accuracy | Disorder Groups | Sz-Prss | 56 Males
KOL-Index: 68 Background Antidepressants are a first line treatment for depression. However, only a third of individuals remit after the first treatment. Common genetic variation likely regulates, in part, antidepressant response, yet the success of previous genome-wide association studies has been limited by sample size. This study performs the largest genetic analysis of prospectively assessed ...
Known for
Performed Magma | Assessed Antidepressant | Heritability | Educational
KOL-Index: 53 S100B is a calcium-binding peptide produced mainly by astrocytes that exert paracrine and autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and in vivo animal experiments to understand S100B's roles in cellular energy metabolism, cytoskeleton modification, cell proliferation, and differentiation. Also, insights have been gained regarding the interaction ...
Known for
S100b Concentrations | Inflammatory Brain | Damage Neurodegeneration | Psychiatric Increased
KOL-Index: 49 Altered adaptive immunity involving T lymphocytes has been found in depressed patients and in stress-induced depression-like behavior in animal models. Peripheral T cells play important roles in homeostasis and function of the central nervous system and thus modulate behavior. However, the T cell phenotype and function associated with susceptibility and resilience to depression remain ...
Known for
Equally Susceptible | Defeat Stress | Depression Behavior | Helper Function
KOL-Index: 47 Neuroticism has been shown to act as an important risk factor for major depressive disorder (MDD). Genetic and neuroimaging research has independently revealed biological correlates of neurotic personality including cortical alterations in brain regions of high relevance for affective disorders. Here we investigated the influence of a polygenic score for neuroticism (PGS) on cortical brain ...
Known for
Associations Neurotic | Regions Pgs | Morphometric Overlap | Potential Relevance
KOL-Index: 47 The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study with a dimensional, PD/AG-related anxiety phenotype based on the Agoraphobia Cognition Questionnaire (ACQ) in a sample of 1370 healthy German volunteers of the CRC TRR58 MEGA study wave ...
Known for
Conjunction | Increased Fear Network | Glrb Gene Rs78726293 | Generalized Startle Reaction
KOL-Index: 46 Repetitive transcranial magnetic stimulation (rTMS) enables the local and non-invasive modulation of cortical activity and has proved to achieve antidepressant effects. To a lesser extent, rTMS is investigated as a treatment option for anxiety disorders. As the prefrontal cortex and the amygdala represent key components of human emotion regulation, we investigated how prefrontally applied ...
Known for
Fear-Relevant Paradigm | Continuous Theta Burst Stimulation | Dorsolateral Prefrontal Cortex | Antidepressant Effects

Mood and Anxiety Disorders Research Unit, Department of Psychiatry and Psychotherapy, Albert-Schweitzer-Campus 1, University of Muenster, Muenster, Germany

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