Khailash P Bhatia

Khailash P Bhatia

Department of Clinical and MOVEMENT Neurosciences, UCL Queen Square Institute of Neurology, London, United Kingdom | Department of Clinical and Movement Neurosciences, ...

KOL Resume for Khailash P Bhatia  (movement, disease extrapyramidal, disease, extrapyramidal, extrapyramidal movement, disorders)


Department of Clinical and MOVEMENT Neurosciences, UCL Queen Square Institute of Neurology, London, United Kingdom

Service of Neurology, Hospital Clinic, Barcelona, Spain and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.


UCL Queen Square Institute of Neurology Department of Clinical and Movement Neurosciences, Queen Square, London WC1N 3BG, United Kingdom. Electronic address:

Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London, UK


Department of Clinical and Movement Neurosciences, Queen Square, London, United Kingdom

The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK


Sobell Department of Movement Neuroscience, Institute of Neurology, UCL, National Hospital for Neurology, Queen Square, London, UK

UCL Queen's Square, Institute of Neurology, London, United Kingdom

From the Department of Neurology (C.G.), Charité University Medicine Berlin, Germany; Department of Clinical Neurosciences (D.M.), Cumming School of Medicine, University of Calgary and Hotchkiss Brain Institute, AB, Canada; Department of Neurology (A.J.E.), James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, University of Cincinnati, OH; Division of Neurology (A.E.L.), Edmond J. Safra Program in Parkinson's Disease Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital-UHN, University of Toronto, ON, Canada; Department of Clinical and Movement Neurosciences (K.P.B.), Queen Square Institute of Neurology, University College London; and Neurosciences Research Centre (M.E.), Molecular and Clinical Sciences Institute, St George's University of London.


1University College London (UCL), Institute of Neurology, London, United Kingdom.

Sobell Department of Motor Neuroscience and Movement Disorders UCL Institute of Neurology, Queen Square, London, WC1N3BG, UK


Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, UK

Institute of Neurology, UCL, London, United Kingdom

Sarosh R. Irani and Kailash P. Bhatia contributed equally to this work.


Prominent publications by Khailash P Bhatia

KOL Index score: 14504

BACKGROUND: Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a cause of Parkinson's disease (PD). The International LRRK2 Consortium was established to answer three key clinical questions: can LRRK2-associated PD be distinguished from idiopathic PD; which mutations in LRRK2 are pathogenic; and what is the age-specific cumulative risk of PD for individuals who inherit or are at risk of inheriting a deleterious mutation in LRRK2?

METHODS: Researchers from 21 ...

Known for Mutations Lrrk2 |  National Institute |  Genetic Penetrance |  Parkinson Disease |  Motor Symptoms
KOL Index score: 14366

BACKGROUND: Sleep disorders are common in multiple system atrophy (MSA), but the prevalence of excessive daytime sleepiness (EDS) is not well known.

OBJECTIVE: To assess the frequency and associations of EDS in MSA.

DESIGN: Survey of EDS in consecutive patients with MSA and comparison with patients with Parkinson disease (PD) and individuals without known neurologic disease.

SETTING: Twelve tertiary referral centers.

PARTICIPANTS: Eighty-six consecutive patients with MSA; 86 patients ...

Known for Excessive Daytime Sleepiness |  Patients Msa |  Multiple Atrophy |  Restless Legs Syndrome |  Sleep Disorders
KOL Index score: 14238

Mitochondrial transport plays an important role in matching mitochondrial distribution to localized energy production and calcium buffering requirements. Here, we demonstrate that Miro1, an outer mitochondrial membrane (OMM) protein crucial for the regulation of mitochondrial trafficking and distribution, is a substrate of the PINK1/Parkin mitochondrial quality control system in human dopaminergic neuroblastoma cells. Moreover, Miro1 turnover on damaged mitochondria is altered in ...

Known for Mitochondrial Transport |  Parkin Ubiquitin Ligase |  Tumor Cells |  Miro Ubiquitination |  Damaged Mitochondria
KOL Index score: 13285

Paroxysmal dyskinesia can be subdivided into three clinical syndromes: paroxysmal kinesigenic dyskinesia or choreoathetosis, paroxysmal exercise-induced dyskinesia, and paroxysmal non-kinesigenic dyskinesia. Each subtype is associated with the known causative genes PRRT2, SLC2A1 and PNKD, respectively. Although separate screening studies have been carried out on each of the paroxysmal dyskinesia genes, to date there has been no large study across all genes in these disorders and little ...

Known for Paroxysmal Dyskinesia |  Prrt2 Mutations |  Episodic Ataxia |  Hemiplegic Migraine |  Genetic Heterogeneity
KOL Index score: 12912

DYT1 primary torsion dystonia is an autosomal dominant movement disorder due to a 3-bp GAG deletion in the TOR1A gene, which becomes manifest in only 30-40% of mutation carriers. Investigating the factors regulating this reduced penetrance might add new insight into the mechanisms underlying the disease. The pathophysiology of dystonia has been related to basal ganglia dysfunctions that lead to the most prominent motor symptoms. However, subclinical sensory deficits have also been ...

Known for Dyt1 Mutation |  Sensory Stimuli |  Manifesting Carriers |  Temporal Processing |  New Insight
KOL Index score: 11821

The brain-derived neurotrophic factor gene (BDNF) is one of many genes thought to influence synaptic plasticity in the adult brain and shows a common single nucleotide polymorphism (BDNF Val66Met) in the normal population that is associated with differences in hippocampal volume and episodic memory. It is also thought to influence possible synaptic changes in motor cortex following a simple motor learning task. Here we extend these studies by using new non-invasive transcranial magnetic ...

Known for Neurotrophic Factor |  Common Polymorphism |  Human Cortical Plasticity |  Adult Brain |  Val66val Individuals

PRRT2 gene mutations

KOL Index score: 11645

OBJECTIVE: The proline-rich transmembrane protein (PRRT2) gene was recently identified using exome sequencing as the cause of autosomal dominant paroxysmal kinesigenic dyskinesia (PKD) with or without infantile convulsions (IC) (PKD/IC syndrome). Episodic neurologic disorders, such as epilepsy, migraine, and paroxysmal movement disorders, often coexist and are thought to have a shared channel-related etiology. To investigate further the frequency, spectrum, and phenotype of PRRT2 ...

Known for Prrt2 Gene |  Pkd Hm |  Episodic Ataxia |  Male Membrane Proteins |  Hemiplegic Migraine
KOL Index score: 11524

We used PET to examine the pattern and time course of changes produced by repetitive transcranial magnetic stimulation (rTMS) over the dorsal premotor cortex (PMd) in healthy subjects and in patients with primary focal dystonia. Subjects received 1800 stimuli of subthreshold 1 Hz rTMS or sham stimulation to the left PMd. Afterwards, we measured regional cerebral blood flow (rCBF) as a marker of synaptic activity at rest and during performance of freely selected random finger movement. In ...

Known for Premotor Cortex |  Focal Arm Dystonia |  Neuronal Activity |  Healthy Subjects Patients |  Stimulation Rtms
KOL Index score: 11433

Approximately 10% of patients diagnosed clinically with early Parkinson's disease (PD) have normal dopaminergic functional imaging (Scans Without Evidence of Dopaminergic Deficit [SWEDDs]). An important subgroup of SWEDDs are those with asymmetric rest tremor resembling parkinsonian tremor. Clinical and pathophysiological features which could help to distinguish SWEDDs from PD have not been explored. We therefore studied clinical details including non-motor symptoms in 25 tremulous ...

Known for Swedds Patients |  Asymmetric Resting Tremor |  Nonmotor Symptoms |  Clinical Overlap |  Dopaminergic Deficit
KOL Index score: 11178

Cervical dystonia is a neurological disorder characterized by sustained, involuntary movements of the head and neck. Most cases of cervical dystonia are idiopathic, with no obvious cause, yet some cases are acquired, secondary to focal brain lesions. These latter cases are valuable as they establish a causal link between neuroanatomy and resultant symptoms, lending insight into the brain regions causing cervical dystonia and possible treatment targets. However, lesions causing cervical ...

Known for Cervical Dystonia |  Brain Lesions |  Network Localization |  Lesion Locations |  Basal Ganglia
KOL Index score: 11066

The PLA2G6 gene encodes a group VIA calcium-independent phospholipase A2 beta enzyme that selectively hydrolyses glycerophospholipids to release free fatty acids. Mutations in PLA2G6 have been associated with disorders such as infantile neuroaxonal dystrophy, neurodegeneration with brain iron accumulation type II and Karak syndrome. More recently, PLA2G6 was identified as the causative gene in a subgroup of patients with autosomal recessive early-onset dystonia-parkinsonism. ...

Known for Lipid Peroxidation |  Mitochondrial Dysfunction |  Pla2g6 Gene |  Phospholipases Humans |  Loss Ipla2via
KOL Index score: 11041

BACKGROUND: Consensus criteria for classifying tremor disorders were published by the International Parkinson and Movement Disorder Society in 1998. Subsequent advances with regard to essential tremor, tremor associated with dystonia, and other monosymptomatic and indeterminate tremors make a significant revision necessary.

OBJECTIVES: Convene an international panel of experienced investigators to review the definition and classification of tremor.

METHODS: Computerized MEDLINE searches ...

Known for Consensus Statement |  Task Force |  Movement Disorder |  Classification Tremor |  International Parkinson
KOL Index score: 10951

We have established that the frequency of LRRK2 mutations in a series of 118 cases of familial Parkinson's disease is 5.1%. In the largest family with autosomal dominant, late-onset Parkinson's disease where affected subjects share a Y1699C missense mutation we provide a detailed clinical, pathological and imaging report. The phenotype in this large British kindred included asymmetrical, levodopa-responsive parkinsonism where unilateral leg tremor at onset and foot dystonia were ...

Known for Mutations Lrrk2 |  Mutational Analysis |  Familial Parkinsons Disease |  Genetic Data |  Onset Parkinson
KOL Index score: 10908

OBJECTIVE: Spinocerebellar ataxia type 2 (SCA2) has been reported as the commonest dominant hereditary ataxia in India. However, India is an ethnically and religiously diverse population. Previous studies have not clearly indicated exact ethnic and religious origins, and must therefore be interpreted with caution. The purpose of this study was to determine the prevalence of different SCA mutations in a relatively homogeneous population from eastern India.

METHODS: We identified 28 ...

Known for Eastern India |  Sca1 Sca2 |  Slow Saccades |  Cerebellar Ataxia |  Autosomal Dominant


Khailash P Bhatia: Influence Statistics

Sample of concepts for which Khailash P Bhatia is among the top experts in the world.
Concept World rank
clinical clues investigations #1
dystonia tdt #1
skin temporal discrimination #1
fmd questionnaires #1
bhc mutations #1
distinct movement disorder #1
maladaptive synaptic plasticity #1
dystonia genes #1
adultonset dystoniaparkinsonism #1
psychogenic parkinsonism #1
cdpjm #1
linked parkinsonism #1
subsequent parkinsonism #1
abnormal inhibitory control #1
dystonia anarthria aphonia #1
aphonia dystonia #1
betapropeller protein #1
genetic diseases dystonia #1
melatonin 2 fvc #1
corticobasal syndrome dystonia #1
14 pkd patients #1
photic myoclonus #1
epilepsy photic myoclonus #1
sensory tricks groups #1
patients obvious decrement #1
arm swing aopcd #1
phaselocked driven disruption #1
normal subjects estimates #1
swedds swedds patients #1
thap1 mutations dystonia #1
mrigfus vim #1
electrophysiologic features psm #1
genetic bsn #1
pathophysiology ped #1
statementdystonia #1
defective temporal processing #1
dystonia – #1
adultonset dystonic tics #1
clinical approach review #1
patients longstanding dystonia #1
musicians dystonia deficits #1
type education medical #1
cns ubiquitinprotein ligases #1
torticollis aged #1
pseudodystonia dystonia #1
twstrspsych #1
cervical dystonia controls #1
adult surviving patients #1
dystonia syndrome #1

Key People For Movement Disorders

Top KOLs in the world
Anthony Edward Lang
parkinson disease movement disorders subthalamic nucleus
Joseph J Jankovic
movement disorders parkinson disease essential tremor
Khailash P Bhatia
movement disorders cervical dystonia parkinson disease
essential tremor motor cortex magnetic stimulation
Stanley Fahn
parkinson disease movement disorders botulinum toxin
C David Marsden
parkinsons disease basal ganglia substantia nigra

Khailash P Bhatia:Expert Impact

Concepts for whichKhailash P Bhatiahas direct influence:Movement disorders,  Cervical dystonia,  Parkinson disease,  Parkinsons disease,  Essential tremor,  Basal ganglia,  Movement disorder,  Primary dystonia.

Khailash P Bhatia:KOL impact

Concepts related to the work of other authors for whichfor which Khailash P Bhatia has influence:Parkinson disease,  Movement disorders,  Essential tremor,  Cervical dystonia,  Basal ganglia,  Deep brain stimulation,  Botulinum toxin.



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Department of Clinical and MOVEMENT Neurosciences, UCL Queen Square Institute of Neurology, London, United Kingdom | Department of Clinical and Movement Neurosciences, University College London, London, UK | Department of Clinical and Movement Neuros

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