Prominent publications by Nick W Watkin

KOL Index score: 14277

PURPOSE: Sentinel node biopsy is used to evaluate the nodal status of patients with clinically node-negative penile carcinoma. Its use is not widespread, and the majority of patients with clinically node-negative disease undergo an elective inguinal lymph node dissection. Reservations about the use of sentinel node biopsy include the fact that most current results come from one institution and the supposedly long learning curve associated with the procedure. The purpose of this study was ...

Known for Node Biopsy |  Squamous Cell |  Penile Carcinoma |  Negative Sentinel |  Nodal Status
KOL Index score: 13448

BACKGROUND: The European Association of Urology (EAU) guidelines advise an elective bilateral lymphadenectomy in clinically node-negative (cN0) patients with high-risk penile carcinoma (≥pT2, G3, or lymphovascular invasion [LVI]).

OBJECTIVE: Our aim was to assess prognostic factors for occult metastasis and to determine whether current EAU guidelines accurately stratify patients at high risk.

DESIGN, SETTING, AND PARTICIPANTS: Data of 342 cN0 patients with histologically proven invasive ...

Known for Lymph Node |  Negative Patients |  Occult Inguinal |  Penile Carcinoma |  Eau Guidelines
KOL Index score: 10284

BACKGROUND: Dynamic sentinel node biopsy (DSNB) in combination with ultrasound scan (USS) has been the technique of choice at our centre since 2004 for the assessment of nonpalpable inguinal lymph nodes (cN0) in patients with squamous cell carcinoma of the penis (SCCp). Sensitivity and false-negative rates may vary depending on whether results are reported per patient or per node basin, and with or without USS.

OBJECTIVE: To determine the long-term outcome of patients undergoing DSNB and ...

Known for Node Biopsy |  Patients Dsnb |  Squamous Cell |  Inguinal Basins |  Sentinel Lymph
KOL Index score: 9766

CONTEXT: Penile cancer has high mortality once metastatic spread has occurred. Local treatment can be mutilating and devastating for the patient. Progress has been made in organ-preserving local treatment, lymph node management, and multimodal treatment of lymphatic metastases, requiring an update of the European Association of Urology guidelines.

OBJECTIVE: To provide an evidence-based update of treatment recommendations based on the literature published since 2008.


Known for Penile Cancer |  Eau Guidelines |  2014 Update |  Adjuvant Chemotherapy |  Local Treatment
KOL Index score: 9000

BACKGROUND: Urethral stricture is a common cause of difficulty passing urine in men with prevalence of 0.5 %; about 62,000 men in the UK. The stricture is usually sited in the bulbar part of the urethra causing symptoms such as reduced urine flow. Initial treatment is typically by endoscopic urethrotomy but recurrence occurs in about 60% of men within 2 years. The best treatment for men with recurrent bulbar stricture is uncertain. Repeat endoscopic urethrotomy opens the narrowing but it ...

Known for Urethral Stricture |  Endoscopic Urethrotomy |  24 Months |  Urethroplasty Versus |  Recurrent Bulbar
KOL Index score: 8460

BACKGROUND: A systematic literature review did not identify a formally validated patient-reported outcome measure (PROM) for urethral stricture surgery.

OBJECTIVE: Devise a PROM for urethral stricture surgery and evaluate its psychometric properties in a pilot study to determine suitability for wider implementation.

DESIGN, SETTING, AND PARTICIPANTS: Constructs were identified from existing condition-specific and health-related quality of life (HRQoL) instruments. Men scheduled for ...

Known for Urethral Stricture Surgery |  Reported Outcome |  Content Validity |  Internal Consistency |  Psychometric Properties
KOL Index score: 8364

CONTEXT: Management of men with penile squamous cell carcinoma (PSCC) who have high-risk features following radical inguinal lymphadenectomy (ILND) remains controversial. European Association of Urology guidelines state that adjuvant inguinal radiotherapy (AIRT) is "not generally recommended". Despite this, many centres continue to offer AIRT to a subset of men.

OBJECTIVE: To undertake a systematic review of the evidence on AIRT in node-positive men with PSCC.


Known for Adjuvant Radiotherapy |  European Association |  Inguinal Lymph |  Penile Cancer |  Risk Bias
KOL Index score: 7941

BACKGROUND: Studies of interventions for urethral stricture have inferred patient benefit from clinician-driven outcomes or questionnaires lacking scientifically robust evidence of their measurement properties for men with this disease.

OBJECTIVE: To evaluate urethral reconstruction from the patients' perspective using a validated patient-reported outcome measure (PROM).

DESIGN, SETTING, AND PARTICIPANTS: Forty-six men with anterior urethral stricture at four UK urology centres completed ...

Known for Urethral Stricture |  Reported Outcome |  Validated Patient |  Treatment Satisfaction |  Urinary Symptoms
KOL Index score: 7577

AIMS: To determine whether Ki-67 immunoexpression in penile squamous cell carcinoma (PSCC) has a prognostic value and correlates with lymph node metastasis, human papillomavirus (HPV) infection and patient survival.

METHODS: 148 formalin-fixed paraffin-embedded PSCC samples were tissue-microarrayed, including 97 usual-type SCCs, 17 basaloid, 15 pure verrucous carcinomas, 2 warty and 17 mixed-type tumours. All samples were immunostained for Ki-67 protein. HPV DNA was detected with ...

Known for Squamous Cell |  Tumor Carcinoma |  Pscc Prognostic |  Tumour Grade |  Ki67 Expression
KOL Index score: 6878

IntroductionThe management of the regional lymph nodes in penile cancer patients, particularly when these lymph nodes are impalpable, remains controversial. Prophylactic bilateral inguinal lymphadenectomy is associated with high morbidity and is often unnecessary. However, there is no non-invasive or minimally invasive staging technique that can determine the lymph node status of penile cancer patients with 100% accuracy.MethodsWe reviewed the current literature to examine the role of ...

Known for Lymph Nodes |  Minimally Invasive |  Penile Cancer |  Node Biopsy |  Distant Metastases
KOL Index score: 6754

BACKGROUND: Urethral stricture affects 0.9% of men. Initial treatment is urethrotomy. Approximately, half of the strictures recur within 4 yr. Options for further treatment are repeat urethrotomy or open urethroplasty.

OBJECTIVE: To compare the effectiveness and cost-effectiveness of urethrotomy with open urethroplasty in adult men with recurrent bulbar urethral stricture.

DESIGN, SETTING, AND PARTICIPANTS: This was an open label, two-arm, patient-randomised controlled trial. UK National ...

Known for Urethral Stricture |  Urethrotomy Urethroplasty |  Versus Endoscopic |  Treatment Recurrent |  Male Adult
KOL Index score: 6286

OBJECTIVES: To improve the prognostic allocation of patients with penile squamous-cell carcinoma (PSCC) receiving regional lymph node dissection (LND).

PATIENTS AND METHODS: An international, multicenter, retrospective study was performed on patients with PSCC who received regional LND, with or without perioperative therapy, from 1980 to 2017. We first used a random forest (RF) method with missing data imputation. Additionally, data were modeled using Cox proportional hazard regression, ...

Known for Squamous Cell |  Perioperative Chemotherapy |  Patients Pscc |  Lymph Node |  Adjuvant Radiotherapy
KOL Index score: 6145

OBJECTIVE: To develop a novel postoperative prognostic tool, which attempts to integrate both pathological tumour stage and histopathological factors, for prediction of cancer-specific mortality (CSM) of squamous cell carcinoma of the penis (SCCP).

PATIENTS AND METHODS: Patients with SCCP treated with inguinal lymph node dissection (ILND) or sentinel LN biopsy at a single institution were used for nomogram development and internal validation (n = 434), while a second cohort was used for ...

Known for Squamous Cell |  Modified Staging |  Internal Validation |  Penis Sccp |  Model Performance
KOL Index score: 5978

OBJECTIVE: To evaluate the significance of close surgical margins in organ-sparing surgery (OSS) in the treatment of penile squamous cell carcinoma (pSCC) and clinicopathological factors that may influence local recurrence.

PATIENTS AND METHODS: At our tertiary referral centre, between March 2001 and September 2012, 332 patients treated with OSS for pSCC had clear surgical margins. As the focus was the impact of close clear margins on local recurrence, patients with positive margins were ...

Known for Local Recurrence Patients |  Sparing Surgery |  Squamous Cell |  Multivariate Analysis |  Surgical Margins
KOL Index score: 5915

OBJECTIVE: To examine the tissue expression of DNA topoisomerase I (Topo I) and IIalpha (Topo II), to pursue the possibility of future chemotherapy regimens for squamous cell carcinoma of the penis (SCCP), as high expression of Topo I might indicate sensitivity to the camptothecins, whereas high Topo II might indicate sensitivity to etoposide.

PATIENTS AND METHODS: In all, 73 patients with SCCP were reviewed and then tissue samples microarrayed. These were then stained with ...

Known for Expression Topo |  Tumor Carcinoma |  Type Dna |  Squamous Cell |  Antigens Neoplasm


Nick W Watkin: Influence Statistics

Sample of concepts for which Nick W Watkin is among the top experts in the world.
Concept World rank
dsnb uss #3

Key People For Penile Cancer

Top KOLs in the world
Simon Horenblas
penile cancer sentinel node cell carcinoma
Suks S Minhas
penile cancer erectile dysfunction european association
Philippe E Spiess
penile cancer radical cystectomy neoadjuvant chemotherapy
Curtis Alvin Pettaway
prostate cancer african ancestry lymph node
Antonio Leopoldo Cubilla
squamous cell human papillomavirus penile cancer
Oliver Walter Hakenberg
penile cancer radical prostatectomy cell carcinoma

Nick W Watkin:Expert Impact

Concepts for whichNick W Watkinhas direct influence:Penile cancer,  Node biopsy,  Adjuvant radiotherapy,  Urethral stricture,  European association,  Human papillomavirus,  Lymph node,  Squamous cell carcinoma.

Nick W Watkin:KOL impact

Concepts related to the work of other authors for whichfor which Nick W Watkin has influence:Penile cancer,  Lymph node,  Urethral stricture,  Squamous cell,  European association.



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St. George’s University Hospitals, NHS Foundation Trust, London, United Kingdom; | Penile Cancer Centre, St George's University Hospitals NHS Trust, London, UK | Penile Cancer Centre, St George's Healthcare NHS Trust, London, UK. | Department of Urol

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