Gordon D Raphael: Influence Statistics

Gordon D Raphael

Gordon D Raphael

Bethesda Allergy, Asthma and Research Center, LLC Bethesda, MDUSACorrespondenceraphael4@comcast.net | Asthma, Allergy and Clinical Research, Bethesda, Maryland, and | Asthma, ...

Gordon D Raphael: Expert Impact

Concepts for which Gordon D Raphael has direct influence: Persistent asthma , Gustatory rhinitis , Allergic rhinitis , Seasonal allergic rhinitis , Perennial allergic rhinitis , Glandular secretion , Nasal secretions .

Gordon D Raphael: KOL impact

Concepts related to the work of other authors for which for which Gordon D Raphael has influence: Allergic rhinitis , Nasal mucosa , Inhaled corticosteroids , Fluticasone propionate , Persistent asthma , Acoustic rhinometry , Leukotriene receptor antagonists .

KOL Resume for Gordon D Raphael

Year
2013

Bethesda Allergy, Asthma and Research Center, LLC Bethesda,

2012

Asthma, Allergy and Clinical Research, Bethesda, Maryland, and

2007

Environmental Information Association, Bethesda, Maryland.

Bethesda, MD, Bethesda, MD

2006

Private practice, Bethesda, Maryland

2002

St. John’s Medical Research Group (JHB), Springfield, Missouri, USA

2001

Madison, Wis, Bethesda, Md, Orange, Calif, and Research Triangle Park, NC

aUniversity of Wisconsin–Madison Medical School; bPrivate practice, Bethesda; cClinical Trials of Orange County; dGlaxo Wellcome Inc, Research Triangle Park

1999

From aprivate practice, Bethesda; bthe Department of Family Medicine, Southwestern Medical School, Dallas; cAllergy Associates Research Center, Portland; and dGlaxo Wellcome Inc, Research Triangle Park

1998

From Bethesda, Maryland;

1992

Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, and Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Md, USA

1991

From the Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., U.S.A.

1990

Bethesda, Md., USA

1989

From the Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USA

Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.

Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

1988

Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

1987

Medical Staff Fellow, Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

1978

Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, MD 20014, USA

Prominent publications by Gordon D Raphael

KOL-Index: 12992 . BACKGROUND: Both inhaled corticosteroids and leukotriene modifiers are used in the maintenance treatment of persistent asthma. OBJECTIVE: The goal was to compare the efficacy and safety of low-dose fluticasone propionate (FP) and montelukast as first-line maintenance therapy in symptomatic patients by using short-acting beta2-agonists alone to treat persistent asthma. METHODS: In this ...
Known for Persistent Asthma | Fp Montelukast | Dose Fluticasone | Shortacting Beta2agonists
KOL-Index: 12045 . BACKGROUND: Previous studies have shown that diphenhydramine and desloratadine effectively relieve symptoms of seasonal allergic rhinitis (SAR). OBJECTIVE: To compare the relative efficacy of 50 mg of diphenhydramine hydrochloride, 5 mg of desloratadine, and placebo in relieving symptoms in patients with moderate-to-severe SAR. METHODS: In this 1-week, multicenter, parallel-group, ...
Known for Allergic Rhinitis | Desloratadine Patients | Antagonists Histamine | Diphenhydramine Hydrochloride
KOL-Index: 11961 . BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration. However, the long-term safety and efficacy of ciclesonide are unknown. OBJECTIVE: To demonstrate the long-term safety of intranasal ciclesonide, 200 microg once ...
Known for Intranasal Ciclesonide | Allergic Rhinitis | Intraocular Pressure | 200 Microg
KOL-Index: 10925 . Nasal provocation tests with normal saline and methacholine (MC) were performed in 25 atopic and 27 nonatopic subjects in an effort to assess the sources of protein in induced airway secretions. Nasal lavages obtained at baseline and after provocation were analyzed for albumin, total protein, secretory IgA (sIgA), and total IgA. Compared with baseline levels or saline provocation, MC ...
Known for Induced Nasal | Total Protein | Secretory Iga Siga | Albumin Percent
KOL-Index: 10428 . A new nasal aerosol solution formulation of ciclesonide containing a hydrofluoroalkane propellant (CIC-HFA) delivered via a metered-dose inhaler is currently in clinical development as a potential treatment for allergic rhinitis (AR). This study evaluated the efficacy and tolerability of CIC-HFA 74- or 148-microgram doses compared with placebo in patients with perennial AR (PAR). Patients ...
Known for Allergic Rhinitis | Placebo Patients | Ciclesonide Nasal Aerosol | Tolerability Study
KOL-Index: 9755 . Nasal provocation tests were performed on nine atopic and 15 nonatopic subjects in order to assess the sources of protein in histamine-induced secretions and to examine the bilateral secretory response to unilaterally applied topical histamine (the nasonasal reflex). Nasal lavages were assayed for the following proteins: albumin, total protein, secretory IgA (sIgA), nonsecretory IgA (serum ...
Known for Nasal Secretion | Secretory Iga | Total Protein | Response Histamine
KOL-Index: 8970 . The antimicrobial proteins lactoferrin (Lf) and lysozyme (Ly) are invariably found in nasal secretions. To investigate the cellular sources and the secretory control of these nasal proteins in vivo, 34 adult subjects underwent nasal provocation tests with methacholine (MC), histamine (H), and gustatory stimuli. Nasal lavages were collected and analyzed for total protein (TP), albumin ...
Known for Nasal Secretions | Gel Electrophoresis | Glandular Secretion | Total Protein
KOL-Index: 8617 . Allergic rhinitis is characterized by a profuse rhinorrhea in addition to paroxysms of sneezing, nasal congestion, and pruritus. To define better the sources of nasal secretion produced during rhinitis, nasal allergen challenges were performed on nine atopic subjects with seasonal rhinitis. A single dose of allergen was sprayed into one side of the nose, and nasal lavages were collected ...
Known for Nasal Secretion | Total Protein | Lactoferrin Male | Allergen Challenge
KOL-Index: 8454 . BACKGROUND: Inhaled corticosteroids are recommended for the treatment of persistent asthma. Comparative clinical studies evaluating 2 or more doses of these agents are few. OBJECTIVE: We sought to compare the efficacy and safety of 2 doses of fluticasone propionate (88 micrograms twice daily and 220 micrograms twice daily) with 2 doses of beclomethasone dipropionate (168 micrograms twice ...
Known for Fluticasone Propionate | Persistent Asthma | Dose Beclomethasone | Inhaled Corticosteroids
KOL-Index: 7322 . The secretion of proteins from the human nasal mucosa induced by histamine, alpha-adrenergic, beta-adrenergic, and cholinergic agonists was studied in vivo and in vitro. Glandular secretion of lactoferrin, lysozyme (in vivo only), and respiratory glycoconjugates (RGCs) was measured. Vascular permeability was determined in vivo by albumin secretion in relationship to the other proteins. ...
Known for Glandular Secretion | Nasal Mucosa | Vascular Permeability | Lactoferrin Lysozyme
KOL-Index: 7171 . Neutrophil specific granule deficiency (SGD) is a congenital disorder associated with an impaired inflammatory response and a deficiency of several granule proteins. The underlying abnormality causing the deficiencies is unknown. We examined mRNA transcription and protein synthesis of two neutrophil granule proteins, lactoferrin and myeloperoxidase in SGD. Metabolically labeled SGD ...
Known for Granule Deficiency | Gene Expression | Sgd Patients | Neutrophil Lactoferrin
KOL-Index: 7032 . To compare the efficacy and safety of fluticasone propionate and zafirlukast in patients with relatively stable persistent asthma who were previously treated with inhaled corticosteroids and short-acting beta(2)-agonists.A total of 440 patients (> or =12 years of age) previously treated with inhaled corticosteroids (beclomethasone dipropionate or triamcinolone acetonide) and short-acting ...
Known for Persistent Asthma | Fluticasone Propionate | Inhaled Corticosteroids | Efficacy Safety
KOL-Index: 6770 . OBJECTIVE: Some patients with allergic rhinitis (AR) may prefer nonaqueous intranasal corticosteroid aerosols because of unwanted attributes of aqueous formulations. The mandatory removal of chlorofluorocarbon-propelled nonaqueous aerosols from the market limited available treatment options. To fulfill this unmet need, a nonaqueous, hydrofluoroalkane-propelled beclomethasone dipropionate ...
Known for Allergic Rhinitis | Beclomethasone Dipropionate | Inhalation Administration | Nasal Aerosol
KOL-Index: 6402 . The consumption of certain foods causes watery rhinorrhea (gustatory rhinitis) in many individuals. To examine the underlying mechanisms responsible for this common phenomenon, 12 subjects ingested control foods and positive foods (foods that cause rhinorrhea). Nasal lavages performed 10 minutes after each food challenge were analyzed for albumin and total protein. Positive food challenge, ...
Known for Gustatory Rhinitis | Total Protein | Topical Atropine | Submucosal Glands
KOL-Index: 6069 . To examine the sources of IgG in nasal secretions, nasal provocation tests with histamine (H) and methacholine (MC) were performed on 22 subjects. Nasal lavages were assayed for IgG, total protein, albumin (Alb), nonsecretory IgA (nonsIgA), and secretory IgA (sIgA). H stimulation dramatically increased the secretion of IgG, nonsIgA, and Alb and also increased the proportion of these ...
Known for Total Protein | Nasal Secretions | Secretory Iga | Provocation Tests

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Bethesda Allergy, Asthma and Research Center, LLC Bethesda, MDUSACorrespondenceraphael4@comcast.net | Asthma, Allergy and Clinical Research, Bethesda, Maryland, and | Asthma, Allergy and Clinical Research, Bethesda, Maryland | Environmental Informati