• Disease
  • Persistent
  • Persistent Asthma
  • Gordon D Raphael

    Prominent publications by Gordon D Raphael

    KOL Index score: 12992

    BACKGROUND: Both inhaled corticosteroids and leukotriene modifiers are used in the maintenance treatment of persistent asthma.

    OBJECTIVE: The goal was to compare the efficacy and safety of low-dose fluticasone propionate (FP) and montelukast as first-line maintenance therapy in symptomatic patients by using short-acting beta2-agonists alone to treat persistent asthma.

    METHODS: In this multicenter, randomized, double-blind, double-dummy, parallel-group study, 533 patients (>15 years old) ...

    Also Ranks for: Persistent Asthma |  fp montelukast |  dose fluticasone |  shortacting beta2agonists |  propionate compared
    KOL Index score: 12045

    BACKGROUND: Previous studies have shown that diphenhydramine and desloratadine effectively relieve symptoms of seasonal allergic rhinitis (SAR).

    OBJECTIVE: To compare the relative efficacy of 50 mg of diphenhydramine hydrochloride, 5 mg of desloratadine, and placebo in relieving symptoms in patients with moderate-to-severe SAR.

    METHODS: In this 1-week, multicenter, parallel-group, randomized, double-blind, double-dummy, placebo-controlled study, 610 patients with moderate-to-severe SAR ...

    Also Ranks for: Allergic Rhinitis |  desloratadine patients |  antagonists histamine |  diphenhydramine hydrochloride |  symptom scores
    KOL Index score: 11961

    BACKGROUND: Ciclesonide is a corticosteroid in development for allergic rhinitis that has been shown to be safe and effective in seasonal allergic rhinitis and perennial allergic rhinitis (PAR) trials of up to 6 weeks in duration. However, the long-term safety and efficacy of ciclesonide are unknown.

    OBJECTIVE: To demonstrate the long-term safety of intranasal ciclesonide, 200 microg once daily, in patients with PAR.

    METHODS: Patients (> or = 12 years old) with a 2-year or longer history ...

    Also Ranks for: Intranasal Ciclesonide |  allergic rhinitis |  intraocular pressure |  200 microg |  52 weeks
    KOL Index score: 10925

    Nasal provocation tests with normal saline and methacholine (MC) were performed in 25 atopic and 27 nonatopic subjects in an effort to assess the sources of protein in induced airway secretions. Nasal lavages obtained at baseline and after provocation were analyzed for albumin, total protein, secretory IgA (sIgA), and total IgA. Compared with baseline levels or saline provocation, MC provocation increased the secretion of albumin (p less than 0.025), total protein (p less than 0.001), ...

    Also Ranks for: Induced Nasal |  total protein |  secretory iga siga |  albumin percent |  saline provocation
    KOL Index score: 10428

    A new nasal aerosol solution formulation of ciclesonide containing a hydrofluoroalkane propellant (CIC-HFA) delivered via a metered-dose inhaler is currently in clinical development as a potential treatment for allergic rhinitis (AR). This study evaluated the efficacy and tolerability of CIC-HFA 74- or 148-microgram doses compared with placebo in patients with perennial AR (PAR). Patients ≥12 years of age with a ≥ 2-year history of PAR were randomized in a placebo-controlled, ...

    Also Ranks for: Allergic Rhinitis |  placebo patients |  ciclesonide nasal aerosol |  tolerability study |  cic hfa
    KOL Index score: 9755

    Nasal provocation tests were performed on nine atopic and 15 nonatopic subjects in order to assess the sources of protein in histamine-induced secretions and to examine the bilateral secretory response to unilaterally applied topical histamine (the nasonasal reflex). Nasal lavages were assayed for the following proteins: albumin, total protein, secretory IgA (sIgA), nonsecretory IgA (serum IgA), and total IgA. Histamine stimulation produced a profound ipsilateral protein secretion ...

    Also Ranks for: Nasal Secretion |  secretory iga |  total protein |  response histamine |  provocation tests
    KOL Index score: 8970

    The antimicrobial proteins lactoferrin (Lf) and lysozyme (Ly) are invariably found in nasal secretions. To investigate the cellular sources and the secretory control of these nasal proteins in vivo, 34 adult subjects underwent nasal provocation tests with methacholine (MC), histamine (H), and gustatory stimuli. Nasal lavages were collected and analyzed for total protein (TP), albumin (Alb), Lf, and Ly. MC (25 mg), H (1 mg), and gustatory stimuli (spicy foods) all increased the ...

    Also Ranks for: Nasal Secretions |  gel electrophoresis |  glandular secretion |  total protein |  submucosal glands
    KOL Index score: 8617

    Allergic rhinitis is characterized by a profuse rhinorrhea in addition to paroxysms of sneezing, nasal congestion, and pruritus. To define better the sources of nasal secretion produced during rhinitis, nasal allergen challenges were performed on nine atopic subjects with seasonal rhinitis. A single dose of allergen was sprayed into one side of the nose, and nasal lavages were collected bilaterally for 7 hours. Nasal lavages were assayed for protein (total protein, albumin, lactoferrin, ...

    Also Ranks for: Nasal Secretion |  total protein |  lactoferrin male |  allergen challenge |  atopic subjects
    KOL Index score: 8454

    BACKGROUND: Inhaled corticosteroids are recommended for the treatment of persistent asthma. Comparative clinical studies evaluating 2 or more doses of these agents are few.

    OBJECTIVE: We sought to compare the efficacy and safety of 2 doses of fluticasone propionate (88 micrograms twice daily and 220 micrograms twice daily) with 2 doses of beclomethasone dipropionate (168 micrograms twice daily and 336 micrograms twice daily) in subjects with persistent asthma.

    METHODS: Three hundred ...

    Also Ranks for: Fluticasone Propionate |  persistent asthma |  dose beclomethasone |  inhaled corticosteroids |  greater improvements
    KOL Index score: 7322

    The secretion of proteins from the human nasal mucosa induced by histamine, alpha-adrenergic, beta-adrenergic, and cholinergic agonists was studied in vivo and in vitro. Glandular secretion of lactoferrin, lysozyme (in vivo only), and respiratory glycoconjugates (RGCs) was measured. Vascular permeability was determined in vivo by albumin secretion in relationship to the other proteins. Muscarinic stimulation by methacholine induced significant glandular secretion (lactoferrin, lysozyme ...

    Also Ranks for: Glandular Secretion |  nasal mucosa |  vascular permeability |  lactoferrin lysozyme |  muscarinic receptors
    KOL Index score: 7171

    Neutrophil specific granule deficiency (SGD) is a congenital disorder associated with an impaired inflammatory response and a deficiency of several granule proteins. The underlying abnormality causing the deficiencies is unknown. We examined mRNA transcription and protein synthesis of two neutrophil granule proteins, lactoferrin and myeloperoxidase in SGD. Metabolically labeled SGD nucleated marrow cells produced normal amounts of myeloperoxidase, but there was no detectable synthesis of ...

    Also Ranks for: Granule Deficiency |  gene expression |  sgd patients |  neutrophil lactoferrin |  nasal secretions
    KOL Index score: 7032

    To compare the efficacy and safety of fluticasone propionate and zafirlukast in patients with relatively stable persistent asthma who were previously treated with inhaled corticosteroids and short-acting beta(2)-agonists.A total of 440 patients (> or =12 years of age) previously treated with inhaled corticosteroids (beclomethasone dipropionate or triamcinolone acetonide) and short-acting beta(2)-agonists were included in this randomized double-blind study. After an 8-day run-in period, ...

    Also Ranks for: Persistent Asthma |  fluticasone propionate |  inhaled corticosteroids |  efficacy safety |  pulmonary function
    KOL Index score: 6770

    OBJECTIVE: Some patients with allergic rhinitis (AR) may prefer nonaqueous intranasal corticosteroid aerosols because of unwanted attributes of aqueous formulations. The mandatory removal of chlorofluorocarbon-propelled nonaqueous aerosols from the market limited available treatment options. To fulfill this unmet need, a nonaqueous, hydrofluoroalkane-propelled beclomethasone dipropionate (BDP) nasal aerosol was developed and approved for treatment of AR nasal symptoms. As part of the ...

    Also Ranks for: Allergic Rhinitis |  beclomethasone dipropionate |  inhalation administration |  nasal aerosol |  aqueous formulations
    KOL Index score: 6402

    The consumption of certain foods causes watery rhinorrhea (gustatory rhinitis) in many individuals. To examine the underlying mechanisms responsible for this common phenomenon, 12 subjects ingested control foods and positive foods (foods that cause rhinorrhea). Nasal lavages performed 10 minutes after each food challenge were analyzed for albumin and total protein. Positive food challenge, but not control food challenge, induced rhinorrhea in all subjects. Positive food challenge ...

    Also Ranks for: Gustatory Rhinitis |  total protein |  topical atropine |  submucosal glands |  nasal lavages
    KOL Index score: 6069

    To examine the sources of IgG in nasal secretions, nasal provocation tests with histamine (H) and methacholine (MC) were performed on 22 subjects. Nasal lavages were assayed for IgG, total protein, albumin (Alb), nonsecretory IgA (nonsIgA), and secretory IgA (sIgA). H stimulation dramatically increased the secretion of IgG, nonsIgA, and Alb and also increased the proportion of these proteins compared to total protein. H-induced protein secretion was significantly inhibited by nasal ...

    Also Ranks for: Total Protein |  nasal secretions |  secretory iga |  provocation tests |  humans immunoglobulin


    Gordon D Raphael: Influence Statistics

    Sample of concepts for which Gordon D Raphael is among the top experts in the world.
    Concept World rank
    doses bdp nasal #2
    rhinorrhea produced #2
    lysozyme percent #2
    profuse rhinorrhea #2
    bdp nasal doses #2
    nonaqueous intranasal #2
    ipsilateral protein #2
    oncedaily bdp nasal #2
    gustatory rhinitis syndrome #2
    histamine responses patients #2
    pretreatment topical atropine #2
    rhinitis produced #2
    lactoferrin percent #2
    positive foods foods #2
    antimicrobial factors lfn #2
    spicy hot foods #2
    nasal pretreatment #2
    secretion recurrent #2
    mast cells centrifugation #2
    lavages assayed #2
    albumin sinusitis #2
    igg lzm #2
    patients lfn #2
    positive foods #2
    95 bdp nasal #2
    produced rhinorrhea #2
    glandular antimicrobial factors #2
    contralateral secretions #2
    profuse watery rhinorrhea #2
    siga lzm #2
    lfn lzm #2
    rhinorrhea secretion #2
    nsiga #2
    lzm histamine responses #2
    positive spicy foods #2
    positive spicy #2
    lactoferrin male allergic #2
    µg 320 #2
    syndrome pretreatment #2
    atropine gustatory rhinitis #2
    lzm siga #2
    nsiga siga #2
    80 µg placebo #2

    Key People For Persistent Asthma

    Top KOLs in the world
    William W Busse
    severe asthma allergic rhinitis lung function
    Stanley J Szefler
    asthma control lung function inhaled corticosteroids
    Paul M O'Byrne
    airway hyperresponsiveness mild asthma bone marrow
    Peter John Barnes
    nitric oxide chronic obstructive oxidative stress
    Søren Erik Pedersen
    asthma control fluticasone propionate lung function
    Scott T Weiss
    normative aging study lung function airway responsiveness

    Gordon D Raphael:Expert Impact

    Concepts for whichGordon D Raphaelhas direct influence:Persistent asthma,  Gustatory rhinitis,  Allergic rhinitis,  Seasonal allergic rhinitis,  Perennial allergic rhinitis,  Glandular secretion,  Nasal secretions,  Intranasal ciclesonide.

    Gordon D Raphael:KOL impact

    Concepts related to the work of other authors for whichfor which Gordon D Raphael has influence:Allergic rhinitis,  Nasal mucosa,  Inhaled corticosteroids,  Fluticasone propionate,  Persistent asthma,  Acoustic rhinometry,  Leukotriene receptor antagonists.



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