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KOL Resume for W Donald Shields (infantile spinal muscular atrophy, syndrome, syndromes, muscular, atrophy, spinal, spinal muscular atrophy)
| Year | |
|---|---|
| 2016 | UCLA Medical Center, Los Angeles, CA, USA |
| 2014 | David Geffen School of Medicine at UCLA Pediatric Epilepsy Program Los Angeles California U.S.A |
| 2013 | Mattel Children's Hospital and David Geffen School of Medicine at UCLA Division of Neurology Department of Pediatrics Los Angeles California U.S.A Department of Pediatrics, UCLA, Box 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USA |
| 2011 | Division of Pediatric Neurology, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles, CA, USA Department of Neurology‐Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, U.S.A |
| 2010 | Mattel Children's Hospital at the University of California-Los Angeles, Los Angeles, CA, USA From the Departments of Neurosurgery (M.H., T.R.V., G.W.M.) and Neurology (H.V.V.), Divisions of Pediatric Neurology (M.S.P., J.Y.W., J.T.L., J.H.M., S.Y., W.D.S., R.S.), Neuroradiology (N.S.), and Neuropathology (H.V.V.), David Geffen School of Medicine, University of California, Los Angeles. |
| 2009 | UCLA Department of Pediatrics, California, U.S.A Neurology |
| 2008 | Department of Pediatrics, University of California at Los Angeles (UCLA), Los Angeles, California, U.S.A From Neuroradiology (N.S., J. Kung, S.J.S., J. Koo), Pediatric Neurology (S.K., J.Y.W., J.T.L., R.S., W.D.S.), Neurology (R.S., W.D.S., J.E., H.V.V.), Neuropathology (H.M., W.H.Y., H.V.V.), Neurosurgery (I.F., G.W.M.), Neurobiology (J.E.), Psychiatry and Behavioral Sciences (J.E.), The Brain Research Institute (J.E., W.H.Y., H.V.V., G.W.M.), and The Mental Retardation Research Center (H.V.V., G.W.M.), David Geffen School of Medicine, University of California, Los Angeles, CA. |
| 2007 | Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA Division of Pediatric Neurology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California |
| 2006 | UCLA Departments of Neurology and Pediatrics, CA, United States Department of Pediatrics, University of California at Los Angeles |
| 2005 | From the Divisions of Neurosurgery (Dr. Mathern), Pediatric Neurology (Drs. Jonas, Koh, Wu, Sankar, and Shields, S. Yudovin), Neuropathology (Dr. Vinters), and Departments of Neurology (Drs. Shields and Vinters), and Psychiatry and Biobehavioral Sciences (Drs. Asarnow and LoPresti), The Brain Research Institute (Drs. Shields, Vinters, and Mathern) and The Mental Retardation Research Center (Drs. Asarnow, Shields, Vinters, and Mathern); David Geffen School of Medicine; University of California, Los Angeles. The Mental Retardation Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, U.S.A |
| 2004 | Division of Pediatric Neurology David Geffen School of Medicine at University of California Los Angeles, 22-474 MDCC, Box 91572, 90095, Los Angeles, CA, USA From the Royal Children’s Hospital (Dr. Mackay), Victoria, Australia; Hospital for Sick Children (Drs. Weiss and Snead, T. Adams-Webber and D. Stephens) and Faculty of Medicine (Drs. Weiss and Snead, D. Stephens), University of Toronto, Ontario, Canada; Loma Linda University School of Medicine (Dr. Ashwal), CA; Montefiore Medical Center (Drs. Ballaban-Gill and Shinnar), Albert Einstein College of Medicine, New York; University of California at Irvine (Dr. Baram) and Mattel Children’s Hospital, University of California at Los Angeles (Dr. Shields); Miami Children’s Hospital (Dr. Duchowny), FL; National Institute of Neurological Disorders and Stroke (Dr. Hirtz), NIH, Washington, DC; Medical College of Virginia (Dr. Pellock), Virginia Commonwealth University, Richmond; and Cleveland Clinic Foundation (Dr. Wyllie), OH. |
| 2003 | Neurology and Pediatrics, University of California at Los Angeles, Los Angeles; and |
| 2002 | Division of Pediatric Neurology, Mattel Children's Hospital, University of California, Los Angeles, California 90095, USA. Departments of Neurology and Pediatrics University of California, Los Angeles Los Angeles, California 90095, USA Mattel Children's Hospital at UCLA, Los Angeles, California, U.S.A |
| 2001 | Department of Neurology and Pediatrics, University of California, Los Angeles |
| 2000 | UCLA Medical Center, Los Angeles, CA 90095, USA |
| 1999 | The Mental Retardation Research Center, University of California, Los Angeles, Los Angeles, U.S.A Department of Psychiatry, Mental Retardation Research Center, Departments of Pediatrics and Neurology and, Department of Psychology, UCLA, Los Angeles, Calif., USA |
| 1998 | UCLA School of Medicine, Los Angeles, Calijornia |
| 1997 | Department of Psychiatry and Biobehavioral Sciences. University of California. Los Angeles |
| 1996 | Department of Pediatric Neurology, UCLA Medical Center, 90095, Los Angeles, CA, USA |
| 1995 | From the Department of Pediatrics and Neurology; University of California; Los Angeles, School of Medicine; Los Angeles, California, USA |
| 1994 | Division of Pediatric Neurology, UCLA School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90024‐1752, U.S.A. Departments of Neurology and Pediatrics |
| 1993 | Department of Pediatrics, Neurology, University of California at Los Angeles School of Medicine, Los Angeles, California |
| 1992 | Departments of Neurology and Pediatrics. University of California at Los Angeles |
| 1991 | Dr. Caplan, Assistant Professor, is with the Division of Child Psychiatry, Pediatric Epilepsy Research Group, University of California, Los Angeles. Dr. Shields, Associate Professor, and Ms. Yudovin are with the Departments of Neurology and Pediatrics, Pediatric Epilepsy Research Group, University of California, Los Angeles. Dr. Mori, Assistant Clinical Professor, is currently affiliated with the Department of Psychiatry, University of California at Irvine. Divisions of Pediatric Neurology, UCLA School of Medicine Los Angeles, CA |
| 1990 | Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, CA Division of Endocrinology and Metabolism, University of California at Los Angeles School of Medicine, USA |
| 1989 | Associate Professor and Chief, Division of Pediatric Neurology, UCLA School of Medicine, Los Angeles, California |
| 1988 | Department of Pediatrics University of California, Los Angeles, School of Medicine USA |
| 1984 | Departments of Pediatrics |
| 1982 | Department of Neurology, University of California, Los Angeles, Calif. USA |
| 1981 | Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90024 |
Prominent publications by W Donald Shields
Vigabatrin (VGB) is a structural analogue of gamma-aminobutyric acid (GABA) that irreversibly inhibits GABA-transaminase (GABA-T), increasing brain levels of GABA. VGB is under assessment for treatment of infantile spasms (IS) and refractory complex partial seizures (CPS). Response can be rapid with spasm cessation following approximately 2 weeks of therapy. Patients with symptomatic tuberous sclerosis (TS) and other patients have achieved spasm cessation. Comparison with ACTH has been ...
| Known for Vgb Patients | 12 Weeks | Adults Cps | Treatment Infantile Spasms | Visual Field |
Efficacy and Safety of Levetiracetam in Children with Partial Seizures: An Open‐label Trial
[ PUBLICATION ]
PURPOSE: To assess the efficacy and safety of levetiracetam (LEV) as adjunctive therapy in children with treatment-resistant partial-onset seizures.
METHODS: Children (aged 6-12 years) with treatment-resistant partial-onset seizures receiving one standard antiepileptic drug (AED) were eligible. After a 4-week baseline period, children received LEV in a 6-week titration phase (target dose, 40 mg/kg/day) followed by an 8-week evaluation phase. Seizure frequency during the evaluation period ...
| Known for Partial Seizures | Lev Children | Efficacy Safety | Combination Epilepsies | Seizure Frequency |
Magnetic resonance imaging abnormalities associated with vigabatrin in patients with epilepsy
[ PUBLICATION ]
PURPOSE: Vigabatrin used to treat infantile spasms (IS) has been associated with transient magnetic resonance imaging (MRI) abnormalities. We carried out a retrospective review to better characterize the frequency of those abnormalities in IS and in children and adults treated with vigabatrin for refractory complex partial seizures (CPS).
METHODS: Medical records and 332 cranial MRIs from 205 infants (aged 16 years) with CPS were re-reviewed. Prespecified MRI abnormalities were defined ...
| Known for Magnetic Resonance | Mri Abnormalities | Vigabatrin Cps | Children Adults | Infants Prevalence |
Psychopathology and Pediatric Complex Partial Seizures: Seizure‐related, Cognitive, and Linguistic Variables
[ PUBLICATION ]
PURPOSE: This study examined the role of cognition, language, seizure-related, and demographic variables in the psychopathology of children with complex partial seizure disorder (CPS) of average intelligence.
METHODS: One-hundred one CPS and 102 normal children, aged 5.1 to 16.9 years, had a structured psychiatric interview and cognitive and language testing. Parents provided demographic, perinatal, and seizure-related information, as well as behavioral information through the Child ...
| Known for Complex Partial | Linguistic Variables | Psychopathology Children | Disorders Child | Cognitive Deficits |
Measures of Psychopathology in Children With Complex Partial Seizures and Primary Generalized Epilepsy With Absence
[ PUBLICATION ]
OBJECTIVE: This investigation examined psychopathology in 48 children with complex partial seizures (CPS), 39 children with primary generalized epilepsy with absence (PGE), and 59 nonepileptic children, aged 5 to 16 years, by comparing the Child Behavior Checklist (CBCL) and the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS).
METHOD: The CBCL was completed by parents and the K-SADS was administered to both parent and child.
RESULTS: The CBCL ...
| Known for Complex Partial Seizures | Absence Epilepsy | Psychopathology Children | Cps Pge | Primary Generalized |
FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsy
[ PUBLICATION ]
OBJECTIVE: Patients with cortical dysplasia (CD) are difficult to treat because the MRI abnormality may be undetectable. This study determined whether fluorodeoxyglucose (FDG)-PET/MRI coregistration enhanced the recognition of CD in epilepsy surgery patients.
METHODS: Patients from 2004-2007 in whom FDG-PET/MRI coregistration was a component of the presurgical evaluation were compared with patients from 2000-2003 without this technique. For the 2004-2007 cohort, neuroimaging and clinical ...
| Known for Cortical Dysplasia | Type Patients | Mri Coregistration | Presurgical Evaluation | Fluorodeoxyglucose Pet |
OBJECTIVE: To determine the current best practice for treatment of infantile spasms in children.
METHODS: Database searches of MEDLINE from 1966 and EMBASE from 1980 and searches of reference lists of retrieved articles were performed. Inclusion criteria were the documented presence of infantile spasms and hypsarrhythmia. Outcome measures included complete cessation of spasms, resolution of hypsarrhythmia, relapse rate, developmental outcome, and presence or absence of epilepsy or an ...
| Known for Infantile Spasms | Insufficient Evidence | Medical Treatment | Adrenocorticotropic Hormone Acth | Developmental Outcome |
PURPOSE: This study compared frontotemporal brain volumes in children with childhood absence epilepsy (CAE) to age- and gender-matched children without epilepsy. It also examined the association of these volumes with seizure, demographic, perinatal, intelligence quotient (IQ), and psychopathology variables.
METHODS: Twenty-six children with CAE, aged 7.5-11.8 years, and 37 children without epilepsy underwent brain magnetic resonance imaging (MRI) scans at 1.5 Tesla. Tissue was segmented, ...
| Known for Childhood Absence Epilepsy | Frontal Lobe | Brain Volumes | Children Cae | Intelligence Tests |
PURPOSE: This study examined affective disorders, anxiety disorders, and suicidality in children with epilepsy and their association with seizure-related, cognitive, linguistic, family history, social competence, and demographic variables.
METHODS: A structured psychiatric interview, mood self-report scales, as well as cognitive and language testing were administered to 100 children with complex partial seizures (CPSs), 71 children with childhood absence epilepsy (CAE), and 93 normal ...
| Known for Anxiety Disorders | Pediatric Epilepsy | Suicidal Ideation | Social Competence | Suicide Attempt |
Formal Thought Disorder and Psychopathology in Pediatric Primary Generalized and Complex Partial Epilepsy
[ PUBLICATION ]
OBJECTIVE: To examine whether formal thought disorder and psychopathology occurred in children with complex partial seizures (CPS) rather than children with primary generalized epilepsy with absences (PGE) or nonepileptic children.
METHOD: Formal thought disorder was coded in 30 children with CPS, 24 children with PGE, and 61 nonepileptic children, and structured interview-based psychiatric diagnoses were obtained for the epileptic subjects.
RESULTS: The CPS subjects had significantly ...
| Known for Complex Partial Epilepsy | Formal Thought Disorder | Cps Pge | Illogical Thinking | Primary Generalized |
Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex
[ PUBLICATION ]
BACKGROUND: The unambiguous identification of the epileptogenic tubers in individuals with tuberous sclerosis complex (TSC) can be challenging. We assessed whether magnetic source imaging (MSI) and coregistration of (18)fluorodeoxyglucose PET (FDG-PET) with MRI could improve the identification of the epileptogenic regions noninvasively in children with TSC.
METHODS: In addition to standard presurgical evaluation, 28 children with intractable epilepsy from TSC referred from 2000 to 2007 ...
| Known for Seizure Freedom | Children Tsc | Intractable Epilepsy | Tuberous Sclerosis | Younger Age |
Postoperative Seizure Control and Antiepileptic Drug Use in Pediatric Epilepsy Surgery Patients: The UCLA Experience, 1986–1997
[ PUBLICATION ]
PURPOSE: Young children with refractory symptomatic epilepsy are at risk for developing neurologic and cognitive disabilities. Stopping the seizures may prevent these disabilities, but it is unclear whether resective surgery is associated with adequate long-term seizure control.
METHODS: This study determined pre- and postsurgery seizure frequency and antiepileptic drug (AED) use (6 months to 10 years) in children with symptomatic seizures from unilateral cortical dysplasia (CD; n = 64) ...
| Known for Seizure Control | Surgery Patients | Antiepileptic Drug | Ucla Experience | 5 Years |
Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone
[ PUBLICATION ]
PURPOSE: This study investigated the short-term response to a standardized hormonal therapy protocol for treatment of infantile spasms.
METHODS: Twenty-seven children with video electroencephalography (EEG)-confirmed infantile spasms received very high dose (8 mg/kg/day, max 60 mg/day) oral prednisolone for 2 weeks. Response (absence of both hypsarrhythmia and spasms) to prednisolone was ascertained by repeat overnight video-EEG. Responders were tapered over 2 weeks and nonresponders ...
| Known for Infantile Spasms | Dose Prednisolone | Adrenocorticotropic Hormone | 2 Weeks | Acth Initial Treatment |
PURPOSE: Evidence for a poor psychiatric, social, and vocational adult outcome in childhood absence epilepsy (CAE) suggests long-term unmet mental health, social, and vocational needs. This cross-sectional study examined behavioral/emotional, cognitive, and linguistic comorbidities as well as their correlates in children with CAE.
METHODS: Sixty-nine CAE children aged 9.6 (SD = 2.49) years and 103 age- and gender-matched normal children had semistructured psychiatric interviews, as well ...
| Known for Children Cae | Childhood Absence Epilepsy | Child Behavior | Anxiety Disorders | Psychiatric Interviews |
W Donald Shields: Influence Statistics
| Concept | World rank |
|---|---|
| recentonset infantile spasms | #1 |
| childhood children epilepsy | #1 |
| time cortical resection | #1 |
| logical sequences physicians | #1 |
| infant intention vigabatrin | #1 |
| etiologies west | #1 |
| goal epilepsy surgery | #1 |
| series developmental outcomes | #1 |
| special pediatric | #1 |
| lives unfortunate children | #1 |
| infantile spasms physicians | #1 |
| seizures cps | #1 |
| achieved spasm | #1 |
| lennoxgastaut unverrichtlundborg syndrome | #1 |
| suicidal ideation 33 | #1 |
| videoelectroencephalogram total | #1 |
| subsequent openlabel treatment | #1 |
| cpss cae | #1 |
| etiologies wests syndrome | #1 |
| dosedependent spasm reduction | #1 |
| safety vigabatrin | #1 |
| cps pge | #1 |
| cortical resection child | #1 |
| postsurgery developmental | #1 |
| infantile spasms seizures | #1 |
| shields wd | #1 |
| drugs vagus | #1 |
| seizure control level | #1 |
| broad therapeutic options | #1 |
| 1 hemispherotomy | #1 |
| disorder cps | #1 |
| hemispheric resection | #1 |
| statementthe extension | #1 |
| efficacy treatment responders | #1 |
| big consequences | #1 |
| postsurgical development | #1 |
| infantile united | #1 |
| children catastrophic | #1 |
| intractable infantile | #1 |
| cognition language | #1 |
| retardation catastrophic | #1 |
| controlling seizures association | #1 |
| effects intractable epilepsy | #1 |
| response lowdose vigabatrin | #1 |
| infantile sturgeweber syndrome | #1 |
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Key People For Infantile Spasms
W Donald Shields:Expert Impact
Concepts for whichW Donald Shieldshas direct influence:Infantile spasms, Pertussis immunization, Thought disorder, Complex partial, Complex partial epilepsy, Pediatric epilepsy, Status epilepticus, Complex partial seizures.
W Donald Shields:KOL impact
Concepts related to the work of other authors for whichfor which W Donald Shields has influence:Infantile spasms, Epilepsy surgery, West syndrome, Antiepileptic drugs, Cortical dysplasia, Status epilepticus, Tuberous sclerosis.
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