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    • Susana Fiorentino
    • Susana Fiorentino

      Susana Fiorentino

      Grupo de Inmunobiología y Biología Celular, Unidad de Investigación en Ciencias Biomédicas, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia, ...



      KOL Resume for Susana Fiorentino


      Grupo de Inmunobiología y Biología Celular, Unidad de Investigación en Ciencias Biomédicas, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia, javeriana.edu.co


      Grupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, P.O. Box 56710 Bogotá DC, Colombia;, (L.Y.R.);, (S.F.)

      Group of Immunobiology and Cell Biology, Faculty of Sciences, Pontificia Universidad Javeriana, Bogotá, Colombia


      Pontificia Universidad Javeriana, Bogotá, Colombia


      Grupo de Inmunobiología y Biología Celular, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia


      Grupo de Inmunobiología y Unidad de Investigación en Ciencias Biomédicas, Pontificia Universidad Javeriana, POB 56710, Bogotá DC, Colombia


      Grupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Bogotá, Colombia.


      Grupo De Inmunobiología Y Biología Celular Departamento De Microbiología Facultad De Ciencias Pontificia Universidad Javeriana Bogotá Colombia


      Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Carrera 7 N. 43-82 Building 52, Office 608, Bogotá, Colombia


      Grupo de Inmunobiología y Biología Celular. Departamento de Microbiología. Facultad de Ciencias, Pontificia Universidad Javeriana, Carrera 7 N. 43-82 Building 52, Office 608, Bogotá, Colombia


      Immunology and Cellular Biology Group, Faculty of Sciences, Pontificia Universidad Javeriana Bogotá, Colombia


      Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá

      Inserm U580, France, Université Paris Descartes, Faculté de Médecine René Descartes, Paris, France.


      Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Universidad Javeriana, Bogotá, Colombia


      Grupo de Inmunobiologia y Biologia Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia


      Grupo de Inmunobiología and Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia


      Immunobiology Group, Faculty of Science, Pontificia Universidad Javeriana, Bogotá, Colombia


      Grupo de Inmunobiologı́a and Departamento de Microbiologı́a, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota, Colombia

      INSERM U462, Centre G. Hayem, Hôpital Saint-Louis, 1, Avenue Claude Vellefaux, 75010 Paris, France



      Susana Fiorentino: Influence Statistics

      Sample of concepts for which Susana Fiorentino is among the top experts in the world.
      Concept World rank
      presente frações #2
      extract caesalpinia spinosa #2
      hypothesis great extent #2
      phytochemicals p2et #2
      celular apoptosis #2
      presente fracciones #2
      p2et model p2et #2
      extract p2et #2
      negativamente expresión #2
      preparadas utilizando #2
      apoptosis immunogenic signals #2
      volunteers p2et #2
      palliacea fractions apoptosis #2
      palliacea identificados #2
      expresión objetivo #2
      colombian healthy volunteers #2
      desreplicación #2
      mitocondria regula #2
      control p2et #2
      fracciones expresión #2
      chemotherapeutic evaluated #2
      dependente mitocôndria #2
      doxorubicin leukemia cell #2
      p2et induction #2
      p2ets doses #2
      fragmentation icd #2
      spinosa design #2
      standardized p2et #2
      p2et capsules #2
      immunostimulant role #2
      ethyl gallate mechanism #2
      standardized extract p2et #2
      p2et fraction combination #2
      negativamente expressão #2
      térmico petiveria #2
      hsp70 resultados #2
      métodos frações #2
      condensation clonogenic #2
      p2et caesalpinia spinosa #2
      p2et combination #2
      mutagenicity oecd #2
      mitocôndria regula #2
      protein hsp70 structure #2
      tumor chromatin concentration #2
      atividade membrana #2
      tumoral growth promoters #2
      p2et mammospheres #2
      k562 fraction #2
      caesalpinia p2et #2
      biológica presente #2


      Prominent publications by Susana Fiorentino

      KOL-Index: 8606

      Cancer stem cells (CSC) are the primary cell type responsible for metastasis and relapse. ABC-transporters are integral membrane proteins involved in the translocation of substrates across membranes protecting CSC from chemotherapeutic agents. A plant extract derived from C. spinosa (P2Et) previously investigated for its antitumor activity has been shown to reduce lung and spleen metastasis in mice that have been transplanted with breast cancer cells, suggesting that P2Et has a ...

      Known for Cancer Stem | Standardized Extract | Caesalpinia Spinosa | Activity Doxorubicin | Antineoplastic Agents
      KOL-Index: 7348

      BACKGROUND: Several treatment alternatives are available for primary breast cancer, although those for metastatic disease or inflammation associated with tumor progression are ineffective. Therefore, there is a great need for new therapeutic alternatives capable of generating an immune response against residual tumor cells, thus contributing to eradication of micrometastases and cancer stem cells. The use of complex natural products is an excellent therapeutic alternative widely used by ...

      Known for Breast Cancer | Caesalpinia Spinosa | Primary Tumor | P2et Fraction | Dna Fragmentation
      KOL-Index: 6786

      BACKGROUND: Enhancement of tumor cell sensitivity may help facilitate a reduction in drug dosage using conventional chemotherapies. Consequently, it is worthwhile to search for adjuvants with the potential of increasing chemotherapeutic drug effectiveness and improving patient quality of life. Natural products are a very good source of such adjuvants.

      METHODS: The biological activity of a fraction enriched in hydrolysable polyphenols (P2Et) obtained from Caesalpinia spinosa was evaluated ...

      Known for Caesalpinia Spinosa | P2et Fraction | Natural Products | Biological Activity | Caspase 3
      KOL-Index: 6457

      Polyphenols have tumoricidal effects via anti-proliferative, anti-angiogenic and cytotoxic mechanisms and have recently been demonstrated to modulate the immune response through their anti- or pro- oxidant activity. Nevertheless, it remains controversial whether antioxidant-rich supplements have real beneficial effects on health, especially in complex diseases such as cancer. We previously identified a polyphenol-rich extract obtained from Caesalpinia spinosa (P2Et) with anti-tumor ...

      Known for Tumor Growth | Rich Extract | Regulatory Cells | Caesalpinia Spinosa | Immune Response
      KOL-Index: 6374

      Plant polysaccharides present an interesting potential as immunomodulators, particularly in the induction of antitumoral responses, principally because of their molecular complexity and low in vivo toxicity. Activation of dendritic cells (DCs) could improve antitumoral responses usually diminished in cancer patients, and natural adjuvants provide a possibility of inducing this activation. Herein, we investigated the immunomodulatory activity of a neutral plant polysaccharide ...

      Known for Caesalpinia Spinosa | Dendritic Cells | Immunomodulatory Activity | Phenotypic Maturation | Cell Differentiation
      KOL-Index: 6373

      BACKGROUND: Papular urticaria caused by flea bite presents clinical symptoms of hypersensitive reaction accompanied by skin lesions. Diagnostic and therapeutic approaches to the disease often go unrewarded, partly because of our incomplete understanding of the underlying immunopathogenesis.

      OBJECTIVE: To characterize the immune response to the flea bite in patients with papular urticaria.

      METHODS: This study included 45 randomly selected patients and 17 controls. Cutaneous allergy tests ...

      Known for Papular Urticaria | Flea Bite | Skin Lesions | Immune Response | Immunoblot Analysis
      KOL-Index: 6191

      Epstein-Barr virus (EBV) is a persistent virus with oncogenic capacity that has been implicated in the development of aggressive B cell lymphomas, primarily in immunosuppressed individuals, although it can be present in immunocompetent individuals. Changes in the function and clonal diversity of T lymphocytes might be implied by viral persistence and lymphoma development. The aim of the present study was to evaluate the frequency, phenotype, function and clonotypical distribution of ...

      Known for Barr Virus | Diffuse Large | Lymphoma Patients | Positive Ebv | Cd8 Cells
      KOL-Index: 6109

      ETHNOPHARMACOLOGICAL RELEVANCE: Folk medicine uses aqueous and alcoholic extracts from Petiveria alliacea (Phytolaccaceae) in leukemia and breast cancer treatment in the Caribbean, Central and South America. Herein, we validated the biological activity of a Petiveria alliacea fraction using a metastatic breast adenocarcinoma model (4T1).

      MATERIALS AND METHODS: Petiveria alliacea fraction biological activity was determined estimating cell proliferation, cell colony growth capacity and ...

      Known for Petiveria Alliacea | Balb Mice | Ethnopharmacological Relevance | Cell Tumor | Folk Medicine
      KOL-Index: 6023

      In this study, we demonstrate that the pro-inflammatory cytokine interferon-gamma (IFN-gamma) induces the active release of the constitutive form of the 70-kDa heat shock protein (HSC70) from K562 erythroleukemic cells. Treatment of K562 cells with IFN-gamma induced the upregulation of the inducible form of the 70-kDa heat shock protein (HSP70), but not the constitutive form of HSC70 within the cytosol, in a proteasome-dependent manner. In addition, IFN-gamma induced the downregulation ...

      Known for Induced Release | Human Tumors | Hsc70 Heat | K562 Cells | Shock Proteins
      KOL-Index: 5494

      Induction and execution of apoptosis programs are generally believed to be mediated through a hierarchy of caspase activation. By using two cellular variants obtained from the L1210 cell line (L1210/S and L1210/0), we have shown previously that staurosporine induces apoptotic cell death through both caspase-dependent and caspase-independent pathways. Both pathways normally coexisted in L1210/S cells, whereas L1210/0 cells lacked the ability to activate caspases despite the confirmed ...

      Known for Caspase Activation | Tumor Cells | Apaf1 Expression | L1210 Cell | Apoptosis Apoptotic
      KOL-Index: 5412

      Timely negative regulation of the immune system is critical to allow it to perform its duty while maintaining it under tight control to avoid overactivation. We previously reported that the neuronal receptor neuropilin-1 (NP-1) is expressed in human lymph nodes. However, the role of NP-1 interaction with its physiological ligand semaphorin-3A (Sema-3A) on immune cells remains elusive. Here we show that Sema-3A is expressed by activated DC and T cells, and that its secretion in DC/T cell ...

      Known for Cell Proliferation | Immunosuppressive Role | Actin Cytoskeleton | Sema3a Secretion | Semaphorin3a Tlymphocytes
      KOL-Index: 5330

      BACKGROUND: There is ethnopharmacological evidence that Petiveria alliacea can have antitumor activity; however, the mechanism of its cytotoxic activity is not well understood. We assessed multiple in vitro biological activities of an ethyl acetate soluble plant fraction over several tumor cell lines.

      METHODS: Tumor cell lines were evaluated using the following tests: trypan blue exclusion test, MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide], flow cytometry, ...

      Known for Petiveria Alliacea | Cell Tumor | Dna Fragmentation | Cytotoxic Activity | Animal Models
      KOL-Index: 5315

      Epstein-Barr virus (EBV) is an oncogenic virus associated with the development of aggressive and poor-prognosis B-cell lymphomas in patients infected with human immunodeficiency virus (HIV+ patients). The most important risk factors for these malignancies include immune dysfunction, chronic immune activation, and loss of T-cell receptor (TCR) repertoire. The combination of all these factors can favor the reactivation of EBV, malignant cell transformation, and clinical progression toward ...

      Known for Hiv Patients | Tcr Repertoire | Virus Ebv | Epstein Barr | Cd8 Cells
      KOL-Index: 5196

      Recent findings suggest that part of the anti-tumor effects of several chemotherapeutic agents require an intact immune system. This is in part due to the induction of immunogenic cell death. We have identified a gallotannin-rich fraction, obtained from Caesalpinia spinosa (P2Et) as an anti-tumor agent in both breast carcinoma and melanoma. Here, we report that P2Et treatment results in activation of caspase 3 and 9, mobilization of cytochrome c and externalization of annexin V in tumor ...

      Known for Tumor Cells | Immune Activation | P2et Anti | Caesalpinia Spinosa | Mouse Model
      KOL-Index: 4702

      Una fracción de Petiveria alliacea induce apoptosis dependiente de la mitocondria y regula la expresión de la proteína HSP70. Objetivo: Evaluar la actividad biológica in vitro de extractos de Petiveria alliacea utilizando líneas celulares tumorales. Materiales y Métodos: Las fracciones de P.alliacea fueron preparadas mediante un protocolo de purificación biodirigido. La actividad biológica fue caracterizada utilizando dos líneas celulares tumorales de origen humano, donde se analizaron ...

      Known for Petiveria Alliacea | Induces Apoptosis | Biological Activity | Cell Viability | Mitochondrial Membrane

      Key People For Petiveria Alliacea

      Top KOLs in the world
      Rabi Ann Musah
      direct analysis mass spectrometry petiveria alliacea
      Roman Kubec
      petiveria alliacea amino acids allium discoloration
      Lawrence A D Williams
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      Seokwon Kim
      petiveria alliacea allium siculum lachrymatory principle
      Maria Cláudia Marx Young
      chemical composition essential oil antifungal activity
      Vanderlan da S Bolzani
      endophytic fungus piper aduncum isoprene units

      Susana Fiorentino:Expert Impact

      Concepts for whichSusana Fiorentinohas direct influence:Petiveria alliacea,  Caesalpinia spinosa,  P2et extract,  Immunogenic signals,  Papular urticaria,  Standardized extract,  Flea bite,  Epstein barr.

      Susana Fiorentino:KOL impact

      Concepts related to the work of other authors for whichfor which Susana Fiorentino has influence:Heat shock,  Petiveria alliacea,  Papular urticaria,  Natural products,  Medicinal plants,  Caesalpinia spinosa,  Flea bite.



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      Grupo de Inmunobiología y Biología Celular, Unidad de Investigación en Ciencias Biomédicas, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia, javeriana.edu.co | Grupo de Inmunobiología y Biología Celular, Unidad de Investigaci

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