• KOL
    • Photodynamic Therapy
    • R Rox Anderson
    • R Rox Anderson: Influence Statistics

      R Rox Anderson

      R Rox Anderson

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      Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA. | Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA. | ...

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      R Rox Anderson:Expert Impact

      Concepts for whichR Rox Andersonhas direct influence:Photodynamic therapy,Laser treatment,Human skin,Yag laser,Early glottic cancer,Confocal microscopy,Sebaceous glands,Thermal damage.

      R Rox Anderson:KOL impact

      Concepts related to the work of other authors for whichfor which R Rox Anderson has influence:Photodynamic therapy,Yag laser,Confocal microscopy,Human skin,Hair removal,Wound healing,Acne vulgaris.

      KOL Resume for R Rox Anderson

      Year
      2021

      Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA.

      2020

      Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston

      2019

      Dr. Lee is with the Department of Dermatology at Brown University in Providence, Rhode Island.

      Wellman Center for Photomedicine

      Shriner's Hospital for Children- Boston, Boston, MA 02114.

      Harvard Medical School

      Massachusetts General Hospital

      2018

      Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts

      2017

      Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

      Wellman Center for Photomedicine, Massachusetts General Hospital, Boston

      2016

      Wellman Center for Photomedicine, Massachusetts General Hospital (United States)

      Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA

      2015

      Wellman Center for Photomedicine, Department of Dermatology,

      Harvard Medical School Dermatology Cosmetic and Laser Center Massachusetts General Hospital Boston Massachusetts

      2014

      Wellman Center for Photomedicine, Thier 204, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114.

      Department of Dermatology, Massachusetts General Hospital, Boston

      Harvard-MIT Division of Health Sciences and Technology (HST), Cambridge, MA

      2013

      Massachusetts General Hospital Harvard Medical School Wellman Center for Photomedicine and Department of Dermatology Boston Maryland

      Wellman Ctr. for Photomedicine and Harvard Medical School (United States)

      2012

      Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School,40 Blossom Street, 02114 Boston, Massachusetts, United States

      Deparment of Dermatology, Massachusetts General Hospital, Harvard Medical School, Massachusetts 02114

      2011

      Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard University Medical School, Boston, Massachusetts

      55 Fruit St. BHX 630, 02114 Boston, MA

      2010

      Wellman Center for Photomedicine, Massachusetts General Hospital, BHX 630, Bartlett Hall, Boston, Massachusetts 02114

      2009

      Laser and Cosmetic Dermatology Center and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

      55 Fruit St. BHX 630, Boston, MA 02114

      2008

      MGH Laser and Cosmetic Dermatology Center and Wellman Center for Photomedicine, BHX 630, Bartlett Hall, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02445

      From the Departments of Surgery (Zeitels, Burns, Lopez-Guerra, Hillman) and Dermatology (Anderson), Harvard Medical School, and the Center for Laryngeal Surgery and Voice Rehabilitation (Zeitels, Burns, Lopez-Guerra, Hillman) and the Wellman Laboratories of Photomedicine (Anderson), Massachusetts General Hospital, Boston, Massachusetts. This work was supported in part by the Eugene B. Casey Foundation and the Institute of Laryngology and Voice Restoration. The authors have not received commercial financial support, but have received laser instrumentation from KayPENTAX and Laserscope. Dr Zeitels has an equity interest in Endocraft LLC.

      Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston (Dr Anderson).

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      Sample of concepts for which R Rox Anderson is among the top experts in the world.
      Concept World rank
      normalmode ruby laser #1
      yag laser lasers #1
      694 nm 1 #1
      variety field #1
      tongue mucosa crm #1
      minutes fluorescence #1
      epidermal dermal response #1
      microseconddomain #1
      694 nm radiation #1
      thermal vaporization presence #1
      treatment arms nafr #1
      pulses selective #1
      transcutaneous permeation peg #1
      fat fibrous septa #1
      hf sg #1
      afxlmal #1
      small size microcolumns #1
      therapy nevus #1
      treated cherry #1
      energy vessel destruction #1
      colors transient pigmentary #1
      motivation tattoo removal #1
      glottal papillomatosis dysplasia #1
      skin responses laser #1
      pigmented lesions tattoos #1
      melanin strong contrast #1
      755 nm laser #1
      nm laser treatment #1
      venous blood wavelengths #1
      ionizing radiation uvcphotons #1
      transient textural #1
      subsequent uva #1
      cell features combination #1
      afldrug delivery #1
      acne photodynamic therapy #1
      darierwhites disease #1
      ice slurry cryoneurolysis #1
      aged tattooing #1
      351nanometer #1
      water optoacoustic sensor #1
      coagulation zone thickness #1
      efficiency inflation #1
      threshold purpura day #1
      fluorescence spectra lesions #1
      aminolevulinic acid light #1
      total transmittance esophagus #1
      hdta scars #1
      10 40 cm2 #1
      qsrl asians #1
      fp ihc #1
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      Prominent publications by R Rox Anderson

      KOL-Index: 13141

      BACKGROUND AND OBJECTIVES: Q-switched lasers have been used for the treatment of lentigines but post-inflammatory hyperpigmentation (PIH) can be an issue especially in Asians. The 595 nm long-pulsed dye laser (LPDL) has been used for the treatment of vascular lesions and although it is well absorbed by oxyhemoglobin, it is also absorbed by melanin. To use this device for the treatment of facial lentigines, we attached a flat glass lens to the tip of the laser's handpiece, allowing ...

      Known for Facial Lentigines | Lpdl Treatment | Dye Laser | Pulse Duration | Spot Size
      KOL-Index: 12017

      Treatment of glottal papillomatosis and dysplasia was mirror-guided and performed in surgeons' offices in the 19th century. It migrated to the operating room in the 20th century to accommodate direct laryngoscopic surgery, which required assistants to administer anesthesia and procedural support. Presently, the primary treatment goals, which are disease regression and voice restoration or maintenance, are tempered by the morbidity of general anesthesia and potential treatment-induced ...

      Known for Local Anesthesia | Glottal Dysplasia | 19th Century | Dye Laser | Disease Regression
      KOL-Index: 11874

      BACKGROUND: Photodynamic therapy (PDT) with methyl aminolaevulinate (MAL) is effective for thin actinic keratoses (AKs) in field-cancerized skin. Ablative fractional laser resurfacing (AFXL) creates vertical channels that facilitate MAL uptake and may improve PDT efficacy.

      OBJECTIVES: To evaluate efficacy and safety of AFXL-assisted PDT (AFXL-PDT) compared with conventional PDT in field-directed treatment of AK.

      METHODS: Fifteen patients with a total of 212 AKs (severity grade I-III) in ...

      Known for Actinic Keratoses | Photodynamic Therapy | Pdt Treatment | Randomized Clinical Trial | Fractional Co2
      KOL-Index: 11509

      OBJECTIVES: Treatment of glottal papillomatosis and dysplasia was mirror-guided and done in surgeons' offices in the 19th century. It migrated to the operating room in the 20th century to accommodate direct laryngoscopic surgery, which required assistants to administer anesthesia and procedural support. The primary treatment goals, which are disease regression and voice restoration and/or maintenance, are tempered by the morbidity of general anesthesia and potential treatment-induced ...

      Known for Ktp Laser | Glottal Papillomatosis | Nm Pulsed | Disease Regression | General Anesthesia
      KOL-Index: 11442

      BACKGROUND AND OBJECTIVES: Ablative fractional resurfacing (AFR) creates vertical channels that might assist the delivery of topically applied drugs into skin. The purpose of this study was to evaluate drug delivery by CO(2) laser AFR using methyl 5-aminolevulinate (MAL), a porphyrin precursor, as a test drug.

      MATERIALS AND METHODS: Two Yorkshire swine were treated with single-hole CO(2) laser AFR and subsequent topical application of MAL (Metvix(R), Photocure ASA, Oslo, Norway), placebo ...

      Known for Drug Delivery | Co2 Laser | Afr Application | Porphyrin Fluorescence | Skin Depths
      KOL-Index: 11332

      Clinical trials of topical ALA in photodynamic therapy (PDT) of basal cell carcinoma (BCC) show significant recurrence rates. Exogenous 5-aminolevulinic acid (ALA) is converted by intracellular enzymes to photoactive protoporphyrin IX (PpIX) in human tissues. PpIX generates cytotoxic singlet oxygen when irradiated with visible light in the 400–640 nm range. To evaluate variability and heterogeneity in PpIX production by tumors in such trials, and to assess the usefulness of PpIX for ...

      Known for Basal Cell | Topical Application | Ppix Fluorescence | Aminolevulinic Acid | Skin Neoplasms Bcc
      KOL-Index: 11308

      Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is increasingly employed for skin cancer, yet ALA dosing is crude. Using iontophoresis, we developed a rapid and quantifiable system for topical ALA delivery, with measurement of subsequent PpIX fluorescence and phototoxicity. ALA was iontophoresed from a 2% solution into upper inner arm skin of 13 healthy volunteers. Six doses of ALA were delivered with a series of charges varying from 3-120 milliCoulombs (mC); four ...

      Known for Iontophoretic Delivery | Human Skin | Ppix Fluorescence | Quantitative Model | Irradiation Dose
      KOL-Index: 10790

      BACKGROUND AND OBJECTIVE: Port wine stains (PWS) are heterogeneous vascular malformations that can be treated with vascular-selective pulsed dye lasers (PDL). Hypertrophic PWS, especially in adults, are consistently less responsive to PDL. Furthermore, many PWS that respond well initially to PDL treatment may reach a response plateau, becoming unresponsive to further PDL treatments, a phenomenon termed "treatment resistance." Based on the theory of selective photothermolysis, vessels in ...

      Known for 755 Nm Laser | Port Wine | Pdl Treatment | Hypertrophic Pws | Selective Photothermolysis
      KOL-Index: 10586

      Topical aminolevulinic acid is converted into a potent photosensitizer, protoporphyrin, in human hair follicles and sebaceous glands. Photodynamic therapy with topical aminolevulinic acid was tested for the treatment of acne vulgaris, in an open-label prospective human study. Each of 22 subjects with acne on the back was treated in four sites with aminolevulinic acid plus red light, aminolevulinic acid alone, light alone, and untreated control. Half of the subjects were treated once; ...

      Known for Photodynamic Therapy | Acne Vulgaris | Aminolevulinic Acid | Sebaceous Glands | Multiple Treatments
      KOL-Index: 10584

      BACKGROUND AND OBJECTIVES: Pretreatment of skin with ablative fractional lasers (AFXL) enhances the uptake of topical photosensitizers used in photodynamic therapy (PDT). Distribution of photosensitizer into skin layers may depend on depth of laser channels and incubation time. This study evaluates whether depth of intradermal laser channels and incubation time may affect AFXL-assisted delivery of methyl aminolevulinate (MAL).

      MATERIALS AND METHODS: Yorkshire swine were treated with CO2 ...

      Known for Incubation Time | Methyl Aminolevulinate | 180 Minutes | Laser Channels | Channel Depth
      KOL-Index: 10349

      BACKGROUND: Advances in laser technology allow for precise tissue removal and minimal thermal damage. However, mechanisms for cosmetic improvement have not been determined. Investigators have suggested that ablation, collagen shrinkage, and new collagen deposition all contribute to the clinical outcome.

      OBJECTIVE: In a live farm pig, we examined gross and microscopic effects of thermal and mechanical ablation devices to characterize immediate and long-term mechanisms in skin ...

      Known for Yag Laser | Thermal Damage | Wound Healing | Carbon Dioxide | Skin Resurfacing
      KOL-Index: 9807

      In 1995, we reported the construction of a video-rate scanning laser confocal microscope for imaging human skin in vivo. Since then, we have improved the resolution, contrast, depth of imaging, and field of view. Confocal images of human skin are shown with experimentally measured lateral resolution 0.5-1.0 microm and axial resolution (section thickness) 3-5 microm at near-infrared wavelengths of 830 nm and 1064 nm; this resolution compares well to that of histology which is based on ...

      Known for Human Skin | Vivo Confocal | Laser Microscopy | Field View | Comparison Histology
      KOL-Index: 9487

      OBJECTIVES: Varices and ectasias in singers are typically the result of phonotraumatic shearing stresses and/or collision forces on the microcirculation within the superficial lamina propria. These lesions can be debilitating in performing vocalists because of the effect of recurrent hemorrhage and/or as a contributing factor to the morbidity of other mass lesions such as polyps, nodules, and cysts. Phonomicrosurgical treatment of performers is understandably approached with great ...

      Known for Laser Treatment | Nm Pulsed | Superficial Lamina Propria | 39 Patients | Pdl 532

      Key People For Photodynamic Therapy

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      Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA. | Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA. | Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Bo

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