• Disease
  • Esophageal
  • Esophageal Motility
  • Jacqueline Lee

    Prominent publications by Jacqueline Lee

    KOL Index score: 13370

    Neurogenin 3 (Ngn3) is key for endocrine cell specification in the embryonic pancreas and induction of a neuroendocrine cell differentiation program by misexpression in adult pancreatic duct cells. We identify the gene encoding IA1, a zinc-finger transcription factor, as a direct target of Ngn3 and show that it forms a novel branch in the Ngn3-dependent endocrinogenic transcription factor network. During embryonic development of the pancreas, IA1 and Ngn3 exhibit nearly identical ...

    Also Ranks for: Proteins Transcription |  embryonic pancreas |  cell differentiation |  male mice mice |  ectopic expression
    KOL Index score: 10778

    The Yeast Metabolome Database (YMDB, http://www.ymdb.ca) is a richly annotated 'metabolomic' database containing detailed information about the metabolome of Saccharomyces cerevisiae. Modeled closely after the Human Metabolome Database, the YMDB contains >2000 metabolites with links to 995 different genes/proteins, including enzymes and transporters. The information in YMDB has been gathered from hundreds of books, journal articles and electronic databases. In addition to its ...

    Also Ranks for: Yeast Metabolome Database |  saccharomyces cerevisiae |  nmr spectra |  journal articles |  metabolite entry
    KOL Index score: 10565

    BACKGROUND & AIMS: The prevalence of complicated gastroesophageal reflux disease (GERD) increases with age; however, the mechanism by which this occurs is uncertain. This study assessed (1) whether physiologic degradation of the gastroesophageal junction and esophageal motility occurs with aging, and (2) whether these effects are associated with increased esophageal acid exposure and reflux symptoms in the elderly.

    METHODS: Retrospective study of 1307 patients referred for investigations ...

    Also Ranks for: Esophageal Motility |  reflux disease |  acid exposure |  esophagogastric junction |  abdominal length
    KOL Index score: 7890

    Our objectives were to evaluate the safety and tolerability of tirasemtiv over 12 weeks and its effect on the revised ALS Functional Rating Scale (ALSFRS-R) and other secondary functional measures. This randomized, double-blind, placebo-controlled trial enrolled adults with ALS and slow vital capacity (SVC) > 50% from 73 centers in eight countries. Patients who tolerated open-label tirasemtiv 125 mg b.i.d. for one week were randomized to double-blind treatment either to placebo or ...

    Also Ranks for: Amyotrophic Lateral |  primary endpoint |  vital capacity |  muscle strength |  12 weeks
    KOL Index score: 7132

    This study was designed to evaluate the safety and tolerability of single doses of CK-2017357, an orally bioavailable fast skeletal muscle troponin activator, in patients with amyotrophic lateral sclerosis (ALS), and to explore pharmacodynamic markers related to strength, endurance, and function. Sixty-seven patients with ALS received single doses of placebo, CK-2017357 at 250 mg and 500 mg in random order, separated by one week. Safety measures assessments were performed, as well as ...

    Also Ranks for: Amyotrophic Lateral Sclerosis |  skeletal muscle |  single doses |  safety tolerability |  strength endurance
    KOL Index score: 7031

    TNF-α (TNF), a pro-inflammatory cytokine is synthesized as a 26 kDa protein, anchors in the plasma membrane as transmembrane TNF (TmTNF), and is subjected to proteolysis by the TNF-α converting enzyme (TACE) to release the 15 kDa form of soluble TNF (sTNF). TmTNF and sTNF interact with 2 distinct receptors, TNF-R1 (p55) and TNF-R2 (p75), to mediate the multiple biologic effects of TNF described to date. Several anti-TNF biologics that bind to both forms of TNF and block their ...

    Also Ranks for: Tumor Necrosis Factor |  anti tnf |  cells dcs |  cell membrane |  monocytes receptors
    KOL Index score: 6296

    Resveratrol in the fruits of bilberry (Vaccinium myrtillus L.), the lowbush "wild" blueberry (Vaccinium angustifolium Aiton), the rabbiteye blueberry (Vaccinium ashei Reade), and the highbush blueberry (Vaccinium corymbosum L.) were measured using a new assay based on high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The LC-MS/MS assay provided lower limits of detection than previous methods for resveratrol measurement, 90 fmol of trans-resveratrol injected ...

    Also Ranks for: Trans Resveratrol |  vaccinium myrtillus |  highbush blueberry |  liquid chromatography |  hot temperature
    KOL Index score: 5938

    BACKGROUND: There is substantial evidence that cognitive therapy is an effective intervention for the treatment of major depressive disorder. Although dynamic psychotherapies have been widely studied and are commonly practiced worldwide, there are few randomized comparisons of cognitive therapy and dynamic therapy for major depressive disorder.

    METHODS: We are completing data collection on a randomized non-inferiority trial comparing the effectiveness of cognitive therapy and short-term ...

    Also Ranks for: Depressive Disorder |  cognitive therapy |  comparative effectiveness |  mental health |  community setting
    KOL Index score: 4289

    OBJECTIVE: To evaluate ease of use and compliance with dietary modification in the treatment of vertigo in patients with Ménière's disease.

    STUDY DESIGN: Mailed patient retrospective questionnaire and chart review.

    SETTING: Tertiary referral neurotologic private practice.

    SUBJECTS: 136 patients with Ménière's who returned a mailed questionnaire. Mean age at first clinic visit was 53 years, and at questionnaire was 62 years, with 54.4% female subjects. Median initial hearing was AAO-HNS ...

    Also Ranks for: Dietary Modification |  adjunct treatment |  ménière disease |  outcome measures |  free diet
    KOL Index score: 3826

    Rats with hippocampal lesions and sham operated control animals were trained on a go-no-go tone discrimination. For half of the animals of each group the tone was the positive stimulus while for the other half the tone was negative. The hippocampal tone negative group took the greatest number of days to learn the task. Tone generalization tests administered the day after the learning criterion was reached did not yield any differences in either excitatory or inhibitory stimulus control ...

    Also Ranks for: Stimulus Generalization |  discrimination learning |  hippocampal lesions |  sham animals |  acoustic stimulation
    KOL Index score: 3825

    Next-generation sequencing (NGS) can identify and validate new biomarkers of cancer onset, progression and therapy resistance. Substantial archives of formalin-fixed, paraffin-embedded (FFPE) cancer samples from patients represent a rich resource for linking molecular signatures to clinical data. However, performing NGS on FFPE samples is limited by poor RNA purification methods. To address this hurdle, we developed an improved methodology for extracting high-quality RNA from FFPE ...

    Also Ranks for: Pancreatic Cancer |  tumor carcinoma |  ffpe samples |  rna extraction |  derived xenografts
    KOL Index score: 3056

    Background The coronavirus disease 2019 (COVID-19) may have a negative effect on the mental and social health of patients with ESKD on chronic in-center hemodialysis (HD), who have a high burden of psychologic symptoms at baseline and unavoidable treatment-related COVID exposures. The goal of our study was to assess the effect of the COVID-19 pandemic on the psychosocial health of patients on chronic in-center HD. Methods Participants enrolled in the ongoing Technology Assisted ...

    Also Ranks for: Endstage Kidney Disease |  health patients |  participants reported |  hemodialysis hd |  pandemic psychosocial
    KOL Index score: 2923

    Ludwig angina is a rare but potentially lethal infection of the submandibular space that can cause significant upper airway obstruction. We report a case of undiagnosed Ludwig angina that progressed rapidly to death. Ludwig angina was suspected after post-mortem computed tomography (PMCT) found swollen mylohyoid muscle with stranding in subcutaneous fat, thickening of deep fascia, and local lymphadenopathy. Subsequently, an autopsy revealed woody induration of the submental region and ...

    Also Ranks for: Ludwig Angina |  autopsy death |  tomography pmct |  airway obstruction |  floor mouth
    KOL Index score: 2648

    Although large-scale transverse drainages (TDs) such as those of the Susquehanna River above Harrisburg, PA, have been recognized since the nineteenth century, only two systematic surveys have been published of TDs (Ver Steeg, 1930; Oberlander, 1965). A topographic and statistical analysis of TDs in the Susquehanna River basin using Google Earth® and associated overlays identified 653 TDs in the study area, 95% of which contain streams with discharges of <10m3/s (cms). The TD depths ...

    Also Ranks for: Susquehanna River |  transverse drainages |  google earth
    KOL Index score: 2611

    OBJECTIVE: Anorexia nervosa (AN) with compulsive exercise is associated with poor treatment outcomes. This study sought to understand the attitudes of adolescents with AN from various stages of treatment, toward physical activity research practices and physical activity as a component of treatment.

    METHOD: Seventeen adolescents 12-18 years old (15 female) with AN (10 with acknowledged history of compulsive exercise) were recruited from a Canadian Tertiary Care Hospital's Eating Disorder ...

    Also Ranks for: Physical Activity |  anorexia nervosa |  eating disorder |  semi structured


    Jacqueline Lee: Influence Statistics

    Sample of concepts for which Jacqueline Lee is among the top experts in the world.
    Concept World rank
    transverse drainages #6

    Key People For Esophageal Motility

    Top KOLs in the world
    Peter James Kahrilas
    esophagogastric junction chicago classification gastroesophageal reflux disease
    Donald O Castell
    gastroesophageal reflux chest pain esophageal manometry
    John Erik Pandolfino
    chicago classification esophagogastric junction esophageal motility
    A J P M Smout
    functional dyspepsia achalasia patients normal values
    Joel E Richter
    chest pain gastroesophageal reflux eosinophilic esophagitis
    Albert Jan Bredenoord
    eosinophilic esophagitis gastroesophageal reflux chicago classification

    Jacqueline Lee:Expert Impact

    Concepts for whichJacqueline Leehas direct influence:Esophageal motility,  Susquehanna river,  Ludwig angina,  Transverse drainages,  Anal adenocarcinoma,  Amyotrophic lateral sclerosis,  Google earth,  Dietary modification.

    Jacqueline Lee:KOL impact

    Concepts related to the work of other authors for whichfor which Jacqueline Lee has influence:Gastroesophageal reflux disease,  Amyotrophic lateral sclerosis,  Pancreas development,  Endocrine cells,  Esophageal motility,  Reflux esophagitis,  Insm1 promoter.



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    School of Biological Sciences, Monash University, Melbourne, Australia | School of Kinesiology, University of British Columbia, Lower Mall Research Station, Vancouver Canada | School of Kinesiology, The University of British Columbia Canada. Electron