Prominent publications by David L Kleinberg

KOL Index score: 19551

Although the use of the insulin tolerance test (ITT) for the diagnosis of adult GH deficiency is well established, diagnostic peak GH cut-points for other commonly used GH stimulation tests are less clearly established. Despite that fact, the majority of patients in the United States who are evaluated for GH deficiency do not undergo insulin tolerance testing. The aim of this study was to evaluate the relative utility of six different methods of testing for adult GH deficiency currently ...

Known for Adult Gh |  Sensitivity Specificity |  United States |  Hormone Deficiency |  Patients Control Subjects
KOL Index score: 12703

OBJECTIVE: To assess the GH response to GHRH-arginine in apparently healthy adults in relation to cardiovascular risk factors.

DESIGN: Cross-sectional.

PATIENTS: Eighty-six male and female volunteers aged 50-90.

MEASUREMENTS: GH peak response to GHRH-arginine and cardiovascular risk factors, including obesity, insulin resistance, low levels of high density lipoprotein (HDL) cholesterol, elevated triglycerides, and hypertension. The primary outcome measurement was GH response to ...

Known for Insulin Resistance |  Gh Peak |  Cardiovascular Risk |  Hdl Cholesterol |  Body Mass Bmi
KOL Index score: 9484

CONTEXT: Somatostatin analogs have been successfully used to treat patients with GH-secreting pituitary adenomas because they are safe, effective, and usually well tolerated. The results of studies evaluating acromegaly treatment with the somatostatin receptor ligands (SRLs), octreotide and lanreotide, have supported the use of these agents for primary medical therapy before or as an alternative to traditional interventions of surgery and radiotherapy in selected cases.


Known for Tumor Shrinkage |  Primary Medical |  Somatostatin Analogs |  Critical Analysis |  Surgery Radiotherapy
KOL Index score: 9230

Adult female mammary development starts at puberty and is controlled by tightly regulated cross-talk between a group of hormones and growth factors. Although estrogen is the initial driving force and is joined by luteal phase progesterone, both of these hormones require GH-induced IGF-I in the mammary gland in order to act. The same group of hormones, when experimentally perturbed, can lead to development of hyperplastic lesions and increase the chances, or be precursors, of mammary ...

Known for Mammary Development |  Growth Factor |  Gh Igfi |  Precursor Lesions |  Animals Breast
KOL Index score: 9204

BACKGROUND: A novel oral octreotide formulation was tested for efficacy and safety in a phase III, multicenter, open-label, dose-titration, baseline-controlled study in patients with acromegaly.

METHODS: We enrolled 155 complete or partially controlled patients (IGF-1 <1.3 × upper limit of normal [ULN], and 2-h integrated GH <2.5 ng/mL) receiving injectable somatostatin receptor ligand (SRL) for ≥ 3 months. Subjects were switched to 40 mg/d oral octreotide capsules (OOCs), and the dose ...

Known for Oral Octreotide |  Phase Iii |  Efficacy Safety |  Insulinlike Growth Factor |  Acromegaly Adenoma
KOL Index score: 8881

Prolactin has been measured in unextracted human plasma by a sensitive and specific in vitro bioassay. Secretory activity of breast tissue fragments from mid-pregnant mice, incubated in organ culture with human plasma, serves as the histologic end point. Sensitivity is 5 ng/ml (0.14 mU/ml) or somewhat better for ovine prolactin, and approximately 0.42 mU/ml for prolactin activity of human plasma at the dilutions used in the assay. Human growth hormone as it circulates in blood, like the ...

Known for Human Prolactin |  Growth Hormone |  Organ Culture |  Vitro Bioassay |  Large Amounts
KOL Index score: 8584

An analysis of 235 patients with galactorrhea (5.5 per cent males) showed that 20 per cent of all patients, and 34 per cent of women with associated amenorrhea, had radiologically evident pituitary tumors; these patients had the highest serum prolactin concentrations. The largest single group (32 per cent) consisted of women with idiopathic galactorrhea without amenorrhea; prolactin was normal in 86 per cent of these cases. Five patients had the empty-sella syndrome. Prolactin response ...

Known for Pituitary Tumors |  Cent Patients |  Galactorrhea Amenorrhea |  Thyrotropinreleasing Hormone |  Prolactin Response
KOL Index score: 8501

The pituitary gland has been found to be an important factor in mammary development in primates. Hypophysectomy in 12 sexually immature monkeys caused significant inhibition of estradiol (E2)-induced mammary growth and development. A histological index of mammary development in sexually immature hypophysectomized animals was lower (0.82) than in intact E2-treated controls (3.4; P less than 0.008). Hypophysectomy also inhibited growth of the mammary gland as judged by a size index. ...

Known for Mammary Development |  Growth Hormone |  Pituitary Gland |  Concentrations Hgh |  Estradiol Female


David L Kleinberg: Influence Statistics

Sample of concepts for which David L Kleinberg is among the top experts in the world.
Concept World rank
mammarydevelopment #1
042 prolactin activity #1
women risperidone dose #1
inhibitory oprl #1
cases thyrotropin #1
igf13 #1
pg ductal morphogenesis #1
levels mammary gland #1
teb formation #1
prolactin macaca #1
branching 0002 #1
igfi action inhibitor #1
ductal hypertrophy #1
pg dm #1
primates hypophysectomy #1
production igf13 #1
som230 mammary development #1
branching igf #1
branching igfi #1
laboratory growth hormone #1
addition lactalbumin output #1
classic studies lyons #1
ghinduced mammary development #1
pituitary tumor galactorrhea #1
women risperidone #1
lower prolactin responses #1
bromocriptine periodic examination #1
tumors rheumatologic #1
interventions inhibitor #1
igf13 igf1 #1
wellcircumscribed macroadenomas #1
ly 156758 prl #1
igfirelated dm #1
mammary development women #1
oprl stimulated #1
aghd effects #1
branching pg #1
mid pregnant mice #1
including 48 #1
gh total cholesterol #1
155 049 iu #1
early mammary development #1

Key People For Growth Hormone

Top KOLs in the world
Michael O Thorner
growth hormone gh secretion prolactin release
Ron G Rosenfeld
growth factor binding protein turner syndrome
Raymond L Hintz
growth factor insulin receptors binding proteins
Jens Sandahl Sandahl Christiansen
growth hormone body composition turner syndrome
BengtÅke NÅ Bengtsson†
growth hormone body composition gh replacement
David Robert Clemmons
growth factor binding protein smooth muscle

David L Kleinberg:Expert Impact

Concepts for whichDavid L Kleinberghas direct influence:Growth hormone,  Mammary development,  Mammary gland,  Ductal morphogenesis,  Growth factor,  Mammary glands,  Primary therapy,  Pituitary adenomas.

David L Kleinberg:KOL impact

Concepts related to the work of other authors for whichfor which David L Kleinberg has influence:Growth hormone,  Breast cancer,  Pituitary adenomas,  Patients acromegaly,  Mammary gland,  Dopamine agonists,  Prolactin levels.



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Department of Medicine, New York University School of Medicine, New York, USA. | New York University, New York, USA | Department of Medicine, NYU Langone Medical Center, New York, New York. | New York University Langone Medical Center (D.K.), New Yor

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