• Disease
  • Growth
  • Growth Hormone
  • Shlomo Melmed

    Prominent publications by Shlomo Melmed

    KOL Index score: 22654

    Somatostatin (SRIF), a hypothalamic inhibitor of pituitary growth hormone (GH) and thyroid-stimulating hormone (TSH) secretion, binds to five distinct receptor (SSTR) subtypes. We therefore tested SSTR subtype-specific SRIF analogs in primary human fetal pituitary cultures (23-25-wk gestation) to elucidate their role in regulating human pituitary function. Using reverse transcription-PCR, mRNA expression of SSTR2 and SSTR5 were detected in fetal pituitary by 25 wk. SRIF analog affinities ...

    Also Ranks for: Sstr2 Sstr5 |  fetal pituitary |  growth hormone |  messenger receptors |  somatostatin receptor
    KOL Index score: 18629

    We recently described the expression of leukemia inhibitory factor (LIF) in human fetal and murine corticotrophs. LIF and the related cytokine oncostatin M induced basal, and corticotropin-releasing hormone (CRH) induced proopiomelanocortin (POMC) mRNA and ACTH secretion in AtT20 cells. LIF signaling and regulation of POMC gene transcription were therefore tested. Dexamethasone inhibited both basal- and LIF-induced ACTH secretion (P<0.05) and LIF induction of ACTH was also attenuated by ...

    Also Ranks for: Leukemia Inhibitory |  cytokine receptors |  stat pathway |  corticotroph cell |  p005 lif
    KOL Index score: 17341

    Previously, we have shown somatostatin receptor (SSTR) subtype-specific regulation of growth hormone (GH), thyroid-stimulating hormone, and prolactin (PRL) secretion in human fetal pituitary cultures, where GH and thyroid-stimulating hormone are mediated by both SSTR2 and SSTR5, whereas SSTR2 preferentially mediates PRL secretion. We now tested SSTR subtype-selective analogues in primary human GH- and PRL-secreting pituitary adenoma cultures. Analogue affinities determined by membrane ...

    Also Ranks for: Somatostatin Receptor |  growth hormone |  human pituitary |  sstr2 sstr5 |  prl secretion
    KOL Index score: 15218

    Cushing disease is a condition in which the pituitary gland releases excessive adrenocorticotropic hormone (ACTH) as a result of an adenoma arising from the ACTH-secreting cells in the anterior pituitary. ACTH-secreting pituitary adenomas lead to hypercortisolemia and cause significant morbidity and mortality. Pituitary-directed medications are mostly ineffective, and new treatment options are needed. As these tumors express EGFR, we tested whether EGFR might provide a therapeutic target ...

    Also Ranks for: Therapeutic Target |  pituitary adenoma |  acth secretion |  neoplastic humans |  protein kinase
    KOL Index score: 14434

    Neuroendocrine ACTH secretion responds to peripheral inflammatory and stress signals. We previously demonstrated that the proinflammatory cytokine, leukemia inhibitory factor (LIF), affects the hypothalamo-pituitary-adrenal axis (HPA) by stimulating in vitro and in vivo pituitary proopiomelanocortin (POMC) gene expression and ACTH secretion and by potentiating the action of hypothalamic corticotropin releasing hormone (CRH). Whereas pathways shown thus far to regulate POMC expression ...

    Also Ranks for: Pomc Transcription |  pituitary proopiomelanocortin |  acth secretion |  binding proteins |  inhibitory factor
    KOL Index score: 13897

    Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that stimulates the hypothalamo-pituitary-adrenal (HPA) axis through JAK-STAT activation. We show here that LIF-induced JAK2 and STAT3 tyrosine phosphorylation is transient, disappearing within 20 and 40 minutes, respectively. LIF activates the SH2 domain-containing tyrosine phosphatase, SHP-1, with maximal stimulation observed at 30 minutes. SHP-1 is constitutively associated with JAK2, and LIF induces recruitment of ...

    Also Ranks for: Inhibitory Factor |  protein tyrosine |  nonreceptor type |  stat3 shp1 |  pituitary proopiomelanocortin
    KOL Index score: 13524

    CONTEXT: Pasireotide (SOM230) is a novel multireceptor ligand somatostatin analog with affinity for somatostatin receptor subtypes sst(1-3) and sst(5). Because most GH-secreting pituitary adenomas express sst(2) and sst(5), pasireotide has the potential to be more effective than the sst(2)-preferential somatostatin analogs octreotide and lanreotide.

    OBJECTIVE: Our objective was to evaluate the efficacy and safety of three different doses of pasireotide in patients with ...

    Also Ranks for: Pasireotide Patients |  efficacy safety |  biochemical response |  insulinlike growth factor |  aged octreotide
    KOL Index score: 13500

    Pituitary somatotroph adenomas result in dysregulated growth hormone (GH) hypersecretion and acromegaly; however, regulatory mechanisms that promote GH hypersecretion remain elusive. Here, we provide evidence that STAT3 directly induces somatotroph tumor cell GH. Evaluation of pituitary tumors revealed that STAT3 expression was enhanced in human GH-secreting adenomas compared with that in nonsecreting pituitary tumors. Moreover, STAT3 and GH expression were concordant in a somatotroph ...

    Also Ranks for: Growth Hormone |  pituitary somatotroph |  stat3 expression |  gh3 cells |  tumor cell
    KOL Index score: 13444

    Leukemia inhibitory factor (LIF) is a pleiotropic neuroimmune cytokine that promotes corticotroph cell differentiation and induces proopiomelanocortin (POMC) mRNA expression and adrenocorticotropin hormone (ACTH) secretion. However, molecular mechanisms for this induction remain elusive. We therefore developed ACTH-secreting AtT20 transformants for wild-type or mutated STAT3, a cytokine signaling molecule, to address whether STAT3 is a determinant of LIF-mediated ACTH regulation. We show ...

    Also Ranks for: Leukemia Inhibitory |  stat3 lif |  factor signal |  pomc promoter |  acth secretion
    KOL Index score: 12299

    Pituitary tumor-transforming gene (PTTG), the index mammalian securin, is abundantly expressed in several tumors and regulates tumor growth and progression. Molecular mechanisms elucidating PTTG regulation and actions remain elusive. Here, we provide evidence that PTTG acts as a signal transducer and activator of transcription factor 3 (STAT3) target gene. Total STAT3 and Tyr705 phosphorylated STAT3 were concordantly expressed with PTTG in human colorectal tumors (n=97 and n=95, ...

    Also Ranks for: Cell Growth |  pttg expression |  colorectal cancer |  signal transducer |  molecular mechanisms


    Shlomo Melmed: Influence Statistics

    Sample of concepts for which Shlomo Melmed is among the top experts in the world.
    Concept World rank
    secreting gh #1
    adenohypophyseal cells lif #1
    gon lif #1
    adenomas induces #1
    correlation serum lif #1
    securin animals #1
    pttg1 securin protein #1
    disordered somatic growth #1
    cyclic receptors acromegaly #1
    hypothalamic hormonal regulation #1
    decreased proliferation senescence #1
    reference populations followup #1
    7 nm basal #1
    gon sgsm #1
    sxn101742 endopeptidase domain #1
    incubation att20 cells #1
    crh sstr5 #1
    sstr5 fetal pituitary #1
    tsa pttg1 #1
    enhanced responses doxorubicin #1
    acth pancreatic carcinoma #1
    chapter 12 acromegaly #1
    growth hormone acromegaly #1
    local growth hormone #1
    lif adenohypophysis #1
    srif compounds prl #1
    pomc acth secretion #1
    pituitary corticotroph #1
    tpit acth #1
    jak2 60 minutes #1
    acromegaly receiving #1
    serum lif #1
    sstr2 bim23a387 #1
    genes wlds #1
    10 microm incorporation #1
    pituitary p21 #1
    egfr erbb1 lapatinib #1
    il11 15 ± #1
    hpomc #1
    pituitary p21 levels #1
    pituitary adenomas chapter #1
    pomc cdna acth #1
    prolactin secretion seizures #1
    lif ebpbeta #1
    acromegaly cohort patients #1
    endogenous oct1 oct1 #1
    receptor prolactinoma #1
    octreotide inhibitory #1
    rats securin #1
    insulin 7 nm #1

    Key People For Growth Hormone

    Top KOLs in the world
    Michael O Thorner
    growth hormone gh secretion prolactin release
    Ron G Rosenfeld
    growth factor binding protein turner syndrome
    Raymond L Hintz
    growth factor insulin receptors binding proteins
    Jens Sandahl Sandahl Christiansen
    growth hormone body composition turner syndrome
    BengtÅke NÅ Bengtsson†
    growth hormone body composition gh replacement
    David Robert Clemmons
    growth factor binding protein smooth muscle

    Shlomo Melmed:Expert Impact

    Concepts for whichShlomo Melmedhas direct influence:Growth hormone,  Pituitary tumor,  Pituitary tumors,  Inhibitory factor,  Pituitary adenomas,  Leukemia inhibitory,  Growth factor,  Insulinlike growth factor.

    Shlomo Melmed:KOL impact

    Concepts related to the work of other authors for whichfor which Shlomo Melmed has influence:Growth hormone,  Pituitary adenomas,  Patients acromegaly,  Gene expression,  Multiple endocrine,  Transsphenoidal surgery,  Cushing disease.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Pituitary Center, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA. | Department of Medicine, Cedars‐Sinai Research Institute, University of California School of Med