Prominent publications by WenHui Du

KOL Index score: 11809

Systemic lupus erythematosus (SLE) is a complex systemic disease influenced by genetic and environmental factors. The exact pathogenesis of SLE is still unknown. Recently, several genome-wide association studies (GWA) in European population have found many novel susceptibility genes for SLE including TNFAIP3. In order to examine whether TNFAIP3 is associated with SLE in Chinese Han population, we genotyped one of its non-synonymous mutation SNP rs2230926, showing significant association ...

Known for Tnfaip3 Gene |  Systemic Lupus Erythematosus |  Sle Chinese Population |  Nucleotide Polymorphism |  Snp Rs2230926
KOL Index score: 10954

PSORS1 (psoriasis susceptibility gene 1) is a major susceptibility locus for psoriasis. Several fine-mapping studies have highlighted a 300-kb candidate region of PSORS1 where multiple biologically plausible candidate genes were suggested. The most recent study has indicated HLA-Cw6 as the primary PSORS1 risk allele within the candidate region in a Caucasian population. In this study, a family-based association analysis of the PSORS1 locus was performed by analyzing 10 polymorphic ...

Known for Chinese Population |  Psoriasis Susceptibility |  Fine Mapping |  Risk Haplotypes |  Psors1 Region
KOL Index score: 9226

An oligonucleotide biochip that specifically detects point mutations in the gyrA and parC genes of Neisseria gonorrhoeae was designed and subsequently evaluated with 87 untreated clinical specimens. The susceptibilities of the N. gonorrhoeae strains were tested to determine the prevalence of ciprofloxacin-resistant strains in Anhui Province, People's Republic of China. Conventional DNA sequencing was also performed to identify mutations in gyrA and parC and to confirm the biochip data. ...

Known for Ciprofloxacin Resistance |  Neisseria Gonorrhoeae |  Oligonucleotide Biochip |  Parc Mutations |  Asp95 Gyra
KOL Index score: 7082

OBJECTIVE: To report and analyze the mutations of the double-stranded RNA-specific adenosine deaminase (DSRAD) gene in 2 Chinese pedigrees with dyschromatosis symmetrica hereditaria (DSH).

DESIGN: Pedigree study.

SETTING: Anhui province of China.

PATIENTS: Two Chinese families, consisting of 19 individuals (family 1) and 5 individuals (family 2).

INTERVENTIONS: We directly performed mutation detection of the DSRAD gene in 2 Chinese families with DSH by sequencing. The whole coding region ...

Known for Frameshift Mutations |  Adenosine Deaminase |  Dsrad Gene |  Dyschromatosis Symmetrica |  Chinese Families
KOL Index score: 6467

Brooke-Spiegler syndrome (BSS) is an autosomal dominant disease characterized by cylindromas, trichoepitheliomas and occasionally spiradenomas. The disease gene was mapped to 16q12-13, and mutations in the CYLD gene were identified in families with BSS. In the present report, we describe a large consanguineous Chinese family with BSS showing an intra-family phenotypic variability. Clinically, some affected individuals only revealed discrete small skin-coloured tumors whereas the proband ...

Known for Tumor Suppressor |  Cyld Gene |  Spiegler Syndrome |  Cylindromas Trichoepitheliomas |  Adenoid Cystic Carcinoma
KOL Index score: 6356

Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibility, and report a new association within the LCE gene cluster at 1q21.

Known for Lce Gene Cluster |  Psoriasis Genome |  Susceptibility Variants |  Xuejun Zhang |  Mhc Il12b
KOL Index score: 6314

Very few articles have aimed to illuminate the clinical profiles of vitiligo in China. We conducted this retrospective survey involving 4118 outpatients with vitiligo in order to identify the differences among various clinical types of vitiligo and their associated disorders. Completed questionnaires (3742) were validated and analysed. Of this large cohort, 1565 (41.8%) individuals presented vitiligo vulgaris, followed by focal, segmental, acrofacial, and universal, in that order. The ...

Known for Clinical Profiles |  Patients Vitiligo |  Alopecia Areata Arthritis |  Age Onset |  20 Years
KOL Index score: 6262

OBJECTIVES: Psoriasis is common in childhood. The aim of this study was to present the clinical and epidemiological profile of childhood psoriasis in China.

METHODS: A total of 277 childhood psoriasis patients younger than 16 years old were enrolled. Statistical analysis and heritability were performed using EPI INFO 6.0, spss 10.0 and Falconer's method.

RESULTS: The median age was 11 years. The male : female ratio was 1:1.13. The median age of onset was 10 years. Of the patients, 48.7% ...

Known for Childhood Psoriasis |  Median Age Onset |  10 Years |  Female Ratio |  Child Preschool
KOL Index score: 6222

Darier’s disease (DD) is an autosomal dominantly inherited skin disorder characterized by loss of adhesion between epidermal cells (acantholysis) and abnormal keratinization. To date, at least 140 mutations in the ATP2A2 gene have been identified as the genetic basis of DD. Here we reported three familial and two sporadic Chinese DD patients totally with four missense mutations (N767D, M494I, M494L, C318F) and one splice-site mutation (1288–6A→G) in ATP2A2 gene, and presented a ...

Known for Atp2a2 Gene |  Chinese Patients |  Darier Disease |  Missense Mutations |  Mutational Analysis
KOL Index score: 6087

Vitiligo is a common skin and hair depigmentary disorder that results from selective destruction of melanocytes. It occurs in a typical multifactorial, polygenic inheritance. Several studies have indicated that vitiligo is associated with some autoimmune diseases. In this paper we examined 6,516 vitiligo patients including clinical characteristics, familial involvement, and their association with other autoimmune diseases. Compared with sporadic vitiligo probands, familial vitiligo ...

Known for Autoimmune Diseases |  Vitiligo Patients |  Rheumatoid Arthritis |  Alopecia Areata |  Diabetes Mellitus
KOL Index score: 5830

BACKGROUND: Acne is a chronic inflammatory disease of the pilosebaceous follicles. Recent studies bring us increasing evidences that hereditary factors play an important but indirect role in acne.

OBJECTIVE: To investigate the possible role of genetic factors in the pathogenesis of acne vulgaris in Chinese Han ethnic group.

PATIENTS AND METHODS: Volunteers of 975 acne cases and 580 controls were included, contributing 3009 and 1825 first-degree relatives, respectively. One thousand and ...

Known for Acne Vulgaris |  Genetic Factors |  Chinese Ethnic |  Case Control |  Predisposition Disease
KOL Index score: 5072

BACKGROUND: Marie Unna hereditary hypotrichosis (MUHH) is a rare autosomal congenital alopecia with progressive hair loss starting in early childhood and accelerating at puberty. A locus for MUHH has been mapped on chromosome 8p21 but no genes for MUHH have been identified to date.

OBJECTIVES: To refine the MUHH locus to a narrow chromosome region to facilitate cloning of the gene.

METHODS: We performed genotyping and linkage analysis in a multigeneration Chinese family with MUHH, using ...

Known for Marie Unna |  Hereditary Hypotrichosis |  Locus Muhh |  Chromosome 8p21 |  Haplotype Analysis
KOL Index score: 4783

BACKGROUND: Psoriasis is a common inflammatory and hyperproliferative skin disease. The pathogenesis of psoriasis remains obscure. Family and twin studies have suggested a strong genetic susceptibility to psoriasis. Eight linkage loci (PSORS1-7, PSORS9) were identified and accepted by the OMIM and an additional 16 susceptibility loci have been suggested so far.

OBJECTIVES: To investigate further three suggested psoriasis susceptibility loci at 2p22.3-11.2, 13q21-32 and 17q22-25.3 in a ...

Known for Susceptibility Loci |  Psoriasis Vulgaris |  Age Onset |  Chromosomes Human |  2p223 112
KOL Index score: 4505

Melanoma, the most aggressive form of skin cancer, causes more than 40,000 deaths each year worldwide. And epidermoid carcinoma is another major form of skin cancer, which could be studied together with melanoma in several aspects. Asparagine synthetase (ASNS) gene encodes an enzyme that catalyzes the glutamine- and ATP-dependent conversion of aspartic acid to asparagine, and its expression is associated with the chemotherapy resistance and prognosis in several human cancers. The present ...

Known for Asparagine Synthetase |  Cell Growth |  Knockdown Asns |  Human Cancers |  Chemotherapy Resistance
KOL Index score: 4371

BACKGROUND: Some studies suggested that human HLA status may potentiate development of the AA phenotype and exists ethic differences. No report has been published about HLA class I alleles associated with AA in Chinese Hans.

OBJECTIVE: To study the distribution of HLA class I alleles and haplotypes in Chinese Hans AA patients and the relation of HLA class I profile with age of onset, severity, duration of current attack, past history and family history.

METHODS: The polymerase chain ...

Known for Age Onset |  Aa Chinese |  Antigen Hla |  Alleles Alopecia |  Hair Loss


WenHui Du: Influence Statistics

Sample of concepts for which WenHui Du is among the top experts in the world.
Concept World rank
instccg tsc2 gene #3
mutation instccg #3
chinese protein tumor #3
instccg #3
recurrent keratin #4
generalized vitiligo probands #4
prevalences chronic urticaria #4
sporadic vitiligo probands #4
6516 vitiligo patients #4
marie unna china #6
urticaria rheumatoid #6
hypotrichosis 5 #6
chinese marie unna #6
snp rs2230926 #7
alopecia areata arthritis #7
prevalences autoimmune diseases #7
generalized vitiligo families #8
frames disease humans #8
krt6a chinese #9
familial vitiligo probands #9
hailey–hailey china #10
china darier #10
prevalences diabetes mellitus #10
chinese hailey #10
prevalences autoimmune #10
hereditary localized alopecia #10
darier china #10
atp2c1 mutations chinese #11
rosea common #11
chinese hailey–hailey #12
oligonucleotide biochip #12
frames chinese #12
hypotrichosis male mutation #12
175 interval #13
1p211–1q213 #13
muhh chromosome #13
hypotrichosis 175 #13
muhh genetically #13
human xuejun zhang #13
muhh performed #13
1q21 adolescent #13
d1s2881 haplotype analysis #13
previous associations mhc #13
vitiligo probands #13
psoriasis chinese populations #13
conformed evidence #13
cluster 1q21 #13
previous locus muhh #13
1q21 xuejun zhang #13
markers d1s248 #13

Key People For Acne Vulgaris

Top KOLs in the world
William James Cunliffe
acne vulgaris benzoyl peroxide sebum excretion rate
James Joseph Leyden
acne vulgaris benzoyl peroxide staphylococcus aureus
Diane M Thiboutot
acne vulgaris adapalene gel sebaceous glands
Brigitte DRENO
metastatic melanoma consultancy funding acne vulgaris
Alan R Shalita
acne vulgaris adapalene gel benzoyl peroxide
Christos Constantin Zouboulis
hidradenitis suppurativa human sebocytes sebaceous glands

WenHui Du:Expert Impact

Concepts for whichWenHui Duhas direct influence:Acne vulgaris,  Pityriasis rosea,  Autoimmune diseases,  Chinese patients,  Missense mutation,  Marie unna,  Pachyonychia congenita,  Lesional skin.

WenHui Du:KOL impact

Concepts related to the work of other authors for whichfor which WenHui Du has influence:Psoriatic arthritis,  Chinese population,  Alopecia areata,  Vitiligo patients,  Acne vulgaris,  Pediatric psoriasis,  Systemic lupus erythematosus.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

Anhui Medical University, 1st Affiliated Hospital, Department of Dermatology, Hefei, China, Department of Dermatology, 1st Affiliated Hospital, Anhui Medical University, Hefei, China. | Anhui Medical University Department of Dermatology Institute of

FREE Custom List