Prominent publications by Jean MEYNADIER

KOL Index score: 12839

This multicenter, randomized, investigator-blinded study compared the efficacy and tolerability of a combination of lymecycline 300 mg/day orally and adapalene topical gel 0.1% (n = 118) to lymecycline 300 mg/day orally plus vehicle gel (n = 124) in patients with moderate to moderately severe acne vulgaris with both inflammatory and noninflammatory lesions. The primary efficacy end point, total lesion count at end point (last observation carried forward), showed a statistically ...

Also Ranks for: Adapalene Gel |  oral administration |  topical therapy |  acne vulgaris |  lymecycline vehicle
KOL Index score: 11773

A randomized, multicentre, investigator-masked study was conducted in 105 patients with mild to moderate acne vulgaris to compare the efficacy and safety of adapalene 0.1% gel with tretinoin 0.025% gel after three months of treatment, with particular emphasis on reduction in inflammatory lesion counts after one week of treatment and impact on quality of life. In terms of efficacy, adapalene gel was found to be superior to tretinoin gel after one week of treatment, with respect to ...

Also Ranks for: Acne Vulgaris |  adapalene tretinoin |  quality life |  gel treatment |  efficacy safety
KOL Index score: 11026

BACKGROUND: Ultraviolet (UV) B-induced effects on the skin immune system have been extensively investigated, but little is known regarding the immunological changes induced by UVA exposure of human skin. Recent data assessing the protection afforded by sunscreens against photoimmunosuppression stress the need for broad-spectrum sunscreens with an adequate UVA protection.

OBJECTIVES: The purpose of this study was first to determine the changes observed in epidermal Langerhans cells (ELC) ...

Also Ranks for: Human Skin |  presenting cell |  epidermal antigen |  uva exposure |  immune protection
KOL Index score: 10356

BACKGROUND: The biologically active form of vitamin D3, calcitriol, may offer a new therapeutic approach to psoriasis. Calcipotriol, a new vitamin D3 analogue, is at least 100 times less calcemic than calcitriol.

OBJECTIVE: Our purpose was to study the efficacy and safety of calcipotriol in the treatment of psoriasis vulgaris.

METHODS: In a right/left comparative, double-blind study, treatment with calcipotriol ointment (50 micrograms/gm) twice daily and placebo was given for 4 weeks. ...

Also Ranks for: Psoriasis Vulgaris |  4 weeks |  efficacy safety |  calcipotriol placebo |  vitamin d3
KOL Index score: 9987

BACKGROUND: Cutaneous exposure to UVB radiation impairs the induction of contact hypersensitivity (CHS). Variable results have been found among studies examining the use of sunscreens to prevent UV-induced immunosuppression.

OBJECTIVE: Our purpose was to determine whether solar-simulated exposure of human skin resulted in an impairment of CHS responses and whether the preapplication of an intermediate sun protection factor (SPF) sunscreen could prevent this locally UV-induced ...

Also Ranks for: Uva Protection |  ultraviolet exposure |  human skin |  dncb sensitization |  contact hypersensitivity
KOL Index score: 8677

BACKGROUND: Adapalene is a new chemical entity that exhibits tretinoin-like activities in the terminal differentiation process.

OBJECTIVE: We evaluated a dose range effect of two concentrations of adapalene gel as acne treatment and compared adapalene 0.1% gel with tretinoin 0.025% gel in the treatment of acne patients in two large multicenter studies.

METHODS: Multicenter, investigator-masked, parallel group studies including 89 acne patients in the dose range study and 591 patients in ...

Also Ranks for: Adapalene Gel |  acne vulgaris |  multicenter studies |  new chemical entity |  01 effective
KOL Index score: 8033

BACKGROUND: In addition to tetracyclines, zinc may constitute an alternative treatment in inflammatory lesions of acne.

OBJECTIVE: To evaluate the place of zinc gluconate in relation to antibiotics in the treatment of acne vulgaris.

METHODS: Zinc was compared to minocycline in a multicenter randomized double-blind trial. 332 patients received either 30 mg elemental zinc or 100 mg minocycline over 3 months. The primary endpoint was defined as the percentage of the clinical success rate on ...

Also Ranks for: Inflammatory Acne |  zinc gluconate |  3 months |  alternative treatment |  1 month
KOL Index score: 7744

Forty-five patients with cutaneous T-cell lymphomas (CTCL), 32 with mycosis fungoides (MF) and 13 with Sézary syndrome (SS), were treated with interferon-alpha 2a (IFN-alpha 2a) (6-9 x 10(6) IU daily) for 3 months. Those responding to treatment were then treated with interferon-alpha alone (6-9 x 10(6) IU three times weekly), and non-responders received a combination of etretinate (0.5 mg/kg/day) and IFN-alpha 2a in similar concentrations. After 12 months of treatment, 28/45 patients ...

Also Ranks for: Cutaneous T‐cell Lymphoma |  drug therapy |  45 patients |  low doses |  interferon alpha
KOL Index score: 6077

The peripheral benzodiazepine receptor (PBR) is a protein of mitochondrial outer membranes utilizing porphyrins as endogenous ligands. PBR is part of a heteromeric receptor complex involved in the formation of mitochondrial permeability transition pores and in the early events of apoptosis. PBR may function as an oxygen-dependent signal generator; recent data indicate that these receptors may preserve the mitochondria of haematopoietic cell lines from damage caused by oxygen radicals. To ...

Also Ranks for: Human Skin |  benzodiazepine receptor |  pbr expression |  epidermal cells |  cell differentiation
KOL Index score: 6027

A randomized double-blind study was designed with 65 patients in order to clarify two points: (1) does addition of a retinoid to psoralen-ultra violet A photochemotherapy (PUVA) of severe psoriasis decrease the UVA energy required to achieve remission, and (2) is there a difference between two retinoids, i.e. etretinate and acitretin. Acitretin-PUVA treatment was significantly superior to placebo-PUVA with respect to several items (decrease in lesional scores after 6 weeks of therapy, ...

Also Ranks for: Severe Psoriasis |  lesional scores |  etretinate acitretin |  photochemotherapy puva |  total dose
KOL Index score: 5280

The present randomized, placebo-controlled double-blind multicenter study included a population of 36 subjects with frequent recurrences (at least once a month) of herpes labialis. Most of the patients had failed to respond adequately to previous treatment with other therapeutic tools, including acyclovir. Either 50 mg of thymopentin or of placebo was administered 3 times a week, by the subcutaneous route, for 6 weeks. Subsequently, the patients were observed for nearly 6 months on the ...

Also Ranks for: Herpes Labialis |  patients thymopentin |  6 weeks |  thymus hormones |  peptide fragments

Key People For Human Skin

Top KOLs in the world
Howard *** *******
contact dermatitis percutaneous absorption human skin
John * ********
human skin retinoic acid ultraviolet irradiation
Peter * *****
stratum corneum barrier function atopic dermatitis
Gary * ******
human skin retinoic acid growth factor
Richard * * ***
stratum corneum reverse iontophoresis drug delivery
Albert * *******
acne vulgaris stratum corneum benzoyl peroxide

Jean MEYNADIER:Expert Impact

Concepts for whichJean MEYNADIERhas direct influence:Human skin,  Plasma exchange,  Tretinoin gel,  Adapalene gel,  Severe psoriasis,  Bullous pemphigoid,  Inflammatory acne,  Acne vulgaris.


Concepts related to the work of other authors for whichfor which Jean MEYNADIER has influence:Acne vulgaris,  Lichen planus,  Adapalene gel,  Notalgia paresthetica,  Atopic dermatitis,  Calcipotriol ointment,  Treatment psoriasis.



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Faculté de Médecine, Montpellier | Hôpital Saint Eloi, Montpellier and Sophia Antipolis, France | Department of Dermatology-Allergology-Photobiology, Hôpital St-Eloi, Montpellier, France | Department of Dermatology, CHU Nantes, Statistician, Paris, D