Prominent publications by Nicholas John White

KOL Index score: 23070

BACKGROUND: Potentially untreatable Plasmodium falciparum malaria threatens the Greater Mekong subregion. A previous series of pilot projects in Myanmar, Laos, Cambodia, and Vietnam suggested that mass drug administration was safe, and when added to provision of early diagnosis and treatment, could reduce the reservoir of P falciparum and interrupts transmission. We examined the effects of a scaled-up programme of this strategy in four townships of eastern Myanmar on the incidence of P ...

Known for Falciparum Malaria |  Early Diagnosis |  Eastern Myanmar |  Mass Drug Administration |  Hotspot Villages
KOL Index score: 21172

BACKGROUND: The borders of Thailand harbour the world's most multidrug resistant Plasmodium falciparum parasites. In 1984 mefloquine was introduced as treatment for uncomplicated falciparum malaria, but substantial resistance developed within 6 years. A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known.

METHODS: The relation between polymorphisms in the P falciparum ...

Known for Mefloquine Resistance |  Gene Copy |  Pfmdr1 Falciparum |  Treatment Failure |  Animals Antimalarials
KOL Index score: 20651

BACKGROUND: Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment and delay emergence of antimalarial drug resistance.

METHODS: In this multicentre, open-label, randomised trial, we recruited patients with uncomplicated P falciparum malaria ...

Known for Plasmodium Falciparum |  Artemether Lumefantrine Artemetherlumefantrine |  Piperaquine Mefloquine |  Based Combination |  Risk Difference
KOL Index score: 20199

BACKGROUND: The emergence and spread of resistance in Plasmodium falciparum malaria to artemisinin combination therapies in the Greater Mekong subregion poses a major threat to malaria control and elimination. The current study is part of a multi-country, open-label, randomised clinical trial (TRACII, 2015-18) evaluating the efficacy, safety, and tolerability of triple artemisinin combination therapies. A very high rate of treatment failure after treatment with ...

Known for Falciparum Malaria |  Treatment Failure |  Piperaquine Resistance |  Thailand Cambodia |  Greater Mekong
KOL Index score: 17196

BACKGROUND: A large fraction of Plasmodium infections do not cause clinical signs and symptoms of disease and persist at densities in blood that are not detectable by microscopy or rapid diagnostic tests. These infections may be critical as a transmission reservoir in areas of low malaria endemicity. Understanding the epidemiology of these infections would be helpful for malaria elimination.

METHODS: A cross-sectional survey was conducted in Thapangthong and Nong Districts of Savannakhet ...

Known for Plasmodium Infections |  Lao Pdr |  Southern Savannakhet |  Falciparum Vivax |  Malaria Elimination
KOL Index score: 16822

BACKGROUND: The emergence and spread of multidrug-resistant Plasmodium falciparum in the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass drug administration (MDA), the presumptive antimalarial treatment of an entire population to clear the subclinical parasite reservoir, is a strategy to accelerate malaria elimination. We report a cluster randomised trial to assess the effectiveness of dihydroartemisinin-piperaquine (DP) MDA in reducing falciparum ...

Known for Falciparum Malaria |  Southeast Asia |  Mass Drug |  Cluster Randomised |  Mda Villages
KOL Index score: 16806

BACKGROUND: A substantial proportion of Plasmodium species infections are asymptomatic with densities too low to be detectable with standard diagnostic techniques. The importance of such asymptomatic plasmodium infections in malaria transmission is probably related to their duration and density. To explore the duration of asymptomatic plasmodium infections and changes in parasite densities over time, a cohort of participants who were infected with Plasmodium parasites was observed over a ...

Known for Plasmodium Falciparum |  Vivax Infections |  Malaria Transmission |  Parasite Densities |  Low Density
KOL Index score: 16662

BACKGROUND: Artemisinin-combination therapy (ACT) is recommended as first-line treatment of falciparum malaria throughout the world, and fixed-dose combinations are preferred by WHO; whether a single gametocytocidal dose of primaquine should be added is unknown. We aimed to compare effectiveness of four fixed-dose ACTs and a loose tablet combination of artesunate and mefloquine, and assess the addition of a single gametocytocidal dose of primaquine.

METHODS: In an open-label randomised ...

Known for Falciparum Malaria |  Artemisinin Combination |  Single Dose Primaquine |  Artesunate Mefloquine |  Artemether Lumefantrine
KOL Index score: 16228

Importance: The quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score has not been well-evaluated in low- and middle-income countries (LMICs).

Objective: To assess the association of qSOFA with excess hospital death among patients with suspected infection in LMICs and to compare qSOFA with the systemic inflammatory response syndrome (SIRS) criteria.

Design, Settings, and Participants: Retrospective secondary analysis of 8 cohort studies and 1 randomized clinical trial ...

Known for Hospital Mortality |  Qsofa Score |  Quick Sequential |  Sirs Criteria |  Suspected Infection
KOL Index score: 16139

BACKGROUND: Malaria still remains a public health problem in some districts of Bhutan despite marked reduction of cases in last few years. To strengthen the country's prevention and control measures, this study was carried out to develop forecasting and prediction models of malaria incidence in the endemic districts of Bhutan using time series and ARIMAX.

METHODS: This study was carried out retrospectively using the monthly reported malaria cases from the health centres to Vector-borne ...

Known for Malaria Cases |  Districts Bhutan |  Arimax Model |  Meteorological Factors |  Moving Average
KOL Index score: 15874

BACKGROUND: Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality. We compared parenteral treatment with either artesunate or quinine in African children with severe malaria.

METHODS: This open-label, randomised trial was undertaken in 11 centres in nine African ...

Known for Severe Falciparum Malaria |  Artesunate Quinine |  African Children |  Parenteral Treatment |  Randomised Trial
KOL Index score: 15773

BACKGROUND: Primaquine is the only available drug that clears mature Plasmodium falciparum gametocytes in infected human hosts, thereby preventing transmission of malaria to mosquitoes. However, concerns about dose-dependent haemolysis in people with glucose-6-phosphate dehydrogenase (G6PD) deficiencies have limited its use. We assessed the dose-response association of single-dose primaquine for gametocyte clearance and for safety in P falciparum malaria.

METHODS: We undertook this ...

Known for Dose Primaquine |  Uncomplicated Malaria |  Plasmodium Falciparum |  Gametocyte Carriage |  Artemether Lumefantrine
KOL Index score: 15042

BACKGROUND: Artefenomel (OZ439) is a novel synthetic trioxolane with improved pharmacokinetic properties compared with other antimalarial drugs with the artemisinin pharmacophore. Artefenomel has been generally well tolerated in volunteers at doses up to 1600 mg and is being developed as a partner drug in an antimalarial combination treatment. We investigated the efficacy, tolerability, and pharmacokinetics of artefenomel at different doses in patients with Plasmodium falciparum or ...

Known for Plasmodium Falciparum |  Antimalarial Activity |  Vivax Malaria |  Artefenomel Oz439 |  400 800
KOL Index score: 14814

BACKGROUND: The effects of malaria and its treatment in the first trimester of pregnancy remain an area of concern. We aimed to assess the outcome of malaria-exposed and malaria-unexposed first-trimester pregnancies of women from the Thai-Burmese border and compare outcomes after chloroquine-based, quinine-based, or artemisinin-based treatments.

METHODS: We analysed all antenatal records of women in the first trimester of pregnancy attending Shoklo Malaria Research Unit antenatal clinics ...

Known for Early Pregnancy |  Malaria Trimester |  Risk Factors Miscarriage |  Adjusted Odds Ratio |  Falciparum Vivax
KOL Index score: 14751

Pregnant women are particularly vulnerable to malaria. The pharmacokinetic properties of antimalarial drugs are often affected by pregnancy, resulting in lower drug concentrations and a consequently higher risk of treatment failure. The objective of this study was to evaluate the population pharmacokinetic properties of piperaquine and dihydroartemisinin in pregnant and nonpregnant women with uncomplicated malaria. Twenty-four pregnant and 24 matched nonpregnant women on the Thai-Myanmar ...

Known for Uncomplicated Malaria |  Nonpregnant Women |  Population Pharmacokinetics |  Dihydroartemisinin Piperaquine |  Pharmacokinetic Properties


Nicholas John White: Influence Statistics

Sample of concepts for which Nicholas John White is among the top experts in the world.
Concept World rank
thailand 1986–2010 #1
treatment failure mefloquine #1
rosetting uninfected rbc #1
quinine dihydroquinine clearance #1
antimalarials arrhythmias #1
unidentified acids #1
years ciprofloxacin #1
plasma concentrations pfhrp2 #1
day 63 #1
artesunate child #1
tetracycline combinations #1
arabinose‐positive #1
illness tetanus #1
cfh f2isops #1
rectal artesunate artesunate #1
intravenous administration piperaquine #1
communityacquired septicaemia #1
induced haemolysis #1
brain severe malaria #1
dhps gene isolates #1
00610 #1
primaquine drug #1
pregnancy falciparum malaria #1
slowly eliminated drugs #1
measurable attenuation #1
combined artesunate #1
stillbirth falciparum #1
antivenom reversal #1
children severe shock #1
vientiane mortality #1
95 falciparum infections #1
clearance quinine #1
mab ara biotype #1
blood venous #1
antimalarial pharmacodynamics #1
metabolite dihydroartemisinin #1
arterolanepiperaquine #1
persistent plasmodium falciparum #1
drugs vivax #1
plasmepsin ii–iii copy #1
linear models malaria #1
pharmacodynamic properties amodiaquine #1
parasite ancestry pcoa #1
falciparum malaria risk #1
specificity bacterial infections #1
plasmodium vivax adherence #1
population estimates parameters #1
murine model hcm #1
dakar score #1
azithromycin azithromycin chromatography #1

Key People For Falciparum Malaria

Top KOLs in the world
Nicholas John White
falciparum malaria plasmodium vivax southeast asia
Sornchai Looareesuwan
falciparum malaria plasmodium vivax southeast asia
Kevin Marsh
severe malaria plasmodium falciparum protozoan antigens
François Henry Nosten
falciparum malaria pregnant women plasmodium vivax
BRIAN M Greenwood
plasmodium falciparum gambian children west africa
Nicholas Philip John Day
severe malaria scrub typhus plasmodium falciparum

Nicholas John White:Expert Impact

Concepts for whichNicholas John Whitehas direct influence:Falciparum malaria,  Severe malaria,  Plasmodium falciparum,  Vivax malaria,  Cerebral malaria,  Severe falciparum malaria,  Plasmodium vivax,  Southeast asia.

Nicholas John White:KOL impact

Concepts related to the work of other authors for whichfor which Nicholas John White has influence:Plasmodium falciparum,  Cerebral malaria,  Typhoid fever,  Pregnant women,  Tuberculous meningitis,  Burkholderia pseudomallei,  Japanese encephalitis.



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Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand; | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom | Mahidol Oxford Research Unit, Faculty of Tropical Med

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