• Disease
  • Platinum
  • Platinum Resistance
  • Yingzi Liu

    Prominent publications by Yingzi Liu

    KOL Index score: 14769

    It is known that excessive adipogenesis contributes to osteoporosis, suggesting that trans-differentiation of adipogenic committed preadipocytes into osteoblasts may be a potential therapeutical approach for osteoporosis. We explored whether bone morphogenic protein 9 (BMP9) could induce 3T3-L1 preadipocytes to trans-differentiate into osteoblasts. BMP9 effectively increased expression of osteogenic markers and promoted mineralization in preadipocytes. However, BMP9 also led to ...

    Also Ranks for: Bmp9 Atra |  catenin signaling |  bmp smad |  retinoic acid |  adipogenic differentiation
    KOL Index score: 12184

    INTRODUCTION: The interpretation of equivocal Papanicolaou (Pap) smear results remains challenging, even with the addition of the high-risk human papillomavirus test (HPV-HR). Recently, methylated zinc finger protein 582 (ZNF582) (ZNF582 (m) ) was reported to be highly associated with cervical cancer. In this study, we compared the performance of ZNF582 (m) detection and HPV-HR genotyping in the triage of cervical atypical squamous cell of undetermined significance (ASC-US) and atypical ...

    Also Ranks for: Sensitivity Specificity |  hpv16 18 |  triage women |  methylated znf582 |  hpv genotyping
    KOL Index score: 6175

    The Min pig (Sus scrofa) is a well-known indigenous breed in China. One of its main advantages over European breeds is its high meat quality. Additionally, different cuts of pig also show some different traits of meat quality. To explore the underlying mechanism responsible for the differences of meat quality between different breeds or cuts, the longissimus dorsi muscle (LM) and the biceps femoris muscle (BF) from Min and Large White pigs were investigated using transcriptome analysis. ...

    Also Ranks for: Meat Quality |  large white |  transcriptome analysis |  chinese indigenous |  muscle skeletal
    KOL Index score: 5811

    Based on our recent investigations on chalcone derivatives as AChE inhibitors, a series of ferulic acid (FA) tertiary amine derivatives similar to chalcone compounds were designed and synthesized. The results of bioactivity evaluation revealed that most of new synthesized compounds had comparable or more potent AChE inhibitory activity than the control drug Rivastigmine. The alteration of carbon chain linking tertiary amine groups and ferulic acid scaffold markedly influenced the ...

    Also Ranks for: Butyrylcholinesterase Inhibitors |  tertiary amine |  molecular docking |  activity ache |  chalcone derivatives
    KOL Index score: 5453

    Ovarian cancer is one of the most lethal malignancies of the female reproductive system. Platinum-resistance is the major obstacle in the successful treatment of ovarian cancer. Previous studies largely failed to identify the key genes associated with platinum-resistance by using candidate genes testing, bioinformatic analysis and GWAS method. The aim of the study was to utilize the whole human Genome-scale CRISPR-Cas9 knockout (GeCKO) library to screen for novel genes involved in ...

    Also Ranks for: Cisplatin Resistance |  ovarian cancer |  cell lines |  crispr cas9 |  genome scale
    KOL Index score: 5390

    Glioma is a common brain malignancy for which new drug development is urgently needed because of radiotherapy and drug resistance. Recent studies have demonstrated that artemisinin (ARS) compounds can display antiglioma activity, but the mechanisms are poorly understood. Using cell lines and mouse models, we investigated the effects of the most soluble ARS analogue artesunate (ART) on glioma cell growth, migration, distant seeding and senescence and elucidated the underlying mechanisms. ...

    Also Ranks for: Cell Senescence |  mevalonate pathway |  mouse models |  artesunate inhibits |  ratelimiting enzyme
    KOL Index score: 5373

    MicroRNAs negatively regulate target gene expression at the post-transcriptional level during carcinogenesis. Recent advances revealed that the expression levels of several miRNAs are up- or down-regulated in endometrial carcinoma (EC). Here we identify dysregulated miRNAs in EC and we elucidate the essential role of let-7a. The expression of 86 miRNAs in EC was found to be different from adjacent normal endometrial tissues. Moreover, miR-let-7 members are down-regulated in EC and let-7 ...

    Also Ranks for: Gene Expression |  carcinoma cells |  targeting aurora |  endometrial cancer |  cell proliferation
    KOL Index score: 3997

    LncRNAs have been suggested to be key modulators in many biological and pathological processes. LncARSR, a recently identified lncRNA, plays crucial roles in the progression of several cancers. However, the role of lncARSR in NSCLC is uninvestigated. In the present study, it was demonstrated that lncARSR expression was higher in NSCLC tissues than in noncancerous tissues. The expression of lncARSR was higher in four NSCLC cell lines than in a normal lung bronchial epithelial line. ...

    Also Ranks for: Cell Lung |  nsclc tissues |  overexpression lncarsr
    KOL Index score: 3874

    A novel exopolysaccharide (EPS), namely, B4-EPS, is produced by Arthrobacter sp. B4. Response surface methodology (RSM) was employed to optimize the fermentation medium for increasing B4-EPS production. Based on Plackett-Burman design (PBD), glucose, yeast extract, and KH2PO4 were selected as significant variables, which were further optimized by a central composite design (CCD). According to response surface and canonical analysis, the optimal medium was composed of 16.94 g/L glucose, ...

    Also Ranks for: Antibiofilm Activity |  biofilm formation |  arthrobacter b4 |  pseudomonas aeruginosa |  maximum yield
    KOL Index score: 3556

    Lung cancer is the common cause of cancer-related death worldwide. Platinum-based chemotherapy is the cornerstone of treatment for lung cancer. Platinum sensitivity is a major possibility for effective cancer treatment. In this study, several potential biomarkers were identified for evaluating and predicting the response to platinum-based chemotherapy. LC-MS-based metabolomics was performed on plasma samples from 43 lung cancer patients with different chemotherapy efficacy. By combing ...

    Also Ranks for: Lung Cancer |  potential biomarkers |  platinumbased chemotherapy |  tandem mass |  acid metabolism
    KOL Index score: 3275

    A novel molecularly imprinted copolymers sensor for fast and direct determination of tartrazine (TZ) was studied. The copolymers were immobilized on the surface of the glassy carbon electrode (GCE) directly via electropolymerization with m-dihydroxybenzene (m-DB) and o-phenylenediamine (o-PD) as monomers. After elution, the copolymer was filled with nanopores that can specially bounds with tartrazine molecule. The developed sensor (MIP-PmDB/PoPD-GCE) determinates tartrazine specifically ...

    Also Ranks for: Molecularly Imprinted |  carbon electrode |  tartrazine tz |  developed sensor |  soft drinks
    KOL Index score: 2753

    Low-dose computed tomography (CT) is desirable for treatment planning and simulation in radiation therapy. Multiple rescanning and replanning during the treatment course with a smaller amount of dose than a single conventional full-dose CT simulation is a crucial step in adaptive radiation therapy. We developed a machine learning-based method to improve image quality of low-dose CT for radiation therapy treatment simulation. We used a residual block concept and a self-attention strategy ...

    Also Ranks for: Image Quality |  computed tomography |  treatment planning |  low dose |  deep learning
    KOL Index score: 2737

    Infections are a major complication of obesity, but the mechanisms responsible for impaired defense against microbes are not well understood. Here, we found that adipocyte progenitors were lost from the dermis during diet-induced obesity (DIO) in humans and mice. The loss of adipogenic fibroblasts from mice resulted in less antimicrobial peptide production and greatly increased susceptibility to Staphylococcus aureus infection. The decrease in adipocyte progenitors in DIO mice was ...

    Also Ranks for: Staphylococcus Aureus |  adipogenic fibroblasts |  diet induced |  anti infective |  l1 cells
    KOL Index score: 2539

    Pre-imidization has been found to have a determining role on the final properties of polyimide (PI) films. In this work, a series of 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA)/2,2'-bis(trifluoromethyl)benzidine (TFMB) PI models with specified pre-imidization degree (pre-ID) were constructed and analyzed on the basis of molecular dynamic (MD) simulation to reveal the real-time evolution of structure and properties that occurred during the pre-imidization process. The MD ...

    Also Ranks for: Molecular Chain |  imidization process |  polyimide films |  md simulation |  thermal expansion


    Yingzi Liu: Influence Statistics

    Sample of concepts for which Yingzi Liu is among the top experts in the world.
    Concept World rank
    genes znf587b #4
    potec #4
    sulf1 resistance #4
    usp17l20 #4
    cisplatin resistance znf587b #4
    cisplatin resistance sulf1 #4
    cck8 rtpcr analysis #4
    19052 genes #4
    sulf1 contributed #4
    znf587b sulf1 #4
    gwas method aim #4
    sema4g potec #4
    sulf1 cisplatin resistance #4
    candidate genes testing #4
    genome crisprcas9 #4
    rtpcr sulf1 #4
    lines gecko #4
    resistance znf587b #4
    sulf1 genes #6
    rs77382849 #7
    b4 eps #7
    eif3a rs77382849 #7
    b4eps #7
    polymorphism eif3a #7
    aurorab let7a #8
    arthrobacter b4 #8
    let7a inhibits #8
    rs10981694 allele #9
    cbctbased sct #9
    eif3a gene #9
    atra bmp9 #10
    bmp9 atra #10
    atp7a platinum resistance #10
    znf587b #10
    specificity znf582 #12
    rs10981694 #12
    platinumbased chemotherapy cornerstone #14
    znf582 hpv16 18 #15
    gecko library #15
    gecko library genes #19
    preimidization degree #19
    chain acetylcholinesterase #20
    rs10981694 polymorphism #20
    residual cervical cells #26
    lncarsr #32
    tertiary amine chain #32
    atp7b platinum #33
    mirnas endometrial cancer #33
    adipogenic fibroblasts #34
    sema4g #35

    Key People For Platinum Resistance

    Top KOLs in the world
    Ahmedin M Jemal
    united states breast cancer addis ababa
    Rebecca L Siegel
    united states colorectal cancer incidence rates
    Ignace B P Vergote
    ovarian cancer neoadjuvant chemotherapy advisory consultancy
    Anil K Sood
    ovarian cancer tumor growth gene expression
    David D L Bowtell
    ovarian cancer gene expression cyclin e1
    Michael Leonard Friedlander
    ovarian cancer maintenance olaparib brca1 genes

    Yingzi Liu:Expert Impact

    Concepts for whichYingzi Liuhas direct influence:Platinum resistance,  Meat quality,  Cisplatin resistance,  Copper transporter,  Large white,  Bmp9 atra,  Atra bmp9,  Antibiofilm activity.

    Yingzi Liu:KOL impact

    Concepts related to the work of other authors for whichfor which Yingzi Liu has influence:Osteogenic differentiation,  Mesenchymal stem cells,  Endometrial cancer,  Platinum resistance,  Ferulic acid,  Meat quality,  Large white pigs.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Department of Radiation Oncology, Emory University, Atlanta, Georgia, USA | Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China, hebmu.edu.cn | Department of Radiation Oncology, Winship Can