Koen Kas

Koen Kas

Department Of Biochemistry, Laboratory Of Molecular Biotechnology, University Of Antwerp, B-2610 Wilrijk, Belgium

Direct Impact

Concepts for which Koen Kas has direct influence:

pleomorphic adenomas
fau gene
salivary glands
genomic structure
situ hybridization
plag1 activation
linkage disequilibrium

External impact

Concepts related to the work of other authors for which Koen Kas has influence:

endocrine neoplasia
radiation hybrids
transcript map
men1 gene
salivary gland
long arm
pleomorphic adenoma

Prominent publications by Koen Kas

KOL-Index: 37 Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by parathyroid, pancreatic, and anterior pituitary tumors. The MEN1 locus has been previously localized to chromosome 11q13, and a 2-Mb gene-rich region flanked by D11S1883 and D11S449 has been defined. We have pursued studies to facilitate identification of the MEN1 gene by narrowing ...
Known for
11q13 Gene | 900-Kb | Valuable Transcriptional Map | 26 Cosmids
KOL-Index: 33 In this report, the identification and molecular characterization of a novel gene, designated TM7SF2, is reported. This gene was found in the FAU neighboring area (FAUNA) to which other genes have been mapped previously. The FAUNA gene cluster is located at chromosome 11q13 between landmarks H4B and D11S2196E. The TM7SF2 gene contains eight coding exons, and their splice site consensus ...
Known for
Characterization Gene | 11q13 Identification | Half Transmembrane | Tm7sf2 Protein
KOL-Index: 26 The activation of the pleomorphic adenoma gene 1 (PLAG1) is the most frequent gain-of-function mutation found in pleomorphic adenomas of the salivary glands. To gain more insight into the regulation of PLAG1 function, we searched for PLAG1-interacting proteins. Using the yeast two-hybrid system, we identified karyopherin alpha2 as a PLAG1-interacting protein. Physical interaction between ...
Known for
Plag1 Mutation | Karyopherin Alpha2 Escorts Proteins | Basic Amino Acids | Nuclear Localization Sequence
KOL-Index: 25 Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by tumours of the parathyroids, pancreas and anterior pituitary that represents one of the familial cancer syndromes. The MEN1 locus has been previously localised to chromosome 11q13, and a <300 kb gene-rich region flanked centromerically by PYGM and telomerically by D11S1783 defined by combined ...
Known for
Neoplasia Men1 | Genes Identified | Gene Endocrine | Transcript Pancreas
KOL-Index: 19 Nature Genetics 15, 17CM74 (1997). Two lines of the PLAG1 sequence (nt 5300–5621) in the 3′ untranslated region were inadvertently deleted from Fig. 2 a. The complete sequence for this region can be obtained from GenBank accession number U65002. We apologize for any inconvenience created by this error.
Known for
3′ Untranslated Region | Inconvenience | Genbank Accession Number U65002
KOL-Index: 18
Known for
Rat Pleiomorphic | Radiation Hybrid | Adenoma Genes
KOL-Index: 14 Pleomorphic adenoma gene (PLAG) 1, the main translocation target in pleomorphic adenomas of the salivary glands, is a member of a new subfamily of zinc finger proteins comprising the tumor suppressor candidate PLAG-like1 (also called ZAC1 or lost on transformation 1) and PLAGL2. In this report, we show that NIH3T3 cells overexpressing PLAG1 or PLAGL2 display the typical markers of neoplastic ...
Known for
Plag1- Plagl2-Induced Transformation | Dna-Binding Domain | Nih3t3 Cells | Anchorage-Independent Growth
KOL-Index: 14 PLAG1, a novel developmentally regulated C2H2 zinc finger gene, is consistently rearranged and overexpressed in pleomorphic adenomas of the salivary glands with 8q12 translocations. In this report, we show that PLAG1 is a nuclear protein that binds DNA in a specific manner. The consensus PLAG1 binding site is a bipartite element containing a core sequence, GRGGC, and a G-cluster, RGGK, ...
Known for
Binds Igf | Core Finger | Transcription Dna | Plag1 Expression
KOL-Index: 13 The FAU gene (FBR-MuSV associated ubiquitously expressed gene) encodes the ribosomal protein S30 fused with a Ubiquitin-like molecule. The FAU gene is expressed in a wide range of tissues, is evolutionarily conserved, and has putative tumour suppressor activity in vitro. The human FAU gene maps to the long arm of chromosome 11 band q13, close to the PYGM locus. This locus is tightly linked ...
Known for
Men1 Tumour | Gene Expressed | Blot Fau | Dgge Parathyroid

Department of Biochemistry, Laboratory of Molecular Biotechnology, University of Antwerp, B-2610 Wilrijk, Belgium

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