• Disease
  • Postviral
  • Postviral Fatigue
  • Postviral Fatigue Syndrome
  • Eleanor J Bell

    Prominent publications by Eleanor J Bell

    KOL Index score: 7842

    OBJECTIVE: To study the association between coxsackie B virus infection and the postviral fatigue syndrome and to assess the immunological abnormalities associated with the syndrome.

    DESIGN: Case-control study of patients with the postviral fatigue syndrome referred by local general practitioners over one year.

    SETTING: General practitioner referrals in Dunbartonshire, Scotland.

    PATIENTS: 254 Patients referred with the postviral fatigue syndrome (exhaustion, myalgia, and other symptoms ...

    Also Ranks for: Postviral Fatigue Syndrome |  coxsackie virus |  chronic female humans |  general practitioner |  immunological abnormalities
    KOL Index score: 7145

    Between August and November 1985, 45 patients with suspected aseptic meningitis were investigated using conventional virus isolation procedures and the mu-antibody capture Coxsackie B IgM enzyme-linked immunoabsorbent assay (ELISA) test, which is well known to cross-react with other members of the enterovirus group. An enterovirus was isolated from 22% of patients compared with 67% who were positive in the ELISA test. Not only was the rate of enterovirus detection increased by using this ...

    Also Ranks for: Aseptic Meningitis |  enterovirus infections |  rapid diagnosis |  viral antigens |  capture elisa
    KOL Index score: 6553

    Stools from 183 babies under 2 years of age admitted to Ruchill Hospital with diarrhoea were examined by electron microscopy, virus culture, bacterial culture and light microscopy. As far as possible, several stools were examined from each patient and the results showed rotaviruses, astroviruses and other viruses in association with symptoms, as well as the expected bacterial pathogens. Examination of several stools from the same patient also showed that in this age group the viral flora ...

    Also Ranks for: Human Child |  preschool cytopathogenic |  electron microscopy |  viral diarrhea |  infantile escherichia
    KOL Index score: 6231

    The role of coxsackie B viruses (CBV) in myo/pericarditis has been well documented; however, interpretation of static high neutralising antibody titres in individual patients has always been difficult. In introducing the mu-antibody capture ELISA test for the detection of CBV-specific IgM, we hoped to overcome this problem. A regimen for the routine serological diagnosis of CBV infections was introduced, using the CBV IgM ELISA as a screening test, followed by neutralisation tests (NT) ...

    Also Ranks for: Serological Diagnosis |  cbv igm cbv |  myalgic encephalomyelitis |  coxsackie viruses |  capture elisa
    KOL Index score: 6201

    Enterovirus-specific probes have been prepared by reverse transcription of conserved sequences in purified Coxsackie B2 virus genomic RNA and molecular cloning techniques. These probes were used in quantitative slot blot hybridizations to test for the presence of enterovirus-specific RNA in skeletal muscle biopsy specimens from 96 patients who had suffered from the postviral fatigue syndrome myalgic encephalomyelitis for up to 20 years. Biopsy specimens from 20 patients were positive for ...

    Also Ranks for: Enterovirus Rna |  postviral fatigue syndrome |  creatine kinase |  skeletal muscle |  reverse transcription
    KOL Index score: 6198

    76 patients with the postviral fatigue syndrome (PVFS) and 30 matched controls were investigated. Virus isolation was attempted from concentrated faecal samples by direct culture and after acid dissociation of virus from antibody. Positive cultures of enteroviruses were obtained from 17 (22%) patients and 2 (7%) controls. An enterovirus-group-specific monoclonal antibody, 5-D8/1, directed against the VP1 polypeptide, was used to detect enteroviral antigen in the circulation, either free ...

    Also Ranks for: Postviral Fatigue Syndrome |  chronic enterovirus |  vp1 antigen |  virus isolation |  pvfs patients
    KOL Index score: 5876

    The stools of 37 newborn babies born in hospital were examined for the presence of virus. An extract of every stool passed by each baby was examined in the electron microscopy and inoculated into cell cultures. The babies were delivered in four separate maternity units (A-D). All the babies from unit A and C(9 babies) were found to be excreting rotavirus though none showed any evidence of diarrhoea. Two of the babies also excreted astrovirus. Subsequently unit A was closed for cleaning ...

    Also Ranks for: Stool Viruses |  cell cultures |  feces humans |  babies examined |  virus observed
    KOL Index score: 5869

    A cumulative review of illness experienced by 13,816 travellers returning to Scotland since 1977, shows an overall attack rate of 36%. Alimentary complaints predominated; 18% of travellers had these alone and a further 10% had other symptoms as well as their gastro-intestinal disorder. Higher attack rates were noted in those taking package holidays. Inexperience of travel, smoking, more southerly travel and younger age (particularly those between 20- and 29-years-old) were other ...

    Also Ranks for: Illness Travel |  attack rate |  health surveys |  younger age |  adult antibodies
    KOL Index score: 3957

    During 1964 and 1965 infections with Coxsackie virus types A4, B1, B2, B4 or B5 were diagnosed in 9 cases of acute pericarditis ( 2 with myocarditis), 1 of acute myocarditis, 8 of Bornholm disease and 1 of acute chest pain attributed to myocardial ischaemia. Echovirus 6 was isolated from a case of Bornholm disease with antibody response to Coxsackie B 1 virus. Echovirus type 25 was isolated from an additional case of acute myocarditis. During epidemics Coxsackie viruses probably ...

    Also Ranks for: Cardiac Disease |  coxsackie virus |  acute myocarditis |  chest pain |  pleurodynia epidemic
    KOL Index score: 3843

    Virological examination of 385 patients with suspected heart disease and 26 with Bornholm disease over a period of 6 years suggested that Coxsackie group B virus infections were associated with at least half the cases of acute myocarditis and one third of the cases of acute non-bacterial pericarditis. Complement-fixation tests revealed only a few cardiac illnesses associated with other infections (influenza and Mycoplasma pneumoniae). No evidence of infection was found in chronic cardiac disease.

    Also Ranks for: Heart Disease |  coxsackievirus infections |  acute myocarditis |  evidence infection |  virological examination
    KOL Index score: 3791

    Between October 1963 and April 1965, 113 children with respiratory disease and 113 children with diarrhoeal disease were matched for age and time of entry into hospital and studied by virus isolation and serological techniques.

    Infections with respiratory syncytial (RS) virus, parainfluenza virus and herpes simplex virus respectively were found in 29, 11 and 12 children in the respiratory illness group but in only 1, 2 and 4 children in the diarrhoeal group. ...

    Also Ranks for: Respiratory Disease |  scotland virus |  neutralization tests |  tract infections |  complement fixation
    KOL Index score: 3561

    Virological investigations of 135 patients showed evidence of enterovirus infection in 8 of 10 with acute pleurodynia, 20 of 30 with acute myocarditis, 8 of 32 with acute pericarditis, 6 of 53 with other cardiac diseases, and 1 of 10 with miscellaneous non-cardiac diseases. These and other reported findings suggest that enteroviruses, particularly those of the coxsackie group, are important causes of acute myocarditis and pericarditis.

    Also Ranks for: Enterovirus Infections |  cardiac disease |  acute pleurodynia |  myocarditis pericarditis |  sex factors
    KOL Index score: 3295

    The results of a twelve-year study of Coxsackie B virus (CBV) infections in patients with a variety of acute and chronic illnesses are reported. CBVs were isolated from only 123 patients most of whom were children with respiratory illness. Virus diagnosis in adults was based mainly on the detection of significant rising or static high neutralizing antibody titres. Between 1972 and 1979 most investigations centred on patients with suspected viral heart disease, 12% of whom were found to ...

    Also Ranks for: Cbv Infections |  coxsackie virus |  myalgic encephalomyelitis |  respiratory illness |  tests pericarditis
    KOL Index score: 3176

    In a prospective study sera from 140 patients with symptoms suggesting a post-viral syndrome and sera from 100 controls were tested for neutralizing antibodies to Coxsackie B viruses. Sixty-five of the patients (46%) and 25 of the controls (25%) had significant antibody titres. The 65 positive cases who had presented with symptoms were followed up and retested six months later and again after one year. Of these 65 patients 36 (55%) were still unwell after one year and high antibody ...

    Also Ranks for: Viral Syndrome |  general practice |  coxsackie viruses |  antibody titres |  65 patients
    KOL Index score: 3142

    Statistical analysis of 833 cases of echovirus infection showed a significantly greater association of type-6 infection with acute pleurodynia, and a suggestive association of type 19 and some other types with cardiac disease and pleurodynia. Published reports and international data from W.H.O. support the suggestion that echo type 6 and 19 viruses share the potentiality of type-B Cox-sackie viruses causing acute carditis and pleurodynia.

    Also Ranks for: Acute Pleurodynia |  cardiac disease |  echovirus infections |  enterovirus human |  male myocarditis


    Eleanor J Bell: Influence Statistics

    Sample of concepts for which Eleanor J Bell is among the top experts in the world.
    Concept World rank
    acute pleurodynia #1

    Key People For Postviral Fatigue Syndrome

    Top KOLs in the world
    Peter O Behan
    chronic fatigue syndrome multiple sclerosis myasthenia gravis
    Eleanor J Bell
    postviral fatigue syndrome acute pleurodynia enterovirus infections
    Wilhelmina M H Behan
    quinolinic acid chronic fatigue syndrome myasthenia gravis
    Doris J Taylor
    skeletal muscle magnetic resonance mitochondrial function
    George Karoly Radda
    skeletal muscle magnetic resonance creatine kinase
    Douglas Lorne Arnold
    multiple sclerosis magnetic resonance brain volume

    Eleanor J Bell:Expert Impact

    Concepts for whichEleanor J Bellhas direct influence:Postviral fatigue syndrome,  Enterovirus infections,  Acute pleurodynia,  Coxsackie virus,  Cardiac disease,  Myalgic encephalomyelitis,  Enterovirus rna,  Viral child child.

    Eleanor J Bell:KOL impact

    Concepts related to the work of other authors for whichfor which Eleanor J Bell has influence:Chronic fatigue syndrome,  Myalgic encephalomyelitis,  Aseptic meningitis,  Dilated cardiomyopathy,  Cfs patients,  Enteroviral rna,  Enterovirus infections.



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    Vale of Leven Hospital, Alexandria. | Regional Virus Laboratory, Ruchill Hospital, Glasgow, Scotland. | Regional Virus Laboratory, Ruchill Hospital, Glasgow G20 9NB, Scotland, U.K. | Regional Virus Laboratory, Bristol, U.K. | Regional Virus Laborator