• Disease
  • Precocious
  • Precocious Puberty
  • Najiba Lahlou

    Prominent publications by Najiba Lahlou

    KOL Index score: 12529

    Previous studies have reported that mesenchymal stem cells (MSC) may be isolated from the synovial membrane by the same protocol as that used for synovial fibroblast cultivation, suggesting that MSC correspond to a subset of the adherent cell population, as MSC from the stromal compartment of the bone marrow (BM). The aims of the present study were, first, to better characterize the MSC derived from the synovial membrane and, second, to compare systematically, in parallel, the ...

    Also Ranks for: Bone Marrow |  synovial membrane |  cells msc |  mesenchymal stem |  transcriptional profiles
    KOL Index score: 12512

    OBJECTIVE: To induce spermatogenesis by cotreatment with growth hormone (GH) and gonadotropin therapy in patients with hypogonadotropic hypogonadism who had failed to respond adequately to conventional treatment.

    DESIGN: Cotreatment with GH (4 IU) and human menopausal gonadotropin, 150 IU of follicle-stimulating hormone and 150 IU of luteinizing hormone (LH), three times a week, and human chorionic gonadotropin, 2,500 IU, two times a week for 24 weeks after unsuccessful treatment for 12 ...

    Also Ranks for: Growth Hormone |  hypogonadotropic hypogonadism |  european society |  human reproduction |  spermatogenesis patients
    KOL Index score: 12309

    CONTEXT: The diagnosis of isolated hypogonadotropic hypogonadism (IHH) in boys with delayed puberty is challenging, as may be the diagnosis of hypogonadotropic hypogonadism (HH) in boys with combined pituitary hormone deficiency (CPHD). Yet, the therapeutic choices for puberty induction depend on accurate diagnosis and may influence future fertility.

    OBJECTIVE: The aim was to assess the utility of baseline inhibin B (INHB) and anti-Mullerian hormone (AMH) measurements to discriminate HH ...

    Also Ranks for: Hypogonadotropic Hypogonadism |  delayed puberty |  mullerian hormone |  genital stage |  sertoli cells
    KOL Index score: 11863

    X-linked adrenoleukodystrophy (ALD) is a severe brain demyelinating disease in boys that is caused by a deficiency in ALD protein, an adenosine triphosphate-binding cassette transporter encoded by the ABCD1 gene. ALD progression can be halted by allogeneic hematopoietic cell transplantation (HCT). We initiated a gene therapy trial in two ALD patients for whom there were no matched donors. Autologous CD34+ cells were removed from the patients, genetically corrected ex vivo with a ...

    Also Ranks for: Cell Gene |  lentiviral vector |  hematopoietic stem |  ald patients |  xlinked adrenoleukodystrophy
    KOL Index score: 11565

    CONTEXT: Klinefelter syndrome (KS) is the most common sex chromosome disorder and a major cause of male infertility. In adult patients, serum inhibin B and anti-Mullerian-hormone (AMH) are undetectable, testosterone secretion is often impaired, and the tubules are depleted of germ cells. Before puberty, inhibin B, AMH, and testosterone levels are within the normal range.

    OBJECTIVE: Sertoli and Leydig cell secretions, including insulin-like peptide-3 (INSL3), were evaluated in infants ...

    Also Ranks for: Klinefelter Syndrome |  sertoli cell |  testosterone levels |  normal range |  inhibin fsh
    KOL Index score: 11152

    STUDY QUESTION: What is the effect of different alkylating agents used without pelvic radiation to treat childhood cancer in girls on the ovarian reserve in survivors?

    SUMMARY ANSWER: Ovarian reserve seems to be particularly reduced in survivors who received procarbazine (in most cases for Hodgkin lymphoma) or high-dose chemotherapy; procarbazine but not cyclophosphamide dose is associated with diminished ovarian reserve.

    WHAT IS KNOWN ALREADY: A few studies have demonstrated diminished ...

    Also Ranks for: Ovarian Reserve |  alkylating agents |  hormone amh |  childhood cancer |  study question
    KOL Index score: 10757

    The impact of treatment of central precocious puberty (CPP) with GnRH agonists on final statural height (FH) remains controversial, and guidelines on the optimal time point for interruption of these treatments have not been established. We analyzed the long term results of 58 girls and 8 boys uniformly treated with triptorelin slow release formulation (Decapeptyl, triptorelin-SR) for CPP and compared their FH with predicted height before treatment and with the FH of a historical group of ...

    Also Ranks for: Treatment Fh |  statural growth |  central precocious puberty |  predicted height |  gnrh agonist
    KOL Index score: 10493

    OBJECTIVE: Many extremely preterm infants develop hyperglycemia in the first week of life during continuous glucose infusion. The objective of this study was to determine whether defective insulin secretion or resistance to insulin was the primary factor involved in transient hyperglycemia of extremely preterm infants.

    METHODS: A prospective comparative study was conducted in appropriate-for-gestational-age preterm infants <30 weeks of gestational age with the aim specifically to ...

    Also Ranks for: Insulin Resistance |  premature infant |  extremely preterm |  transient hyperglycemia |  glucose peptide
    KOL Index score: 10240

    BACKGROUND: Cryptorchidism, the most frequent congenital malformation in full-term male newborns, increases the risk of hypofertility and testicular cancer. Most cases remain idiopathic but epidemiological and experimental studies have suggested a role of both genetic and environmental factors. Physiological testicular descent is regulated by two major Leydig hormones: insulin-like peptide 3 (INSL3) and testosterone.

    OBJECTIVES: To study the endocrine context at birth as a reflection of ...

    Also Ranks for: Idiopathic Cryptorchidism |  insl3 testosterone |  cord blood |  peptide 3 |  testicular cancer
    KOL Index score: 9770

    OBJECTIVE: Our purpose was to evaluate serum antimüllerian hormone as a marker for granulosa cell tumors.

    STUDY DESIGN: Serum antimüllerian hormone concentrations were determined in 16 patients with an adult-type granulosa cell tumor; in female patients with ovarian adenocarcinoma, benign ovarian cysts, or extraovarian cancers; and in normal premenopausal and postmenopausal women. Serum antimüllerian hormone, alpha-inhibin, and estradiol levels were compared in 10 patients with a ...

    Also Ranks for: Granulosa Cell |  antimüllerian hormone |  serum marker |  ovarian cancers |  postmenopausal women


    Najiba Lahlou: Influence Statistics

    Sample of concepts for which Najiba Lahlou is among the top experts in the world.
    Concept World rank
    amh mets #1
    cb levels bpa #1
    birth insl3 #1
    klinefelter syndrome triglycerides #1
    idiopathic cryptorchidism #1
    cdp subjects ihh #1
    orchidism sexual precocity #1
    diagnosis hypogonadotropic hypogonadism #1
    fullterm male newborns #1
    alpha libre #1
    male subjects xyy #1
    pathways testicular descent #1
    extra gonadal choriocarcinomas #1
    negative predictor testosterone #1
    release triptorelin #1
    pjs gynecomastia #1
    insl3 decreased #1
    acth clomipramine #1
    estradiol hormonal levels #1
    triglycerides preschool follicle #1
    68 1179 microg #1
    stimulating inhibin #1
    clinical hormonal status #1
    hand deformities humans #1
    6 623 months #1
    insl3 cb #1
    254 pg #1
    alphaimmunoreactive inhibin #1
    testis enlargement #1
    dht chorionic gonadotropin #1
    plasma lh dht #1
    gnas1 mutant #1
    adult malessupported #1
    lh fsh β #1
    patients isolated micropenis #1
    52 cryptorchid #1
    underlie macro #1
    bpa insl3 #1
    pulsatile gnrh infusion #1
    france insl3 #1
    unite alpha #1
    hcg reliable marker #1
    testicular hormones pubarche #1
    normal range inhibin #1
    free beta chains #1
    gynaecomastia weeks #1
    preparations implant #1
    150 minutes controls #1
    lhrh stimulation test #1

    Key People For Precocious Puberty

    Top KOLs in the world
    Gordon B CUTLER,
    precocious puberty turner syndrome growth hormone
    Ora Hirsch Pescovitz
    precocious puberty growth hormone fibrous dysplasia
    precocious puberty releasing hormone cushing syndrome
    Jean‐Claude Carel
    growth hormone turner syndrome precocious puberty
    Anders Juul
    growth factor semen quality serum levels
    Kevin M Barnes
    precocious puberty growth plate adult height

    Najiba Lahlou:Expert Impact

    Concepts for whichNajiba Lahlouhas direct influence:Precocious puberty,  Central precocious puberty,  Gonadotroph adenoma,  Klinefelter syndrome,  Sexual precocity,  Luteinizing hormone,  Triptorelin pamoate,  Leydig cell.

    Najiba Lahlou:KOL impact

    Concepts related to the work of other authors for whichfor which Najiba Lahlou has influence:Gene therapy,  Precocious puberty,  Klinefelter syndrome,  Insulin resistance,  Leptin levels,  Adipose tissue,  Type 1 diabetes.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Department of Hormonology, BPR Specialized Analyses, 45700 Pannes,  France. | Department of Biological Endocrinology, CHU Cochin, AP-HP, 75014 Paris, France. | Department of Hormonology and Metabolic Disorders, Hôpital Cochin, APHP, Paris-Descartes U