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    • Danniel R Weinberger,
    • Danniel R Weinberger,

      Danniel R Weinberger,

      McKusick-Nathans Department of Genetic Medicine, School of Medicine, Johns Hopkins University Baltimore, MD 21205, USA | The Lieber Institute for Brain Development, Baltimore, ...



      KOL Resume for Danniel R Weinberger,


      McKusick-Nathans Department of Genetic Medicine, School of Medicine, Johns Hopkins University Baltimore, MD 21205, USA

      The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205.

      Lieber Institute for Brain Development; School of Medicine, Johns Hopkins University; Neuroscience and Institute of Genetic Medicine, School of Medicine


      Johns Hopkins School of Medicine

      Lieber Institute for Brain Development, Baltimore, MD 21205 USA



      Danniel R Weinberger,: Influence Statistics

      Sample of concepts for which Danniel R Weinberger, is among the top experts in the world.
      Concept World rank
      association postmortem studies #1
      comt levels comt #1
      dlpfc rcbf dlpfc #1
      thought disorder memory #1
      dlpfc schizophrenia #1
      valine adult #1
      semantic boundaries schizophrenia #1
      nrg3 isoforms #1
      neuroradsology #1
      worse eeg #1
      effects drug treatment #1
      serotonin restoration 123iβcit #1
      large ventricles #1
      brainstem endogenous dopamine #1
      schizophrenia male controls #1
      pi3kakt1dependent #1
      hlaa2 hla antigens #1
      cognitive factor structure #1
      val homozygotes #1
      percent values analysis #1
      healthy caucasian adults #1
      kcnh2 31 #1
      cortical gaba function #1
      placebo period schizophrenia #1
      asymmetries ptr #1
      sham lesioned animals #1
      schizophrenia normal twins #1
      grm3 genotype #1
      striatal neurons patients #1
      neuronal pathology #1
      bdnf hippocampal volume #1
      hippocampal function ws #1
      parietal–striatal brain systems #1
      electrophysiological measures #1
      association serotonergic dysfunction #1
      rs1344706 expression #1
      backgroundattention #1
      expression znf804ae3e4 #1
      comt mrna #1
      theta spectral density #1
      schizophrenia disc1 snps #1
      plasma amine metabolites #1
      neonatal hippocampal damage #1
      daao schizophrenia #1
      akt1 bdnf #1
      schizophrenia replication #1
      pkcɣ #1
      rs10835211 #1
      mdh1 hint1 #1
      llhomozygous individuals #1


      Prominent publications by Danniel R Weinberger,

      KOL-Index: 19410

      IMPORTANCE: The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality of rs1344706.

      OBJECTIVES: To characterize ZNF804A expression in human brain and to investigate how it changes across the life span and how it is affected by rs1344706, schizophrenia, bipolar disorder, and major depressive disorder.

      DESIGN, ...

      Known for Major Depressive Disorder | Rs1344706 Schizophrenia | Znf804a Protein | Fetal Brain | Psychosis Risk
      KOL-Index: 16066

      CONTEXT: NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

      OBJECTIVE: To examine epistasis between NRG1 and selected N-methyl-d-aspartate-glutamate pathway partners implicated in its effects, including ERBB4, AKT1, DLG4, NOS1, and NOS1AP.

      DESIGN: Schizophrenia case-control sample analyzed using machine learning algorithms and logistic regression with ...

      Known for Functional Neuroimaging | Nrg1 Erbb4 | Schizophrenia Risk | Epistasis Genetic | Magnetic Resonance
      KOL-Index: 15731

      Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the prefrontal cortex of the human brain. Genetic variation in the COMT gene (MIM 116790) has been associated with altered prefrontal cortex function and higher risk for schizophrenia, but the specific alleles and their functional implications have been controversial. We analyzed the effects of several single-nucleotide polymorphisms (SNPs) within COMT on mRNA expression levels (using ...

      Known for Enzyme Activity | Genetic Variation | Val Comt | Protein Levels | Postmortem Human
      KOL-Index: 14012

      Brain-derived neurotrophic factor (BDNF) plays an important role in development, synapse remodelling and responses to stress and injury. Its abnormal expression has been implicated in schizophrenia, a neuropsychiatric disorder in which abnormal neural development of the hippocampus and prefrontal cortex has been postulated. To clarify the effects of antipsychotic drugs used in the therapy of schizophrenia on BDNF mRNA, we studied its expression in rats treated with clozapine and ...

      Known for Prefrontal Cortex | Antipsychotic Drugs | Bdnf Mrna Expression | Rat Hippocampus | Neonatal Ventral
      KOL-Index: 13934

      The neuregulin 1 (NRG1) receptor, ErbB4, has been identified as a potential risk gene for schizophrenia. HER4/ErbB4 is a receptor tyrosine kinase whose transcript undergoes alternative splicing in the brain. Exon 16 encodes isoforms containing a metalloprotease cleavable extracellular domain (JM-a), exon 15 for a cleavage resistant form (JM-b) and exon 26 for a cytoplasmic domain (CYT-1) with a phosphotidylinositol-3 kinase (PI3K) binding site. Disease-associated variants in the ErbB4 ...

      Known for Erbb4 Gene | Dlpfc Schizophrenia | Tertiary Receptor | Variant Expression | Splice Isoforms
      KOL-Index: 13892

      CONTEXT: Studies have shown patterns of abnormal dorsolateral prefrontal cortex (DLPFC) functional connectivity with other brain areas in schizophrenia and association of these patterns with a putative susceptibility gene (ZNF804A). However, whether these patterns are trait phenomena linked to genetic risk for illness is unclear.

      OBJECTIVE: To test the hypotheses that altered DLPFC connectivity is (1) a familial, likely heritable feature of genetic risk for schizophrenia, (2) a novel ...

      Known for Patients Schizophrenia | Genetic Risk | Intermediate Phenotype | Prefrontal Cortex | Association Znf804a
      KOL-Index: 13854

      Catechol-O-methyltransferase (COMT) regulates dopamine degradation and is located in a genomic region that is deleted in a syndrome associated with psychosis, making it a promising candidate gene for schizophrenia. COMT also has been shown to influence prefrontal cortex processing efficiency. Prefrontal processing dysfunction is a common finding in schizophrenia, and a background of inefficient processing may modulate the effect of other candidate genes. Using the NIMH sibling study ...

      Known for Statistical Epistasis | Schizophrenia Comt | Candidate Genes | Catechol Methyltransferase | Case Control
      KOL-Index: 13853

      BACKGROUND: Shared neuropathological characteristics of patients with schizophrenia and their siblings might represent intermediate phenotypes that could be used to investigate genetic susceptibility to the illness. We sought to discover previously unidentified gray matter volume differences in patients with schizophrenia and their siblings with optimized voxel-based morphometry.

      METHODS: We studied 169 patients with schizophrenia, 213 of their unaffected siblings, and 212 healthy ...

      Known for Gray Matter | Schizophrenia Siblings | Intermediate Phenotype | Based Morphometry | Hippocampal Volume
      KOL-Index: 13835

      GABA signaling molecules are critical for both human brain development and the pathophysiology of schizophrenia. We examined the expression of transcripts derived from three genes related to GABA signaling [GAD1 (GAD67 and GAD25), SLC12A2 (NKCC1), and SLC12A5 (KCC2)] in the prefrontal cortex (PFC) and hippocampal formation of a large cohort of nonpsychiatric control human brains (n = 240) across the lifespan (from fetal week 14 to 80 years) and in patients with schizophrenia (n = 30-31), ...

      Known for Gaba Signaling | Nkcc1 Kcc2 | Schizophrenia Expression | Messenger Rats | Hippocampal Formation
      KOL-Index: 13827

      DISC1 has been identified as a schizophrenia susceptibility gene based on linkage and SNP association studies and clinical data suggesting that risk SNPs impact on hippocampal structure and function. In cell and animal models, C-terminus-truncated DISC1 disrupts intracellular transport, neural architecture and migration, perhaps because it fails to interact with binding partners involved in neuronal differentiation such as fasciculation and elongation protein zeta-1 (FEZ1), ...

      Known for Binding Partners | Expression Disc1 | Schizophrenia Association | Hippocampal Structure | Signaling Pathway
      KOL-Index: 13762

      Genetic variation in dysbindin (DTNBP1: dystrobrevin-binding protein 1) has recently been shown to be associated with schizophrenia. The dysbindin gene is located at chromosome 6p22.3, one of the most promising susceptibility loci in schizophrenia linkage studies. We attempted to replicate this association in a Japanese sample of 670 patients with schizophrenia and 588 controls. We found a nominally significant association with schizophrenia for four single nucleotide polymorphisms and ...

      Known for Susceptibility Gene | Dysbindin Protein | Neuronal Functions | Human Pair | Akt Phosphorylation
      KOL-Index: 13736

      Dysfunction of the prefrontal cortex in schizophrenia may be associated with abnormalities in synaptic structure and/or function and reflected in altered concentrations of proteins in presynaptic terminals and involved in synaptic plasticity (synaptobrevin/ vesicle-associated membrane protein (VAMP), synaptosomal-associated protein-25 (SNAP-25), syntaxin, synaptophysin and growth-associated protein-43 (GAP-43)). We examined the immunoreactivity of these synapse-associated proteins via ...

      Known for Prefrontal Cortex | Presynaptic Proteins | Patients Schizophrenia | Postnatal Day | Aged Nerve
      KOL-Index: 13404

      To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) established the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference. The goals of the meeting were to 1) identify the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key ...

      Known for Cognitive Domains | Mental Health | Clinical Trials Schizophrenia | National Institute | Test Selection
      KOL-Index: 13165

      OBJECTIVE: The lack of an accepted standard for measuring cognitive change in schizophrenia has been a major obstacle to regulatory approval of cognition-enhancing treatments. A primary mandate of the National Institute of Mental Health's Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative was to develop a consensus cognitive battery for clinical trials of cognition-enhancing treatments for schizophrenia through a broadly based scientific ...

      Known for Cognitive Battery | Matrics Consensus | Mental Health | National Institute | Test Selection
      KOL-Index: 12902

      CONTEXT: The schizophrenia-susceptibility gene dysbindin (DTNBP1 on 6p22.3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain.

      OBJECTIVES: To determine whether brain regions implicated in schizophrenia express dysbindin and whether abnormal levels of dysbindin messenger RNA (mRNA) may be found in this disorder and to test whether sequence variations in ...

      Known for Prefrontal Cortex | Gene Expression | Patients Schizophrenia | Brain Regions | Human Dysbindin

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      Danniel R Weinberger :Expert Impact

      Concepts for whichDanniel R Weinberger has direct influence:Prefrontal cortex,  Patients schizophrenia,  Schizophrenic patients,  Magnetic resonance,  Gene expression,  Bipolar disorder,  Genetic risk,  Monozygotic twins.

      Danniel R Weinberger :KOL impact

      Concepts related to the work of other authors for whichfor which Danniel R Weinberger has influence:Bipolar disorder,  Prefrontal cortex,  Patients schizophrenia,  Magnetic resonance,  Negative symptoms,  Gene expression,  Cognitive impairment.



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      McKusick-Nathans Department of Genetic Medicine, School of Medicine, Johns Hopkins University Baltimore, MD 21205, USA | The Lieber Institute for Brain Development, Baltimore, MD, USA | McKusick-Nathans Institute, Department of Genetic Medicine, John

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