 | Joan M Lappe |
Prominent publications by Joan M Lappe
High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new in vivo imaging technique for assessing 3D microstructure of cortical and trabecular bone at the distal radius and tibia. No studies have investigated the extent to which measurements of the peripheral skeleton by HR-pQCT reflect those of the spine and hip, where the most serious fractures occur. To address this research question, we performed dual-energy X-ray absorptiometry (DXA), central QCT (cQCT), ...
| Also Ranks for: Bone Density | premenopausal women | skeletal sites | hrpqct distal radius | dxa cqct |
Idiopathic osteoporosis (IOP) in premenopausal women is a poorly understood entity in which otherwise healthy women have low-trauma fracture or very low bone mineral density (BMD). In this study, we applied individual trabeculae segmentation (ITS)-based morphological analysis to high-resolution peripheral quantitative computed tomography (HR-pQCT) images of the distal radius and distal tibia to gain greater insight into skeletal microarchitecture in premenopausal women with IOP. HR-pQCT ...
| Also Ranks for: Trabecular Plate | premenopausal women | idiopathic osteoporosis | morphological analysis | computed tomography |
CONTEXT: Deficits in bone acquisition during growth may increase fracture risk. Assessment of bone health during childhood requires appropriate reference values relative to age, sex, and population ancestry to identify bone deficits.
OBJECTIVE: The objective of this study was to provide revised and extended reference curves for bone mineral content (BMC) and areal bone mineral density (aBMD) in children.
DESIGN: The Bone Mineral Density in Childhood Study was a multicenter longitudinal ...
| Also Ranks for: Childhood Study | reference curves | mineral density | sex age | total body |
The bone mineral density in childhood study: bone mineral content and density according to age, sex, and race.
[ PUBLICATION ]
CONTEXT: Low bone mass may increase risk of fracture. Several chronic medical conditions, medications, and lifestyle factors affect bone mineral accrual. Appropriate reference values are essential for identification of children with bone deficits.
OBJECTIVE: Our objective was to establish reference curves for bone mineral content (BMC) and density (BMD) in children.
DESIGN AND SETTING: The Bone Mineral Density in Childhood Study is an ongoing longitudinal study in which measurements are ...
| Also Ranks for: Childhood Study | bone mineral content | mineral density | bmc bmd | lumbar spine |
CONTEXT: Idiopathic osteoporosis (IOP) affects otherwise healthy young individuals with intact gonadal function and no secondary cause of bone fragility. In premenopausal women with IOP, a low trauma fracture is evidence of impaired bone quality and strength. The extent to which low bone mineral density (BMD) by dual-energy x-ray absorptiometry (DXA) reflects low volumetric BMD, bone microstructure, and strength is uncertain in the absence of low trauma fracture.
OBJECTIVE: The objective ...
| Also Ranks for: Premenopausal Women | idiopathic osteoporosis | low bmd | bone fragility | dualenergy xray absorptiometry |
Women With Pregnancy and Lactation–Associated Osteoporosis (PLO) Have Low Bone Remodeling Rates at the Tissue Level
[ PUBLICATION ]
Pregnancy and lactation-associated osteoporosis (PLO) is a rare, severe, early form of osteoporosis in which young women present with fractures, usually multiple vertebral fractures, during late pregnancy or lactation. In studies of idiopathic osteoporosis (IOP) in premenopausal women, we enrolled 78 women with low-trauma fractures and 40 healthy controls, all with normal menses and no secondary cause of bone loss. In 15 of the affected women, the PLO subgroup, fractures had occurred ...
| Also Ranks for: Women Plo | pregnancy lactation | low bone | idiopathic osteoporosis | vertebral fractures |
Abnormal bone microarchitecture and evidence of osteoblast dysfunction in premenopausal women with idiopathic osteoporosis.
[ PUBLICATION ]
CONTEXT: Idiopathic osteoporosis (IOP) in premenopausal women is an uncommon disorder of uncertain pathogenesis in which fragility fractures occur in otherwise healthy women with intact gonadal function. It is unclear whether women with idiopathic low bone mineral density and no history of fragility fractures have osteoporosis.
OBJECTIVE: The objective of the study was to elucidate the microarchitectural and remodeling features of premenopausal women with IOP.
DESIGN: We performed ...
| Also Ranks for: Idiopathic Osteoporosis | premenopausal women | osteoblast dysfunction | fragility fractures | bone microarchitecture |
Bone microarchitecture and stiffness in premenopausal women with idiopathic osteoporosis.
[ PUBLICATION ]
CONTEXT: Idiopathic osteoporosis (IOP) is an uncommon disorder in which low areal bone mineral density (aBMD) and/or fractures occur in otherwise healthy premenopausal women.
OBJECTIVES: Our objectives were to characterize bone mass, microarchitecture, and trabecular bone stiffness in premenopausal IOP and to determine whether women with low aBMD who have never fractured have abnormal microarchitecture and stiffness.
DESIGN, SETTING, AND PATIENTS: We conducted a prospective cohort study ...
| Also Ranks for: Bone Microarchitecture | premenopausal women | radius tibia | low bmd | fracture subjects |
Teriparatide Increases Strength of the Peripheral Skeleton in Premenopausal Women With Idiopathic Osteoporosis: A Pilot HR-pQCT Study
[ PUBLICATION ]
CONTEXT: In premenopausal women with idiopathic osteoporosis (IOP), treatment with teriparatide leads to substantial improvement in bone density and quality at central skeletal sites. The effects of teriparatide may differ on cortical and trabecular bone and also at the central and the peripheral skeleton.
OBJECTIVE: The objective of the study was to determine whether teriparatide was associated with improvements in compartmental volumetric bone mineral density (BMD), bone ...
| Also Ranks for: Radius Tibia | idiopathic osteoporosis | premenopausal women | bone density | iop bmd |
CONTEXT: Premenopausal women with idiopathic osteoporosis (IOP) have abnormal cortical and trabecular bone microarchitecture.
OBJECTIVE: The purpose of this study was to test the hypotheses that teriparatide increases bone mineral density (BMD) and bone formation and improves trabecular microarchitecture and stiffness in women with IOP.
DESIGN: This was an open-label pilot study.
SETTING: The setting was a tertiary care referral center.
PATIENTS: Participants were 21 premenopausal women ...
| Also Ranks for: Premenopausal Women | idiopathic osteoporosis | iop bmd | trabecular bone | primary endpoint |
Abstract: Estimates are that stress fractures during basic training (BT) occur in as many as 14% of US female military recruits. Injuries of this type lead to morbidity ranging from minor pain to serious lifetime disability. Since women are assuming an increasing role in the military, this high risk of stress fracture is of concern. The purpose of this prospective study was to determine factors that predict stress fracture during BT in US Army female recruits. The analysis was part of an ...
| Also Ranks for: Stress Fracture | lifestyle factors | army recruits | 8 weeks | female military |
Height Adjustment in Assessing Dual Energy X-Ray Absorptiometry Measurements of Bone Mass and Density in Children
[ PUBLICATION ]
CONTEXT: In children, bone mineral content (BMC) and bone mineral density (BMD) measurements by dual-energy x-ray absorptiometry (DXA) are affected by height status. No consensus exists on how to adjust BMC or BMD (BMC/BMD) measurements for short or tall stature.
OBJECTIVE: The aim of this study was to compare various methods to adjust BMC/BMD for height in healthy children.
DESIGN: Data from the Bone Mineral Density in Childhood Study (BMDCS) were used to develop adjustment methods that ...
| Also Ranks for: Haz Age | bone mass | ray absorptiometry | dual energy | healthy children |
We compared microarchitecture and mechanical competence parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite-element analysis of radius and tibia to those measured by histomorphometry, micro-CT, and finite-element analysis of transiliac bone biopsies. Correlations were weak to moderate between parameters measured on biopsies and scans.IntroductionHR-pQCT is a new imaging technique that assesses trabecular and cortical bone ...
| Also Ranks for: Bone Biopsy | mechanical competence | radius tibia | computed tomography | resolution peripheral |
CONTEXT: We have previously reported that premenopausal women with idiopathic osteoporosis based on fractures (IOP) or idiopathic low bone mineral density (ILBMD) exhibit markedly reduced bone mass, profoundly abnormal trabecular microstructure, and significant deficits in trabecular bone stiffness. Bone remodeling was heterogeneous. Those with low bone turnover had evidence of osteoblast dysfunction and the most marked deficits in microstructure and stiffness.
OBJECTIVE: Because ...
| Also Ranks for: Marrow Adiposity | premenopausal women | idiopathic osteoporosis | bone remodeling | aged osteogenesis |
Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial
[ PUBLICATION ]
Importance: Evidence suggests that low vitamin D status may increase the risk of cancer.
Objective: To determine if dietary supplementation with vitamin D3 and calcium reduces the risk of cancer among older women.
Design, Setting, and Participants: A 4-year, double-blind, placebo-controlled, population-based randomized clinical trial in 31 rural counties (June 24, 2009, to August 26, 2015-the final date of follow-up). A total of 2303 healthy postmenopausal women 55 years or older were ...
| Also Ranks for: Cancer Incidence | calcium supplementation | vitamin d3 | randomized clinical trial | older women |
Joan M Lappe: Influence Statistics
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Key People For Premenopausal Women
Joan M Lappe:Expert Impact
Concepts for whichJoan M Lappehas direct influence:Premenopausal women, Idiopathic osteoporosis, Bone density, Bone mineral density, Childhood study, Bone mass, Circulating monocytes, Calcium intake.
Joan M Lappe:KOL impact
Concepts related to the work of other authors for whichfor which Joan M Lappe has influence:Bone health, Postmenopausal women, Vitamin deficiency, Body composition, Calcium intake, Physical activity, Stress fractures.
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