• KOL
    • Prenatal Diagnosis
    • Mitchell S Golbus
    • Mitchell S Golbus: Influence Statistics

      Mitchell S Golbus

      Mitchell S Golbus

      Department of Obstetrics, Gynecology and Reproductive Sciences, University California, San Francisco, U.S.A. | Emeritus, Department of Obstetrics, Gynecology and Reproductive ...

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      Mitchell S Golbus:Expert Impact

      Concepts for whichMitchell S Golbushas direct influence:Prenatal diagnosis,Chorionic villus sampling,Amniotic fluid,Situ hybridization,Fetal surgery,Nonimmune hydrops fetalis,Maternal age,Maternal circulation.

      Mitchell S Golbus:KOL impact

      Concepts related to the work of other authors for whichfor which Mitchell S Golbus has influence:Prenatal diagnosis,Situ hybridization,Fetal surgery,Chorionic villus sampling,Amniotic fluid,Gestational age,Congenital diaphragmatic hernia.

      KOL Resume for Mitchell S Golbus

      Year
      1998

      Department of Obstetrics, Gynecology and Reproductive Sciences, University California, San Francisco, U.S.A.

      1996

      Departments of Obstetrics and Gynecology of the following: Maternite Port Royal, Paris, France

      Mt. Sinai, New York, USA

      Division of Reproductive Genetics, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, U.S.A.

      San Francisco, California

      University of Milan, Milan, Italy

      1995

      Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA

      Cytogenetic Laboratory, Herzlia Medical Center, Herzlia, Israel

      1994

      Department of Ob/Gyn and Reproductive Sciences, University of California, San Francisco

      1993

      Department of Obstetrics, Gynecology, and Reproductive Science, University of California, San Francisco, California

      1992

      Departmento de Genetica Medicina, Universidade Estadual de Campinas, Barao Geraldo, Caixa Postal 1170, 13100 Campinas, SP Brazil

      National Institutes of Health, Belhesda, MD, U.S.A.

      Departments of Obstetrics and Gynecology, and Pediatrics, University of California at San Francisco, San Francisco, California

      Yale University School of Medicine, New Haven, CT

      Mount Sinai School of Medicine, New York. NY

      1991

      Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Genetics Unit, University of California, San Francisco, California, U.S.A.

      U‐262, University of California Medical Center, San Francisco, CA 94143, U.S.A

      1990

      Department of Obstetrics, University of California, and San Francisco, United States

      University of California Medical Center, San Francisco 94143.

      U‐262, Univ. Calif. Medical Center, San Francisco, CA 94143‐0720

      San Francisco, California, USA

      1989

      Departments of Obstetrics, Gynecology, and Pediatrics, U-262, University of California Medical Center, 94143-0720, San Francisco, CA, USA

      Department of Diagnostic Radiology, University of California, School of Medicine, San Francisco, 94143

      University of California at San Francisco (M.S.G., J.D.G.)

      1988

      From the Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco

      1987

      Department of Obstetrics, Gynecology and Reproductive Sciences, and Department of Pediatrics, University of California, San Francisco, U.S.A

      San Antonio, Texas, USA

      1986

      the Department of Obstetrics, Gynecology and Reproductive Sciences, University of California Medical Center San Francisco, California, USA.

      Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai School of Medicine New York, New York, USA

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      Sample of concepts for which Mitchell S Golbus is among the top experts in the world.
      Concept World rank
      placentesis delta afp #1
      psychological trauma efforts #1
      publication abortion lens #1
      routine ultrasonic examination #1
      rflp analyses mosaicism #1
      apolipoproteins fetal #1
      grandpaternal mutant allele #1
      husband fetus #1
      placentesis #1
      galactosemia fetus #1
      dmd retarded #1
      humans 5–6 #1
      platelet glucose‐6‐phosphatase #1
      normal range pregnancies #1
      diaphragmatic hernia future #1
      texas hybridizes #1
      diagnosis hemoglobin disease #1
      18 repetitive #1
      platelet glucose6 #1
      fetus conflicting reports #1
      ultrasonic recognition #1
      xp21 microdeletion syndrome #1
      subsequent damage survivor #1
      12 cent #1
      biopsy fetal #1
      midtrimester fetoscopy #1
      progress medical technology #1
      hemoglobinopathies hemophilia #1
      amniocentesis tissue culture #1
      karyotyping lymphangioma #1
      aii 12 cent #1
      chromosome heteroploidy #1
      21 status #1
      indirect techniques laboratory #1
      delta afp 4628 #1
      injections prostaglandins vomiting #1
      examination realtime scanner #1
      tool cure #1
      corpuscular volume 80 #1
      hysterotomy remains #1
      cases chorionic #1
      transcervical loss #1
      ue3 alphafetoprotein afp #1
      fluorescein hybridizes #1
      prenatal diagnosis chs #1
      women amniocentesis #1
      screening program thalassemia #1
      women chorionic #1
      vigor fatigue scores #1
      prior reports losses #1
      Sign-in to see all concepts, it's free!

      Prominent publications by Mitchell S Golbus

      KOL-Index: 12557

      Chorionic villus sampling is a method of prenatal diagnosis in the first trimester of pregnancy in which tissue for genetic study is aspirated from the developing placenta by means of a catheter inserted transcervically under the guidance of ultrasonography. In this seven-center study, we compared the safety and efficacy of chorionic villus sampling in 2278 women with those of amniocentesis at 16 weeks' gestation in 671 women. Both groups were made up primarily of well-educated private ...

      Known for Chorionic Villus Sampling | Women Amniocentesis | Cytogenetic Abnormalities | Trimester Pregnancy | Early Prenatal Diagnosis
      KOL-Index: 12026

      Cytogenetic data are presented for 11,473 chorionic villus sampling (CVS) procedures from nine centres in the U.S. NICHD collaborative study. A successful cytogenetic diagnosis was obtained in 99.7 per cent of cases, with data obtained from the direct method only (26 per cent), culture method only (42 per cent), or a combination of both (32 per cent). A total of 1.1 per cent of patients had a second CVS or amniocentesis procedure for reasons related to the cytogenetic diagnostic ...

      Known for Culture Method | Collaborative Study | Cases Mosaicism | Maternal Cell Contamination | Trisomy Case
      KOL-Index: 11774

      Fluorescence in situ hybridization (FISH) with chromosome-specific probes has been applied to detection of numerical aberrations involving chromosomes 13, 18, and 21 in metaphase and interphase amniocytes. High-complexity, composite probes for chromosomes 13, 18, and 21 were used as hybridization probes for this study. These probes were constructed as chromosome-specific libraries in Bluescribe plasmids and are designated pBS-13, pBS-18, and pBS-21. Elements of these probes bind at ...

      Known for Situ Hybridization | Chromosomes 13 | Human Pair | Numerical Aberrations | Target Chromosome
      KOL-Index: 11519

      BACKGROUND: The finding of an elevated level of maternal serum alpha-fetoprotein during the second trimester of pregnancy may indicate that the fetus has died or is about to die. It is uncertain, however, whether the finding is associated with an increased risk of fetal death later in gestation independent of known causes of elevation, such as the presence of neural-tube defects or multiple gestation.

      METHODS: To address this question, we performed a case-control study of 612 women whose ...

      Known for Fetal Death | Serum Alpha | Fetoprotein Levels | Trimester Maternal | Women Elevated
      KOL-Index: 11008

      Actinomycin D and α-amanitin (an inhibitor of RNA polymerase II) were used to determine the effect of inhibiting RNA synthesis during pre-implantation mouse embryogenesis. Actinomycin D (0.01 μg/ml) was an effective inhibitor of blastulation and of cleavage from the 1 cell stage on. The first cleavage of day 0 (1 cell) embryos cultured for 24 hours in α-amanitin (10−7 to 10−5 M) was reduced to 35-42% from a control value of 60%. Cleavage of day 1 (2 cell) embryos and day 2 (8–12 cell) ...

      Known for Rna Synthesis | Α Amanitin | Mammalian Embryonic | Mouse Embryogenesis | 24 Hours
      KOL-Index: 9956

      OBJECTIVE: Our goal was to develop the most comprehensive database possible to counsel patients about selective termination for fetal abnormalities, because no one center has sufficient data to assess much more than crude loss rates.

      STUDY DESIGN: A total of 183 completed cases of selective termination from 9 centers in 4 countries were combined (169 twins, 11 triplets, 3 quadruplets). Variables included indications, methods, (potassium chloride, exsanguination, air embolus), gestational ...

      Known for Selective Termination | Fetal Abnormalities | Gestational Age | Potassium Chloride | 24 Weeks
      KOL-Index: 9669

      To study the accuracy of prenatal diagnosis and define the natural history of fetal congenital diaphragmatic hernia (CDH), we reviewed experience with CDH at The University of California, San Francisco (UCSF) over the last three years. All nine babies born in our institution (inborns) and six of 11 babies referred from other hospitals after birth (outborns) died, an overall mortality of 75%. All had pulmonary hypoplasia. Forty percent had associated malformations or chromosomal ...

      Known for Prenatal Diagnosis | Diaphragmatic Hernias | Cases Cdh | Congenital Humans Infant | Surgical Repair
      KOL-Index: 9601

      Immunochemical serum assays for human chorionic gonadotropin (hCG), the free ahCG subunit, and progesterone (P) were considered separately and in combination for their ability to screen for chromosomally abnormal pregnancies in the first trimester. Maternal serum was collected from 141 women undergoing chorionic villus sampling at 9-12 menstrual weeks. Trisomy 21 pregnancies had significantly higher hCG levels, while trisomy 18 and 13 pregnancies had markedly lower hCG and progesterone ...

      Known for Human Chorionic | Pregnancy Trimester | Aneuploid Pregnancies | Glycoprotein Hormones | Maternal Serum
      KOL-Index: 9544

      This study demonstrates a clear and current role for multicolor in situ hybridization in expediting positional cloning studies of unknown disease genes. Nine polymorphic DNA cosmids have been mapped to eight ordered locations spanning the Charcot-Marie-Tooth type 1 (CMT1A) disease gene region in distal band 17p11.2, by multicolor in situ hybridization. When used with linkage analysis, these methods have generated a fine physical map and have firmly assigned the CMT1A gene to distal band ...

      Known for Situ Hybridization | Linkage Analysis | Tooth Type | Cmt1a Gene | Charcot Marie
      KOL-Index: 9386

      Chorionic villus sampling (CVS) has emerged as a first trimester alternative to amniocentesis for the prenatal detection of genetic disorders. We report our experience in 600 consecutive CVS procedures to better delineate the safety, efficacy and reliability of this new method of prenatal diagnosis. Adequate samples were obtained at the initial visit in 97 per cent of the cases, and successful cultures were established in 98.7 per cent of these patients. Chromosome abnormalities were ...

      Known for Prenatal Diagnosis | Chorionic Villus Sampling | Cent Cases | Spontaneous Abortion | Chromosome Aberrations
      KOL-Index: 9267

      In a controlled, prospective study of 44 consecutive women with idiopathic habitual abortion, only 5% had symptoms of rheumatic disease. Patients did not differ from control subjects in the frequency of positive results on tests for antinuclear antibody or anti-double-stranded DNA. Levels of C3 and C4 were higher in the habitual aborters. No patients had anti-Ro. The antiphospholipid antibody results were analyzed using 2 methods: the frequency of antiphospholipid antibodies was 9% by ...

      Known for Lupus Anticoagulant | Anticardiolipin Antibody | Habitual Abortion | Antiphospholipid Antibodies | 95 Confidence Interval
      KOL-Index: 9226

      Review of our experience with 45 cases of prenatally diagnosed congenital diaphragmatic hernia (CDH) confirms that most fetuses (77%) will not survive despite optimal pre- and postnatal care. Polyhydramnios, associated anomalies, early diagnosis, and a large volume of herniated viscera (including liver) are associated with a particularly dismal prognosis. After extensive experimental work demonstrated the efficacy, feasibility, and safety of repair in utero, we attempted to salvage six ...

      Known for Diaphragmatic Hernias | Fetal Surgery | Severe Cdh | Herniated Viscera | Maternal Complication
      KOL-Index: 9022

      Selecting appropriate management for the fetus with bilateral congenital hydronephrosis depends on our ability to accurately assess the severity of existing renal damage and to predict the potential for recovery of renal and pulmonary function if the obstruction is relieved. We reviewed our experience with 20 fetuses with congenital bilateral hydronephrosis to determine the prognostic value of various criteria used to assess functional potential, including temporary catheter ...

      Known for Congenital Hydronephrosis | Prognostic Criteria | Management Fetus | Fetal Urine | Renal Function
      KOL-Index: 8695

      We have used chromosome-specific repetitive sequences to detect the most common human aneuploidies prenatally. Together chromosome 21, 13, 18, X, and Y aneuploidy comprises 95% of the chromosome abnormalities that result in a high risk of abnormal phenotypes at birth. The X, Y, and 18 repetitive probes work reliably in multiple tissue types including directly examined and cultured amniocytes, chorionic villus cells, lymphocytes, and cultured fibroblasts. The probe that detects both ...

      Known for Prenatal Diagnosis | Situ Hybridization | Human Pair | Chromosome 21 | Nucleic Acid

      Key People For Prenatal Diagnosis

      Top KOLs in the world
      #1
      Kypros Nicolaides Nicolaides†
      cervical length gestational age maternal factors
      #2
      John M Opitz
      publication abnormalities rett syndrome prenatal diagnosis
      #3
      Mitchell S Golbus
      prenatal diagnosis chorionic villus sampling amniotic fluid
      #4
      John C Hobbins
      amniotic fluid prenatal diagnosis preterm labor
      #5
      Charles H Rodeck
      prenatal diagnosis fetal blood amniotic fluid
      #6
      Joe Leigh Leigh Simpson
      maternal blood prenatal diagnosis fetal cells

      Department of Obstetrics, Gynecology and Reproductive Sciences, University California, San Francisco, U.S.A. | Emeritus, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco | Departments of Obstetri

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