• Prenatal Diagnosis
    • Zoltán Papp
    • Zoltán Papp: Influence Statistics

      Zoltán Papp

      Zoltán Papp

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      Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary;, agnesbalogh@med.unideb.hu, (Á.B.);, ...

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      Zoltán Papp:Expert Impact

      Concepts for whichZoltán Papphas direct influence:Prenatal diagnosis,Heart failure,Hellp syndrome,Twin pregnancies,Amniotic fluid,Cystic fibrosis,Endometrial cancer,Fluorescent pcr.

      Zoltán Papp:KOL impact

      Concepts related to the work of other authors for whichfor which Zoltán Papp has influence:Heart failure,Preserved ejection fraction,Peripartum cardiomyopathy,Prenatal diagnosis,Diastolic dysfunction,Amniotic fluid,Hellp syndrome.

      KOL Resume for Zoltán Papp


      Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary;, (Á.B.);, (Z.P.)

      HAS-US Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Science, 1122 Budapest, Hungary


      Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, 22 Móricz Zsigmond street, Debrecen, 4032 Hungary


      Maternity Private Clinic, H-1126 Budapest, Hungary;,

      Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary


      Maternity Private Department, Kutvolgyi Clinical Block, Semmelweis University, Budapest, Hungary


      HAS‐UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary


      University of Debrecen Division of Clinical Physiology, Department of Cardiology, Research Centre for Molecular Medicine, Faculty of Medicine Debrecen Hungary


      Division of Clinical Physiology, Department of Cardiology, Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

      Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, University of Debrecen, 98 Nagyerdei krt., Debrecen H-4012, Hungary


      Division of Clinical Physiology Institute of Cardiology Research Centre for Molecular Medicine Faculty of Medicine University of Debrecen Debrecen Hungary

      Maternity Private Department, Kutvolgyi Clinical Block, Semmelweis University, Budapest, Hangary


      Division of Clinical Physiology, Faculty of Medicine, Institute of Cardiology, University of Debrecen, Móricz Zs. krt. 22, Debrecen 4032, Hungary

      Departments of Spine Surgery and


      Research Centre for Molecular Medicine, University of Debrecen, Debrecen, Hungary (AT, IE, ZP)

      Department of Medical Chemistry, University of Debrecen, Debrecen, Hungary (PB)

      Maternity Private Clinic of Obstetrics, Gynecology and Clinical Genetics, Budapest, Hungary


      Division of Clinical Physiology, Institute of Cardiology

      Research Center for Molecular Medicine, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary

      Department of Physics and Astronomy, California State University Long Beach, Long Beach, California 90840, USA

      Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Kardiológiai Intézet Debrecen Móricz Zs. krt. 22. 4032

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      Sample of concepts for which Zoltán Papp is among the top experts in the world.
      Concept World rank
      smas bas #1
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      Prominent publications by Zoltán Papp

      KOL-Index: 21240

      OBJECTIVES: Preterm parturition has been associated with decidual vascular disorders and excessive thrombin generation. The objective of this study was to examine maternal plasma concentrations of protein Z in normal pregnancies, as well as in those presenting with spontaneous preterm labor (PTL) and intrauterine bleeding during pregnancy.

      STUDY DESIGN: A cross-sectional study was designed to include patients with preterm labor and intact membranes and those with idiopathic intrauterine ...

      Known for Preterm Labor | Patients Ptl | Pregnant Women | Plasma Protein | Normal Pregnancies
      KOL-Index: 14283

      OBJECTIVES: Preeclampsia is considered an anti-angiogenic state. A role for the anti-angiogenic factors soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and soluble endoglin in preeclampsia has been proposed. Soluble vascular endothelial growth factor receptor-2 (sVEGFR-2) has been detected in human plasma, and the recombinant form of this protein has anti-angiogenic activity. There is a paucity of information about maternal plasma sVEGFR-2 concentrations in patients with ...

      Known for Gestational Age | Endothelial Growth | Preeclampsia Sga | Soluble Vascular | Plasma Concentration
      KOL-Index: 13631

      Insufficient invasion of the spiral arteries by trophoblast cells is associated with the etiology of pre-eclampsia, the syndrome of hemolysis, elevated liver enzymes and low platelet counts (HELLP) and pre-eclampsia-associated intrauterine growth restriction (IUGR). Mannose-binding lectin (MBL) is a component of the innate immune system. MBL-mediated activation of the complement cascade is an important event in the destruction of invading trophoblasts. The gene coding for MBL is ...

      Known for Hellp Syndrome | Binding Lectin | Women Eclampsia | Innate Immune | Trophoblast Cells
      KOL-Index: 13296

      1. Mechanical properties of permeabilized single fibres from rabbit psoas and soleus muscle were determined by measuring the length responses due to abrupt changes in load and the force responses due to isovelocity length changes at different phosphate and Ca2+ concentrations. 2. The length responses due to abrupt increases in load from psoas fibres showed a rapid lengthening during the change in load followed by a phase of lengthening during which the velocity gradually decreased. In ...

      Known for Mechanical Properties | Muscle Fibres | Rabbit Psoas | Force Responses | Lengthening Velocity
      KOL-Index: 13097

      OBJECTIVE: In human heart failure beta-adrenergic-mediated protein kinase A (PKA) activity is down-regulated, while protein kinase C (PKC) activity is up-regulated. PKC-mediated myofilament protein phosphorylation might be detrimental for contractile function in cardiomyopathy. This study was designed to reveal the effects of PKC on myofilament function in human myocardium under basal conditions and upon modulation of protein phosphorylation by PKA and phosphatases.

      METHODS: Isometric ...

      Known for Human Myocardium | Protein Kinase | Pka Pkc | Functional Effects | Mediated Myofilament
      KOL-Index: 13069

      High diastolic stiffness of failing myocardium results from interstitial fibrosis and elevated resting tension (F(passive)) of cardiomyocytes. A shift in titin isoform expression from N2BA to N2B isoform, lower overall phosphorylation of titin, and a shift in titin phosphorylation from N2B to N2BA isoform can raise F(passive) of cardiomyocytes. In left ventricular biopsies of heart failure (HF) patients, aortic stenosis (AS) patients, and controls (CON), we therefore related F(passive) ...

      Known for Titin Isoform | Fpassive Cardiomyocytes | Human Myocardium | Expression Phosphorylation | Resting Tension
      KOL-Index: 12808

      AIMS: This study was designed to evaluate the effects of the Na(+)/Ca(2+) exchange (NCX) inhibitor SEA0400 on Ca(2+) handling in isolated canine ventricular myocytes.

      METHODS AND RESULTS: Intracellular Ca(2+) ([Ca(2+)](i)) transients, induced by either field stimulation or caffeine flush, were monitored using Ca(2+) indicator dyes. [Ca(2+)](i)-dependent modulation of the inhibitory effect of SEA0400 on NCX was characterized by the changes in Ni(2+)-sensitive current in voltage-clamped ...

      Known for Sea0400 Ca2 | Sarcoplasmic Reticulum | Canine Ventricular | Myocytes Cardiac | Type Calcium
      KOL-Index: 11952

      Angiotensin-converting enzyme (ACE) inhibitors represent the fifth most often prescribed drugs. ACE inhibitors decrease 5-year mortality by approximately one-fifth in cardiovascular patients. Surprisingly, there are reports dating back to 1979 suggesting the existence of endogenous ACE inhibitors, which endogenous inhibitory effects are much less characterized than that for the clinically administered ACE inhibitors. Here we aimed to investigate this endogenous ACE inhibition in human ...

      Known for Ace Activity | Converting Enzyme | New Perspectives | Endogenous Inhibitor | Human Sera
      KOL-Index: 11911

      OBJECTIVE: The alterations in contractile proteins underlying enhanced Ca(2+)-sensitivity of the contractile apparatus in end-stage failing human myocardium are still not resolved. In the present study an attempt was made to reveal to what extent protein alterations contribute to the increased Ca(2+)-responsiveness in human heart failure.

      METHODS: Isometric force and its Ca(2+)-sensitivity were studied in single left ventricular myocytes from non-failing donor (n=6) and end-stage failing ...

      Known for Contractile Apparatus | Altered Phosphorylation | Stage Human | Heart Failure | Failing Donor
      KOL-Index: 11885

      Organ injury and impairment are commonly observed in patients with acute heart failure (AHF), and congestion is an essential pathophysiological mechanism of impaired organ function. Congestion is the predominant clinical profile in most patients with AHF; a smaller proportion presents with peripheral hypoperfusion or cardiogenic shock. Hypoperfusion further deteriorates organ function. The injury and dysfunction of target organs (i.e. heart, lungs, kidneys, liver, intestine, brain) in ...

      Known for Organ Dysfunction | Heart Failure Association | Patients Ahf | Failure Acute | Cardiogenic Shock
      KOL-Index: 11871

      BACKGROUND: Placental Protein 13 (PP13), an early biomarker of preeclampsia, is a placenta-specific galectin that binds beta-galactosides, building-blocks of ABO blood-group antigens, possibly affecting its bioavailability in blood.

      METHODS AND FINDINGS: We studied PP13-binding to erythrocytes, maternal blood-group effect on serum PP13 and its performance as a predictor of preeclampsia and intrauterine growth restriction (IUGR). Datasets of maternal serum PP13 in Caucasian (n = 1078) and ...

      Known for Abo Blood | Pp13 Pregnancy | Placental Protein | Maternal Serum | Early Biomarker
      KOL-Index: 11705

      OBJECTIVE: To determine whether chronic suppurative otitis media may cause sensorineural hearing loss.

      METHODS: The files of 121 patients with unilateral chronic suppurative otitis media were reviewed in a retrospective study. Air conduction and bone conduction threshold averages were calculated over the speech frequencies (500 Hz, 1,000 Hz, and 2,000 Hz). Thresholds at 4 kHz were examined separately but in a similar way. Multiple linear regression models were used to clarify the ...

      Known for Sensorineural Hearing Loss | Chronic Otitis | 4 Khz | Media Suppurative | Higher Frequencies
      KOL-Index: 11570

      OBJECTIVE: Phosphorylation of the myosin light chain 2 (MLC-2) isoform expressed as a percentage of total MLC-2 was decreased in failing (21.1+/-2.0%) compared to donor (31.9+/-4.8%) hearts. To assess the functional implications of this change, we compared the effects of MLC-2 dephosphorylation on force development in failing and non-failing (donor) human hearts.

      METHODS: Cooperative effects in isometric force and rate of force redevelopment (K(tr)) were studied in single Triton-skinned ...

      Known for Myosin Light | Failing Human | Chain 2 | Donor Hearts | Force Development
      KOL-Index: 11513

      BACKGROUND: The involvement of the placenta in the pathogenesis of preeclampsia and HELLP syndrome is well established, and placental lesions are also similar in these two syndromes. Here we aimed to examine the placental transcriptome and to identify candidate biomarkers in early-onset preeclampsia and HELLP syndrome.

      METHODS: Placental specimens were obtained at C-sections from women with early-onset preeclampsia and HELLP syndrome, and from controls who delivered preterm or at term. ...

      Known for Hellp Syndrome | Placental Transcriptome | Gene Expression | Earlyonset Preeclampsia | Gestational Age
      KOL-Index: 11181

      The vanilloid receptor (TRPV1 or VR1) is a molecular integrator of various painful stimuli, including capsaicin, acid, and high temperature. It can also be activated by endogenous ligands, like the cannabinoid 1 receptor (CB1) agonist anandamide. TRPV1 is well characterized at the terminals of sensory nerves involved in the pain pathway. There is also evidence that TRPV1 is expressed in the brain but little is known about its function. Here, using commercially available specific ...

      Known for Vanilloid Receptor | Trpv1 Brain | Rat Astrocytes | Neurons Hippocampus | Olfactory Bulb

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      Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary;, agnesbalogh@med.unideb.hu, (Á.B.);, pappz@med.unideb.hu, (Z.P.) | Division of Clinical Physiology, Faculty of Medicine, U

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